Bumbery called the death "sudden and unexpected" and said his wife and family were shocked by it. The statement said the family would be working closely with the medical examiner to determine the cause and asked for privacy.
With his powerful, nearly four-octave vocal range, Cornell was one of the leading voices of the 1990s grunge movement with Soundgarden, which emerged as one of the biggest bands out of Seattle's emerging music scene, joining the likes of Nirvana, Pearl Jam and Alice in Chains.
Formed in 1984 by Cornell, guitarist Kim Thayil and bassist Hiro Yamamoto, Soundgarden's third studio album, Badmotorfinger, in 1991 spawned enormously popular singles "Jesus Christ Pose," "Rusty Cage" and "Outshined" that received regular play on alternative rock radio stations.
Cornell also collaborated with members of what would become Pearl Jam to form Temple of the Dog, which produced a self-titled album in 1991 in tribute to friend Andrew Wood, former frontman for Mother Love Bone.
Three years later, Soundgarden broke through on mainstream radio with the album Superunknown, which debuted at No. 1 on the Billboard 200 and was nominated for a Grammy for Best Rock Record in 1995. It included hit singles "Spoonman," "Fell on Black Days," "Black Hole Sun," "My Wave" and "The Day I Tried to Live."
Soundgarden disbanded in 1997 due to tensions in the band, and Cornell pursued a solo career. In 2001, he joined Audioslave, a supergroup that included former Rage Against the Machine members Tom Morello, Brad Wilk and Tim Commerford. The band released three albums in six years and also performed at a concert billed as Cuba's first outdoor rock concert by an American band, though some Cuban artists have disputed that claim.
Audioslave disbanded in 2007, but Cornell and Soundgarden reunited in 2012 and released the band's sixth studio album, King Animal in 2012.
In addition to his music, Cornell also became involved in philanthropy and started the Chris and Vicky Cornell Foundation to support children facing challenges, including homelessness, poverty, abuse and neglect.
KQED's Kevin L. Jones and Associated Press writer Dennis Waszak in New York contributed to this report.