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She comes to KQED from documentary film, and is director of \u003cem>Worlds of Ursula K. Le Guin\u003c/em>, a feature documentary about the influential science fiction writer. She was Associate Producer of the films \u003cem>Regarding Susan Sontag\u003c/em>, \u003cem>American Jerusalem: Jews and the Making of San Francisco\u003c/em>, \u003cem>EAMES: The Architect & The Painter\u003c/em>, \u003cem>Utopia in Four Movements\u003c/em>, and co-produced and directed \u003cem>Stuffed\u003c/em>, a short film about compulsive hoarding. Arwen was editor of the punk magazine \u003cem>Maximum Rock 'n' Roll\u003c/em>, and has been a contributor to Radio Lab and McSweeney’s. 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Among them will be a cooler with several vials of human cells, sent up by University of California-San Francisco molecular biologist and former astronaut Millie Hughes-Fulford.\u003c/p>\n\u003cp>Hughes-Fulford hopes to figure out why the human immune system takes a beating in space. Her research could help astronauts stay healthy during the months or years it might take to reach Mars. Her findings could also help aging people here on Earth stay healthy.\u003c/p>\n\u003cp>“Our hope is that we can apply the new knowledge across the board to anyone who has an immune problem,” said Hughes-Fulford, \u003ca href=\"http://www.hughesfulfordlab.com/index.html\">whose lab is at the San Francisco VA Medical Center\u003c/a> and who is employed by the Veterans Health Research Institute. The longtime Marin County resident recently moved to Hawaii.\u003c/p>\n\u003cp>Space is a useful place to study the human aging process, because in space the immune suppression process is sped up, said Camille Alleyne, assistant program scientist for the International Space Station (ISS).\u003c/p>\n\u003cfigure id=\"attachment_73278\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_space_head_gear.jpg\">\u003cimg class=\"wp-image-73278 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_space_head_gear-300x169.jpg\" alt=\"In 1991, Millie Hughes-Fulford traveled to space on the Space Shuttle Columbia as a payload specialist responsible for carrying out experiments for other scientists. She was the first woman to travel into space as a working scientist. (Courtesy of NASA)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">In 1991, Millie Hughes-Fulford traveled to space on the shuttle Columbia as a payload specialist responsible for carrying out experiments for other scientists. She was the first woman to travel into space as a working scientist. (Courtesy of NASA)\u003c/figcaption>\u003c/figure>\n\u003cp>In Hughes-Fulford’s experiment, which is funded by the National Institutes of Health, human immune cells will remain at the ISS for one month, exposed to microgravity – the technical term used to describe the lack of gravity experienced in space. After 30 days, the cells will return to Earth on board the same SpaceX spacecraft.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In 1991, Hughes-Fulford was the first woman to travel to space as a working scientist, when she spent nine days on board the Space Shuttle Columbia during its first mission dedicated exclusively to the medical sciences.\u003c/p>\n\u003cp>During that mission, Hughes-Fulford conducted experiments for scientists from around the world, including one with rats that investigated why space travelers become sick. The study found that, in space, cells called T-cells, which regulate the entire immune system, don’t send out the signals they’re supposed to. As a result, space travelers can become sick.\u003c/p>\n\u003cp>“Now we believe it’s gravity that’s causing the changes, the T-cell needing gravity in order to function properly,” said Hughes-Fulford.\u003c/p>\n\u003cfigure id=\"attachment_73279\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Tara_Candelario_holds_blood.jpg\">\u003cimg class=\"wp-image-73279 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Tara_Candelario_holds_blood-300x169.jpg\" alt=\"Tara Candelario held up a vial with human blood at Millie Hughes-Fulford’s lab at the San Francisco VA Medical Center, in March 2011. Candelario, who is still with the lab, is currently extracting immune cells from human blood to send up to the International Space Station on Dec. 16, 2014.<br /> (Michael Goode/KQED)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tara Candelario held up a vial with human blood at Millie Hughes-Fulford’s lab at the San Francisco VA Medical Center, in March 2011. Candelario is currently extracting immune cells from human blood to send up to the International Space Station on Dec. 16, 2014. (Michael Goode/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>With her new experiment, and another one that went up on SpaceX in April, Hughes-Fulford’s goal is to understand which specific genes malfunction in space and what causes them to fail. The experiment will be one of the last things to be loaded onto the spacecraft, and one of the first to be unloaded once it docks with the ISS, said Alleyne. This is because the human cells need to be in a controlled temperature environment.\u003c/p>\n\u003cp>Other experiments traveling to the ISS in December include NASA’s Cloud Aerosol Transport System (CATS), a device that will use lasers to identify sea salt, carbon, water vapor and particulates in the atmosphere. With CATS, scientists are trying to understand what’s happening in the Earth and atmosphere, to inform climate change models, said Alleyne.\u003c/p>\n\u003cp>The resupply mission will leave Cape Canaveral, Florida.\u003c/p>\n\u003cp>\u003cem>The medical animation in this video was produced by Nucleus Media, which holds the copyright.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>You may also be interested in the QUEST documentary \u003ca href=\"http://blogs.kqed.org/science/video/silicon-valley-goes-to-space/\">Silicon Valley Goes to Space.\u003c/a>\u003c/strong>\u003c/p>\n\n","blocks":[],"excerpt":"Former astronaut Millie Hughes-Fulford is sending an experiment into space that could one day help travelers going to Mars and aging people here on Earth. She seeks to understand how a lack of gravity impacts our immune system.","status":"publish","parent":0,"modified":1442631729,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":16,"wordCount":685},"headData":{"title":"Millie Hughes-Fulford: Scientist in Space | KQED","description":"","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Millie Hughes-Fulford: Scientist in Space","datePublished":"2014-11-26T15:00:24.000Z","dateModified":"2015-09-19T03:02:09.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"21110 http://science.kqed.org/quest/?post_type=videos&p=21110","disqusUrl":"https://ww2.kqed.org/quest/2014/11/26/millie-hughes-fulford-scientist-in-space/","disqusTitle":"Millie Hughes-Fulford: Scientist in Space","videoEmbed":"http://www.youtube.com/watch?v=XQ6OlOAtzR4?feature=player_detailpage","source":"Biology","sourceUrl":"https://ww2.kqed.org/quest/category/biology/","path":"/quest/21110/millie-hughes-fulford-scientist-in-space","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>This video and article, originally posted on July 26, 2011, were updated on Nov. 26, 2014.\u003c/em>\u003c/p>\n\u003cfigure id=\"attachment_73277\" class=\"wp-caption alignleft\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_lab_2011.jpg\">\u003cimg class=\"wp-image-73277 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_lab_2011-300x169.jpg\" alt=\"Millie Hughes-Fulford in her lab at the San Francisco VA Medical Center in March 2011.<br /> (Michael Goode/KQED)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Millie Hughes-Fulford in her lab at the San Francisco VA Medical Center in March 2011.\u003cbr> (Michael Goode/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>When SpaceX sends its next spacecraft to resupply the International Space Station on Dec. 16, along with M&M’s and khaki pants for the six astronauts, the rocket will also carry some 40 experiments. Among them will be a cooler with several vials of human cells, sent up by University of California-San Francisco molecular biologist and former astronaut Millie Hughes-Fulford.\u003c/p>\n\u003cp>Hughes-Fulford hopes to figure out why the human immune system takes a beating in space. Her research could help astronauts stay healthy during the months or years it might take to reach Mars. Her findings could also help aging people here on Earth stay healthy.\u003c/p>\n\u003cp>“Our hope is that we can apply the new knowledge across the board to anyone who has an immune problem,” said Hughes-Fulford, \u003ca href=\"http://www.hughesfulfordlab.com/index.html\">whose lab is at the San Francisco VA Medical Center\u003c/a> and who is employed by the Veterans Health Research Institute. The longtime Marin County resident recently moved to Hawaii.\u003c/p>\n\u003cp>Space is a useful place to study the human aging process, because in space the immune suppression process is sped up, said Camille Alleyne, assistant program scientist for the International Space Station (ISS).\u003c/p>\n\u003cfigure id=\"attachment_73278\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_space_head_gear.jpg\">\u003cimg class=\"wp-image-73278 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Millie_Hughes-Fulford_in_space_head_gear-300x169.jpg\" alt=\"In 1991, Millie Hughes-Fulford traveled to space on the Space Shuttle Columbia as a payload specialist responsible for carrying out experiments for other scientists. She was the first woman to travel into space as a working scientist. (Courtesy of NASA)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">In 1991, Millie Hughes-Fulford traveled to space on the shuttle Columbia as a payload specialist responsible for carrying out experiments for other scientists. She was the first woman to travel into space as a working scientist. (Courtesy of NASA)\u003c/figcaption>\u003c/figure>\n\u003cp>In Hughes-Fulford’s experiment, which is funded by the National Institutes of Health, human immune cells will remain at the ISS for one month, exposed to microgravity – the technical term used to describe the lack of gravity experienced in space. After 30 days, the cells will return to Earth on board the same SpaceX spacecraft.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In 1991, Hughes-Fulford was the first woman to travel to space as a working scientist, when she spent nine days on board the Space Shuttle Columbia during its first mission dedicated exclusively to the medical sciences.