CRISPR Pioneer Doudna: Humans on Cusp of 'New Age in Biological Mastery'
Broad Institute Wins Decision Over UC Berkeley in CRISPR Patent Battle
Billions at Stake: UC Berkeley's Day in Court vs. Harvard/MIT Over CRISPR
Yes, Even CRISPR Pioneer Jennifer Doudna Experiences Gender Bias
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The U.S. patent office, in a February \u003ca href=\"https://www.statnews.com/2017/02/15/crispr-patent-ruling/\">ruling\u003c/a> that let the Broad keep its CRISPR patents (for now), relied heavily on those statements — “We weren’t sure if CRISPR/Cas9 would work in … animal cells,” for example — to conclude that when scientists at the Broad \u003ca href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795411/\" target=\"_blank\" rel=\"noopener noreferrer\">CRISPR’d human cells\u003c/a> in 2013, it was a non-obvious advance and therefore deserving of patents.\u003c/p>\n\u003cp class=\"danger-zone\">So it’s striking that the careful, measured Doudna who said CRISPR’ing human cells and thereby curing devastating diseases would be a challenge is hardly in evidence in “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution,” the new book she co-authored with her former student Samuel Sternberg. It went on sale last week.\u003c/p>\n\u003cp class=\"danger-zone\">This Doudna doesn’t hold back. We are “on the cusp of a new age in genetic engineering and biological mastery,” she and Sternberg write, dangling the prospect of “life-changing treatments” and “lifesaving cures.” She says she is “not kidding” that CRISPR could bring about “woolly mammoths, winged lizards, and unicorns. … It won’t be long before CRISPR allows us to bend nature to our will.”\u003c/p>\n\u003cp class=\"danger-zone\">The hyperbole contrasts with CRISPR’s stumbles, including altering parts of genomes (in lab studies, not patients yet) it wasn’t supposed to. “I don’t think we’ll have a version of CRISPR that’s 100 percent perfect, so it comes down to a risk-benefit analysis,” Sternberg, a biochemist at \u003ca href=\"https://www.statnews.com/2016/06/22/rachel-haurwitz-crispr-caribou/\">Caribou Biosciences\u003c/a> (which Doudna co-founded), said in an interview. “There has been phenomenal progress in understanding off-target effects; I think it’s a solvable problem. … We have every reason to be optimistic but I hope we avoided overhyping and didn’t give the impression that there would be windfall of cures in the next couple of years.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>This is not a tell-all. The farthest Doudna goes in addressing the patent fight — a “disheartening twist” — is to say that because of such rivalries she experienced “the gamut of human relationships, from deep friendships to disturbing betrayals.” She doesn’t name the betrayers.\u003c/p>\n\u003cp>An early \u003ca href=\"https://www.nature.com/nature/journal/v546/n7656/full/546030a.html\" target=\"_blank\" rel=\"noopener noreferrer\">review\u003c/a> chastised Doudna for presenting herself as “so flawless” the book “seems more concealing than revealing,” not “insightful [and] candid.”\u003c/p>\n\u003cp>So what she does choose to reveal is fascinating, especially about her collaboration with Emmanuelle Charpentier. The two are so closely linked that all the prizes they’ve won for CRISPR, they’ve won together; among CRISPR watchers “Doudna and Charpentier” is virtually a macro.\u003c/p>\n\u003cp>But the book’s account of their breakthrough experiment showing that CRISPR could be programmed to edit a precise spot in a genome leaves a different impression. We read that “Martin [Jinek, Doudna’s postdoctoral fellow] showed” and “Martin labored tirelessly,” “Martin and I brainstormed” and “designed an experiment,” and when “Martin walked me through the data,” Doudna knew “we’d done it.”\u003c/p>\n\u003cp>That work was described in the 2012 paper, which is widely recognized — by prize committees, the European Patent Office, and many scientists — as the Bastille moment for the CRISPR revolution. It identified the three crucial molecules in the CRISPR system — one to cut, one to guide the cutting enzyme to its target DNA, one to activate the cutting enzyme — that produced a programmable DNA-cutting machine. “We had built the means to rewrite the code of life,” Doudna and Sternberg write. “Nothing after that would ever be the same.”\u003c/p>\n\u003cp>Although Doudna and her collaborators didn’t actually change genomes in cells — their CRISPR molecules altered cell-free DNA in test tubes — that was an obvious next step. How difficult a next step was the core dispute in the patent fight and one that she repeatedly cautioned was no slam dunk. But “Crack in Creation” says that doing so “was immediately clear to us,” and “there were good reasons to expect success.”\u003c/p>\n\u003cp>That contrasts with her cautious statements, cited by the patent office, at the time. When \u003ca href=\"https://www.statnews.com/2015/11/06/hollywood-inspired-scientist-rewrite-code-life/\">Feng Zhang\u003c/a> of the Broad Institute and \u003ca href=\"https://www.statnews.com/2017/06/08/george-church-narcolepsy/\">George Church\u003c/a> of Harvard used CRISPR to edit genes, it was “just as we had proposed in 2012,” according to the book. She was elated that her 2012 work “inspired others to pursue a line of experimentation similar to our own.”\u003c/p>\n\u003cp>Doudna became a public scientist — she’s given a \u003ca href=\"https://www.ted.com/talks/jennifer_doudna_we_can_now_edit_our_dna_but_let_s_do_it_wisely\" target=\"_blank\" rel=\"noopener noreferrer\">TED talk\u003c/a> and will appear on “Sunday Night with Megyn Kelly” — because of her research, but also because she was instrumental in getting the scientific community to focus on ethical issues it raises, especially about editing embryos in a way that would be inherited by future generations (“germline” editing). She writes that she had nightmares that a man asking her about this was Hitler and that she “began to feel a bit like Dr. Frankenstein.”\u003c/p>\n\u003cp>Her own moral journey is intriguing. She feels germline editing can be safe, and the “it’s unnatural!” argument “doesn’t carry much weight with me anymore,” she writes. “It seems to me that we’d be justified in using” CRISPR to eliminate genes that cause untold suffering, such as those for Huntington’s disease. “When I think about the pain that genetic diseases cause families, the stakes are simply too high to exclude the possibility of eventually using germline editing,” as an expert panel also \u003ca href=\"https://www.statnews.com/2017/02/14/national-academy-crispr-report/\">concluded\u003c/a>.