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"content": "\u003cp>About four years ago, Kevin Sinclair inherited an army of clones. Very fluffy clones.\u003c/p>\n\u003cp>“Daisy, Debbie, Denise and Diana,” says \u003ca href=\"https://www.nottingham.ac.uk/biosciences/people/kevin.sinclair\">Sinclair\u003c/a>, a developmental biologist at the University of Nottingham in England.\u003c/p>\n\u003caside class=\"pullquote alignright\">‘It provides another boost to those of us who are hoping this technology might someday be useful for conservation.’\u003ccite>Beth Shapiro,UC Santa Cruz evolutionary biologist\u003c/cite>\u003c/aside>\n\u003cp>The sheep are just four of 13 clones Sinclair shepherds, but they’re the most famous because of their relation to Dolly, the sheep that made headlines two decades ago as the first successfully cloned mammal.\u003c/p>\n\u003cp>” ‘Sister clones’ probably best describes them,” Sinclair says. “They actually come from the exactly the same batch of cells that Dolly came from.”\u003c/p>\n\u003cp>Recently, Sinclair and his colleagues celebrated the sister clones’ ninth birthday, which, he explains, would be like the 70\u003csup>th\u003c/sup> birthday of a human. In an article out Tuesday \u003ca href=\"http://nature.com/articles/doi:10.1038/ncomms12359\">in the journal\u003c/a> \u003cem>Nature Communications\u003c/em>, Sinclair and his colleagues write that the ewes’ age, along with their strapping health, might be a reason for people to start feeling more optimistic about what cloning can do.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Dolly’s life did not turn out as scientists in the cloning field hoped it would. She died young — six-and-a-half — with a nasty lung virus. “That was really just bad luck,” Sinclair says, and had “nothing to do” with the fact that Dolly was a clone.\u003c/p>\n\u003cp>But she also bad osteoarthritis in her knees and rear hip at a surprisingly early age and the tips of her chromosomes were short — \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1122035/\">both signs\u003c/a> that she’d aged more quickly than a normal sheep.\u003c/p>\n\u003cp>“That sort of threw fuel to the fire and strengthened concerns that clones might be aging prematurely,” says Sinclair. Because clones like Dolly were derived from the cell of an adult animal, the thinking went, her body might be set to an older clock from the start.\u003c/p>\n\u003cp>It was a daunting concept for those in the cloning field, because, says Sinclair, “If you’re going to create these animals, they should be normal in every respect. They should be just as healthy as any other animal that’s conceived naturally. If that is not the case, then it raises serious ethical and welfare concerns about creating these animals in the first place.”\u003c/p>\n\u003cp>But, the good health of the 13 clones in the Nottingham herd suggest better prospects for the procedure. Sinclair and his colleagues evaluated the animals’ blood pressure, metabolism, heart function, muscles and joints, looking for signs of premature aging. They even fattened them up (since obesity is a risk factor for metabolic problems including diabetes) and gave them the standard tests to gauge how their bodies would handle glucose and insulin.\u003c/p>\n\u003cp>The results? Normal, normal, normal.\u003c/p>\n\u003cp>“There is nothing to suggest that these animals were anything other than perfectly normal,” says Sinclair. They had slight signs of arthritis (Debbie in particular), but not enough to cause problems. “If I put them in with a bunch of other sheep, you would never be able to identify them,” he says.\u003c/p>\n\u003cp>The scientists haven’t investigated the length of the animals’ chromosome tips, called telomeres. That will have to wait until the animals die, so scientists can get cells from a variety of organs.\u003c/p>\n\u003cp>But \u003ca href=\"http://campusdirectory.ucsc.edu/detail.php?type=people&uid=bashapir\">Beth Shapiro\u003c/a>, an evolutionary biologist at the University of California, Santa Cruz, says the results of this study are already plenty exciting.\u003c/p>\n\u003cp>“It provides another boost to those of us who are hoping this technology might someday be useful for conservation,” says Shapiro, who recently \u003ca href=\"http://press.princeton.edu/titles/10415.html\">wrote a book\u003c/a> called \u003cem>How to Clone a Mammoth: The Science of De-Extinction\u003c/em>. She’s one of the scientists interested in cloning endangered animals to keep them from dying off, and also hopes to – maybe — rescue species that have already gone extinct.