\u003c/p>\n\u003cp>During that mission, Hughes-Fulford conducted experiments for scientists from around the world, including one with rats that investigated why space travelers become sick. The study found that, in space, cells called T-cells, which regulate the entire immune system, don’t send out the signals they’re supposed to. As a result, space travelers can become sick.\u003c/p>\n\u003cp>“Now we believe it’s gravity that’s causing the changes, the T-cell needing gravity in order to function properly,” said Hughes-Fulford.\u003c/p>\n\u003cfigure id=\"attachment_73279\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Tara_Candelario_holds_blood.jpg\">\u003cimg class=\"wp-image-73279 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/07/Tara_Candelario_holds_blood-300x169.jpg\" alt=\"Tara Candelario held up a vial with human blood at Millie Hughes-Fulford’s lab at the San Francisco VA Medical Center, in March 2011. Candelario, who is still with the lab, is currently extracting immune cells from human blood to send up to the International Space Station on Dec. 16, 2014.<br /> (Michael Goode/KQED)\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tara Candelario held up a vial with human blood at Millie Hughes-Fulford’s lab at the San Francisco VA Medical Center, in March 2011. Candelario is currently extracting immune cells from human blood to send up to the International Space Station on Dec. 16, 2014. (Michael Goode/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>With her new experiment, and another one that went up on SpaceX in April, Hughes-Fulford’s goal is to understand which specific genes malfunction in space and what causes them to fail. The experiment will be one of the last things to be loaded onto the spacecraft, and one of the first to be unloaded once it docks with the ISS, said Alleyne. This is because the human cells need to be in a controlled temperature environment.\u003c/p>\n\u003cp>Other experiments traveling to the ISS in December include NASA’s Cloud Aerosol Transport System (CATS), a device that will use lasers to identify sea salt, carbon, water vapor and particulates in the atmosphere. With CATS, scientists are trying to understand what’s happening in the Earth and atmosphere, to inform climate change models, said Alleyne.\u003c/p>\n\u003cp>The resupply mission will leave Cape Canaveral, Florida.\u003c/p>\n\u003cp>\u003cem>The medical animation in this video was produced by Nucleus Media, which holds the copyright.\u003c/em>\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>You may also be interested in the QUEST documentary \u003ca href=\"http://blogs.kqed.org/science/video/silicon-valley-goes-to-space/\">Silicon Valley Goes to Space.\u003c/a>\u003c/strong>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/21110/millie-hughes-fulford-scientist-in-space","authors":["6186"],"categories":["quest_3","quest_4","quest_12"],"tags":["quest_83","quest_544","quest_12269","quest_1451","quest_3620","quest_3351","quest_9909","quest_1918","quest_2349","quest_13","quest_12264","quest_13096","quest_2893","quest_3071"],"featImg":"quest_73276","label":"source_quest_21110"},"quest_17514":{"type":"posts","id":"quest_17514","meta":{"index":"posts_1591205157","site":"quest","id":"17514","score":null,"sort":[1415804432000]},"guestAuthors":[],"slug":"catching-up-on-sleep-science","title":"Catching Up on Sleep Science","publishDate":1415804432,"format":"video","headTitle":"QUEST | KQED Science","labelTerm":{},"content":"\u003cp>\u003cem>This video story was originally produced by \u003ca href=\"http://ww2.kqed.org/quest/author/sheraz-sadiq/\">Sheraz Sadiq\u003c/a> and was updated by\u003ca href=\"http://ww2.kqed.org/quest/author/lisalanders/\"> Lisa Landers\u003c/a> and \u003ca href=\"http://ww2.kqed.org/quest/author/acurry/\">Arwen Curry.\u003c/a>\u003c/em>\u003c/p>\n\u003cp>Be honest – do you ever brag about how little sleep you get? If so, you’re not alone. Humans are the only species that seems to deliberately deprive themselves of sleep. But if you’ve ever uttered a phrase like “I’ll sleep when I’m dead,” it’s time for a wake-up call, scientists say.\u003c/p>\n\u003cfigure id=\"attachment_72675\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/803_SLEEP_polar_bear.jpg\">\u003cimg class=\"size-thumbnail wp-image-72675\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/803_SLEEP_polar_bear-300x169.jpg\" alt=\"Sleep is common to all species that have been studied to date.\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Sleep is common to all species that have been studied to date.\u003c/figcaption>\u003c/figure>\n\u003cp>Researchers have long known that adequate sleep is critical for good health. Insufficient sleep \u003ca href=\"http://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/lack-of-sleep/faq-20057757\">impairs the immune system\u003c/a>, and is associated with everything from \u003ca href=\"http://www.hsph.harvard.edu/nutritionsource/sleep/\">obesity\u003c/a> to cardiovascular disease, stroke to cancer, depression to schizophrenia and \u003ca href=\"http://news.temple.edu/news/2014-03-18/chronic-sleep-disturbance-might-trigger-onset-alzheimer%E2%80%99s\">Alzheimer’s disease\u003c/a>. Now scientists are several steps closer to knowing how sleep keeps us healthy.\u003c/p>\n\u003cp>An important clue about sleep’s function surfaced in \u003ca href=\"http://www.nature.com/neuro/journal/v16/n2/full/nn.3303.html\">a 2013 study\u003c/a> published in the journal \u003cem>\u003ca href=\"http://www.nature.com/neuro/index.html\">Nature Neuroscience\u003c/a> \u003c/em>and conducted at the University of California-Berkeley. The study, by neuroscience professor Matthew Walker and his colleagues, showed that the structural changes the brain experiences as we age damage the quality of deep sleep. This hinders the brain’s ongoing ability to store memories.\u003c/p>\n\u003cfigure id=\"attachment_72671\" class=\"wp-caption alignleft\" style=\"max-width: 264px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Matthew_Walker_AC_800.jpg\">\u003cimg class=\"wp-image-72671 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Matthew_Walker_AC_800-264x169.jpg\" alt=\"Professor Matthew Walker runs the Sleep and Neuroimaging Lab at the University of California-Berkeley Photo by Arwen Curry.\" width=\"264\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Professor Matthew Walker runs the Sleep and Neuroimaging Lab at the University of California-Berkeley.\u003cbr> Photo by Arwen Curry.\u003c/figcaption>\u003c/figure>\n\u003cp>Scientists were already aware of a connection between sleep and memory – now they are developing a working hypothesis about how the mechanism actually works.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>“It’s almost as though your learning system is like a USB stick,” Walker said. “During the day you’re acquiring lots of information rapidly.” This information is lodged in an area of the brain called the hippocampus.\u003c/p>\n\u003cp>But when we sleep, this data is exported to “the hard drive of our brain,” a larger storage space called the cortex.\u003c/p>\n\u003cp>“When we wake up the next day, our USB stick has now been cleared out, so we can start to learn new information anew,” Walker said. “We’ve refreshed our learning capacity.”\u003c/p>\n\u003cp>The idea that we need less sleep as we age is a fallacy, he added. It now appears that the brain is physically unable to achieve the amount of slow-wave, non-rapid-eye-movement sleep needed to consolidate memories as we grow older. By the time we’re 50 years old, non-REM sleep has reduced by half compared to when we were 18 years old. By the time we’re 70, deep sleep is down to about 5 percent.\u003c/p>\n\u003cfigure id=\"attachment_72668\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/402a_sleep_640-288x162.jpg\">\u003cimg class=\"wp-image-72668 size-full\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/402a_sleep_640-288x162.jpg\" alt=\"Scientists use electric pulses to copy the rhythm of slow-wave sleep, which declines as we age.\" width=\"288\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists use electrical pulses to copy the rhythm of slow-wave sleep, which declines as we age.\u003c/figcaption>\u003c/figure>\n\u003cp>This research suggests that improving slow-wave sleep, which takes up about a quarter of the night, could slow the decline of memory as we age. Scientists are investigating \u003ca href=\"http://www.sciencedirect.com/science/article/pii/016643289390140L\">ways to use electrical stimulation to improve deep sleep in older people\u003c/a> by attaching electrodes to the scalp to create a mild current that mimics the pattern of slow-wave sleep.\u003c/p>\n\u003cp>The science of sleep has traditionally been abstract, but advances in imaging technology now allow scientists to peek inside the sleeping brain. In \u003ca href=\"http://www.urmc.rochester.edu/news/story/index.cfm?id=3956\">a groundbreaking 2013 study\u003c/a>, researchers at the University of Rochester Medical Center injected dyes into the brains of sleeping mice, and watched in real-time as the neurons in their brains shrank dramatically by about 60 percent. This increased the spaces between the brain cells, allowing cerebrospinal fluid to easily flow through and cleanse the brain of naturally occurring toxic waste.\u003c/p>\n\u003cfigure id=\"attachment_72672\" class=\"wp-caption alignleft\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Rochester_Brain_Flushing_800.jpg\">\u003cimg class=\"wp-image-72672 size-large\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Rochester_Brain_Flushing_800-640x360.jpg\" alt=\"This photograph shows cerebrospinal fluid (in blue) rinsing toxins from the brain of a sleeping mouse.\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This photograph shows cerebrospinal fluid (in blue) rinsing toxins from the brain of a sleeping mouse. Photo courtesy of the University of Rochester Medical Center.\u003c/figcaption>\u003c/figure>\n\u003cp>“It’s almost as though you’re sort of walking past one of those delightful posh hotels and during the day there’s lots of dirt that happens on the sidewalk,” said Walker. “And then at night, someone comes out with one of those pressure-jet washers and cleans it all out, so that it’s fresh and functional the next day. That’s exactly what we think is now happening during sleep at night.”\u003c/p>\n\u003cp>Of particular note is that chronic sleep deprivation contributes to \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24887018\">the buildup of a toxic protein called beta-amyloid\u003c/a>, which is a predictor of Alzheimer’s disease.