\u003c/p>\n\u003cp>Doudna acknowledges, however, that “it’s difficult to see how we’d do it equitably,” especially when the line between therapy and enhancement is paper thin: Some families might purchase a genetic legacy that gives them less need for sleep, greater endurance, extra-strong bones, leaner or larger muscles, lower risk of diabetes and Alzheimer’s, even less armpit odor — while other families muddle through with the genes nature gave them.\u003c/p>\n\u003cp>That threatens to “transcribe our societies’ financial inequality into our genetic code,” Doudna writes.\u003c/p>\n\u003cp>Her solution? “Redoubl[ing] our commitment to building a society in which all humans are respected and treated equally, regardless of their genetic makeup.”\u003c/p>\n\u003cp>\u003cem>Update, June 14: Doudna, whose office cancelled an interview with STAT before this story ran, said in an email that “positioning Martin Jinek’s role to your readers as above the work of Emmanuelle Charpentier is incorrect and unfair. Our work was conducted closely with Emmanuelle, whose contributions and insights including the role of tracrRNA in the DNA targeting complex were a key aspect of the development of CRISPR-Cas as a gene editing technology.”\u003c/em>\u003c/p>\n\u003cp>\u003cem>\u003cspan style=\"font-weight: 400\">This \u003ca href=\"https://www.statnews.com/2017/06/11/crispr-jennifer-doudna-book/\" target=\"_blank\" rel=\"noopener noreferrer\">story \u003c/a>was originally published by STAT, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery. \u003c/span>\u003c/em>\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp> \u003c/p>\n\n","blocks":[],"excerpt":"In 'A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution,' UC Berkeley's Jennifer Doudna says CRISPR could result in life-saving cures, woolly mammoths and unicorns.","status":"publish","parent":0,"modified":1497976282,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":1318},"headData":{"title":"CRISPR Pioneer Doudna: Humans on Cusp of 'New Age in Biological Mastery' | KQED","description":"In 'A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution,' UC Berkeley's Jennifer Doudna says CRISPR could result in life-saving cures, woolly mammoths and unicorns.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"CRISPR Pioneer Doudna: Humans on Cusp of 'New Age in Biological Mastery'","datePublished":"2017-06-19T22:49:29.000Z","dateModified":"2017-06-20T16:31:22.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"408504 https://ww2.kqed.org/futureofyou/?p=408504","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/06/19/crispr-pioneer-doudna-humans-on-cusp-of-new-age-in-biological-mastery/","disqusTitle":"CRISPR Pioneer Doudna: Humans on Cusp of 'New Age in Biological Mastery'","source":"KQED Future of You","nprByline":"Sharon Begley\u003cbr />\u003ca href=\"https://www.statnews.com/2\">STAT\u003c/a>","path":"/futureofyou/408504/crispr-pioneer-doudna-humans-on-cusp-of-new-age-in-biological-mastery","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>If there was one misstep that doomed the \u003ca href=\"https://www.statnews.com/2017/04/13/crispr-patent-uc-appeal/\">long and bitter fight\u003c/a> by the University of California to wrest key CRISPR patents from the Broad Institute, it was star UC Berkeley scientist Jennifer Doudna’s habit of being scientifically cautious, realistic, and averse to overpromising.\u003c/p>\n\u003cp>A biochemist who co-led a breakthrough \u003ca href=\"http://science.sciencemag.org/content/337/6096/816\" target=\"_blank\" rel=\"noopener noreferrer\">2012 study\u003c/a> of CRISPR-Cas9, Doudna repeatedly emphasized in interviews the challenges of repurposing the molecular system, which bacteria use to fend off viruses, to edit human genomes. The U.S. patent office, in a February \u003ca href=\"https://www.statnews.com/2017/02/15/crispr-patent-ruling/\">ruling\u003c/a> that let the Broad keep its CRISPR patents (for now), relied heavily on those statements — “We weren’t sure if CRISPR/Cas9 would work in … animal cells,” for example — to conclude that when scientists at the Broad \u003ca href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795411/\" target=\"_blank\" rel=\"noopener noreferrer\">CRISPR’d human cells\u003c/a> in 2013, it was a non-obvious advance and therefore deserving of patents.\u003c/p>\n\u003cp class=\"danger-zone\">So it’s striking that the careful, measured Doudna who said CRISPR’ing human cells and thereby curing devastating diseases would be a challenge is hardly in evidence in “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution,” the new book she co-authored with her former student Samuel Sternberg. It went on sale last week.\u003c/p>\n\u003cp class=\"danger-zone\">This Doudna doesn’t hold back. We are “on the cusp of a new age in genetic engineering and biological mastery,” she and Sternberg write, dangling the prospect of “life-changing treatments” and “lifesaving cures.” She says she is “not kidding” that CRISPR could bring about “woolly mammoths, winged lizards, and unicorns. … It won’t be long before CRISPR allows us to bend nature to our will.”\u003c/p>\n\u003cp class=\"danger-zone\">The hyperbole contrasts with CRISPR’s stumbles, including altering parts of genomes (in lab studies, not patients yet) it wasn’t supposed to. “I don’t think we’ll have a version of CRISPR that’s 100 percent perfect, so it comes down to a risk-benefit analysis,” Sternberg, a biochemist at \u003ca href=\"https://www.statnews.com/2016/06/22/rachel-haurwitz-crispr-caribou/\">Caribou Biosciences\u003c/a> (which Doudna co-founded), said in an interview. “There has been phenomenal progress in understanding off-target effects; I think it’s a solvable problem. … We have every reason to be optimistic but I hope we avoided overhyping and didn’t give the impression that there would be windfall of cures in the next couple of years.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>This is not a tell-all. The farthest Doudna goes in addressing the patent fight — a “disheartening twist” — is to say that because of such rivalries she experienced “the gamut of human relationships, from deep friendships to disturbing betrayals.” She doesn’t name the betrayers.\u003c/p>\n\u003cp>An early \u003ca href=\"https://www.nature.com/nature/journal/v546/n7656/full/546030a.html\" target=\"_blank\" rel=\"noopener noreferrer\">review\u003c/a> chastised Doudna for presenting herself as “so flawless” the book “seems more concealing than revealing,” not “insightful [and] candid.”\u003c/p>\n\u003cp>So what she does choose to reveal is fascinating, especially about her collaboration with Emmanuelle Charpentier. The two are so closely linked that all the prizes they’ve won for CRISPR, they’ve won together; among CRISPR watchers “Doudna and Charpentier” is virtually a macro.