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"disqusTitle": "For Some With Autism, a Miracle Treatment That Fades Fast",
"title": "For Some With Autism, a Miracle Treatment That Fades Fast",
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"content": "\u003cp>The story is a familiar one: the saga of a loving parent's quest to save a child. This time it's about the mother of a boy with autism. The mother scours the medical literature in search of any kind of treatment, however far-fetched and experimental. She finds one that seems promising, something involving magnetic fields, and moves mountains to get it for her son as part of a research protocol.\u003c/p>\n\u003caside class=\"pullquote alignright\">One teen goes from being a boy with no friends to a boy asked to the homecoming dance by four different girls. But the benefits began to fade after just a few months.\u003c/aside>\n\u003cp>Then, seeing that it helps, she devotes herself to getting more of it. Ultimately the mother starts a foundation to promote research into the new treatment, hoping to prove its value and one day make it part of standard care, not just for her son but for other children with autism, too.\u003c/p>\n\u003cp>This particular version of the story, though, is tinged with irony. The treatment in this case is \u003ca href=\"http://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies.shtml#part_152879\">transcranial magnetic stimulation\u003c/a>, and the mother is a Minneapolis woman named Kim Hollingsworth Taylor. In 2012, Taylor's son, age 14 at the time and on the high-functioning end of the autism spectrum, was part of a trial of TMS that seemed to relieve a few of his autism symptoms for several days, making him able to read social cues more accurately and to complete cognitive tasks in far less time than before.\u003c/p>\n\u003cp>Pleased with the results, Taylor found a way the following year for her son to get more treatments in Boston, twice a week over the course of 10 weeks, even though TMS had not been approved by the Food and Drug Administration for autism symptoms (and still has not).\u003c/p>\n\u003cp>During this time, Taylor says, her son's autism symptoms disappeared, and he went from being a boy with no friends to being a boy who was asked to the homecoming dance by four different girls. The change thrilled her so much that she started a small nonprofit to advance research into the use of TMS for autism. Taylor, who has a background as a financial analyst in the medical technology industry, called the foundation \u003ca href=\"https://clearlypresent.org/\">Clearly Present\u003c/a>, the phrase her son used to describe how he felt after treatment. \"It's like there's more of me here now,\" he told her.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>[contextly_sidebar id=\"RlJDDGPFUABA2mxpccf34tsLq1ak6UvR\"]\u003c/p>\n\u003cp>But the benefits began to fade after just a few months. Three years after his last treatment, Taylor's now 18-year-old son is back to where he was before he started on TMS. And he says he doesn't want to try it again if it means again disrupting the family life and moving to Boston with his father for another three-month stretch.\u003c/p>\n\u003cp>So here is Taylor, committed to organizing scientific conferences and soliciting research funding through the Clearly Present Foundation, with the personal impetus for her labors having disappeared.\u003c/p>\n\u003cp>\"Like most people I would crawl on broken glass to make things a little better for my kid,\" Taylor said in a recent phone interview. So she finds it \"profoundly sad\" that there's no place closer to home that could offer TMS to her son — and frustrating to be in the midst of a demanding volunteer project that, for now at least, doesn't seem likely to help her own child.\u003c/p>\n\u003cp>In an \u003ca href=\"https://spectrumnews.org/features/deep-dive/magnetic-promise-can-brain-stimulation-treat-autism-2/\">article on TMS\u003c/a> for Spectrum, a Web magazine about autism science, the writer Lydia Denworth called the story of the Clearly Present Foundation \"a cautionary tale for anyone who reads too much into TMS' benefits.\" Another cautionary tale is \u003ca href=\"http://www.npr.org/sections/health-shots/2016/07/08/484812170/what-an-hour-of-emotion-makes-visible\">featured\u003c/a> in the latest episode of NPR's podcast and program \u003ca href=\"http://www.npr.org/podcasts/510307/invisibilia\">Invisibilia\u003c/a>, about a middle-aged physician on the autism spectrum who also tried TMS. The treatment, which the woman (also named Kim, but not related to Taylor) underwent twice, enabled her to perceive subtle emotions in others for the first time in her life. Then, after less than an hour, that insight disappeared.\u003c/p>\n\u003cp>How did she feel about getting this brief insight into how most people experience feelings? \"It could be that you would get a glimpse of this and you couldn't have it, and it would be completely heartbreaking and you couldn't get over it,\" she told Invisibilia host Alix Spiegel. But after reflection, the physician told Spiegel, her feelings were mixed — depression, yes, but also gratitude that she'd had a chance to gain a deeper understanding of what it means to be human.