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"caption": "The 18th century French botanist Louis Lémery wrote that asparagus causes \"a filthy and disagreeable smell in the urine, as everybody knows.\" Not everybody, Louis. Not everybody.",
"description": "The 18th century French botanist Louis Lémery wrote that asparagus causes \"a filthy and disagreeable smell in the urine, as everybody knows.\" Not everybody, Louis. Not everybody",
"title": "The 18th century French botanist Louis Lémery wrote that asparagus causes \"a filthy and disagreeable smell in the urine, as everybody knows.\" Not everybody, Louis. Not everybody.",
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"disqusTitle": "We Unravel The Science Mysteries Of Asparagus Pee",
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"content": "\u003cp>As Ben Franklin noted, some of you have \"the Power of changing, by slight means, the smell of another discharge ... our water. A few stems of asparagus eaten, shall give our urine a disagreeable odour.\" Apparently this is so common a power that the 18th century French botanist Louis Lémery wrote that asparagus causes \"a filthy and disagreeable smell in the urine, as everybody knows.\"\u003c/p>\n\u003cp>Everybody except me, anyway.\u003c/p>\n\u003cp>I'd never heard of this particular side effect of asparagus until I was in my 20s, and I ate plenty of asparagus growing up. The difference between people like myself and people like Lémery lies somewhere among more than 800 different genes, according to a new study that searched for genetic differences between those who claim they can and those who claim they can't smell asparagus pee.\u003c/p>\n\u003cp>The researchers asked nearly 7,000 participants if they could detect a distinct smell in their urine after eating asparagus. About 40 percent of them strongly agreed they could. The other 4,161 people (I imagine) were confused by the question. According to the study, \u003ca href=\"http://www.bmj.com/content/355/bmj.i6071\">published in \u003cem>BMJ \u003c/em>on Tuesday\u003c/a>, these people share some combination of at least 871 different genetic alterations that may blunt their ability to smell asparagus pee.\u003c/p>\n\u003cp>All of these mutations create different variations of genes that code for smell receptors, says \u003ca href=\"https://www.hsph.harvard.edu/lorelei-mucci/\">Lorelei Mucci\u003c/a>, an epidemiologist at Harvard University and the senior author on the study. They were all strongly associated with the inability to smell asparagus pee, but Mucci says it's hard to tell which of those 871 gene variations actually cause the insensitivity.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Three of the mutations make good culprits, however, because they change the shape of a smell receptor. \"These were probably damaging, leading to a big change in the protein structure\" of the receptor, Mucci says. Then again, it could also be any of the other mutations, she quickly hedges.\u003c/p>\n\u003cp>Even if a mutation doesn't directly affect a key protein, it could affect other, related genes. And still some other mutations that came up in the study might be completely spurious correlations with no effect whatsoever on smell. \"We need to do a lot more additional work on the specific variants,\" Mucci says.\u003c/p>\n\u003cp>There are different ideas about what's actually in asparagus pee that makes it smell unique. Most scientists agree that it probably starts with \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/24099657\">asparagusic acid\u003c/a>, a sulfur compound found only in asparagus. What comes out the other end is harder to say.\u003c/p>\n\u003cp>\"There's still disagreement on how many or which sulfur compounds are involved,\" says \u003ca href=\"http://www.monell.org/faculty/people/pelchat\">Marcia Pelchat\u003c/a>, a food scientist at Monell Chemical Senses Center who has studied asparagus pee and was not involved with the study.\u003c/p>\n\u003cp>Compounds called thiols, or mercaptans, which are powerfully odorous chemicals that smell like garlic or rotten eggs, are present and likely contribute. But nobody has yet flushed out the details on how we're metabolizing asparagus, Pelchat says.\u003c/p>\n\u003cp>It could be considered a blessing for those who do not smell asparagus pee. \"It's amazing that for something that tastes so good like asparagus, the resulting odor is so horrible,\" Mucci says. \"What's fascinating about it is it happens very quickly. When it does happen, it is so strong. It's unbelievable.\"\u003c/p>\n\u003cp>On the day Pelchat did her study on asparagus pee, she remembers the stench in the restroom. \"It brought tears to my eyes,\" she says.