\u003c/p>\n\u003cp>But the book’s account of their breakthrough experiment showing that CRISPR could be programmed to edit a precise spot in a genome leaves a different impression. We read that “Martin [Jinek, Doudna’s postdoctoral fellow] showed” and “Martin labored tirelessly,” “Martin and I brainstormed” and “designed an experiment,” and when “Martin walked me through the data,” Doudna knew “we’d done it.”\u003c/p>\n\u003cp>That work was described in the 2012 paper, which is widely recognized — by prize committees, the European Patent Office, and many scientists — as the Bastille moment for the CRISPR revolution. It identified the three crucial molecules in the CRISPR system — one to cut, one to guide the cutting enzyme to its target DNA, one to activate the cutting enzyme — that produced a programmable DNA-cutting machine. “We had built the means to rewrite the code of life,” Doudna and Sternberg write. “Nothing after that would ever be the same.”\u003c/p>\n\u003cp>Although Doudna and her collaborators didn’t actually change genomes in cells — their CRISPR molecules altered cell-free DNA in test tubes — that was an obvious next step. How difficult a next step was the core dispute in the patent fight and one that she repeatedly cautioned was no slam dunk. But “Crack in Creation” says that doing so “was immediately clear to us,” and “there were good reasons to expect success.”\u003c/p>\n\u003cp>That contrasts with her cautious statements, cited by the patent office, at the time. When \u003ca href=\"https://www.statnews.com/2015/11/06/hollywood-inspired-scientist-rewrite-code-life/\">Feng Zhang\u003c/a> of the Broad Institute and \u003ca href=\"https://www.statnews.com/2017/06/08/george-church-narcolepsy/\">George Church\u003c/a> of Harvard used CRISPR to edit genes, it was “just as we had proposed in 2012,” according to the book. She was elated that her 2012 work “inspired others to pursue a line of experimentation similar to our own.”\u003c/p>\n\u003cp>Doudna became a public scientist — she’s given a \u003ca href=\"https://www.ted.com/talks/jennifer_doudna_we_can_now_edit_our_dna_but_let_s_do_it_wisely\" target=\"_blank\" rel=\"noopener noreferrer\">TED talk\u003c/a> and will appear on “Sunday Night with Megyn Kelly” — because of her research, but also because she was instrumental in getting the scientific community to focus on ethical issues it raises, especially about editing embryos in a way that would be inherited by future generations (“germline” editing). She writes that she had nightmares that a man asking her about this was Hitler and that she “began to feel a bit like Dr. Frankenstein.”\u003c/p>\n\u003cp>Her own moral journey is intriguing. She feels germline editing can be safe, and the “it’s unnatural!” argument “doesn’t carry much weight with me anymore,” she writes. “It seems to me that we’d be justified in using” CRISPR to eliminate genes that cause untold suffering, such as those for Huntington’s disease. “When I think about the pain that genetic diseases cause families, the stakes are simply too high to exclude the possibility of eventually using germline editing,” as an expert panel also \u003ca href=\"https://www.statnews.com/2017/02/14/national-academy-crispr-report/\">concluded\u003c/a>.\u003c/p>\n\u003cp>Doudna acknowledges, however, that “it’s difficult to see how we’d do it equitably,” especially when the line between therapy and enhancement is paper thin: Some families might purchase a genetic legacy that gives them less need for sleep, greater endurance, extra-strong bones, leaner or larger muscles, lower risk of diabetes and Alzheimer’s, even less armpit odor — while other families muddle through with the genes nature gave them.\u003c/p>\n\u003cp>That threatens to “transcribe our societies’ financial inequality into our genetic code,” Doudna writes.\u003c/p>\n\u003cp>Her solution? “Redoubl[ing] our commitment to building a society in which all humans are respected and treated equally, regardless of their genetic makeup.”\u003c/p>\n\u003cp>\u003cem>Update, June 14: Doudna, whose office cancelled an interview with STAT before this story ran, said in an email that “positioning Martin Jinek’s role to your readers as above the work of Emmanuelle Charpentier is incorrect and unfair. Our work was conducted closely with Emmanuelle, whose contributions and insights including the role of tracrRNA in the DNA targeting complex were a key aspect of the development of CRISPR-Cas as a gene editing technology.”\u003c/em>\u003c/p>\n\u003cp>\u003cem>\u003cspan style=\"font-weight: 400\">This \u003ca href=\"https://www.statnews.com/2017/06/11/crispr-jennifer-doudna-book/\" target=\"_blank\" rel=\"noopener noreferrer\">story \u003c/a>was originally published by STAT, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery. \u003c/span>\u003c/em>\u003c/p>\n\u003cp> \u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"floatright"},"numeric":["floatright"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/408504/crispr-pioneer-doudna-humans-on-cusp-of-new-age-in-biological-mastery","authors":["byline_futureofyou_408504"],"categories":["futureofyou_452","futureofyou_1","futureofyou_73"],"tags":["futureofyou_1308","futureofyou_94","futureofyou_1275","futureofyou_790"],"label":"source_futureofyou_408504"},"futureofyou_338066":{"type":"posts","id":"futureofyou_338066","meta":{"index":"posts_1591205157","site":"futureofyou","id":"338066","score":null,"sort":[1487263047000]},"guestAuthors":[],"slug":"broad-institute-wins-decision-over-uc-berkeley-in-crispr-patent-battle","title":"Broad Institute Wins Decision Over UC Berkeley in CRISPR Patent Battle","publishDate":1487263047,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{},"content":"\u003cp>The U.S. patent office has delivered a potentially lucrative victory to bioengineer \u003ca href=\"https://www.broadinstitute.org/zhang-lab\">Feng Zhang\u003c/a> of the Broad Institute in Massachusetts, regarding patents for an extraordinarily useful gene-editing tool.\u003c/p>\n\u003cp>\u003ca href=\"http://www.npr.org/tags/419142387/crispr\">CRISPR\u003c/a>, a technology that's already worth billions of dollars, is shaping up to play a big role in medicine and medical research because it can edit DNA with unprecedented accuracy. But exactly who has the right to profit from the technology has been up for debate.\u003c/p>\n\u003cp>Wednesday the U.S. Patent and Trademark Office said patents issued to the Broad Institute in 2014, and then challenged by the University of California, Berkeley, are in fact valid.\u003c/p>\n\u003cp>\"It's a pretty monumental decision here,\" said \u003ca href=\"http://www.nyls.edu/faculty/faculty-profiles/faculty_profiles/jacob-s-sherkow/\">Jacob Sherkow\u003c/a>, an associate professor at the New York Law School, who has been tracking the dispute closely.