The definition of life is in flux, complexity is overrated, and humans are shrinking. Viruses are supposed to be sleek, pared-down, dead-eyed machines. But when one microbiologist stumbled upon a GIANT virus, hundreds of times bigger than any seen before, all that went out the window.  The discovery opened the door not only to a new cast of microscopic characters with names like Mimivirus, Mamavirus, and Megavirus, but also to basic questions: How did we miss these until now? Have they been around since the beginning? What if evolution could go … backwards? In this episode from 2015,  join former co-hosts Jad Abumrad and Robert Krulwich as they grill Radiolab regular Carl Zimmer on these paradoxical viruses – they’re so big that they can get their own viruses! - and what they can tell us about the nature of life.  Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In this episode we introduce you to a part of our bodies that was invisible to Western scientists until about five years ago; it’s called "the interstitium," a vast network of fluid channels inside the tissues around our organs that scientists have just begun to see, name, and understand. Along the way we look at how new technologies rub up against long-standing beliefs, and how millions of scientists and doctors failed to see what was right in front (and inside!) of their noses. We also find out how mapping the anatomy of this hidden infrastructure may help solve one of the fundamental mysteries of cancer, and perhaps provide a bridge between ancient and modern medicine. Special thanks to Aaron Wickenden, Jessica Clark, Mara Zepeda, Darryl Holliday, Dr. Amy Chang, Kate Sassoon, Guy Huntley, John Jacobson, Scotty G, and the Village Zendo EPISODE CREDITS -  Reported by - Lulu Miller and Jenn Brandel Produced by - Matt Kielty with help from - Ekedi Fausther-Keeys with mixing help from - Arianne Wack Fact-checking by - Natalie Middleton and Edited by  - Alex Neason EPISODE CITATIONS - Articles:  Check out reporter Jenn Brandel’s companion essay to this episode in Orion magazine, titled, Invisible Landscapes (https://zpr.io/NKuxvYY84RvH), which argues that the discovery of the interstitium could challenge established practices of compartmentalizing in science and society. Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Back when Robert was kid, he had a chance encounter with then President John F. Kennedy. The interaction began with a hello and ended with a handshake. And like many of us who have touched greatness, 14 year old Robert was left wondering if maybe some of Kennedy would stay with him. Back in 2017, when this episode first aired, Robert found himself still pondering that encounter and question. And so with the help of what was brand new science back then, and a helping hand from Neil Degrasse Tyson, he set out to satisfy this curiosity once and for all. EPISODE CREDITS: Produced by - Simon Adler with help from - Only Human: Amanda Aronczyk, Kenny Malone, Jillian Weinberger and Elaine Chen. EPISODE CITATIONS: Videos: The Handshake Experiment (https://zpr.io/buzgQeJJLqvY) Books: Neil deGrasse Tyson's newest book is called "Astrophysics for People in A Hurry." (https://zpr.io/idRcrMu3Kj8c) Ed Yong, “I Contain Multitudes.” (https://zpr.io/ff5imFP3kA6s) Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!   Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.   Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Back in February of 2022, anyone who knew anything thought the War in Ukraine would be over in a few weeks. Russia simply had more bodies to fight with and more steel to kill with. Fast-forward to today, however, and the war is anything but over. Ukraine has held and regained territory with shocking resilience. Stranger still, a small, cheap gadget that up until now was little more than a toy, has been central to their success. Today on Radiolab, we track the deployment of this weapon and wonder what happens when you have to look your enemy in the eye before you pull the trigger.  Special thanks to Anna Kaliusna and her team for her footage from the frontline, Yulia Tarisuk for her help with all things Ukrainian language related. And Hanna Rose Shell for her helping us understand the history of camouflage. EPISODE CREDITS: Reported by - Simon Adler Produced by - Simon Adler Original music and sound design contributed by - Simon Adler and Jeremy Bloom with mixing by - Jeremy Bloom Fact-checking by - Natalie Middleton and Edited by - Becca Bressler   EPISODE CITATIONS: AUDIO: On the Media, “The Fog of War” (https://zpr.io/8NKDM2xHWzRp) Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