\u003c/p>\n\u003cp>The smell has been likened to being something akin to rotten cabbages or, sometimes, cooked cabbages. \"Maybe skunkish,\" Pelchat says. Then she asks me, \"Can you smell skunk?\" I can. \"Cabbage? Brussel sprouts?\" I can smell those, too. \"I would think that you could [smell asparagus pee]. Even fewer than 10 stalks ought to do it,\" she says.\u003c/p>\n\u003cp>Well, challenge accepted. I try a recipe from Pelchat: broiled asparagus in olive oil and kosher salt and pepper. Eight spears and 30 minutes later, I pee into an empty yogurt container. I get a hint of something vaguely cabbage-like. Did I imagine it? I lift the cup of my pee to my face and take a deep whiff. Nothing. It didn't smell good, but not really plant-like.\u003c/p>\n\u003cp>A friend of mine is waiting in the living room. \"Come smell my pee,\" I say.\u003c/p>\n\u003cp>\"Oh yeah, I can smell it,\" she says. But it's different. \"If I had eaten as many thick stalks as you had eaten, I would have to turn my head away because of the smell.\"\u003c/p>\n\u003cp>It's like a light plant scent, according to my friend's sister, who also smells my pee. \"Maybe you are special,\" she says. Maybe I can detect a slight fragrance after all. I'm no longer sure, and I don't want to keep sniffing my own urine.\u003c/p>\n\u003cp>It is apparent that some people really can't smell asparagus pee. Most people can't, if Mucci's study is any indication, making Lémery's generalizations feel a little arrogant. But whether everybody actually produces the odor is somewhat controversial.\u003c/p>\n\u003cp>\"Two big genetic studies have only come up with markers near olfactory receptors. That strongly suggests it's probably [that] everybody produces it but not everybody detects it,\" Pelchat says.\u003c/p>\n\u003cp>However, \u003ca href=\"http://www.imperial.ac.uk/people/s.c.mitchell\">Dr. Steve Mitchell\u003c/a>, a professor of medicine at Imperial College London who has extensively studied asparagus urine and was not involved with the study, wrote to me in an email, \"I, for one, do not produce an urinary odour after eating asparagus but can smell the odour from others.\"\u003c/p>\n\u003cp>\"I'm not arguing there couldn't be [non-producers],\" Pelchat says. \"But it's not likely to have a genetic basis.\" If some people don't produce the smell or produce different smells, Mitchell says it may be due to a confluence of things. Anything between the efficiency of the person's intestines to different gut bacteria involved might alter the smell of someone's urine after eating asparagus.\u003c/p>\n\u003cp>Why this is even a thing is \"a much deeper philosophical aspect,\" Mitchell writes. Is there a genetic advantage or disadvantage to smelling asparagus pee that thus led to the spread of these genes?\u003c/p>\n\u003cp>\"Do not know,\" Mitchell writes.\u003c/p>\n\u003cp>Mucci thinks being unable to detect the \"after-smell\" of asparagus might be useful, since the odor may discourage some people from eating this highly nutritious vegetable. \"That is the case of my daughter,\" Pelchat tells me. \"But I think my son liked to eat asparagus even more because it produces this disgusting phenomenon.\"\u003c/p>\n\u003cp>\u003cem>Angus Chen is on Twitter \u003ca href=\"https://twitter.com/angrchen\">@angrchen\u003c/a>.\u003c/em> \u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>Copyright 2016 \u003ca href=\"http://www.npr.org/\" target=\"_blank\">NPR\u003c/a>.\u003c/em> \u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>As Ben Franklin noted, some of you have \"the Power of changing, by slight means, the smell of another discharge ... our water. A few stems of asparagus eaten, shall give our urine a disagreeable odour.\" Apparently this is so common a power that the 18th century French botanist Louis Lémery wrote that asparagus causes \"a filthy and disagreeable smell in the urine, as everybody knows.\"\u003c/p>\n\u003cp>Everybody except me, anyway.\u003c/p>\n\u003cp>I'd never heard of this particular side effect of asparagus until I was in my 20s, and I ate plenty of asparagus growing up. The difference between people like myself and people like Lémery lies somewhere among more than 800 different genes, according to a new study that searched for genetic differences between those who claim they can and those who claim they can't smell asparagus pee.\u003c/p>\n\u003cp>The researchers asked nearly 7,000 participants if they could detect a distinct smell in their urine after eating asparagus. About 40 percent of them strongly agreed they could. The other 4,161 people (I imagine) were confused by the question. According to the study, \u003ca href=\"http://www.bmj.com/content/355/bmj.i6071\">published in \u003cem>BMJ \u003c/em>on Tuesday\u003c/a>, these people share some combination of at least 871 different genetic alterations that may blunt their ability to smell asparagus pee.