\u003c/p>\n\u003cp>Autism is a developmental disorder that \u003ca href=\"http://www.cdc.gov/ncbddd/autism/hcp-dsm.html\">can be disabling\u003c/a>, and there's no cure. That makes families uniquely vulnerable to the potential of untested treatment. The fear is that TMS could turn out to be the latest in a \u003ca href=\"http://oepf.org/sites/default/files/Desperate%20for%20an%20autism%20cure.pdf\">long string\u003c/a> of untested or off-label treatments for autism, from chelation therapy to hyperbaric oxygen chambers to gluten-free diets, that desperate parents have been spending money on for decades.\u003c/p>\n\u003cp>None of these treatments has proven beneficial in clinical trials, and some have actually caused harm. FDA officials worry that even if a treatment is relatively safe, it could still divert precious resources away from proven treatments, such as behavioral interventions and certain drugs.\u003c/p>\n\u003cp>Companies promoting untested approaches face \"possible legal action if they continue to make false or misleading claims about products and therapies claiming to treat or cure autism,\" the FDA wrote in a \u003ca href=\"http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm394757.htm\">consumer bulletin\u003c/a> in 2014. \"Some of these so-called therapies carry significant health risks.\"\u003c/p>\n\u003cp>It's easy to understand the enthusiasm for a treatment like TMS, which is noninvasive, nonpharmacological and already has FDA clearance for one condition — \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492646/\">severe depression\u003c/a> that doesn't respond to other treatments. It has \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122183/\">few known side effects\u003c/a>, though it has been shown, in very rare cases, to cause seizures.\u003c/p>\n\u003cp>The treatment involves placing a relatively small and very powerful electromagnet on the scalp, and sending pulses of magnetic waves directly into the brain to activate or deactivate particular neurons. It has been used experimentally in autism, mostly in hopes of developing a better diagnostic tool. But as news percolates of this research application, more and more people want to try it for themselves or their children.\u003c/p>\n\u003cp>\u003cstrong>Research on TMS\u003c/strong>\u003c/p>\n\u003cp>But for autism, the science of TMS treatment is, according to researcher \u003ca href=\"https://vivo.brown.edu/display/loberman\">Lindsay Oberman\u003c/a>, \"still in its infancy.\"\u003c/p>\n\u003cp>\"I know it's easy to get overly optimistic given the media coverage and web posts about the remarkable responses some people with autism have reported after participating in a TMS study,\" Oberman, a research psychologist at Brown University and Bradley Hospital in Rhode Island, wrote last March in a \u003ca href=\"https://www.autismspeaks.org/blog/2016/03/25/transcranial-magnetic-stimulation-autism-evidence-benefit\">blog post\u003c/a> for the advocacy group Autism Speaks.\u003c/p>\n\u003cp>But those studies have been very few — just \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24127165\">13 in the medical literature to date\u003c/a> — and they tend to focus on only a select group of subjects: adults, generally male, who are high-functioning and do not have epilepsy. It's risky, then, to generalize to how TMS would affect women or children with autism, or people with more severe symptoms.\u003c/p>\n\u003cp>\"I caution against drawing conclusions from the preliminary results of the TMS studies that I and others have conducted,\" wrote Oberman in her blog post.\u003c/p>\n\u003cp>Among those 13 trials of TMS for autism, which involve fewer than 200 people altogether, only one is a double-blind, randomized trial — the type of trial designed to rule out the so-called placebo effect (improvements that occur because subjects expect them to).\u003c/p>\n\u003cp>In the \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24280031\">double-blind study\u003c/a>, conducted in Australia on 28 high-functioning adults diagnosed with autism or Asperger's syndrome, the 15 people in the treatment group showed some improvement, compared with the 13 controls, in terms of better social skills and reduced anxiety, both immediately after the treatment and at the one-month follow-up.\u003c/p>\n\u003cp>The real excitement over TMS for autism, however, does not come from the medical literature. It comes from popular testimonials of people on the autism spectrum who credit TMS for heightening their emotional sensitivity and leading to fewer obsessions, fewer repetitive actions and improved social skills.\u003c/p>\n\u003cp>John Elder Robison, an author and autism activist, describes his own experience in his \u003ca href=\"http://www.npr.org/sections/health-shots/2016/04/21/475112703/electric-currents-and-an-emotional-awakening-for-one-man-with-autism\">latest book\u003c/a>, \u003cem>Switched On: A Memoir of Brain Change and Emotional Awakening\u003c/em>. The alterations of TMS were life-affirming, he writes, but they were tinged with sadness, too, because his insights into others' emotions showed him how troubled most people's inner lives really are.\u003c/p>\n\u003cp>\"Before the TMS, I had fantasized that the emotional cues I was missing in my autism would bring me closer to people,\" \u003ca href=\"http://well.blogs.nytimes.com/2016/03/18/an-experimental-autism-treatment-cost-me-my-marriage/?_r=5\">Robison wrote\u003c/a> earlier this year in \u003cem>The New York Times\u003c/em>. \"The reality was very different. The signals I now picked up about what my fellow humans were feeling overwhelmed me. They seemed scared, alarmed, worried and even greedy. The beauty I envisioned was nowhere to be found.