While scouring the Sonoran Desert for objects left behind by migrants crossing into the United States, anthropologist Jason De León happened upon something he didn't expect to get left behind: a human arm, stripped of flesh. This macabre discovery sent him reeling, needing to know what exactly happened to the body, and how many migrants die that way in the wilderness. In researching border-crosser deaths in the Arizona desert, he noticed something surprising. Sometime in the late-1990s, the number of migrant deaths shot up dramatically and have stayed high since. Jason traced this increase to a Border Patrol policy still in effect, called “Prevention Through Deterrence.” First aired in 2018 and over three episodes, Radiolab investigates this policy, its surprising origins, and the people whose lives were changed forever because of it. Part 3: What Remains  The third episode in our Border Trilogy follows anthropologist Jason De León after he makes a grisly discovery in Arivaca, Arizona. In the middle of carrying out his pig experiments with his students, Jason finds the body of a 30-year-old female migrant. With the help of the medical examiner and some local humanitarian groups, Jason discovers her identity. Her name was Maricela. Jason then connects with her family, including her brother-in-law, who survived his own harrowing journey through Central America and the Arizona desert. With the human cost of Prevention Through Deterrence weighing on our minds, we try to parse what drives migrants like Maricela to cross through such deadly terrain, and what, if anything, could deter them. Special thanks to Carlo Albán, Sandra Lopez-Monsalve, Chava Gourarie, Lynn M. Morgan, Mike Wells and Tom Barry. CORRECTION: An earlier version of this episode, when it originally aired, incorrectly stated that a person's gender can be identified from bone remains. We've adjusted the audio to say that a person's sex can be identified from bone remains. CITATIONS: Books: Jason De Léon’s book The Land of Open Graves (https://zpr.io/vZbTarDzGQWK)  Timothy Dunn’s book Blockading the Border and Human Rights (https://zpr.io/VTPWNJPusaCn) Joseph Nevin's book, Operation Gatekeeper (https://zpr.io/UTnHFzRstAEw) Articles: Rubio-Goldsmith, Raquel, Melissa McCormick, Daniel Martinez, and Inez Duarte. 2006. “The ‘Funnel Effect’ & Recovered Bodies of Unauthorized Migrants Processed by the Pima County Office of the Medical Examiner, 1990-2005.” (https://zpr.io/R3wSpyVCXQhJ) SSRN Electronic Journal. Check out more of Caitlin Dickerson's reporting for The Atlantic (https://zpr.io/GAfC2nfEaBeK). Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

While scouring the Sonoran Desert for objects left behind by migrants crossing into the United States, anthropologist Jason De León happened upon something he didn't expect to get left behind: a human arm, stripped of flesh. This macabre discovery sent him reeling, needing to know what exactly happened to the body, and how many migrants die that way in the wilderness.  In researching border-crosser deaths in the Arizona desert, he noticed something surprising. Sometime in the late-1990s, the number of migrant deaths shot up dramatically and have stayed high since. Jason traced this increase to a Border Patrol policy still in effect, called “Prevention Through Deterrence.” First aired in 2018 and over three episodes, Radiolab investigates this policy, its surprising origins, and the people whose lives were changed forever because of it. Part 2: Hold the Line After the showdown in court with Bowie High School, Border Patrol brings in a fresh face to head its dysfunctional El Paso Sector: Silvestre Reyes. The first Mexican-American to ever hold the position, Reyes knows something needs to change and has an idea how to do it. One Saturday night at midnight, with the element of surprise on his side, Reyes unveils ... Operation Blockade. It wins widespread support for the Border Patrol in El Paso, but sparks major protests across the Rio Grande. Soon after, he gets a phone call that catapults his little experiment onto the national stage, where it works so well that it diverts migrant crossing patterns along the entire U.S.