\u003c/p>\n\u003cp>All of these mutations create different variations of genes that code for smell receptors, says \u003ca href=\"https://www.hsph.harvard.edu/lorelei-mucci/\">Lorelei Mucci\u003c/a>, an epidemiologist at Harvard University and the senior author on the study. They were all strongly associated with the inability to smell asparagus pee, but Mucci says it's hard to tell which of those 871 gene variations actually cause the insensitivity.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Three of the mutations make good culprits, however, because they change the shape of a smell receptor. \"These were probably damaging, leading to a big change in the protein structure\" of the receptor, Mucci says. Then again, it could also be any of the other mutations, she quickly hedges.\u003c/p>\n\u003cp>Even if a mutation doesn't directly affect a key protein, it could affect other, related genes. And still some other mutations that came up in the study might be completely spurious correlations with no effect whatsoever on smell. \"We need to do a lot more additional work on the specific variants,\" Mucci says.\u003c/p>\n\u003cp>There are different ideas about what's actually in asparagus pee that makes it smell unique. Most scientists agree that it probably starts with \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/24099657\">asparagusic acid\u003c/a>, a sulfur compound found only in asparagus. What comes out the other end is harder to say.\u003c/p>\n\u003cp>\"There's still disagreement on how many or which sulfur compounds are involved,\" says \u003ca href=\"http://www.monell.org/faculty/people/pelchat\">Marcia Pelchat\u003c/a>, a food scientist at Monell Chemical Senses Center who has studied asparagus pee and was not involved with the study.\u003c/p>\n\u003cp>Compounds called thiols, or mercaptans, which are powerfully odorous chemicals that smell like garlic or rotten eggs, are present and likely contribute. But nobody has yet flushed out the details on how we're metabolizing asparagus, Pelchat says.\u003c/p>\n\u003cp>It could be considered a blessing for those who do not smell asparagus pee. \"It's amazing that for something that tastes so good like asparagus, the resulting odor is so horrible,\" Mucci says. \"What's fascinating about it is it happens very quickly. When it does happen, it is so strong. It's unbelievable.\"\u003c/p>\n\u003cp>On the day Pelchat did her study on asparagus pee, she remembers the stench in the restroom. \"It brought tears to my eyes,\" she says.\u003c/p>\n\u003cp>The smell has been likened to being something akin to rotten cabbages or, sometimes, cooked cabbages. \"Maybe skunkish,\" Pelchat says. Then she asks me, \"Can you smell skunk?\" I can. \"Cabbage? Brussel sprouts?\" I can smell those, too. \"I would think that you could [smell asparagus pee]. Even fewer than 10 stalks ought to do it,\" she says.\u003c/p>\n\u003cp>Well, challenge accepted. I try a recipe from Pelchat: broiled asparagus in olive oil and kosher salt and pepper. Eight spears and 30 minutes later, I pee into an empty yogurt container. I get a hint of something vaguely cabbage-like. Did I imagine it? I lift the cup of my pee to my face and take a deep whiff. Nothing. It didn't smell good, but not really plant-like.\u003c/p>\n\u003cp>A friend of mine is waiting in the living room. \"Come smell my pee,\" I say.\u003c/p>\n\u003cp>\"Oh yeah, I can smell it,\" she says. But it's different. \"If I had eaten as many thick stalks as you had eaten, I would have to turn my head away because of the smell.\"\u003c/p>\n\u003cp>It's like a light plant scent, according to my friend's sister, who also smells my pee. \"Maybe you are special,\" she says. Maybe I can detect a slight fragrance after all. I'm no longer sure, and I don't want to keep sniffing my own urine.\u003c/p>\n\u003cp>It is apparent that some people really can't smell asparagus pee. Most people can't, if Mucci's study is any indication, making Lémery's generalizations feel a little arrogant. But whether everybody actually produces the odor is somewhat controversial.\u003c/p>\n\u003cp>\"Two big genetic studies have only come up with markers near olfactory receptors. That strongly suggests it's probably [that] everybody produces it but not everybody detects it,\" Pelchat says.\u003c/p>\n\u003cp>However, \u003ca href=\"http://www.imperial.ac.uk/people/s.c.mitchell\">Dr. Steve Mitchell\u003c/a>, a professor of medicine at Imperial College London who has extensively studied asparagus urine and was not involved with the study, wrote to me in an email, \"I, for one, do not produce an urinary odour after eating asparagus but can smell the odour from others.