\"\u003c/p>\n\u003cp>But while Robison says his heightened emotions have generally persisted in the eight years since his first treatment, even his doctors say his response is unusually robust.\u003c/p>\n\u003cp>It's easy to see why parents would grab at cures that promise to bring back their sons and daughters, to give their children a voice, stop them from self-harm, or offer them a chance at friendship and independence. But quite apart from the question of whether the traits of autism are symptoms to be treated or differences to be embraced — a debate at the heart of the \u003ca href=\"http://stevesilberman.com/book/neurotribes/\">neurodiversity movement\u003c/a> — Oberman says it's too soon to institute TMS as a treatment, especially for children, whose brains are still developing.\u003c/p>\n\u003cp>It's difficult to predict the long-term consequences for children of routinely disrupting their brain activity. And it's hard to know, for children and adults alike, the details of how best to offer TMS for autism: how often it should be used, for how long a period, in which regions of the brain, and for what purposes.\u003c/p>\n\u003cp>\"There are still many things that we do not understand about how the developing brain responds to TMS or any form of neural intervention,\" Oberman told me by email this week. \"And if the goal with TMS is to 'rewire' or affect the connectivity of the brain in order to improve symptoms, we first have to understand what degree of connectivity and wiring is healthy at any given age, and what type of stimulation will improve the functioning of these areas.\"\u003c/p>\n\u003cp>In other words, scientific evidence about the efficacy of TMS in autism is not in yet, and it's accumulating the way most scientific evidence does: with painful slowness.\u003c/p>\n\u003cp>Among the still-unanswered questions about TMS is how it works and which autistic behaviors it best targets. Put 10 clinicians in a room, Oberman says, and you're likely to get 10 different answers. Her own research interest is in social communication, she says, but other symptoms — poor executive functioning, depression, irritability, poor language skills — are just as likely to be affected.\u003c/p>\n\u003cp>\"We've been using TMS for adults with autism who have other co-morbid conditions such as obsessive-compulsive disorder and depression,\" says Eric Hollander, director of the Autism and OCD Spectrum Program at Montefiore Medical Center and the Albert Einstein College of Medicine in the Bronx. \"And we've had good luck in terms of reducing the severity of some compulsive behaviors, as well as anxiety.\"\u003c/p>\n\u003cp>Hollander has found TMS useful for relieving such autism symptoms as agitation, self-injury, and behavioral rigidity. But he says many questions about TMS for autism are still unanswered, including which brain regions to target, the optimal frequency and duration of treatment, and the best schedule for booster therapy for long-term maintenance.\u003c/p>\n\u003cp>In addition to all these questions about \u003cem>how\u003c/em> TMS should be used, scientists don't really know much about who the best candidates for TMS are. Is it best aimed at those on the high-functioning end of the spectrum? Only for adults? Only for those without epilepsy or other co-existing problems?\u003c/p>\n\u003cp>And what are the ethical implications of recommending TMS for a use not approved by the FDA? Even though it is legal (doctors can prescribe any FDA-approved drug or device for any purpose, not only the purpose for which it was originally approved), that does not make it the right thing to do.\u003c/p>\n\u003cp>One way to answer these questions is through a multicenter therapeutic trial of TMS for autism, something that Taylor and the Clearly Present Foundation have been trying to help organize. But clinical trials are expensive and would require a major grant, which members of the coalition of researchers Taylor has assembled, known as the \u003ca href=\"http://onlinelibrary.wiley.com/doi/10.1002/aur.1567/abstract\">TMS Therapy for Autism Consensus Group\u003c/a>, have spent the past two years trying to obtain. They're talking now about first coordinating a number of pilot studies at individual institutions, on the way to gearing up to a large-scale, multicenter clinical trial.\u003c/p>\n\u003cp>There are already a few studies of TMS and autism underway: One in Canada is looking for improvement in executive function in 50 adolescents and young adults; another in France is looking for changes in social cognition in 60 adults; and one in Israel (the one most relevant to children) is looking for changes in social interaction in 20 children and adolescents who have autism or an intellectual disability or both.\u003c/p>\n\u003cp>In the meantime, Oberman says the only safe way to receive TMS for autism, for adults and children alike, is by being part of a research trial — which means going to \u003ca href=\"https://clinicaltrials.gov/ct2/results?term=autism+tms&Search=Search\">clinicaltrials.gov\u003c/a> to volunteer to be a study subject.\u003c/p>\n\u003cp>\"I would not recommend receiving TMS 'treatments' from a clinician outside of a research study,\" she says, \"as there is no standard protocol, nor strong evidence that any given protocol is likely to lead to long-term improvements in symptoms of autism spectrum disorder. Anyone who tells you otherwise is simply misleading you.\"\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>Science writer \u003c/em>\u003ca href=\"http://www.robinhenig.com/\">Robin Marantz Henig\u003c/a> \u003cem>is a contributing writer for \u003c/em>The New York Times Magazine\u003cem> and the author of nine books.\u003c/em> \u003cem>She also serves on the board of advisers for\u003c/em> \u003cem>Spectrum magazine.\u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Hope+Still+Races+Ahead+Of+Evidence+In+Magnet+Treatment+For+Autism&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n",