\u003c/p>\n\u003cp>\"It seems to reward the most valuable aspect of CRISPR to the Broad Institute,\" Sherkow told Shots.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The proceedings aren't entirely settled, but as Sherkow sees the situation, the Broad Institute — a joint venture of Harvard University and MIT — will hold the patent for using CRISPR in human beings, other animals, and plants. Sherkow told Shots he believes Cal's patent, which has not yet been issued, could be limited to bacteria.\u003c/p>\n\u003cp>\"Obviously the patents covering the application of this technology in human cells ... are going to be much more financially valuable than using the same technology in bacteria,\" Sherkow says, \"because one can develop drugs and other therapies from them.\"\u003c/p>\n\u003cp>Investors Wednesday seemed to agree with this assessment. The value of companies that were spun off to license the Broad patents rose sharply, while the company based on the Berkeley patent lost value.\u003c/p>\n\u003cp>Potentially, tens of billions of dollars are at stake here, both for the companies and for the universities.\u003c/p>\n\u003cp>Biochemist \u003ca href=\"https://www.hhmi.org/scientists/jennifer-doudna\">Jennifer Doudna\u003c/a>, of U.C. Berkeley and the Howard Hughes Medical Institute, discovered the biology that underlies this technology along with a European colleague, \u003ca href=\"https://www.mpg.de/9343753/infektionsbiologie-charpentier\">Emmanuelle Charpentier\u003c/a>, who is now director of the Institute for Infection Biology at the Max Planck Institute in Berlin.\u003c/p>\n\u003cp>Doudna told Shots she isn't convinced that Berkeley is the big loser here. She said the ruling paves the way for her patent application to move forward.\u003c/p>\n\u003cp>\"We're looking forward to having our patent issued,\" she said. \"And our patent is a very broad patent that covers the composition and the use of this technology in all cell types.\"\u003c/p>\n\u003cp>If the patent office rules the way Doudna hopes it will, people wanting to use CRISPR in higher organisms will have get licenses from both Berkeley and the Broad Institute.\u003c/p>\n\u003cp>\"That's the thing that I think is a bit crazy about the way the decision comes down,\" Doudna said. \"It leaves the field — the situation — where a license would be necessary from both parties. There's not further clarity at this stage.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>There's yet another possibility: Berkeley could appeal Wednesday's ruling, and once again challenge the Broad Institute's patents. Doudna said the university hasn't decided what to do just yet.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Broad+Institute+Wins+Big+Battle+Over+CRISPR+Gene-Editing+Patent&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n","blocks":[],"excerpt":"CRISPR technology is already worth billions of dollars, investors say. This ruling seems to affirm the biggest piece of the pie goes to the Broad, over patent rival University of California, Berkeley.","status":"publish","parent":0,"modified":1487263912,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":17,"wordCount":523},"headData":{"title":"Broad Institute Wins Decision Over UC Berkeley in CRISPR Patent Battle | KQED","description":"CRISPR technology is already worth billions of dollars, investors say. This ruling seems to affirm the biggest piece of the pie goes to the Broad, over patent rival University of California, Berkeley.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Broad Institute Wins Decision Over UC Berkeley in CRISPR Patent Battle","datePublished":"2017-02-16T16:37:27.000Z","dateModified":"2017-02-16T16:51:52.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"338066 https://ww2.kqed.org/futureofyou/?p=338066","disqusUrl":"https://ww2.kqed.org/futureofyou/2017/02/16/broad-institute-wins-decision-over-uc-berkeley-in-crispr-patent-battle/","disqusTitle":"Broad Institute Wins Decision Over UC Berkeley in CRISPR Patent Battle","source":"KQED Future of You","nprByline":"Richard Harris\u003cbr />NPR Shots","nprStoryId":"515459773","nprApiLink":"http://api.npr.org/query?id=515459773&apiKey=MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004","nprHtmlLink":"http://www.npr.org/sections/health-shots/2017/02/15/515459773/broad-institute-wins-big-battle-over-crispr-gene-editing-patent?ft=nprml&f=515459773","nprRetrievedStory":"1","nprPubDate":"Thu, 16 Feb 2017 09:22:00 -0500","nprStoryDate":"Wed, 15 Feb 2017 19:31:00 -0500","nprLastModifiedDate":"Thu, 16 Feb 2017 09:05:42 -0500","nprAudio":"https://ondemand.npr.org/anon.npr-mp3/npr/me/2017/02/20170216_me_broad_institute_wins_big_battle_over_crispr_gene-editing_patent.mp3?orgId=1&topicId=1128&d=190&p=3&story=515459773&t=progseg&e=515529274&seg=16&ft=nprml&f=515459773","nprAudioM3u":"http://api.npr.org/m3u/1515529417-49b234.m3u?orgId=1&topicId=1128&d=190&p=3&story=515459773&t=progseg&e=515529274&seg=16&ft=nprml&f=515459773","path":"/futureofyou/338066/broad-institute-wins-decision-over-uc-berkeley-in-crispr-patent-battle","audioUrl":"https://ondemand.npr.org/anon.npr-mp3/npr/me/2017/02/20170216_me_broad_institute_wins_big_battle_over_crispr_gene-editing_patent.mp3?orgId=1&topicId=1128&d=190&p=3&story=515459773&t=progseg&e=515529274&seg=16&ft=nprml&f=515459773","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>The U.S. patent office has delivered a potentially lucrative victory to bioengineer \u003ca href=\"https://www.broadinstitute.org/zhang-lab\">Feng Zhang\u003c/a> of the Broad Institute in Massachusetts, regarding patents for an extraordinarily useful gene-editing tool.\u003c/p>\n\u003cp>\u003ca href=\"http://www.npr.org/tags/419142387/crispr\">CRISPR\u003c/a>, a technology that's already worth billions of dollars, is shaping up to play a big role in medicine and medical research because it can edit DNA with unprecedented accuracy. But exactly who has the right to profit from the technology has been up for debate.\u003c/p>\n\u003cp>Wednesday the U.S. Patent and Trademark Office said patents issued to the Broad Institute in 2014, and then challenged by the University of California, Berkeley, are in fact valid.\u003c/p>\n\u003cp>\"It's a pretty monumental decision here,\" said \u003ca href=\"http://www.nyls.edu/faculty/faculty-profiles/faculty_profiles/jacob-s-sherkow/\">Jacob Sherkow\u003c/a>, an associate professor at the New York Law School, who has been tracking the dispute closely.\u003c/p>\n\u003cp>\"It seems to reward the most valuable aspect of CRISPR to the Broad Institute,\" Sherkow told Shots.