Weinstein then named two other women, she says — an actress and a model — who he claimed to have had sexual relationships with, and whose careers he had advanced as a result. "I'll never be that girl," she said, and left.
"Got down the elevator. By the time I got to the bottom, the lobby, I had a completely different career," Arquette says. Roles started to disappear, and new opportunities didn't seem to come.
She's not the only actress who believes Weinstein damaged their career: Mira Sorvino, Ashley Judd, Daryl Hannah and Annabella Sciorra all are among those who say the producer retaliated against them professionally.
Annabella Sciorra, who alleges Weinstein raped her, told the New Yorker that she felt the impact on her career almost immediately.
"From 1992, I didn't work again until 1995," Sciorra says. "I just kept getting this pushback of 'We heard you were difficult; we heard this or that.' I think that that was the Harvey machine."
Others recounted similar stories, saying they believed Weinstein told producers and directors to avoid casting them. Lord of the Rings director Peter Jackson confirmed in the New Zealand publication Stuff last year that Weinstein and his brother orchestrated a smear campaign that led him to avoid casting Judd and Sorvino.
"I burst out crying," Sorvino wrote on Twitter after seeing the story. "There it is, confirmation that Harvey Weinstein derailed my career."
"All of us have lost work," says Arquette. "You have the most powerful businesspeople in the world protecting [Weinstein] for years."
Now, Arquette says her focus is on supporting the women she says have been "raped and brutalized" by him. She says there are other women who have not yet come forward out of fear of being retaliated against like she was, and she hopes they'll feel more secure to do so now that he's been criminally charged.
"There are a lot more women, and a lot of lives and careers have been destroyed," she says. "And maybe they'll feel safer to be able to do that now."
Harvey Weinstein has denied all allegations of nonconsensual sex — as well as assertions that he retaliated professionally against women who rebuffed him. His lawyers have signaled that he will plead not guilty, and they have painted him as the victim of a Hollywood witch hunt.
"This is not a witch hunt," says Arquette, her voice rising. "This is not a witch hunt. This is [about] men who have done really horrible things and gotten away with it for years....
"No more. We say no more."