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"excerpt": "A few people with high-functioning autism say they've been briefly helped by exposure to transcranial magnetic stimulation. But there's a cost, one mother found, to getting ahead of the science.",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>The story is a familiar one: the saga of a loving parent's quest to save a child. This time it's about the mother of a boy with autism. The mother scours the medical literature in search of any kind of treatment, however far-fetched and experimental. She finds one that seems promising, something involving magnetic fields, and moves mountains to get it for her son as part of a research protocol.\u003c/p>\n\u003caside class=\"pullquote alignright\">One teen goes from being a boy with no friends to a boy asked to the homecoming dance by four different girls. But the benefits began to fade after just a few months.\u003c/aside>\n\u003cp>Then, seeing that it helps, she devotes herself to getting more of it. Ultimately the mother starts a foundation to promote research into the new treatment, hoping to prove its value and one day make it part of standard care, not just for her son but for other children with autism, too.\u003c/p>\n\u003cp>This particular version of the story, though, is tinged with irony. The treatment in this case is \u003ca href=\"http://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies.shtml#part_152879\">transcranial magnetic stimulation\u003c/a>, and the mother is a Minneapolis woman named Kim Hollingsworth Taylor. In 2012, Taylor's son, age 14 at the time and on the high-functioning end of the autism spectrum, was part of a trial of TMS that seemed to relieve a few of his autism symptoms for several days, making him able to read social cues more accurately and to complete cognitive tasks in far less time than before.\u003c/p>\n\u003cp>Pleased with the results, Taylor found a way the following year for her son to get more treatments in Boston, twice a week over the course of 10 weeks, even though TMS had not been approved by the Food and Drug Administration for autism symptoms (and still has not).\u003c/p>\n\u003cp>During this time, Taylor says, her son's autism symptoms disappeared, and he went from being a boy with no friends to being a boy who was asked to the homecoming dance by four different girls. The change thrilled her so much that she started a small nonprofit to advance research into the use of TMS for autism. Taylor, who has a background as a financial analyst in the medical technology industry, called the foundation \u003ca href=\"https://clearlypresent.org/\">Clearly Present\u003c/a>, the phrase her son used to describe how he felt after treatment. \"It's like there's more of me here now,\" he told her.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>But the benefits began to fade after just a few months. Three years after his last treatment, Taylor's now 18-year-old son is back to where he was before he started on TMS. And he says he doesn't want to try it again if it means again disrupting the family life and moving to Boston with his father for another three-month stretch.\u003c/p>\n\u003cp>So here is Taylor, committed to organizing scientific conferences and soliciting research funding through the Clearly Present Foundation, with the personal impetus for her labors having disappeared.\u003c/p>\n\u003cp>\"Like most people I would crawl on broken glass to make things a little better for my kid,\" Taylor said in a recent phone interview. So she finds it \"profoundly sad\" that there's no place closer to home that could offer TMS to her son — and frustrating to be in the midst of a demanding volunteer project that, for now at least, doesn't seem likely to help her own child.\u003c/p>\n\u003cp>In an \u003ca href=\"https://spectrumnews.org/features/deep-dive/magnetic-promise-can-brain-stimulation-treat-autism-2/\">article on TMS\u003c/a> for Spectrum, a Web magazine about autism science, the writer Lydia Denworth called the story of the Clearly Present Foundation \"a cautionary tale for anyone who reads too much into TMS' benefits.\" Another cautionary tale is \u003ca href=\"http://www.npr.org/sections/health-shots/2016/07/08/484812170/what-an-hour-of-emotion-makes-visible\">featured\u003c/a> in the latest episode of NPR's podcast and program \u003ca href=\"http://www.npr.org/podcasts/510307/invisibilia\">Invisibilia\u003c/a>, about a middle-aged physician on the autism spectrum who also tried TMS. The treatment, which the woman (also named Kim, but not related to Taylor) underwent twice, enabled her to perceive subtle emotions in others for the first time in her life. Then, after less than an hour, that insight disappeared.\u003c/p>\n\u003cp>How did she feel about getting this brief insight into how most people experience feelings? \"It could be that you would get a glimpse of this and you couldn't have it, and it would be completely heartbreaking and you couldn't get over it,\" she told Invisibilia host Alix Spiegel. But after reflection, the physician told Spiegel, her feelings were mixed — depression, yes, but also gratitude that she'd had a chance to gain a deeper understanding of what it means to be human.