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The proceedings aren't entirely settled, but as Sherkow sees the situation, the Broad Institute — a joint venture of Harvard University and MIT — will hold the patent for using CRISPR in human beings, other animals, and plants. Sherkow told Shots he believes Cal's patent, which has not yet been issued, could be limited to bacteria.\u003c/p>\n\u003cp>\"Obviously the patents covering the application of this technology in human cells ... are going to be much more financially valuable than using the same technology in bacteria,\" Sherkow says, \"because one can develop drugs and other therapies from them.\"\u003c/p>\n\u003cp>Investors Wednesday seemed to agree with this assessment. The value of companies that were spun off to license the Broad patents rose sharply, while the company based on the Berkeley patent lost value.\u003c/p>\n\u003cp>Potentially, tens of billions of dollars are at stake here, both for the companies and for the universities.\u003c/p>\n\u003cp>Biochemist \u003ca href=\"https://www.hhmi.org/scientists/jennifer-doudna\">Jennifer Doudna\u003c/a>, of U.C. Berkeley and the Howard Hughes Medical Institute, discovered the biology that underlies this technology along with a European colleague, \u003ca href=\"https://www.mpg.de/9343753/infektionsbiologie-charpentier\">Emmanuelle Charpentier\u003c/a>, who is now director of the Institute for Infection Biology at the Max Planck Institute in Berlin.\u003c/p>\n\u003cp>Doudna told Shots she isn't convinced that Berkeley is the big loser here. She said the ruling paves the way for her patent application to move forward.\u003c/p>\n\u003cp>\"We're looking forward to having our patent issued,\" she said. \"And our patent is a very broad patent that covers the composition and the use of this technology in all cell types.\"\u003c/p>\n\u003cp>If the patent office rules the way Doudna hopes it will, people wanting to use CRISPR in higher organisms will have get licenses from both Berkeley and the Broad Institute.\u003c/p>\n\u003cp>\"That's the thing that I think is a bit crazy about the way the decision comes down,\" Doudna said. \"It leaves the field — the situation — where a license would be necessary from both parties. There's not further clarity at this stage.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>There's yet another possibility: Berkeley could appeal Wednesday's ruling, and once again challenge the Broad Institute's patents. Doudna said the university hasn't decided what to do just yet.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Broad+Institute+Wins+Big+Battle+Over+CRISPR+Gene-Editing+Patent&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/338066/broad-institute-wins-decision-over-uc-berkeley-in-crispr-patent-battle","authors":["byline_futureofyou_338066"],"categories":["futureofyou_452","futureofyou_1062","futureofyou_1","futureofyou_73"],"tags":["futureofyou_91","futureofyou_94","futureofyou_790","futureofyou_80","futureofyou_89"],"label":"source_futureofyou_338066"},"futureofyou_295997":{"type":"posts","id":"futureofyou_295997","meta":{"index":"posts_1591205157","site":"futureofyou","id":"295997","score":null,"sort":[1481216406000]},"guestAuthors":[],"slug":"billions-at-stake-uc-berkeley-gets-day-in-court-vs-harvardmit","title":"Billions at Stake: UC Berkeley's Day in Court vs. Harvard/MIT Over CRISPR","publishDate":1481216406,"format":"standard","headTitle":"KQED Future of You | KQED Science","labelTerm":{"site":"futureofyou"},"content":"\u003cp>It's called CRISPR-Cas9 — one of the century's biggest scientific breakthroughs in genetic engineering\u003cem> — \u003c/em>and now three major universities are battling it out in court over who owns a patent on the revolutionary technology.\u003c/p>\n\u003cp>On Tuesday, UC Berkeley lawyers defended the university's claim to patent\u003cem> \u003c/em>CRISPR in a dispute that went before a panel of judges at the U.S Patent and Trademark headquarters in Alexandria, Virginia\u003cem>. \u003c/em>The Broad Institute of MIT and Harvard is also claiming it owns the rights to CRISPR.\u003c/p>\n\u003cp>CRISPR is a gene-editing tool that allows scientists to manipulate DNA by snipping out part of a mutated gene and substituting a healthy gene. It has huge implications \u003cem>—\u003c/em> from yielding new cancer therapies to correcting genetic disorders to modifying plant and animal DNA.\u003c/p>\n\u003ch3>Editing DNA Using CRISPR\u003c/h3>\n\u003cdiv class=\"row textColumnWidth\">\n\u003cdiv class=\"small-12 large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296418\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR01.png\" alt=\"crispr01\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01.png 750w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-160x285.png 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-240x427.png 240w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-375x667.png 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-520x925.png 520w\" sizes=\"(max-width: 750px) 100vw, 750px\">\u003c/div>\n\u003cdiv class=\"small-12 large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296419\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR02.png\" alt=\"crispr02\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02.png 750w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-160x285.png 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-240x427.png 240w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-375x667.png 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-520x925.png 520w\" sizes=\"(max-width: 750px) 100vw, 750px\">\u003c/div>\n\u003cdiv class=\"small-12 large-4 columns large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296420\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR_03_Bug.jpg\" alt=\"crispr_03_bug\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug-160x285.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug-240x427.jpg 240w\" sizes=\"(max-width: 375px) 100vw, 375px\">\u003c/div>\n\u003c/div>\n\u003cp>\"If Berkeley wins it means they’re essentially going to control which commercial companies are able to develop the technology going forward and that will be a huge change in the status quo,\" says New York Law School professor says Jake Sherkow.\u003c/p>\n\u003cp>Sherkow says billions of dollars could be at stake. Companies that use the technology will likely need to pay royalties to whomever owns it -- Broad or Berkeley. Many start-ups including \u003ca href=\"https://www.addgene.org/\" target=\"_blank\">Addgene\u003c/a> -- a biotech non-profit working with Broad -- are already using CRISPR.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Both UC Berkeley and the Broad Institute of MIT and Harvard claim to have invented the technology and filed for patents.