\u003c/p>\n\u003cp>Walker’s research also suggests strong connections between sleep and creativity and emotional regulation. But with all we’ve learned about sleep, there remains much more to be discovered.\u003c/p>\n\u003cp>“If you think about it,” said Walker, “we’ve understood the other three main biological drives – eating, drinking and reproducing – for many tens, if not hundreds, of years. But the fourth main biological drive, common across all species that we’ve studied, which is to sleep, remains that quintessential mystery.”\u003c/p>\n\u003cp>One thing is clear: \u003ca href=\"http://www.gallup.com/poll/166553/less-recommended-amount-sleep.aspx\">People are sleeping demonstrably less than they did 70 years ago\u003c/a>. An estimated 70 million Americans suffer from some form of chronic sleep disorder, and 40 percent get less than the recommended amount of sleep – seven and a half to eight hours a night.\u003c/p>\n\u003cp>Contributing factors include multi-tasking, the invasion of technology in the bedroom and long commute times, which rob us of precious free hours, Walker said. But the biggest culprit may be our own attitudes.\u003c/p>\n\u003cp>“I think where we’re at in modern-day society is a problematic relationship with sleep,” he said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“We know that sleep is fundamentally important at the most basic of biological levels,” he said. “But something strange has happened – sleep has received a stigma. There’s some kind of intonation which suggests that getting sufficient sleep is equivalent to being lazy. We wear this badge of sleep deprivation like some kind of honor emblem on our arm, and that’s profoundly misguided.”\u003c/p>\n\u003ch2>Additional Links\u003c/h2>\n\u003cul>\n\u003cli>\u003ca href=\"https://www.youtube.com/watch?v=yTIDkj9Tn58\">Watch the full episode of QUEST.\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://www.kqed.org/a/forum/R201408261000\">Forum with Michael Krasny: sleep expert Matthew Walker\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://blogs.kqed.org/stateofhealth/2014/08/27/sleep-apps-myths-and-more-strategies-for-a-good-nights-rest/\">Sleep Apps, Myths and More: Strategies for a Good Night’s Rest\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://www.kqed.org/a/forum/R201311270930\">Forum with Dave Iverson: sleep therapy as a treatment for depression\u003c/a>\u003c/li>\n\u003c/ul>\n\n","blocks":[],"excerpt":"Sleep: It’s more important than you might think. Watch the video to see how sleep imprints memories, regulates emotions, and cleanses the brain of toxins. ","status":"publish","parent":0,"modified":1442634965,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":21,"wordCount":1052},"headData":{"title":"Catching Up on Sleep Science | KQED","description":"Sleep: It’s more important than you might think. Watch the video to see how sleep imprints memories, regulates emotions, and cleanses the brain of toxins. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Catching Up on Sleep Science","datePublished":"2014-11-12T15:00:32.000Z","dateModified":"2015-09-19T03:56:05.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"17514 http://science.kqed.org/quest/video/catching-up-on-sleep-science/","disqusUrl":"https://ww2.kqed.org/quest/2014/11/12/catching-up-on-sleep-science/","disqusTitle":"Catching Up on Sleep Science","videoEmbed":"https://www.youtube.com/watch?v=HW1HxGJAjqY","source":"Health","sourceUrl":"http://ww2.kqed.org/quest/category/health/","path":"/quest/17514/catching-up-on-sleep-science","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>This video story was originally produced by \u003ca href=\"http://ww2.kqed.org/quest/author/sheraz-sadiq/\">Sheraz Sadiq\u003c/a> and was updated by\u003ca href=\"http://ww2.kqed.org/quest/author/lisalanders/\"> Lisa Landers\u003c/a> and \u003ca href=\"http://ww2.kqed.org/quest/author/acurry/\">Arwen Curry.\u003c/a>\u003c/em>\u003c/p>\n\u003cp>Be honest – do you ever brag about how little sleep you get? If so, you’re not alone. Humans are the only species that seems to deliberately deprive themselves of sleep. But if you’ve ever uttered a phrase like “I’ll sleep when I’m dead,” it’s time for a wake-up call, scientists say.\u003c/p>\n\u003cfigure id=\"attachment_72675\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/803_SLEEP_polar_bear.jpg\">\u003cimg class=\"size-thumbnail wp-image-72675\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/803_SLEEP_polar_bear-300x169.jpg\" alt=\"Sleep is common to all species that have been studied to date.\" width=\"300\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Sleep is common to all species that have been studied to date.\u003c/figcaption>\u003c/figure>\n\u003cp>Researchers have long known that adequate sleep is critical for good health. Insufficient sleep \u003ca href=\"http://www.mayoclinic.org/diseases-conditions/insomnia/expert-answers/lack-of-sleep/faq-20057757\">impairs the immune system\u003c/a>, and is associated with everything from \u003ca href=\"http://www.hsph.harvard.edu/nutritionsource/sleep/\">obesity\u003c/a> to cardiovascular disease, stroke to cancer, depression to schizophrenia and \u003ca href=\"http://news.temple.edu/news/2014-03-18/chronic-sleep-disturbance-might-trigger-onset-alzheimer%E2%80%99s\">Alzheimer’s disease\u003c/a>. Now scientists are several steps closer to knowing how sleep keeps us healthy.\u003c/p>\n\u003cp>An important clue about sleep’s function surfaced in \u003ca href=\"http://www.nature.com/neuro/journal/v16/n2/full/nn.3303.html\">a 2013 study\u003c/a> published in the journal \u003cem>\u003ca href=\"http://www.nature.com/neuro/index.html\">Nature Neuroscience\u003c/a> \u003c/em>and conducted at the University of California-Berkeley. The study, by neuroscience professor Matthew Walker and his colleagues, showed that the structural changes the brain experiences as we age damage the quality of deep sleep. This hinders the brain’s ongoing ability to store memories.\u003c/p>\n\u003cfigure id=\"attachment_72671\" class=\"wp-caption alignleft\" style=\"max-width: 264px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Matthew_Walker_AC_800.jpg\">\u003cimg class=\"wp-image-72671 size-thumbnail\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Matthew_Walker_AC_800-264x169.jpg\" alt=\"Professor Matthew Walker runs the Sleep and Neuroimaging Lab at the University of California-Berkeley Photo by Arwen Curry.\" width=\"264\" height=\"169\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Professor Matthew Walker runs the Sleep and Neuroimaging Lab at the University of California-Berkeley.\u003cbr> Photo by Arwen Curry.\u003c/figcaption>\u003c/figure>\n\u003cp>Scientists were already aware of a connection between sleep and memory – now they are developing a working hypothesis about how the mechanism actually works.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>“It’s almost as though your learning system is like a USB stick,” Walker said. “During the day you’re acquiring lots of information rapidly.” This information is lodged in an area of the brain called the hippocampus.\u003c/p>\n\u003cp>But when we sleep, this data is exported to “the hard drive of our brain,” a larger storage space called the cortex.\u003c/p>\n\u003cp>“When we wake up the next day, our USB stick has now been cleared out, so we can start to learn new information anew,” Walker said. “We’ve refreshed our learning capacity.”\u003c/p>\n\u003cp>The idea that we need less sleep as we age is a fallacy, he added. It now appears that the brain is physically unable to achieve the amount of slow-wave, non-rapid-eye-movement sleep needed to consolidate memories as we grow older. By the time we’re 50 years old, non-REM sleep has reduced by half compared to when we were 18 years old. By the time we’re 70, deep sleep is down to about 5 percent.\u003c/p>\n\u003cfigure id=\"attachment_72668\" class=\"wp-caption alignright\" style=\"max-width: 288px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/402a_sleep_640-288x162.jpg\">\u003cimg class=\"wp-image-72668 size-full\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/402a_sleep_640-288x162.jpg\" alt=\"Scientists use electric pulses to copy the rhythm of slow-wave sleep, which declines as we age.\" width=\"288\" height=\"162\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Scientists use electrical pulses to copy the rhythm of slow-wave sleep, which declines as we age.\u003c/figcaption>\u003c/figure>\n\u003cp>This research suggests that improving slow-wave sleep, which takes up about a quarter of the night, could slow the decline of memory as we age. Scientists are investigating \u003ca href=\"http://www.sciencedirect.com/science/article/pii/016643289390140L\">ways to use electrical stimulation to improve deep sleep in older people\u003c/a> by attaching electrodes to the scalp to create a mild current that mimics the pattern of slow-wave sleep.\u003c/p>\n\u003cp>The science of sleep has traditionally been abstract, but advances in imaging technology now allow scientists to peek inside the sleeping brain. In \u003ca href=\"http://www.urmc.rochester.edu/news/story/index.cfm?id=3956\">a groundbreaking 2013 study\u003c/a>, researchers at the University of Rochester Medical Center injected dyes into the brains of sleeping mice, and watched in real-time as the neurons in their brains shrank dramatically by about 60 percent. This increased the spaces between the brain cells, allowing cerebrospinal fluid to easily flow through and cleanse the brain of naturally occurring toxic waste.\u003c/p>\n\u003cfigure id=\"attachment_72672\" class=\"wp-caption alignleft\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Rochester_Brain_Flushing_800.jpg\">\u003cimg class=\"wp-image-72672 size-large\" src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2014/10/Rochester_Brain_Flushing_800-640x360.jpg\" alt=\"This photograph shows cerebrospinal fluid (in blue) rinsing toxins from the brain of a sleeping mouse.\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">This photograph shows cerebrospinal fluid (in blue) rinsing toxins from the brain of a sleeping mouse. Photo courtesy of the University of Rochester Medical Center.\u003c/figcaption>\u003c/figure>\n\u003cp>“It’s almost as though you’re sort of walking past one of those delightful posh hotels and during the day there’s lots of dirt that happens on the sidewalk,” said Walker. “And then at night, someone comes out with one of those pressure-jet washers and cleans it all out, so that it’s fresh and functional the next day. That’s exactly what we think is now happening during sleep at night.”