\u003c/p>\n\u003cp>Autism is a developmental disorder that \u003ca href=\"http://www.cdc.gov/ncbddd/autism/hcp-dsm.html\">can be disabling\u003c/a>, and there's no cure. That makes families uniquely vulnerable to the potential of untested treatment. The fear is that TMS could turn out to be the latest in a \u003ca href=\"http://oepf.org/sites/default/files/Desperate%20for%20an%20autism%20cure.pdf\">long string\u003c/a> of untested or off-label treatments for autism, from chelation therapy to hyperbaric oxygen chambers to gluten-free diets, that desperate parents have been spending money on for decades.\u003c/p>\n\u003cp>None of these treatments has proven beneficial in clinical trials, and some have actually caused harm. FDA officials worry that even if a treatment is relatively safe, it could still divert precious resources away from proven treatments, such as behavioral interventions and certain drugs.\u003c/p>\n\u003cp>Companies promoting untested approaches face \"possible legal action if they continue to make false or misleading claims about products and therapies claiming to treat or cure autism,\" the FDA wrote in a \u003ca href=\"http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm394757.htm\">consumer bulletin\u003c/a> in 2014. \"Some of these so-called therapies carry significant health risks.\"\u003c/p>\n\u003cp>It's easy to understand the enthusiasm for a treatment like TMS, which is noninvasive, nonpharmacological and already has FDA clearance for one condition — \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492646/\">severe depression\u003c/a> that doesn't respond to other treatments. It has \u003ca href=\"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122183/\">few known side effects\u003c/a>, though it has been shown, in very rare cases, to cause seizures.\u003c/p>\n\u003cp>The treatment involves placing a relatively small and very powerful electromagnet on the scalp, and sending pulses of magnetic waves directly into the brain to activate or deactivate particular neurons. It has been used experimentally in autism, mostly in hopes of developing a better diagnostic tool. But as news percolates of this research application, more and more people want to try it for themselves or their children.\u003c/p>\n\u003cp>\u003cstrong>Research on TMS\u003c/strong>\u003c/p>\n\u003cp>But for autism, the science of TMS treatment is, according to researcher \u003ca href=\"https://vivo.brown.edu/display/loberman\">Lindsay Oberman\u003c/a>, \"still in its infancy.\"\u003c/p>\n\u003cp>\"I know it's easy to get overly optimistic given the media coverage and web posts about the remarkable responses some people with autism have reported after participating in a TMS study,\" Oberman, a research psychologist at Brown University and Bradley Hospital in Rhode Island, wrote last March in a \u003ca href=\"https://www.autismspeaks.org/blog/2016/03/25/transcranial-magnetic-stimulation-autism-evidence-benefit\">blog post\u003c/a> for the advocacy group Autism Speaks.\u003c/p>\n\u003cp>But those studies have been very few — just \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24127165\">13 in the medical literature to date\u003c/a> — and they tend to focus on only a select group of subjects: adults, generally male, who are high-functioning and do not have epilepsy. It's risky, then, to generalize to how TMS would affect women or children with autism, or people with more severe symptoms.\u003c/p>\n\u003cp>\"I caution against drawing conclusions from the preliminary results of the TMS studies that I and others have conducted,\" wrote Oberman in her blog post.\u003c/p>\n\u003cp>Among those 13 trials of TMS for autism, which involve fewer than 200 people altogether, only one is a double-blind, randomized trial — the type of trial designed to rule out the so-called placebo effect (improvements that occur because subjects expect them to).\u003c/p>\n\u003cp>In the \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24280031\">double-blind study\u003c/a>, conducted in Australia on 28 high-functioning adults diagnosed with autism or Asperger's syndrome, the 15 people in the treatment group showed some improvement, compared with the 13 controls, in terms of better social skills and reduced anxiety, both immediately after the treatment and at the one-month follow-up.\u003c/p>\n\u003cp>The real excitement over TMS for autism, however, does not come from the medical literature. It comes from popular testimonials of people on the autism spectrum who credit TMS for heightening their emotional sensitivity and leading to fewer obsessions, fewer repetitive actions and improved social skills.\u003c/p>\n\u003cp>John Elder Robison, an author and autism activist, describes his own experience in his \u003ca href=\"http://www.npr.org/sections/health-shots/2016/04/21/475112703/electric-currents-and-an-emotional-awakening-for-one-man-with-autism\">latest book\u003c/a>, \u003cem>Switched On: A Memoir of Brain Change and Emotional Awakening\u003c/em>. The alterations of TMS were life-affirming, he writes, but they were tinged with sadness, too, because his insights into others' emotions showed him how troubled most people's inner lives really are.\u003c/p>\n\u003cp>\"Before the TMS, I had fantasized that the emotional cues I was missing in my autism would bring me closer to people,\" \u003ca href=\"http://well.blogs.nytimes.com/2016/03/18/an-experimental-autism-treatment-cost-me-my-marriage/?