\u003c/p>\n\u003cp>For example, if biologists noticed that the population of an important species was plummeting toward extinction, and that its absence would likely cause a cascade of changes to the ecosystem, the researchers might consider cloning the animals to help boost the population back up to sustainable numbers.\u003c/p>\n\u003cp>“This science is showing us [that] if we can get by what we know is the trickiest and least efficient part of this process, then the clones that are born are, in essence, just like anything else that’s alive — perfectly healthy and perfectly capable of living to old age,” says Shapiro.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>As for the sheep clones in his care, Sinclair says “they will continue to lead normal sheep lives.” Once they reach the ripe old age of about 10, they’ll be euthanized and the researchers will do a detailed post-mortem analysis of their bodies.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg decoding=\"async\" src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=%27Clone+Sisters%27+Of+Dolly+The+Sheep+Are+Alive+And+Kicking&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>About four years ago, Kevin Sinclair inherited an army of clones. Very fluffy clones.\u003c/p>\n\u003cp>“Daisy, Debbie, Denise and Diana,” says \u003ca href=\"https://www.nottingham.ac.uk/biosciences/people/kevin.sinclair\">Sinclair\u003c/a>, a developmental biologist at the University of Nottingham in England.\u003c/p>\n\u003caside class=\"pullquote alignright\">‘It provides another boost to those of us who are hoping this technology might someday be useful for conservation.’\u003ccite>Beth Shapiro,UC Santa Cruz evolutionary biologist\u003c/cite>\u003c/aside>\n\u003cp>The sheep are just four of 13 clones Sinclair shepherds, but they’re the most famous because of their relation to Dolly, the sheep that made headlines two decades ago as the first successfully cloned mammal.\u003c/p>\n\u003cp>” ‘Sister clones’ probably best describes them,” Sinclair says. “They actually come from the exactly the same batch of cells that Dolly came from.”\u003c/p>\n\u003cp>Recently, Sinclair and his colleagues celebrated the sister clones’ ninth birthday, which, he explains, would be like the 70\u003csup>th\u003c/sup> birthday of a human. In an article out Tuesday \u003ca href=\"http://nature.com/articles/doi:10.1038/ncomms12359\">in the journal\u003c/a> \u003cem>Nature Communications\u003c/em>, Sinclair and his colleagues write that the ewes’ age, along with their strapping health, might be a reason for people to start feeling more optimistic about what cloning can do.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Dolly’s life did not turn out as scientists in the cloning field hoped it would. She died young — six-and-a-half — with a nasty lung virus. “That was really just bad luck,” Sinclair says, and had “nothing to do” with the fact that Dolly was a clone.\u003c/p>\n\u003cp>But she also bad osteoarthritis in her knees and rear hip at a surprisingly early age and the tips of her chromosomes were short — \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1122035/\">both signs\u003c/a> that she’d aged more quickly than a normal sheep.\u003c/p>\n\u003cp>“That sort of threw fuel to the fire and strengthened concerns that clones might be aging prematurely,” says Sinclair. Because clones like Dolly were derived from the cell of an adult animal, the thinking went, her body might be set to an older clock from the start.\u003c/p>\n\u003cp>It was a daunting concept for those in the cloning field, because, says Sinclair, “If you’re going to create these animals, they should be normal in every respect. They should be just as healthy as any other animal that’s conceived naturally. If that is not the case, then it raises serious ethical and welfare concerns about creating these animals in the first place.”\u003c/p>\n\u003cp>But, the good health of the 13 clones in the Nottingham herd suggest better prospects for the procedure. Sinclair and his colleagues evaluated the animals’ blood pressure, metabolism, heart function, muscles and joints, looking for signs of premature aging. They even fattened them up (since obesity is a risk factor for metabolic problems including diabetes) and gave them the standard tests to gauge how their bodies would handle glucose and insulin.\u003c/p>\n\u003cp>The results? Normal, normal, normal.