\"\u003c/p>\n\u003cp>\"I'm not arguing there couldn't be [non-producers],\" Pelchat says. \"But it's not likely to have a genetic basis.\" If some people don't produce the smell or produce different smells, Mitchell says it may be due to a confluence of things. Anything between the efficiency of the person's intestines to different gut bacteria involved might alter the smell of someone's urine after eating asparagus.\u003c/p>\n\u003cp>Why this is even a thing is \"a much deeper philosophical aspect,\" Mitchell writes. Is there a genetic advantage or disadvantage to smelling asparagus pee that thus led to the spread of these genes?\u003c/p>\n\u003cp>\"Do not know,\" Mitchell writes.\u003c/p>\n\u003cp>Mucci thinks being unable to detect the \"after-smell\" of asparagus might be useful, since the odor may discourage some people from eating this highly nutritious vegetable. \"That is the case of my daughter,\" Pelchat tells me. \"But I think my son liked to eat asparagus even more because it produces this disgusting phenomenon.\"\u003c/p>\n\u003cp>\u003cem>Angus Chen is on Twitter \u003ca href=\"https://twitter.com/angrchen\">@angrchen\u003c/a>.\u003c/em> \u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game and Brown has some lessons he'd like to share. ",
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"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
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"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
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"tagline": "Politics from a personal perspective",
"info": "Political Breakdown is a new series that explores the political intersection of California and the nation. Each week hosts Scott Shafer and Marisa Lagos are joined with a new special guest to unpack politics -- with personality — and offer an insider’s glimpse at how politics happens.",
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"possible": {
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"info": "Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.",
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"pri-the-world": {
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"title": "PRI's The World: Latest Edition",
"info": "Each weekday, host Marco Werman and his team of producers bring you the world's most interesting stories in an hour of radio that reminds us just how small our planet really is.",
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},
"radiolab": {
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"title": "Radiolab",
"info": "A two-time Peabody Award-winner, Radiolab is an investigation told through sounds and stories, and centered around one big idea. In the Radiolab world, information sounds like music and science and culture collide. Hosted by Jad Abumrad and Robert Krulwich, the show is designed for listeners who demand skepticism, but appreciate wonder. WNYC Studios is the producer of other leading podcasts including Freakonomics Radio, Death, Sex & Money, On the Media and many more.",
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},
"reveal": {
"id": "reveal",
"title": "Reveal",
"info": "Created by The Center for Investigative Reporting and PRX, Reveal is public radios first one-hour weekly radio show and podcast dedicated to investigative reporting. Credible, fact based and without a partisan agenda, Reveal combines the power and artistry of driveway moment storytelling with data-rich reporting on critically important issues. The result is stories that inform and inspire, arming our listeners with information to right injustices, hold the powerful accountable and improve lives.Reveal is hosted by Al Letson and showcases the award-winning work of CIR and newsrooms large and small across the nation. In a radio and podcast market crowded with choices, Reveal focuses on important and often surprising stories that illuminate the world for our listeners.",
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"officialWebsiteLink": "https://www.revealnews.org/episodes/",
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},
"rightnowish": {
"id": "rightnowish",
"title": "Rightnowish",
"tagline": "Art is where you find it",
"info": "Rightnowish digs into life in the Bay Area right now… ish. Journalist Pendarvis Harshaw takes us to galleries painted on the sides of liquor stores in West Oakland. We'll dance in warehouses in the Bayview, make smoothies with kids in South Berkeley, and listen to classical music in a 1984 Cutlass Supreme in Richmond. Every week, Pen talks to movers and shakers about how the Bay Area shapes what they create, and how they shape the place we call home.",
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"order": 16
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