_r=5\">Robison wrote\u003c/a> earlier this year in \u003cem>The New York Times\u003c/em>. \"The reality was very different. The signals I now picked up about what my fellow humans were feeling overwhelmed me. They seemed scared, alarmed, worried and even greedy. The beauty I envisioned was nowhere to be found.\"\u003c/p>\n\u003cp>But while Robison says his heightened emotions have generally persisted in the eight years since his first treatment, even his doctors say his response is unusually robust.\u003c/p>\n\u003cp>It's easy to see why parents would grab at cures that promise to bring back their sons and daughters, to give their children a voice, stop them from self-harm, or offer them a chance at friendship and independence. But quite apart from the question of whether the traits of autism are symptoms to be treated or differences to be embraced — a debate at the heart of the \u003ca href=\"http://stevesilberman.com/book/neurotribes/\">neurodiversity movement\u003c/a> — Oberman says it's too soon to institute TMS as a treatment, especially for children, whose brains are still developing.\u003c/p>\n\u003cp>It's difficult to predict the long-term consequences for children of routinely disrupting their brain activity. And it's hard to know, for children and adults alike, the details of how best to offer TMS for autism: how often it should be used, for how long a period, in which regions of the brain, and for what purposes.\u003c/p>\n\u003cp>\"There are still many things that we do not understand about how the developing brain responds to TMS or any form of neural intervention,\" Oberman told me by email this week. \"And if the goal with TMS is to 'rewire' or affect the connectivity of the brain in order to improve symptoms, we first have to understand what degree of connectivity and wiring is healthy at any given age, and what type of stimulation will improve the functioning of these areas.\"\u003c/p>\n\u003cp>In other words, scientific evidence about the efficacy of TMS in autism is not in yet, and it's accumulating the way most scientific evidence does: with painful slowness.\u003c/p>\n\u003cp>Among the still-unanswered questions about TMS is how it works and which autistic behaviors it best targets. Put 10 clinicians in a room, Oberman says, and you're likely to get 10 different answers. Her own research interest is in social communication, she says, but other symptoms — poor executive functioning, depression, irritability, poor language skills — are just as likely to be affected.\u003c/p>\n\u003cp>\"We've been using TMS for adults with autism who have other co-morbid conditions such as obsessive-compulsive disorder and depression,\" says Eric Hollander, director of the Autism and OCD Spectrum Program at Montefiore Medical Center and the Albert Einstein College of Medicine in the Bronx. \"And we've had good luck in terms of reducing the severity of some compulsive behaviors, as well as anxiety.\"\u003c/p>\n\u003cp>Hollander has found TMS useful for relieving such autism symptoms as agitation, self-injury, and behavioral rigidity. But he says many questions about TMS for autism are still unanswered, including which brain regions to target, the optimal frequency and duration of treatment, and the best schedule for booster therapy for long-term maintenance.\u003c/p>\n\u003cp>In addition to all these questions about \u003cem>how\u003c/em> TMS should be used, scientists don't really know much about who the best candidates for TMS are. Is it best aimed at those on the high-functioning end of the spectrum? Only for adults? Only for those without epilepsy or other co-existing problems?\u003c/p>\n\u003cp>And what are the ethical implications of recommending TMS for a use not approved by the FDA? Even though it is legal (doctors can prescribe any FDA-approved drug or device for any purpose, not only the purpose for which it was originally approved), that does not make it the right thing to do.\u003c/p>\n\u003cp>One way to answer these questions is through a multicenter therapeutic trial of TMS for autism, something that Taylor and the Clearly Present Foundation have been trying to help organize. But clinical trials are expensive and would require a major grant, which members of the coalition of researchers Taylor has assembled, known as the \u003ca href=\"http://onlinelibrary.wiley.com/doi/10.1002/aur.1567/abstract\">TMS Therapy for Autism Consensus Group\u003c/a>, have spent the past two years trying to obtain. They're talking now about first coordinating a number of pilot studies at individual institutions, on the way to gearing up to a large-scale, multicenter clinical trial.\u003c/p>\n\u003cp>There are already a few studies of TMS and autism underway: One in Canada is looking for improvement in executive function in 50 adolescents and young adults; another in France is looking for changes in social cognition in 60 adults; and one in Israel (the one most relevant to children) is looking for changes in social interaction in 20 children and adolescents who have autism or an intellectual disability or both.\u003c/p>\n\u003cp>In the meantime, Oberman says the only safe way to receive TMS for autism, for adults and children alike, is by being part of a research trial — which means going to \u003ca href=\"https://clinicaltrials.gov/ct2/results?term=autism+tms&Search=Search\">clinicaltrials.gov\u003c/a> to volunteer to be a study subject.\u003c/p>\n\u003cp>\"I would not recommend receiving TMS 'treatments' from a clinician outside of a research study,\" she says, \"as there is no standard protocol, nor strong evidence that any given protocol is likely to lead to long-term improvements in symptoms of autism spectrum disorder. Anyone who tells you otherwise is simply misleading you.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>Science writer \u003c/em>\u003ca href=\"http://www.robinhenig.com/\">Robin Marantz Henig\u003c/a> \u003cem>is a contributing writer for \u003c/em>The New York Times Magazine\u003cem> and the author of nine books.\u003c/em> \u003cem>She also serves on the board of advisers for\u003c/em> \u003cem>Spectrum magazine.\u003c/em>\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Hope+Still+Races+Ahead+Of+Evidence+In+Magnet+Treatment+For+Autism&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"title": "American Suburb: The Podcast",