\u003c/p>\n\u003cp>“There is nothing to suggest that these animals were anything other than perfectly normal,” says Sinclair. They had slight signs of arthritis (Debbie in particular), but not enough to cause problems. “If I put them in with a bunch of other sheep, you would never be able to identify them,” he says.\u003c/p>\n\u003cp>The scientists haven’t investigated the length of the animals’ chromosome tips, called telomeres. That will have to wait until the animals die, so scientists can get cells from a variety of organs.\u003c/p>\n\u003cp>But \u003ca href=\"http://campusdirectory.ucsc.edu/detail.php?type=people&uid=bashapir\">Beth Shapiro\u003c/a>, an evolutionary biologist at the University of California, Santa Cruz, says the results of this study are already plenty exciting.\u003c/p>\n\u003cp>“It provides another boost to those of us who are hoping this technology might someday be useful for conservation,” says Shapiro, who recently \u003ca href=\"http://press.princeton.edu/titles/10415.html\">wrote a book\u003c/a> called \u003cem>How to Clone a Mammoth: The Science of De-Extinction\u003c/em>. She’s one of the scientists interested in cloning endangered animals to keep them from dying off, and also hopes to – maybe — rescue species that have already gone extinct.\u003c/p>\n\u003cp>For example, if biologists noticed that the population of an important species was plummeting toward extinction, and that its absence would likely cause a cascade of changes to the ecosystem, the researchers might consider cloning the animals to help boost the population back up to sustainable numbers.\u003c/p>\n\u003cp>“This science is showing us [that] if we can get by what we know is the trickiest and least efficient part of this process, then the clones that are born are, in essence, just like anything else that’s alive — perfectly healthy and perfectly capable of living to old age,” says Shapiro.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>As for the sheep clones in his care, Sinclair says “they will continue to lead normal sheep lives.” Once they reach the ripe old age of about 10, they’ll be euthanized and the researchers will do a detailed post-mortem analysis of their bodies.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg decoding=\"async\" src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=%27Clone+Sisters%27+Of+Dolly+The+Sheep+Are+Alive+And+Kicking&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game – and Brown has some lessons he'd like to share. ",
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"info": "Political Breakdown is a new series that explores the political intersection of California and the nation. Each week hosts Scott Shafer and Marisa Lagos are joined with a new special guest to unpack politics -- with personality — and offer an insider’s glimpse at how politics happens.",
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"possible": {
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"info": "Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.",
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},
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"tagline": "Art is where you find it",
"info": "Rightnowish digs into life in the Bay Area right now… ish. Journalist Pendarvis Harshaw takes us to galleries painted on the sides of liquor stores in West Oakland. We'll dance in warehouses in the Bayview, make smoothies with kids in South Berkeley, and listen to classical music in a 1984 Cutlass Supreme in Richmond. Every week, Pen talks to movers and shakers about how the Bay Area shapes what they create, and how they shape the place we call home.",
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"title": "Snap Judgment",
"tagline": "Real stories with killer beats",
"info": "The Snap Judgment radio show and podcast mixes real stories with killer beats to produce cinematic, dramatic radio. Snap's musical brand of storytelling dares listeners to see the world through the eyes of another. This is storytelling... with a BEAT!! Snap first aired on public radio stations nationwide in July 2010. Today, Snap Judgment airs on over 450 public radio stations and is brought to the airwaves by KQED & PRX.",
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},
"soldout": {
"id": "soldout",
"title": "SOLD OUT: Rethinking Housing in America",
"tagline": "A new future for housing",
"info": "Sold Out: Rethinking Housing in America",
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