\u003c/p>\n\u003cp>Of particular note is that chronic sleep deprivation contributes to \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24887018\">the buildup of a toxic protein called beta-amyloid\u003c/a>, which is a predictor of Alzheimer’s disease.\u003c/p>\n\u003cp>Walker’s research also suggests strong connections between sleep and creativity and emotional regulation. But with all we’ve learned about sleep, there remains much more to be discovered.\u003c/p>\n\u003cp>“If you think about it,” said Walker, “we’ve understood the other three main biological drives – eating, drinking and reproducing – for many tens, if not hundreds, of years. But the fourth main biological drive, common across all species that we’ve studied, which is to sleep, remains that quintessential mystery.”\u003c/p>\n\u003cp>One thing is clear: \u003ca href=\"http://www.gallup.com/poll/166553/less-recommended-amount-sleep.aspx\">People are sleeping demonstrably less than they did 70 years ago\u003c/a>. An estimated 70 million Americans suffer from some form of chronic sleep disorder, and 40 percent get less than the recommended amount of sleep – seven and a half to eight hours a night.\u003c/p>\n\u003cp>Contributing factors include multi-tasking, the invasion of technology in the bedroom and long commute times, which rob us of precious free hours, Walker said. But the biggest culprit may be our own attitudes.\u003c/p>\n\u003cp>“I think where we’re at in modern-day society is a problematic relationship with sleep,” he said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>“We know that sleep is fundamentally important at the most basic of biological levels,” he said. “But something strange has happened – sleep has received a stigma. There’s some kind of intonation which suggests that getting sufficient sleep is equivalent to being lazy. We wear this badge of sleep deprivation like some kind of honor emblem on our arm, and that’s profoundly misguided.”\u003c/p>\n\u003ch2>Additional Links\u003c/h2>\n\u003cul>\n\u003cli>\u003ca href=\"https://www.youtube.com/watch?v=yTIDkj9Tn58\">Watch the full episode of QUEST.\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://www.kqed.org/a/forum/R201408261000\">Forum with Michael Krasny: sleep expert Matthew Walker\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://blogs.kqed.org/stateofhealth/2014/08/27/sleep-apps-myths-and-more-strategies-for-a-good-nights-rest/\">Sleep Apps, Myths and More: Strategies for a Good Night’s Rest\u003c/a>\u003c/li>\n\u003cli>\u003ca href=\"http://www.kqed.org/a/forum/R201311270930\">Forum with Dave Iverson: sleep therapy as a treatment for depression\u003c/a>\u003c/li>\n\u003c/ul>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/17514/catching-up-on-sleep-science","authors":["6444"],"categories":["quest_4","quest_12"],"tags":["quest_83","quest_135","quest_13038","quest_13048","quest_13044","quest_423","quest_13042","quest_13045","quest_13047","quest_13052","quest_13050","quest_13040","quest_13046","quest_12269","quest_13201","quest_13035","quest_1451","quest_11723","quest_10537","quest_1788","quest_13039","quest_13036","quest_1916","quest_13041","quest_9816","quest_13037","quest_2031","quest_13","quest_10538","quest_2655","quest_13034","quest_13051","quest_2893","quest_3021","quest_12094","quest_13043","quest_3071","quest_13049"],"featImg":"quest_72659","label":"source_quest_17514"},"quest_26725":{"type":"posts","id":"quest_26725","meta":{"index":"posts_1591205157","site":"quest","id":"26725","score":null,"sort":[1320686328000]},"guestAuthors":[],"slug":"sniffing-out-mr-right","title":"Sniffing Out Mr. Right","publishDate":1320686328,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2011/11/07/sniffing-out-mr-right/sniffingdogs/\" rel=\"attachment wp-att-26726\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/11/SniffingDogs.jpg\" alt=\"\" title=\"SniffingDogs\" width=\"640\" height=\"357\" class=\"alignleft size-full wp-image-26726\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/11/SniffingDogs.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2011/11/SniffingDogs-400x223.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>Lots of animals pick their mate at least partly by how they smell. And a bunch of studies show that it may not be that different in people. \u003c/p>\n\u003cp>My favorite ones are those where women \u003ca href=\"http://ww2.kqed.org/quest/2008/09/29/the-nose-knows/\">sniff the shirts of various men\u003c/a> and pick out the ones that smell the best to them. The ones they like best are usually from men whose immune systems are most different from theirs.\u003c/p>\n\u003cp>This makes some sense if you think about it. The strongest immune system is a varied one. It can fight off lots of different kinds of bacteria, parasites, and viruses.\u003c/p>\n\u003cp>And since our immune system is programmed by our genes and our genes come from mom and dad, the more different mom and dad’s genes are, the more varied your immune system will be. So ideally you would choose a mate that would give your children the stronger immune system. That mate would have an immune system very different from yours. \u003c/p>\n\u003cp>One way you might be able to find that particular mate is if different immune systems have different odors. The stinky guys share your immune system; the pleasant smelling ones have a different one.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>This seems to be what is happening in these armpit smelling experiments. So at least some amount of attraction between people is happening with the nose.\u003c/p>\n\u003cp>But what I found even more interesting was that oral contraceptives mess with this system. Women on the pill tend to prefer the smell of men with similar immune systems. Some scientists think this is because pregnant women prefer family around them and family tends to have a similar immune system.\u003c/p>\n\u003cp>When I first read this I thought, “Wow, this is going to really mess up future generations’ immune systems. Maybe it even helps to explain the recent rise in allergies and autoimmune diseases.”\u003c/p>\n\u003cp>But then I caught myself and thought a little harder. It is probably not that likely that the recent increases in allergies and autoimmune diseases would have happened so quickly if the pill were the main culprit. And besides, there is undoubtedly more to human mate selection than smell!\u003c/p>\n\u003cp>We are complicated. There are all sorts of cues that cause someone to fall in love. Pheromones may play a role but they are certainly not the whole story.\u003c/p>\n\u003cp>For example, some studies use photos and ask women which men are the most attractive. The women in these studies tend to pick men with more similar immune systems (apparently there is some correlation between facial symmetry and the immune system).\u003c/p>\n\u003cp>And when scientists look at couples who actually have children together, they get mixed results. An \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">early study\u003c/a> pointed to Europeans having children with partners with different immune system genes. But a \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000925\">deeper look at that data\u003c/a> and looking at a larger group of couples showed that this didn’t seem to be the case. Differing immune systems had little impact on who women chose to have children with. \u003c/p>\n\u003cp>The most that could be said was that women tended to avoid men with really similar immune systems. A bit similar was OK.\u003c/p>\n\u003cp>Of course we could already be seeing the effects of the pill in these studies. Maybe if the women in these studies hadn’t been on the pill when they met their partners, they might have chosen someone with a more dissimilar immune system.\u003c/p>\n\u003cp>Scientists need to look at people who did not meet while women were on the pill. Then we will have a better idea of how big a role your nose plays in choosing your soul mate. And how worried we should be about the pill’s effect on that selection.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.pbs.org/wgbh/evolution/library/01/6/l_016_08.html\">Nice PBS video about the t-shirt smelling experiments.\u003c/a>\u003c/p>\n\n","blocks":[],"excerpt":"Biology may have made it so that women prefer the smell of men with different immune systems from their own. Disturbingly, the pill may turn this on its head so that women like the way men with similar immune systems smell. ","status":"publish","parent":0,"modified":1320354005,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":18,"wordCount":628},"headData":{"title":"Sniffing Out Mr. Right | KQED","description":"Biology may have made it so that women prefer the smell of men with different immune systems from their own. Disturbingly, the pill may turn this on its head so that women like the way men with similar immune systems smell. ","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Sniffing Out Mr. Right","datePublished":"2011-11-07T17:18:48.000Z","dateModified":"2011-11-03T21:00:05.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"26725 http://science.kqed.org/quest/?p=26725","disqusUrl":"https://ww2.kqed.org/quest/2011/11/07/sniffing-out-mr-right/","disqusTitle":"Sniffing Out Mr. Right","path":"/quest/26725/sniffing-out-mr-right","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003ca href=\"http://ww2.kqed.org/quest/2011/11/07/sniffing-out-mr-right/sniffingdogs/\" rel=\"attachment wp-att-26726\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/11/SniffingDogs.jpg\" alt=\"\" title=\"SniffingDogs\" width=\"640\" height=\"357\" class=\"alignleft size-full wp-image-26726\" srcset=\"https://ww2.kqed.org/app/uploads/sites/39/2011/11/SniffingDogs.jpg 640w, https://ww2.kqed.org/app/uploads/sites/39/2011/11/SniffingDogs-400x223.jpg 400w\" sizes=\"(max-width: 640px) 100vw, 640px\">\u003c/a>Lots of animals pick their mate at least partly by how they smell. And a bunch of studies show that it may not be that different in people. \u003c/p>\n\u003cp>My favorite ones are those where women \u003ca href=\"http://ww2.kqed.org/quest/2008/09/29/the-nose-knows/\">sniff the shirts of various men\u003c/a> and pick out the ones that smell the best to them. The ones they like best are usually from men whose immune systems are most different from theirs.\u003c/p>\n\u003cp>This makes some sense if you think about it. The strongest immune system is a varied one. It can fight off lots of different kinds of bacteria, parasites, and viruses.