"tagline": "The flip side of gentrification, told through one town",
"info": "Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?",
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"order": 19
},
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"id": "baycurious",
"title": "Bay Curious",
"tagline": "Exploring the Bay Area, one question at a time",
"info": "KQED’s new podcast, Bay Curious, gets to the bottom of the mysteries — both profound and peculiar — that give the Bay Area its unique identity. And we’ll do it with your help! You ask the questions. You decide what Bay Curious investigates. And you join us on the journey to find the answers.",
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},
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"info": "The day's top stories from BBC News compiled twice daily in the week, once at weekends.",
"airtime": "MON-FRI 9pm-10pm, TUE-FRI 1am-2am",
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},
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},
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"tagline": "California, day by day",
"info": "KQED’s statewide radio news program providing daily coverage of issues, trends and public policy decisions.",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-California-Report-Podcast-Tile-703x703-1.jpg",
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"officialWebsiteLink": "/californiareport",
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"order": 8
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1MDAyODE4NTgz",
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},
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"title": "The California Report Magazine",
"tagline": "Your state, your stories",
"info": "Every week, The California Report Magazine takes you on a road trip for the ears: to visit the places and meet the people who make California unique. The in-depth storytelling podcast from the California Report.",
"airtime": "FRI 4:30pm-5pm, 6:30pm-7pm, 11pm-11:30pm",
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"order": 10
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM3NjkwNjk1OTAz",
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},
"city-arts": {
"id": "city-arts",
"title": "City Arts & Lectures",
"info": "A one-hour radio program to hear celebrated writers, artists and thinkers address contemporary ideas and values, often discussing the creative process. Please note: tapes or transcripts are not available",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/05/cityartsandlecture-300x300.jpg",
"officialWebsiteLink": "https://www.cityarts.net/",
"airtime": "SUN 1pm-2pm, TUE 10pm, WED 1am",
"meta": {
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"source": "City Arts & Lectures"
},
"link": "https://www.cityarts.net",
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"tuneIn": "https://tunein.com/radio/City-Arts-and-Lectures-p692/",
"rss": "https://www.cityarts.net/feed/"
}
},
"closealltabs": {
"id": "closealltabs",
"title": "Close All Tabs",
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"info": "Close All Tabs breaks down how digital culture shapes our world through thoughtful insights and irreverent humor.",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2025/02/CAT_2_Tile-scaled.jpg",
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"officialWebsiteLink": "/podcasts/closealltabs",
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"source": "kqed",
"order": 1
},
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"code-switch-life-kit": {
"id": "code-switch-life-kit",
"title": "Code Switch / Life Kit",
"info": "\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />",
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"meta": {
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}
},
"commonwealth-club": {
"id": "commonwealth-club",
"title": "Commonwealth Club of California Podcast",
"info": "The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.",
"airtime": "THU 10pm, FRI 1am",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.commonwealthclub.org/podcasts",
"meta": {
"site": "news",
"source": "Commonwealth Club of California"
},
"link": "/radio/program/commonwealth-club",
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"apple": "https://itunes.apple.com/us/podcast/commonwealth-club-of-california-podcast/id976334034?mt=2",
"google": "https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw",
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}
},
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"id": "forum",
"title": "Forum",
"tagline": "The conversation starts here",
"info": "KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.",