\u003cem> \u003c/em>\u003c/p>\n\u003cp>Berkeley filed first and even though Broad filed later, Broad fast-tracked its application, which was approved while Berkeley's was still pending. This is what Berkeley is contesting -- the fact that Broad's application was approved while its own was still under review.\u003c/p>\n\u003cp>The court has already ruled that the patent will be issued to the scientists who prove the CRISPR technology works in transforming the genes of a particular kind of cell -- \u003cem>eukaryotic\u003c/em> cells, those found in plants and animals, including humans.\u003c/p>\n\u003cp>In their research, Broad Institute bioengineer Feng Zhang and his team used eukaryotic cells, whereas UC Berkeley biochemist Jennifer Doudna used bacteria cells, not eukaryotic cells.\u003c/p>\n\u003cp>However, Doudna argues that UC Berkeley has a right to the patent because any skilled scientist could apply her team's research technique to eukaryotic cells.\u003c/p>\n\u003cp>Berkeley's lawyers faced more intense questioning on Tuesday than the Broad's.\u003c/p>\n\u003cp>\"It does speak to some of the judges' skepticism of the University of California's claims,\" says Sherkow.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The patent judges could make a decision by February but Sherkow says whichever side loses will likely appeal. So a final resolution may not come until 2018 or 2019.\u003c/p>\n\n","blocks":[],"excerpt":"Who owns the rights to CRISPR? That's up to U.S. patent judges and the decision could be worth billions. ","status":"publish","parent":0,"modified":1481222679,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":464},"headData":{"title":"Billions at Stake: UC Berkeley's Day in Court vs. Harvard/MIT Over CRISPR | KQED","description":"Who owns the rights to CRISPR? That's up to U.S. patent judges and the decision could be worth billions. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Billions at Stake: UC Berkeley's Day in Court vs. Harvard/MIT Over CRISPR","datePublished":"2016-12-08T17:00:06.000Z","dateModified":"2016-12-08T18:44:39.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"295997 http://ww2.kqed.org/futureofyou/?p=295997","disqusUrl":"https://ww2.kqed.org/futureofyou/2016/12/08/billions-at-stake-uc-berkeley-gets-day-in-court-vs-harvardmit/","disqusTitle":"Billions at Stake: UC Berkeley's Day in Court vs. Harvard/MIT Over CRISPR","path":"/futureofyou/295997/billions-at-stake-uc-berkeley-gets-day-in-court-vs-harvardmit","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>It's called CRISPR-Cas9 — one of the century's biggest scientific breakthroughs in genetic engineering\u003cem> — \u003c/em>and now three major universities are battling it out in court over who owns a patent on the revolutionary technology.\u003c/p>\n\u003cp>On Tuesday, UC Berkeley lawyers defended the university's claim to patent\u003cem> \u003c/em>CRISPR in a dispute that went before a panel of judges at the U.S Patent and Trademark headquarters in Alexandria, Virginia\u003cem>. \u003c/em>The Broad Institute of MIT and Harvard is also claiming it owns the rights to CRISPR.\u003c/p>\n\u003cp>CRISPR is a gene-editing tool that allows scientists to manipulate DNA by snipping out part of a mutated gene and substituting a healthy gene. It has huge implications \u003cem>—\u003c/em> from yielding new cancer therapies to correcting genetic disorders to modifying plant and animal DNA.\u003c/p>\n\u003ch3>Editing DNA Using CRISPR\u003c/h3>\n\u003cdiv class=\"row textColumnWidth\">\n\u003cdiv class=\"small-12 large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296418\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR01.png\" alt=\"crispr01\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01.png 750w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-160x285.png 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-240x427.png 240w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-375x667.png 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR01-520x925.png 520w\" sizes=\"(max-width: 750px) 100vw, 750px\">\u003c/div>\n\u003cdiv class=\"small-12 large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296419\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR02.png\" alt=\"crispr02\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02.png 750w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-160x285.png 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-240x427.png 240w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-375x667.png 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR02-520x925.png 520w\" sizes=\"(max-width: 750px) 100vw, 750px\">\u003c/div>\n\u003cdiv class=\"small-12 large-4 columns large-4 columns\">\u003cimg class=\"aligncenter size-full wp-image-296420\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/12/CRISPR_03_Bug.jpg\" alt=\"crispr_03_bug\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug-160x285.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2016/12/CRISPR_03_Bug-240x427.jpg 240w\" sizes=\"(max-width: 375px) 100vw, 375px\">\u003c/div>\n\u003c/div>\n\u003cp>\"If Berkeley wins it means they’re essentially going to control which commercial companies are able to develop the technology going forward and that will be a huge change in the status quo,\" says New York Law School professor says Jake Sherkow.\u003c/p>\n\u003cp>Sherkow says billions of dollars could be at stake. Companies that use the technology will likely need to pay royalties to whomever owns it -- Broad or Berkeley. Many start-ups including \u003ca href=\"https://www.addgene.org/\" target=\"_blank\">Addgene\u003c/a> -- a biotech non-profit working with Broad -- are already using CRISPR.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Both UC Berkeley and the Broad Institute of MIT and Harvard claim to have invented the technology and filed for patents.\u003cem> \u003c/em>\u003c/p>\n\u003cp>Berkeley filed first and even though Broad filed later, Broad fast-tracked its application, which was approved while Berkeley's was still pending. This is what Berkeley is contesting -- the fact that Broad's application was approved while its own was still under review.\u003c/p>\n\u003cp>The court has already ruled that the patent will be issued to the scientists who prove the CRISPR technology works in transforming the genes of a particular kind of cell -- \u003cem>eukaryotic\u003c/em> cells, those found in plants and animals, including humans.\u003c/p>\n\u003cp>In their research, Broad Institute bioengineer Feng Zhang and his team used eukaryotic cells, whereas UC Berkeley biochemist Jennifer Doudna used bacteria cells, not eukaryotic cells.\u003c/p>\n\u003cp>However, Doudna argues that UC Berkeley has a right to the patent because any skilled scientist could apply her team's research technique to eukaryotic cells.