-Mexico Border. Years later, in the Arizona desert, anthropologist Jason de León realizes that in order to accurately gauge how many migrants die crossing the desert, he must first understand how human bodies decompose in such an extreme environment. He sets up a macabre experiment, and what he finds is more drastic than anything he could have expected. Special thanks to Sherrie Kossoudji at the University of Michigan, Lynn M. Morgan, Cheryl Howard, Andrew Hansen, William Sabol, Donald B. White, Daniel Martinez, Michelle Mittelstadt at the Migration Policy Institute, Former Executive Assistant to the El Paso Mayor Mark Smith, Retired Assistant Border Patrol Sector Chief Clyde Benzenhoefer, Paul Anderson, Eric Robledo, Maggie Southard Gladstone and Kate Hall. CORRECTION: An earlier version of this piece, when the episode originally published in 2018, incorrectly stated that Silvestre Reyes's brother died in a car accident in 1968; it was actually his father who died in the accident.  We also omitted a detail about the 1997 GAO report that we quote, namely that it predicted that as deaths in the mountains and deserts might rise, deaths in other areas might also fall. The audio was adjusted accordingly. EPISODE CREDITS:  Reported by - Latif Nasser with help from - Tracie Hunte Produced by - Matt Kielty with help from - Bethel Habte, Latif Nasser EPISODE CITATIONS: Art: Jason de Leon's latest work is a global participatory art project called Hostile Terrain 94 (https://zpr.io/dNEyVpAiNXjv), which will be exhibited at over 70 different locations around the world in 2020.  Read more about it here (https://zpr.io/uwDfu9bXFriv).     Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

While scouring the Sonoran Desert for objects left behind by migrants crossing into the United States, anthropologist Jason De León happened upon something he didn't expect to get left behind: a human arm, stripped of flesh. This macabre discovery sent him reeling, needing to know what exactly happened to the body, and how many migrants die that way in the wilderness. In researching border-crosser deaths in the Arizona desert, he noticed something surprising. Sometime in the late-1990s, the number of migrant deaths shot up dramatically and have stayed high since. Jason traced this increase to a Border Patrol policy still in effect, called “Prevention Through Deterrence.” In a series first aired back in 2018, over three episodes, Radiolab investigates this policy, its surprising origins, and the people whose lives were changed forever because of it. Part 1: Hole in the Fence We begin one afternoon in May 1992, when a student named Albert stumbled in late for history class at Bowie High School in El Paso, Texas. His excuse: Border Patrol. Soon more stories of students getting stopped and harassed by Border Patrol started pouring in. So begins the unlikely story of how a handful of Mexican-American high schoolers in one of the poorest neighborhoods in the country stood up to what is today the country’s largest federal law enforcement agency. They had no way of knowing at the time, but what would follow was a chain of events that would drastically change the US-Mexico border. Special thanks to Centro de Salud Familiar La Fe, Estela Reyes López, Barbara Hines, Lynn M. Morgan, Mallory Falk, Francesca Begos and Nancy Wiese from Hachette Book Group, Professor Michael Olivas at the University of Houston Law Center, and Josiah McC. Heyman at the Center for Interamerican and Border Studies. EPISODE CREDITS:  Reported by - Latif Nasser, Tracie Hunte Produced by - Matt Kielty with help from - Bethel Habte, Tracie Hunte, Latif Nasser CITATIONS Books: Jason De Léon’s book The Land of Open Graves (https://zpr.io/vZbTarDzGQWK)  Timothy Dunn’s book Blockading the Border and Human Rights (https://zpr.io/VTPWNJPusaCn) Joseph Nevin's book, Operation Gatekeeper (https://zpr.io/UTnHFzRstAEw) Articles: Rubio-Goldsmith, Raquel, Melissa McCormick, Daniel Martinez, and Inez Duarte. 2006. “The ‘Funnel Effect’ & Recovered Bodies of Unauthorized Migrants Processed by the Pima County Office of the Medical Examiner, 1990-2005.” SSRN Electronic Journal. (https://zpr.io/R3wSpyVCXQhJ) Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!   Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.   Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Producer Sindhu Gnanasambandan wants to know how she can live the longest feeling life possible. The answer leads her on a journey to make one week feel like two. And the journey leads her to a whole new answer. Special thanks to Jo Eidman, Nathan Peereboom, Kristin Lin, Stacey Reimann, Ash Sanders… and an extra special thanks to Jae Minard for editorial support EPISODE CREDITS Reported by - Sindhu Gnanasambandan Produced by - Sindhu Gnanasambandan Original music and sound design contributed by - Jeremy Bloom with mixing help from - Arianne Wack Fact-checking by - Emily Krieger and Edited by  - Pat Walters   Our newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.   Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.