\u003c/p>\n\u003cp>And since our immune system is programmed by our genes and our genes come from mom and dad, the more different mom and dad’s genes are, the more varied your immune system will be. So ideally you would choose a mate that would give your children the stronger immune system. That mate would have an immune system very different from yours. \u003c/p>\n\u003cp>One way you might be able to find that particular mate is if different immune systems have different odors. The stinky guys share your immune system; the pleasant smelling ones have a different one.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>This seems to be what is happening in these armpit smelling experiments. So at least some amount of attraction between people is happening with the nose.\u003c/p>\n\u003cp>But what I found even more interesting was that oral contraceptives mess with this system. Women on the pill tend to prefer the smell of men with similar immune systems. Some scientists think this is because pregnant women prefer family around them and family tends to have a similar immune system.\u003c/p>\n\u003cp>When I first read this I thought, “Wow, this is going to really mess up future generations’ immune systems. Maybe it even helps to explain the recent rise in allergies and autoimmune diseases.”\u003c/p>\n\u003cp>But then I caught myself and thought a little harder. It is probably not that likely that the recent increases in allergies and autoimmune diseases would have happened so quickly if the pill were the main culprit. And besides, there is undoubtedly more to human mate selection than smell!\u003c/p>\n\u003cp>We are complicated. There are all sorts of cues that cause someone to fall in love. Pheromones may play a role but they are certainly not the whole story.\u003c/p>\n\u003cp>For example, some studies use photos and ask women which men are the most attractive. The women in these studies tend to pick men with more similar immune systems (apparently there is some correlation between facial symmetry and the immune system).\u003c/p>\n\u003cp>And when scientists look at couples who actually have children together, they get mixed results. An \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">early study\u003c/a> pointed to Europeans having children with partners with different immune system genes. But a \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000925\">deeper look at that data\u003c/a> and looking at a larger group of couples showed that this didn’t seem to be the case. Differing immune systems had little impact on who women chose to have children with. \u003c/p>\n\u003cp>The most that could be said was that women tended to avoid men with really similar immune systems. A bit similar was OK.\u003c/p>\n\u003cp>Of course we could already be seeing the effects of the pill in these studies. Maybe if the women in these studies hadn’t been on the pill when they met their partners, they might have chosen someone with a more dissimilar immune system.\u003c/p>\n\u003cp>Scientists need to look at people who did not meet while women were on the pill. Then we will have a better idea of how big a role your nose plays in choosing your soul mate. And how worried we should be about the pill’s effect on that selection.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://www.pbs.org/wgbh/evolution/library/01/6/l_016_08.html\">Nice PBS video about the t-shirt smelling experiments.\u003c/a>\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/26725/sniffing-out-mr-right","authors":["6177"],"categories":["quest_4"],"tags":["quest_209","quest_1192","quest_1197","quest_1451","quest_10399","quest_10401","quest_10400","quest_10402","quest_13202","quest_10403","quest_3319"],"featImg":"quest_26726","label":"quest"},"quest_19213":{"type":"posts","id":"quest_19213","meta":{"index":"posts_1591205157","site":"quest","id":"19213","score":null,"sort":[1302883204000]},"guestAuthors":[],"slug":"exercise-may-protect-against-stress-related-cellular-aging","title":"Exercise May Protect Against Stress-Related Cellular Aging","publishDate":1302883204,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/04/exercise.jpg\" alt=\"\">\u003cem> Exercise prevents the shortening of telomeres caused by psychological stress. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/mikebaird/3539161615/\">mikebaird\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>New research by Nobel Prize winning UCSF researcher, \u003ca href=\"http://biochemistry.ucsf.edu/labs/blackburn/\">Elizabeth Blackburn\u003c/a>, provides a possible mechanism by which exercise protects against stress-related chromosome aging.\u003c/p>\n\u003cp>The findings, presented this month at the \u003ca href=\"http://www.aacr.org/\">American Association for Cancer Research\u003c/a> 102nd Annual Meeting, were based on earlier research showing that stress accelerates telomere shortening. \u003ca href=\"http://en.wikipedia.org/wiki/Telomere\">Telomeres\u003c/a> are protective strands of DNA found on the end of chromosomes that protect them from degradation during cell division. Telomere length is associated with cellular health, and is a known marker of cell aging.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Shorter telomeres are associated with cell death and chromosome instability, which can lead to inflammation. In immune cells, short telomeres can predict poorer prognosis in patients with heart disease and cancer.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In a previous study by Blackburn, psychological stress was associated with shorter telomeres in the lymphocytes of caregivers of chronically ill children. This was the first demonstration that telomere length is correlated to perceived stress. In the current study, co-authored by biochemist Jue Lin, telomere length was again associated with stress levels, this time in primary caregivers looking after a family member with dementia. However when the researchers looked at the immune cells in those who exercised, there was no association between stress and telomere length.\u003c/p>\n\u003cp>Another study, led by Eli Puterman, examined the impact of exercise on the telomeres of healthy women who had been victims of child abuse. In this study those who exercised were protected against the effects of stress on telomere length.\u003c/p>\n\u003cp>“We saw a relationship between childhood trauma and short telomere length but the relationship seems to go away in people who exercise vigorously at least three times a week,” said Lin in a \u003ca href=\"http://www.universityofcalifornia.edu/news/article/25267\">press release\u003c/a>.\u003c/p>\n\u003cp>Exercise is known to beneficially impact immune function and several other aspects of health. This new research illuminates on one possible mechanism by which physical activity exerts its helpful effects.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n","blocks":[],"excerpt":"New research by Nobel Prize winning UCSF researcher, Elizabeth Blackburn, provides a possible mechanism by which exercise protects against stress-related chromosome aging.","status":"publish","parent":0,"modified":1302883204,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":12,"wordCount":329},"headData":{"title":"Exercise May Protect Against Stress-Related Cellular Aging | KQED","description":"New research by Nobel Prize winning UCSF researcher, Elizabeth Blackburn, provides a possible mechanism by which exercise protects against stress-related chromosome aging.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Exercise May Protect Against Stress-Related Cellular Aging","datePublished":"2011-04-15T16:00:04.000Z","dateModified":"2011-04-15T16:00:04.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"19213 http://www.kqed.org/quest/blog/?p=13800","disqusUrl":"https://ww2.kqed.org/quest/2011/04/15/exercise-may-protect-against-stress-related-cellular-aging/","disqusTitle":"Exercise May Protect Against Stress-Related Cellular Aging","path":"/quest/19213/exercise-may-protect-against-stress-related-cellular-aging","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2011/04/exercise.jpg\" alt=\"\">\u003cem> Exercise prevents the shortening of telomeres caused by psychological stress. Image courtesy of \u003ca href=\"http://www.flickr.com/photos/mikebaird/3539161615/\">mikebaird\u003c/a>.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>New research by Nobel Prize winning UCSF researcher, \u003ca href=\"http://biochemistry.ucsf.edu/labs/blackburn/\">Elizabeth Blackburn\u003c/a>, provides a possible mechanism by which exercise protects against stress-related chromosome aging.\u003c/p>\n\u003cp>The findings, presented this month at the \u003ca href=\"http://www.aacr.org/\">American Association for Cancer Research\u003c/a> 102nd Annual Meeting, were based on earlier research showing that stress accelerates telomere shortening. \u003ca href=\"http://en.wikipedia.org/wiki/Telomere\">Telomeres\u003c/a> are protective strands of DNA found on the end of chromosomes that protect them from degradation during cell division. Telomere length is associated with cellular health, and is a known marker of cell aging.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>Shorter telomeres are associated with cell death and chromosome instability, which can lead to inflammation. In immune cells, short telomeres can predict poorer prognosis in patients with heart disease and cancer.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In a previous study by Blackburn, psychological stress was associated with shorter telomeres in the lymphocytes of caregivers of chronically ill children. This was the first demonstration that telomere length is correlated to perceived stress. In the current study, co-authored by biochemist Jue Lin, telomere length was again associated with stress levels, this time in primary caregivers looking after a family member with dementia. However when the researchers looked at the immune cells in those who exercised, there was no association between stress and telomere length.\u003c/p>\n\u003cp>Another study, led by Eli Puterman, examined the impact of exercise on the telomeres of healthy women who had been victims of child abuse. In this study those who exercised were protected against the effects of stress on telomere length.\u003c/p>\n\u003cp>“We saw a relationship between childhood trauma and short telomere length but the relationship seems to go away in people who exercise vigorously at least three times a week,” said Lin in a \u003ca href=\"http://www.universityofcalifornia.edu/news/article/25267\">press release\u003c/a>.