\u003c/p>\n\u003cp>Berkeley's lawyers faced more intense questioning on Tuesday than the Broad's.\u003c/p>\n\u003cp>\"It does speak to some of the judges' skepticism of the University of California's claims,\" says Sherkow.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The patent judges could make a decision by February but Sherkow says whichever side loses will likely appeal. So a final resolution may not come until 2018 or 2019.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/295997/billions-at-stake-uc-berkeley-gets-day-in-court-vs-harvardmit","authors":["5432"],"categories":["futureofyou_452","futureofyou_73","futureofyou_1064"],"tags":["futureofyou_91","futureofyou_94","futureofyou_790","futureofyou_80","futureofyou_89"],"featImg":"futureofyou_297041","label":"futureofyou"},"futureofyou_121640":{"type":"posts","id":"futureofyou_121640","meta":{"index":"posts_1591205157","site":"futureofyou","id":"121640","score":null,"sort":[1456965243000]},"guestAuthors":[],"slug":"yes-even-crispr-pioneer-jennifer-doudna-experiences-gender-bias","title":"Yes, Even CRISPR Pioneer Jennifer Doudna Experiences Gender Bias","publishDate":1456965243,"format":"standard","headTitle":"Future of You | KQED Future of You | KQED Science","labelTerm":{"term":54,"site":"futureofyou"},"content":"\u003cp>A Google search for the exact phrase \"\u003ca href=\"https://www.google.com/?gws_rd=ssl#q=%22barriers+to+women+in+science%22\" target=\"_blank\" rel=\"noopener\">barriers to women in science\u003c/a>\" brings up 85,000 results. \"\u003ca href=\"https://www.google.com/?gws_rd=ssl#q=%22barriers+for+women+in+science%22\" target=\"_blank\" rel=\"noopener\">Barriers for women in science\u003c/a>\" fetches another 30k and change.\u003c/p>\n\u003caside class=\"pullquote alignright\">\"I've gotten to a point where I do now see signs of the glass ceiling.\"\u003ccite>Jennifer Doudna\u003c/cite>\u003c/aside>\n\u003cp>Here's a 2010 \u003ca href=\"http://www.aauw.org/files/2013/02/Why-So-Few-Women-in-Science-Technology-Engineering-and-Mathematics.pdf\" target=\"_blank\" rel=\"noopener\">report\u003c/a> from the American Association of University Women that found negative stereotypes contributing to implicit bias against females in the STEM fields. This 2014 \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102172\" target=\"_blank\" rel=\"noopener\">survey\u003c/a> found 70 percent of female scientist trainees doing fieldwork had experienced sexual harassment.\u003c/p>\n\u003cp>So no, it's not a new concept. And yet, it was still a little unnerving to hear someone as prestigious as Jennifer Doudna -- a pioneer of the gene-editing technique CRISPR whom \u003ca href=\"http://www.nytimes.com/2015/05/12/science/jennifer-doudna-crispr-cas9-genetic-engineering.html\" target=\"_blank\" rel=\"noopener\">The New York Times\u003c/a> said \"helped make one of the most monumental discoveries in biology\" -- \u003ca href=\"http://www.kqed.org/a/forum/R201602151000\" target=\"_blank\" rel=\"noopener\">say on KQED Forum recently\u003c/a> that she, too, was hitting the proverbial glass ceiling. When asked if she'd ever experienced gender discrimination, she told host Michael Krasny:\u003c/p>\n\u003cblockquote>\u003cp>\"This topic comes up a lot and I have to say, earlier in my career, honestly, I never gave it a thought. I didn't think about my gender, I pursued my passion for science and research. But I do have to tell you, as I've gone on in my career, particularly the last 10 years or so, I've gotten to a point where I do now see signs of the glass ceiling. I don't think it's always intentional bias, but ... I do experience bias against women in some settings.\u003c/p>\n\u003cp>\"I think that what we're seeing is that it's very difficult for women to break into the top echelons of leadership in science. I'm not talking so much here about university leadership, but more leadership in the highest levels of public policy and the government, as well as in company board rooms.\"\u003c/p>\u003c/blockquote>\n\u003cp>[soundcloud url=\"https://api.soundcloud.com/tracks/247244078\" params=\"color=ff5500&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false\" width=\"100%\" height=\"166\" iframe=\"true\" /]\u003cbr>\n\u003cstrong>Overcoming Bias\u003c/strong>\u003c/p>\n\u003cp>Doudna is not alone. Last month, a panel at the Women in Science Summit in San Francisco shared personal experiences of gender discrimination.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"All along the way I would hear about my opportunities in science,\" said oceanographer Anne Russell. \"For example, ‘You could marry this guy, he’s a really good hydrologist.' [Or] you’d be talking to someone about your ideas and then he puts his arm around you.”\u003c/p>\n\u003cp>Russell now runs her own lab. But she is still aware of the potential for being minimized. When the press covers her research, she said, she makes sure she is the one piloting the boat.\u003c/p>\n\u003cp>Dawn Wright, chief scientist at the Environmental System Research Institute, said she was once on a months-long expedition at sea where she was one of five women on board, and the only woman of color. Despite her trepidation, she became friends with a male oil driller who had never worked with an African-American, let alone one who was a female scientist. She urged her colleagues, outnumbered in the male-dominated sciences, to persevere.\u003c/p>\n\u003cp>\"There is peril out there; we can't avoid it,\" she said. \"But there are really, really good things that can come from it as well if we continue to be courageous.\"\u003c/p>\n\u003cp>Finally there was Jonathan Eisen, a microbiologist at the University of California, Davis who has become an outspoken critic on social media of the lack of diversity at scientific conferences. He said his awareness about barriers to women's participation started when he saw a nanny watching a baby outside a scientific conference; she'd been hired so the infant's mother could attend the conference.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“It was literally one of those light bulb epiphany moments where my privilege in my life came front and center to me, because it had never occurred to me to that this would be an issue for anybody,” Eisen said. “I changed on that day from being an oblivious, privileged person to being a little less oblivious, privileged person,” he said.\u003c/p>\n\n","blocks":[],"excerpt":"\"I've gotten to a point where I do now see signs of the glass ceiling.