"airtime": "MON-FRI 9am-11am, 10pm-11pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED Forum with Mina Kim and Alexis Madrigal",
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"source": "kqed",
"order": 9
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz",
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}
},
"freakonomics-radio": {
"id": "freakonomics-radio",
"title": "Freakonomics Radio",
"info": "Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. It is produced in partnership with WNYC.",
"imageSrc": "https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/freakonomicsRadio.png",
"officialWebsiteLink": "http://freakonomics.com/",
"airtime": "SUN 1am-2am, SAT 3pm-4pm",
"meta": {
"site": "radio",
"source": "WNYC"
},
"link": "/radio/program/freakonomics-radio",
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},
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"id": "fresh-air",
"title": "Fresh Air",
"info": "Hosted by Terry Gross, \u003cem>Fresh Air from WHYY\u003c/em> is the Peabody Award-winning weekday magazine of contemporary arts and issues. One of public radio's most popular programs, Fresh Air features intimate conversations with today's biggest luminaries.",
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"info": "A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.",
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"rss": "https://feeds.npr.org/510051/podcast.xml"
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},
"hidden-brain": {
"id": "hidden-brain",
"title": "Hidden Brain",
"info": "Shankar Vedantam uses science and storytelling to reveal the unconscious patterns that drive human behavior, shape our choices and direct our relationships.",
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"officialWebsiteLink": "https://www.npr.org/series/423302056/hidden-brain",
"airtime": "SUN 7pm-8pm",
"meta": {
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"source": "NPR"
},
"link": "/radio/program/hidden-brain",
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"how-i-built-this": {
"id": "how-i-built-this",
"title": "How I Built This with Guy Raz",
"info": "Guy Raz dives into the stories behind some of the world's best known companies. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists—and the movements they built.",
"imageSrc": "https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/howIBuiltThis.png",
"officialWebsiteLink": "https://www.npr.org/podcasts/510313/how-i-built-this",
"airtime": "SUN 7:30pm-8pm",
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},
"link": "/radio/program/how-i-built-this",
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},
"hyphenacion": {
"id": "hyphenacion",
"title": "Hyphenación",
"tagline": "Where conversation and cultura meet",
"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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},
"jerrybrown": {
"id": "jerrybrown",
"title": "The Political Mind of Jerry Brown",
"tagline": "Lessons from a lifetime in politics",
"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game – and Brown has some lessons he'd like to share. ",
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"order": 18
},
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}
},
"latino-usa": {
"id": "latino-usa",
"title": "Latino USA",
"airtime": "MON 1am-2am, SUN 6pm-7pm",
"info": "Latino USA, the radio journal of news and culture, is the only national, English-language radio program produced from a Latino perspective.",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/latinoUsa.jpg",
"officialWebsiteLink": "http://latinousa.org/",
"meta": {
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"source": "npr"
},
"link": "/radio/program/latino-usa",
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"apple": "https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=79681317&at=11l79Y&ct=nprdirectory",
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"rss": "https://feeds.npr.org/510016/podcast.xml"
}
},
"marketplace": {
"id": "marketplace",
"title": "Marketplace",
"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
"airtime": "MON-FRI 4pm-4:30pm, MON-WED 6:30pm-7pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Marketplace-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.marketplace.org/",
"meta": {
"site": "news",
"source": "American Public Media"
},
"link": "/radio/program/marketplace",
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"rss": "https://feeds.publicradio.org/public_feeds/marketplace-pm/rss/rss"
}
},
"masters-of-scale": {
"id": "masters-of-scale",
"title": "Masters of Scale",
"info": "Masters of Scale is an original podcast in which LinkedIn co-founder and Greylock Partner Reid Hoffman sets out to describe and prove theories that explain how great entrepreneurs take their companies from zero to a gazillion in ingenious fashion.",
"airtime": "Every other Wednesday June 12 through October 16 at 8pm (repeats Thursdays at 2am)",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Masters-of-Scale-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://mastersofscale.com/",
"meta": {
"site": "radio",
"source": "WaitWhat"
},
"link": "/radio/program/masters-of-scale",
"subscribe": {
"apple": "http://mastersofscale.app.link/",
"rss": "https://rss.art19.com/masters-of-scale"
}
},
"mindshift": {
"id": "mindshift",
"title": "MindShift",
"tagline": "A podcast about the future of learning and how we raise our kids",
"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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