\u003c/p>\n\u003cp>Exercise is known to beneficially impact immune function and several other aspects of health. This new research illuminates on one possible mechanism by which physical activity exerts its helpful effects.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.76355 -122.458\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/19213/exercise-may-protect-against-stress-related-cellular-aging","authors":["10218"],"categories":["quest_12"],"tags":["quest_83","quest_966","quest_1451","quest_3785","quest_2898","quest_3025"],"featImg":"quest_13803","label":"quest"},"quest_851":{"type":"posts","id":"quest_851","meta":{"index":"posts_1591205157","site":"quest","id":"851","score":null,"sort":[1222700435000]},"guestAuthors":[],"slug":"the-nose-knows","title":"The Nose Knows","publishDate":1222700435,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/09/nose.jpg\">\u003cem>Love is in the air\u003c/em>\u003c/span>I love you. Because you smell different than I do. Not quite Titanic or Casablanca or even Olivia Newton-John in Grease. But smells may be part of the reason why we fall in love with a certain person. At least that is what a \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">new study\u003c/a> argues.\u003c/p>\n\u003cp>We've known for awhile that animals find their \"true love\" partly through smells. One of the things they are sensing is whether the potential mate has a different set of MHC genes. \u003c/p>\n\u003cp>MHC genes are a big part of our immune system. These genes are used to create the huge number of antibodies that we each make to battle bacteria, viruses, etc. Everyone has a different set of these antibodies.\u003c/p>\n\u003cp>The more varied your MHC genes are, the more invaders your immune system can recognize and defeat. So two parents with very different MHC genes will have kids with immune systems that can recognize (and so defeat) lots of different kinds of bacteria and viruses. Parents with similar MHC genes will have kids with less varied immune systems. (This is a big reason why \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=131\">inbred animals\u003c/a> are so sickly.) \u003c/p>\n\u003cp>Animals can tell about a potential mate's MHC genes through smell. And people might be able to do this as well.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Lots of experiments have been done where men or women \u003ca href=\"http://ww2.kqed.org/quest/2008/03/05/dna-and-love/\">sniff the sweaty t-shirts of members of the opposite sex\u003c/a> to see which t-shirt smells better. If the potential mates are of the same ethnic group, the sniffers tend to prefer mates with very dissimilar MHC genes. If the potential mates were of different ethnic groups, the sniffers preferred mates with somewhat but not wildly dissimilar MHC genes. \u003c/p>\n\u003cp>The \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">new study\u003c/a> looked at a group of 30 European American couples from Utah and 30 Yoruba couples from Nigeria. Thankfully there was no sweat smelling involved. Instead the researchers compared the DNA between the spouses of each couple in many different places throughout their genome. \u003c/p>\n\u003cp>What they found was that for the Utah couples, the DNA around the MHC genes was much less alike than the DNA almost everywhere else. This did not appear to be the case for the Yoruba couples. This suggests that at least for these 30 couples from Utah, having a very different set of MHC genes may have been part of picking a spouse.\u003c/p>\n\u003cp>Why the difference between the Utahans and the Yorubans? It is hard to say without more data but one possibility has to do with how much of a role social factors play in picking a spouse in each society. Perhaps the European Americans are freer to choose a mate. If this is the case, then they might be more likely to follow some sort of biological imperative.\u003c/p>\n\u003cp>Another possibility is that this smell test is only a big deal if the potential mates are all very similar to start with. The Utah couples all had pretty similar DNA to each other to begin with. The Yoruba couples' DNA was less alike. \u003c/p>\n\u003cp>Of course, this is a total of 60 couples and so is in no way exhaustive and may be proven wrong tomorrow. But it adds to a growing pile of evidence that suggests how mate selection works at the biological level. And it shows the wide range of things we can learn about ourselves by studying our DNA in great detail. Maybe it even gives perfume companies some ideas too.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n","blocks":[],"excerpt":"We've known for awhile that animals find their \"true love\" partly through smells. One of the things they are sensing is whether the potential mate has a different set of MHC genes. People might be able to do this as well.","status":"publish","parent":0,"modified":1222700435,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":14,"wordCount":581},"headData":{"title":"The Nose Knows | KQED","description":"We've known for awhile that animals find their "true love" partly through smells. One of the things they are sensing is whether the potential mate has a different set of MHC genes. People might be able to do this as well.","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"The Nose Knows","datePublished":"2008-09-29T15:00:35.000Z","dateModified":"2008-09-29T15:00:35.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"851 http://www.kqed.org/quest/blog/?p=851","disqusUrl":"https://ww2.kqed.org/quest/2008/09/29/the-nose-knows/","disqusTitle":"The Nose Knows","path":"/quest/851/the-nose-knows","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/09/nose.jpg\">\u003cem>Love is in the air\u003c/em>\u003c/span>I love you. Because you smell different than I do. Not quite Titanic or Casablanca or even Olivia Newton-John in Grease. But smells may be part of the reason why we fall in love with a certain person. At least that is what a \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">new study\u003c/a> argues.\u003c/p>\n\u003cp>We've known for awhile that animals find their \"true love\" partly through smells. One of the things they are sensing is whether the potential mate has a different set of MHC genes. \u003c/p>\n\u003cp>MHC genes are a big part of our immune system. These genes are used to create the huge number of antibodies that we each make to battle bacteria, viruses, etc. Everyone has a different set of these antibodies.\u003c/p>\n\u003cp>The more varied your MHC genes are, the more invaders your immune system can recognize and defeat. So two parents with very different MHC genes will have kids with immune systems that can recognize (and so defeat) lots of different kinds of bacteria and viruses. Parents with similar MHC genes will have kids with less varied immune systems. (This is a big reason why \u003ca href=\"http://www.thetech.org/genetics/ask.php?id=131\">inbred animals\u003c/a> are so sickly.) \u003c/p>\n\u003cp>Animals can tell about a potential mate's MHC genes through smell. And people might be able to do this as well.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Lots of experiments have been done where men or women \u003ca href=\"http://ww2.kqed.org/quest/2008/03/05/dna-and-love/\">sniff the sweaty t-shirts of members of the opposite sex\u003c/a> to see which t-shirt smells better. If the potential mates are of the same ethnic group, the sniffers tend to prefer mates with very dissimilar MHC genes. If the potential mates were of different ethnic groups, the sniffers preferred mates with somewhat but not wildly dissimilar MHC genes. \u003c/p>\n\u003cp>The \u003ca href=\"http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000184\">new study\u003c/a> looked at a group of 30 European American couples from Utah and 30 Yoruba couples from Nigeria. Thankfully there was no sweat smelling involved. Instead the researchers compared the DNA between the spouses of each couple in many different places throughout their genome. \u003c/p>\n\u003cp>What they found was that for the Utah couples, the DNA around the MHC genes was much less alike than the DNA almost everywhere else. This did not appear to be the case for the Yoruba couples. This suggests that at least for these 30 couples from Utah, having a very different set of MHC genes may have been part of picking a spouse.\u003c/p>\n\u003cp>Why the difference between the Utahans and the Yorubans? It is hard to say without more data but one possibility has to do with how much of a role social factors play in picking a spouse in each society. Perhaps the European Americans are freer to choose a mate. If this is the case, then they might be more likely to follow some sort of biological imperative.\u003c/p>\n\u003cp>Another possibility is that this smell test is only a big deal if the potential mates are all very similar to start with. The Utah couples all had pretty similar DNA to each other to begin with. The Yoruba couples' DNA was less alike. \u003c/p>\n\u003cp>Of course, this is a total of 60 couples and so is in no way exhaustive and may be proven wrong tomorrow. But it adds to a growing pile of evidence that suggests how mate selection works at the biological level. And it shows the wide range of things we can learn about ourselves by studying our DNA in great detail. Maybe it even gives perfume companies some ideas too.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> 37.332 -121.903\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/851/the-nose-knows","authors":["6177"],"categories":["quest_4","quest_12"],"tags":["quest_848","quest_1192","quest_1197","quest_1451","quest_3351","quest_2349","quest_2526","quest_2666","quest_2881"],"label":"quest"},"quest_635":{"type":"posts","id":"quest_635","meta":{"index":"posts_1591205157","site":"quest","id":"635","score":null,"sort":[1212785951000]},"guestAuthors":[],"slug":"vaccines-one-small-risk-for-a-child-one-giant-benefit-for-mankind","title":"Vaccines: One Small Risk for a Child, One Giant Benefit for Mankind","publishDate":1212785951,"format":"standard","headTitle":"QUEST | KQED Science","labelTerm":{"site":"quest"},"content":"\u003cfigure class=\"wp-caption alignnone\" style=\"max-width: 300px\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/06/lightningstrike1.jpg\" width=\"300\" height=\"198\">\u003cfigcaption class=\"wp-caption-text\">You're as likely to be struck by lightning as to have a severe reaction to a vaccine.\u003c/figcaption>\u003c/figure>\n\u003cp>I was reading an \u003ca href=\"http://www.time.com/time/health/article/0,8599,1721109,00.html\">article in Time\u003c/a> last week about parents not vaccinating their children. The story was about how this phenomenon is becoming more widespread.