\"","status":"publish","parent":0,"modified":1508352153,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":15,"wordCount":717},"headData":{"title":"Yes, Even CRISPR Pioneer Jennifer Doudna Experiences Gender Bias | KQED","description":""I've gotten to a point where I do now see signs of the glass ceiling."","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Yes, Even CRISPR Pioneer Jennifer Doudna Experiences Gender Bias","datePublished":"2016-03-03T00:34:03.000Z","dateModified":"2017-10-18T18:42:33.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"121640 http://ww2.kqed.org/futureofyou/?p=121640","disqusUrl":"https://ww2.kqed.org/futureofyou/2016/03/02/yes-even-crispr-pioneer-jennifer-doudna-experiences-gender-bias/","disqusTitle":"Yes, Even CRISPR Pioneer Jennifer Doudna Experiences Gender Bias","nprByline":"Lisa Marie Potter and Jon Brooks","path":"/futureofyou/121640/yes-even-crispr-pioneer-jennifer-doudna-experiences-gender-bias","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>A Google search for the exact phrase \"\u003ca href=\"https://www.google.com/?gws_rd=ssl#q=%22barriers+to+women+in+science%22\" target=\"_blank\" rel=\"noopener\">barriers to women in science\u003c/a>\" brings up 85,000 results. \"\u003ca href=\"https://www.google.com/?gws_rd=ssl#q=%22barriers+for+women+in+science%22\" target=\"_blank\" rel=\"noopener\">Barriers for women in science\u003c/a>\" fetches another 30k and change.\u003c/p>\n\u003caside class=\"pullquote alignright\">\"I've gotten to a point where I do now see signs of the glass ceiling.\"\u003ccite>Jennifer Doudna\u003c/cite>\u003c/aside>\n\u003cp>Here's a 2010 \u003ca href=\"http://www.aauw.org/files/2013/02/Why-So-Few-Women-in-Science-Technology-Engineering-and-Mathematics.pdf\" target=\"_blank\" rel=\"noopener\">report\u003c/a> from the American Association of University Women that found negative stereotypes contributing to implicit bias against females in the STEM fields. This 2014 \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102172\" target=\"_blank\" rel=\"noopener\">survey\u003c/a> found 70 percent of female scientist trainees doing fieldwork had experienced sexual harassment.\u003c/p>\n\u003cp>So no, it's not a new concept. And yet, it was still a little unnerving to hear someone as prestigious as Jennifer Doudna -- a pioneer of the gene-editing technique CRISPR whom \u003ca href=\"http://www.nytimes.com/2015/05/12/science/jennifer-doudna-crispr-cas9-genetic-engineering.html\" target=\"_blank\" rel=\"noopener\">The New York Times\u003c/a> said \"helped make one of the most monumental discoveries in biology\" -- \u003ca href=\"http://www.kqed.org/a/forum/R201602151000\" target=\"_blank\" rel=\"noopener\">say on KQED Forum recently\u003c/a> that she, too, was hitting the proverbial glass ceiling. When asked if she'd ever experienced gender discrimination, she told host Michael Krasny:\u003c/p>\n\u003cblockquote>\u003cp>\"This topic comes up a lot and I have to say, earlier in my career, honestly, I never gave it a thought. I didn't think about my gender, I pursued my passion for science and research. But I do have to tell you, as I've gone on in my career, particularly the last 10 years or so, I've gotten to a point where I do now see signs of the glass ceiling. I don't think it's always intentional bias, but ... I do experience bias against women in some settings.\u003c/p>\n\u003cp>\"I think that what we're seeing is that it's very difficult for women to break into the top echelons of leadership in science. I'm not talking so much here about university leadership, but more leadership in the highest levels of public policy and the government, as well as in company board rooms.\"\u003c/p>\u003c/blockquote>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='100%' height='166'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=https://api.soundcloud.com/tracks/247244078&visual=true&color=ff5500&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false'\n title='https://api.soundcloud.com/tracks/247244078'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp>\u003cbr>\n\u003cstrong>Overcoming Bias\u003c/strong>\u003c/p>\n\u003cp>Doudna is not alone. Last month, a panel at the Women in Science Summit in San Francisco shared personal experiences of gender discrimination.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"All along the way I would hear about my opportunities in science,\" said oceanographer Anne Russell. \"For example, ‘You could marry this guy, he’s a really good hydrologist.' [Or] you’d be talking to someone about your ideas and then he puts his arm around you.”\u003c/p>\n\u003cp>Russell now runs her own lab. But she is still aware of the potential for being minimized. When the press covers her research, she said, she makes sure she is the one piloting the boat.\u003c/p>\n\u003cp>Dawn Wright, chief scientist at the Environmental System Research Institute, said she was once on a months-long expedition at sea where she was one of five women on board, and the only woman of color. Despite her trepidation, she became friends with a male oil driller who had never worked with an African-American, let alone one who was a female scientist. She urged her colleagues, outnumbered in the male-dominated sciences, to persevere.\u003c/p>\n\u003cp>\"There is peril out there; we can't avoid it,\" she said. \"But there are really, really good things that can come from it as well if we continue to be courageous.\"\u003c/p>\n\u003cp>Finally there was Jonathan Eisen, a microbiologist at the University of California, Davis who has become an outspoken critic on social media of the lack of diversity at scientific conferences. He said his awareness about barriers to women's participation started when he saw a nanny watching a baby outside a scientific conference; she'd been hired so the infant's mother could attend the conference.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“It was literally one of those light bulb epiphany moments where my privilege in my life came front and center to me, because it had never occurred to me to that this would be an issue for anybody,” Eisen said. “I changed on that day from being an oblivious, privileged person to being a little less oblivious, privileged person,” he said.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/futureofyou/121640/yes-even-crispr-pioneer-jennifer-doudna-experiences-gender-bias","authors":["byline_futureofyou_121640"],"programs":["futureofyou_54"],"categories":["futureofyou_1","futureofyou_73"],"tags":["futureofyou_94","futureofyou_791","futureofyou_790","futureofyou_270","futureofyou_80"],"featImg":"futureofyou_341963","label":"futureofyou_54"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. 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You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. 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