One of the great things about living in San Francisco is that perfect pairings are available in all parts of town. Let me explain what I mean by this term: often, an evening out for me will involve dinner and drinks before or after at a location that is in the general vicinity of dinner. When the food and the drinks combine to make for a perfect dining experience, I consider this to be a "perfect pairing."
Some perfect pairings are across town. For instance, I happen to think that dinner at SPQR preceded by a drink at The Alembic is a perfect, if high maintenance, pairing. But that pairing usually involves a cab ride in between as The Alembic is in the Haight and SPQR is in Pacific Heights.
However, some pairings are not quite as far flung. And some have proven to be perfect time and again.
A new "perfect pairing" for me is close to Union Square and therefore perfect for entertaining out-of-town visitors who are already downtown and looking to meet for dinner. I've done it several times recently, and have complete confidence whenever meeting visitors and friends alike for this outing.