\u003c/p>\n\u003cp>These kinds of stories are weird to me because vaccines are pretty safe. The risk of an adverse side effect is incredibly small. For example, the \u003ca href=\"http://www.cdc.gov/mmwr/preview/mmwrhtml/00046738.htm\">risk for anaphylaxis\u003c/a> from the Hepatitis B Virus vaccination is around 1 in 600,000. This is about the same risk as being struck by lightning (1 in 700,000).\u003c/p>\n\u003cp>Of course, the article wasn't talking about known risks. Instead, it was referring to a hypothesized link between vaccines and autism.\u003c/p>\n\u003cp>People proposed this link when they noticed that cases of autism and the number of vaccinations were rising at the same time. Of course, just because two things happen to occur at the same time, this does not mean they are causally linked. For example, the increase in global temperature is not related to the decrease in the world's populations of pirates (despite what the \u003ca href=\"http://www.venganza.org/about/open-letter/\">Pastafarians\u003c/a> say).\u003c/p>\n\u003cp>So how could an increased number of vaccinations cause an increase in the number of cases of autism? I have seen two ideas put forth. The first is that thimerosal is to blame. The second is that there are so many vaccinations now that we are stressing out the body's immune system. Most likely neither idea is valid.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Thimerosal is a mercury-based preservative that used to be used in vaccines. Even though there haven't been any good studies on the effects of thimerosal on brain development, everyone knows mercury is bad for the brain. So the idea behind thimerosal makes some sense.\u003c/p>\n\u003cp>Back in 2001, vaccine manufacturers decided to eliminate thimerosal from their vaccines. We would predict, then, that cases of autism should go down significantly if thimerosal was linked to autism. They haven't. In fact, in one \u003ca href=\"http://www.webmd.com/brain/autism/news/20080107/thimerosal-down-but-autism-rising\">California study\u003c/a>, cases have continued to climb. So thimerosal is most likely not to blame.\u003c/p>\n\u003cp>Another point that has been made is that there are so many vaccines now that we are stressing out our bodies' immune systems. Again, this concern is unfounded.\u003c/p>\n\u003cp>Vaccines are injections of viral proteins. Our bodies see the proteins and raise antibodies to them. Then when a virus invades, we have antibodies that recognize the virus and target it for destruction.\u003c/p>\n\u003cp>It is the number of viral proteins that matter in terms of taxing the body's immune system and not the number of vaccinations. All of the current vaccines put together do not have as many viral proteins as the old smallpox vaccine (150 vs. 200). So the number of vaccines is unlikely to be the issue.\u003c/p>\n\u003cp>What all of this means is that vaccines are probably not responsible for the significant increase in the number of cases of autism. What is responsible? No one knows for sure.\u003c/p>\n\u003cp>It may be that the rise just comes from all of us recognizing the symptoms more. Or it could be due to some cause we don't know about or understand.\u003c/p>\n\u003cp>What we do know is that vaccines save many lives. I assume no one wants to go back to the early 20th century when polio epidemics swept the country. For example, 2,500 cases of \u003ca title=\"polio\" href=\"http://en.wikipedia.org/wiki/Polio\" target=\"_blank\">polio\u003c/a> ended up at one Los Angeles hospital between May and November of 1934. And in 1952, the U.S. had 21,000 cases of paralytic polio.\u003c/p>\n\u003cp>We can prevent this sort of thing from happening by making sure everyone is vaccinated. And yet there are people who choose to hide behind the people who take the miniscule risk of getting vaccinated.\u003c/p>\n\u003cp>Is this a matter of free choice? Should parents be allowed to opt out of vaccinating their children even if it risks society at large?\u003c/p>\n\u003cp>One idea, I suppose, is to have people who choose not to be vaccinated to sign a waiver saying they accept full responsibility for their actions. In practice this would mean that health insurance and the government would not be responsible for their children's health care bills if they become ill with one of the diseases they refused to be vaccinated against.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>And if your infant, grandma, or immuno-suppressed cousin came down with a disease these folks refused to be vaccinated against, then you could sue the un-vaccinated for damages. The common good isn't enough to encourage these folks. Perhaps threats to their pocketbook will be.\u003c/p>\n\n","blocks":[],"excerpt":null,"status":"publish","parent":0,"modified":1478825924,"stats":{"hasAudio":false,"hasVideo":false,"hasChartOrMap":false,"iframeSrcs":[],"hasGoogleForm":false,"hasGallery":false,"hasHearkenModule":false,"hasPolis":false,"paragraphCount":19,"wordCount":761},"headData":{"title":"Vaccines: One Small Risk for a Child, One Giant Benefit for Mankind | KQED","description":"I was reading an article in Time last week about parents not vaccinating their children. The story was about how this phenomenon is becoming more widespread. These kinds of stories are weird to me because vaccines are pretty safe. The risk of an adverse side effect is incredibly small. For example, the risk for anaphylaxis","ogTitle":"","ogDescription":"","ogImgId":"","twTitle":"","twDescription":"","twImgId":"","schema":{"@context":"http://schema.org","@type":"Article","headline":"Vaccines: One Small Risk for a Child, One Giant Benefit for Mankind","datePublished":"2008-06-06T20:59:11.000Z","dateModified":"2016-11-11T00:58:44.000Z","image":"https://cdn.kqed.org/wp-content/uploads/2020/02/KQED-OG-Image@1x.png"}},"disqusIdentifier":"635 http://www.kqed.org/quest/blog/?p=635","disqusUrl":"https://ww2.kqed.org/quest/2008/06/06/vaccines-one-small-risk-for-a-child-one-giant-benefit-for-mankind/","disqusTitle":"Vaccines: One Small Risk for a Child, One Giant Benefit for Mankind","path":"/quest/635/vaccines-one-small-risk-for-a-child-one-giant-benefit-for-mankind","audioTrackLength":null,"parsedContent":[{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003cfigure class=\"wp-caption alignnone\" style=\"max-width: 300px\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2008/06/lightningstrike1.jpg\" width=\"300\" height=\"198\">\u003cfigcaption class=\"wp-caption-text\">You're as likely to be struck by lightning as to have a severe reaction to a vaccine.\u003c/figcaption>\u003c/figure>\n\u003cp>I was reading an \u003ca href=\"http://www.time.com/time/health/article/0,8599,1721109,00.html\">article in Time\u003c/a> last week about parents not vaccinating their children. The story was about how this phenomenon is becoming more widespread.\u003c/p>\n\u003cp>These kinds of stories are weird to me because vaccines are pretty safe. The risk of an adverse side effect is incredibly small. For example, the \u003ca href=\"http://www.cdc.gov/mmwr/preview/mmwrhtml/00046738.htm\">risk for anaphylaxis\u003c/a> from the Hepatitis B Virus vaccination is around 1 in 600,000. This is about the same risk as being struck by lightning (1 in 700,000).\u003c/p>\n\u003cp>Of course, the article wasn't talking about known risks. Instead, it was referring to a hypothesized link between vaccines and autism.\u003c/p>\n\u003cp>People proposed this link when they noticed that cases of autism and the number of vaccinations were rising at the same time. Of course, just because two things happen to occur at the same time, this does not mean they are causally linked. For example, the increase in global temperature is not related to the decrease in the world's populations of pirates (despite what the \u003ca href=\"http://www.venganza.org/about/open-letter/\">Pastafarians\u003c/a> say).\u003c/p>\n\u003cp>So how could an increased number of vaccinations cause an increase in the number of cases of autism? I have seen two ideas put forth. The first is that thimerosal is to blame. The second is that there are so many vaccinations now that we are stressing out the body's immune system. Most likely neither idea is valid.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>","attributes":{"named":{},"numeric":[]}},{"type":"component","content":"","name":"ad","attributes":{"named":{"label":"fullwidth"},"numeric":["fullwidth"]}},{"type":"contentString","content":"\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Thimerosal is a mercury-based preservative that used to be used in vaccines. Even though there haven't been any good studies on the effects of thimerosal on brain development, everyone knows mercury is bad for the brain. So the idea behind thimerosal makes some sense.\u003c/p>\n\u003cp>Back in 2001, vaccine manufacturers decided to eliminate thimerosal from their vaccines. We would predict, then, that cases of autism should go down significantly if thimerosal was linked to autism. They haven't. In fact, in one \u003ca href=\"http://www.webmd.com/brain/autism/news/20080107/thimerosal-down-but-autism-rising\">California study\u003c/a>, cases have continued to climb. So thimerosal is most likely not to blame.\u003c/p>\n\u003cp>Another point that has been made is that there are so many vaccines now that we are stressing out our bodies' immune systems. Again, this concern is unfounded.\u003c/p>\n\u003cp>Vaccines are injections of viral proteins. Our bodies see the proteins and raise antibodies to them. Then when a virus invades, we have antibodies that recognize the virus and target it for destruction.\u003c/p>\n\u003cp>It is the number of viral proteins that matter in terms of taxing the body's immune system and not the number of vaccinations. All of the current vaccines put together do not have as many viral proteins as the old smallpox vaccine (150 vs. 200). So the number of vaccines is unlikely to be the issue.\u003c/p>\n\u003cp>What all of this means is that vaccines are probably not responsible for the significant increase in the number of cases of autism. What is responsible? No one knows for sure.\u003c/p>\n\u003cp>It may be that the rise just comes from all of us recognizing the symptoms more. Or it could be due to some cause we don't know about or understand.\u003c/p>\n\u003cp>What we do know is that vaccines save many lives. I assume no one wants to go back to the early 20th century when polio epidemics swept the country. For example, 2,500 cases of \u003ca title=\"polio\" href=\"http://en.wikipedia.org/wiki/Polio\" target=\"_blank\">polio\u003c/a> ended up at one Los Angeles hospital between May and November of 1934. And in 1952, the U.S. had 21,000 cases of paralytic polio.\u003c/p>\n\u003cp>We can prevent this sort of thing from happening by making sure everyone is vaccinated. And yet there are people who choose to hide behind the people who take the miniscule risk of getting vaccinated.\u003c/p>\n\u003cp>Is this a matter of free choice? Should parents be allowed to opt out of vaccinating their children even if it risks society at large?\u003c/p>\n\u003cp>One idea, I suppose, is to have people who choose not to be vaccinated to sign a waiver saying they accept full responsibility for their actions. In practice this would mean that health insurance and the government would not be responsible for their children's health care bills if they become ill with one of the diseases they refused to be vaccinated against.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>And if your infant, grandma, or immuno-suppressed cousin came down with a disease these folks refused to be vaccinated against, then you could sue the un-vaccinated for damages. The common good isn't enough to encourage these folks. Perhaps threats to their pocketbook will be.\u003c/p>\n\n\u003c/div>\u003c/p>","attributes":{"named":{},"numeric":[]}}],"link":"/quest/635/vaccines-one-small-risk-for-a-child-one-giant-benefit-for-mankind","authors":["6177"],"categories":["quest_4","quest_5","quest_12"],"tags":["quest_256","quest_378","quest_575","quest_1328","quest_1451","quest_3351","quest_1791","quest_2011","quest_2133","quest_2252","quest_2349","quest_2931","quest_3054","quest_3055","quest_3056","quest_3078"],"label":"quest"}},"programsReducer":{"possible":{"id":"possible","title":"Possible","info":"Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. 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Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.","airtime":"SUN 2pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.possible.fm/","meta":{"site":"news","source":"Possible"},"link":"/radio/program/possible","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/possible/id1677184070","spotify":"https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"}},"1a":{"id":"1a","title":"1A","info":"1A is home to the national conversation. 1A brings on great guests and frames the best debate in ways that make you think, share and engage.","airtime":"MON-THU 11pm-12am","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/1a.jpg","officialWebsiteLink":"https://the1a.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/1a","subscribe":{"npr":"https://rpb3r.app.goo.gl/RBrW","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=1188724250&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/1A-p947376/","rss":"https://feeds.npr.org/510316/podcast.xml"}},"all-things-considered":{"id":"all-things-considered","title":"All Things Considered","info":"Every weekday, \u003cem>All Things Considered\u003c/em> hosts Robert Siegel, Audie Cornish, Ari Shapiro, and Kelly McEvers present the program's trademark mix of news, interviews, commentaries, reviews, and offbeat features. 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You ask the questions. You decide what Bay Curious investigates. 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Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />","airtime":"SUN 9pm-10pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Code-Switch-Life-Kit-Podcast-Tile-360x360-1.jpg","meta":{"site":"radio","source":"npr"},"link":"/radio/program/code-switch-life-kit","subscribe":{"apple":"https://podcasts.apple.com/podcast/1112190608?mt=2&at=11l79Y&ct=nprdirectory","google":"https://podcasts.google.com/feed/aHR0cHM6Ly93d3cubnByLm9yZy9yc3MvcG9kY2FzdC5waHA_aWQ9NTEwMzEy","spotify":"https://open.spotify.com/show/3bExJ9JQpkwNhoHvaIIuyV","rss":"https://feeds.npr.org/510312/podcast.xml"}},"commonwealth-club":{"id":"commonwealth-club","title":"Commonwealth Club of California Podcast","info":"The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.","airtime":"THU 10pm, FRI 1am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.commonwealthclub.org/podcasts","meta":{"site":"news","source":"Commonwealth Club of California"},"link":"/radio/program/commonwealth-club","subscribe":{"apple":"https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2","google":"https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw","tuneIn":"https://tunein.com/radio/Commonwealth-Club-of-California-p1060/"}},"considerthis":{"id":"considerthis","title":"Consider This","tagline":"Make sense of the day","info":"Make sense of the day. Every weekday afternoon, Consider This helps you consider the major stories of the day in less than 15 minutes, featuring the reporting and storytelling resources of NPR. Plus, KQED’s Bianca Taylor brings you the local KQED news you need to know.","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Consider-This-Podcast-Tile-703x703-1.jpg","imageAlt":"Consider This from NPR and KQED","officialWebsiteLink":"/podcasts/considerthis","meta":{"site":"news","source":"kqed","order":"7"},"link":"/podcasts/considerthis","subscribe":{"apple":"https://podcasts.apple.com/podcast/id1503226625?mt=2&at=11l79Y&ct=nprdirectory","npr":"https://rpb3r.app.goo.gl/coronavirusdaily","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM1NS9wb2RjYXN0LnhtbA","spotify":"https://open.spotify.com/show/3Z6JdCS2d0eFEpXHKI6WqH"}},"forum":{"id":"forum","title":"Forum","tagline":"The conversation starts here","info":"KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.","airtime":"MON-FRI 9am-11am, 10pm-11pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED Forum with Mina Kim and Alexis Madrigal","officialWebsiteLink":"/forum","meta":{"site":"news","source":"kqed","order":"8"},"link":"/forum","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/kqeds-forum/id73329719","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz","npr":"https://www.npr.org/podcasts/432307980/forum","stitcher":"https://www.stitcher.com/podcast/kqedfm-kqeds-forum-podcast","rss":"https://feeds.megaphone.fm/KQINC9557381633"}},"freakonomics-radio":{"id":"freakonomics-radio","title":"Freakonomics Radio","info":"Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. 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Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.","airtime":"MON-THU 11am-12pm","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Here-And-Now-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"http://www.wbur.org/hereandnow","meta":{"site":"news","source":"npr"},"link":"/radio/program/here-and-now","subsdcribe":{"apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?mt=2&id=426698661","tuneIn":"https://tunein.com/radio/Here--Now-p211/","rss":"https://feeds.npr.org/510051/podcast.xml"}},"how-i-built-this":{"id":"how-i-built-this","title":"How I Built This with Guy Raz","info":"Guy Raz dives into the stories behind some of the world's best known companies. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists—and the movements they built.","imageSrc":"https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/howIBuiltThis.png","officialWebsiteLink":"https://www.npr.org/podcasts/510313/how-i-built-this","airtime":"SUN 7:30pm-8pm","meta":{"site":"news","source":"npr"},"link":"/radio/program/how-i-built-this","subscribe":{"npr":"https://rpb3r.app.goo.gl/3zxy","apple":"https://itunes.apple.com/us/podcast/how-i-built-this-with-guy-raz/id1150510297?mt=2","tuneIn":"https://tunein.com/podcasts/Arts--Culture-Podcasts/How-I-Built-This-p910896/","rss":"https://feeds.npr.org/510313/podcast.xml"}},"inside-europe":{"id":"inside-europe","title":"Inside Europe","info":"Inside Europe, a one-hour weekly news magazine hosted by Helen Seeney and Keith Walker, explores the topical issues shaping the continent. No other part of the globe has experienced such dynamic political and social change in recent years.","airtime":"SAT 3am-4am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Inside-Europe-Podcast-Tile-300x300-1.jpg","meta":{"site":"news","source":"Deutsche Welle"},"link":"/radio/program/inside-europe","subscribe":{"apple":"https://itunes.apple.com/us/podcast/inside-europe/id80106806?mt=2","tuneIn":"https://tunein.com/radio/Inside-Europe-p731/","rss":"https://partner.dw.com/xml/podcast_inside-europe"}},"latino-usa":{"id":"latino-usa","title":"Latino USA","airtime":"MON 1am-2am, SUN 6pm-7pm","info":"Latino USA, the radio journal of news and culture, is the only national, English-language radio program produced from a Latino perspective.","imageSrc":"https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/latinoUsa.jpg","officialWebsiteLink":"http://latinousa.org/","meta":{"site":"news","source":"npr"},"link":"/radio/program/latino-usa","subscribe":{"npr":"https://rpb3r.app.goo.gl/xtTd","apple":"https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=79681317&at=11l79Y&ct=nprdirectory","tuneIn":"https://tunein.com/radio/Latino-USA-p621/","rss":"https://feeds.npr.org/510016/podcast.xml"}},"live-from-here-highlights":{"id":"live-from-here-highlights","title":"Live from Here Highlights","info":"Chris Thile steps to the mic as the host of Live from Here (formerly A Prairie Home Companion), a live public radio variety show. 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Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg","imageAlt":"KQED MindShift: How We Will Learn","officialWebsiteLink":"/mindshift/","meta":{"site":"news","source":"kqed","order":"2"},"link":"/podcasts/mindshift","subscribe":{"apple":"https://podcasts.apple.com/us/podcast/mindshift-podcast/id1078765985","google":"https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5","npr":"https://www.npr.org/podcasts/464615685/mind-shift-podcast","stitcher":"https://www.stitcher.com/podcast/kqed/stories-teachers-share","spotify":"https://open.spotify.com/show/0MxSpNYZKNprFLCl7eEtyx"}},"morning-edition":{"id":"morning-edition","title":"Morning Edition","info":"\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.","airtime":"MON-FRI 3am-9am","imageSrc":"https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg","officialWebsiteLink":"https://www.npr.org/programs/morning-edition/","meta":{"site":"news","source":"npr"},"link":"/radio/program/morning-edition"},"onourwatch":{"id":"onourwatch","title":"On Our Watch","tagline":"Police secrets, unsealed","info":"For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. 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