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"disqusTitle": "How A Birth at Stanford 50 Years Ago Launched Search for Down Syndrome Test",
"title": "How A Birth at Stanford 50 Years Ago Launched Search for Down Syndrome Test",
"headTitle": "State of Health | KQED News",
"content": "\u003cp>\u003cem>This story comes to us via\u003c/em> Only Human, \u003cem>a new podcast from WNYC Studios. Hosted by Mary Harris, \u003c/em>\u003ca href=\"http://www.wnyc.org/shows/onlyhuman/\" target=\"_blank\">Only Human\u003c/a>\u003cem> tells stories we all can relate to. Because every body has a story. Subscribe to \u003c/em>Only Human\u003cem> on iTunes or wherever you like to get your podcasts. \u003c/em>\u003c/p>\n\u003chr>\n\u003cp>When Lee Herzenberg remembers the day her son Michael was born, she laughs and calls it a \"cool birth.\" Her obstetrician was a friend, and she describes it almost like a party — \"a little bit painful, but that you forget very quickly.\" Lee even got a kick out of the fact that a resident learned to do an episiotomy on her.\u003c/p>\n\u003cp>It was November 1961, and she was at the newly christened Palo Alto-Stanford Hospital Center; her husband, Len, was a biology professor on campus. Like most fathers at the time, he didn't attend the birth, which meant he wasn't there when Michael started turning blue.\u003c/p>\n\u003cp>The nurses whisked the newborn off to the nursery without telling Lee anything was wrong.\u003c/p>\n\u003cp>It was then that a doctor noticed the characteristic features of Down syndrome: floppy muscles, eyes that slanted upward. They got Michael breathing again, but doctors thought his prognosis was grim. They gave Michael just a few months to live. A daisy chain of physicians was called, and Lee says it was a pediatrics professor who told her husband what had happened. Then Len was dispatched to tell Lee.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>She remembers the moment with uncharacteristic emotion. \"We hugged each other, and it was a terrible conversation to realize that you'd lost the baby, but the baby was lost,\" Lee says now. \"We knew immediately what we'd do. We had already made the decision that it was not a good thing to take the baby home, and so we didn't.\"\u003c/p>\n\u003cp>In the 1960s — an era before neurodiversity movements and early intervention programs — many people still called people with Down syndrome \"mongoloids.\" Playwright Arthur Miller institutionalized his son, Daniel, in 1966. A few years later, \u003ca href=\"https://repository.library.georgetown.edu/handle/10822/1031271\" target=\"_blank\">an article\u003c/a> in \u003cem>The Atlantic Monthly\u003c/em> argued that \"a Down's is not a person.\"\u003c/p>\n\u003cp>Lee and Len Herzenberg had seen friends struggle with the birth of a child with Down syndrome and had even gone with a colleague to an institution, where he dropped off his own infant daughter.\u003c/p>\n\u003cp>So, they decided Michael would never come home.\u003c/p>\n\u003cp>But Michael wasn't absolutely lost to them. Michael's birth sparked their search for a blood test that has revolutionized prenatal care in this country.\u003c/p>\n\u003cp>I made the mistake of telling one scientist I was reporting about \"Len Herzenberg's lab.\" He corrected me instantly: \"Len \u003cem>and Lee's\u003c/em> lab.\" Because Lee Herzenberg was \"leaning in\" decades before Sheryl Sandberg coined the phrase. At 81, Lee, a professor of genetics, is still running the lab she and her husband founded more than 50 years ago. Len died in 2013.\u003c/p>\n\u003cp>The lab is a quirky place, even by Stanford standards. Lee rarely sits on chairs, preferring cushions on the floor. She's often accompanied by her bichon frise, Gigi. Researchers can often be found working in this basement office well into the night.\u003c/p>\n\u003cp>But Lee Herzenberg isn't just quirky. She is one of the few professors at Stanford — possibly the only one — never to have officially graduated from college. Instead, she trained by her husband's side, auditing courses while he got his Ph.D. at Caltech (women weren't allowed to attend at the time) and working at his labs at the Pasteur Institute in Paris and the National Institutes of Health.\u003c/p>\n\u003cp>And the science that's been done here has changed the course of medicine.\u003c/p>\n\u003cp>The Herzenbergs are best known as the creators of the modern-day \u003ca href=\"http://www.bio.umass.edu/micro/immunology/facs542/facswhat.htm\" target=\"_blank\">fluorescence-activated flow cytometer\u003c/a>, or FACS. It was a machine born out of frustration: Len couldn't stand squinting down a microscope looking at cells.\u003c/p>\n\u003cp>Before the FACS, a biologist peering at slides could feel like he was playing a really intense round of \"Where's Waldo,\" staring at crowds of all kinds of cells, trying to pinpoint the exact ones he was looking for. Not only was it annoying — Len Herzenberg worried it wasn't particularly scientific. He wanted a way to find and describe cells that didn't rely on his worn-out eyes.\u003c/p>\n\u003cp>The FACS allows you to pour cells in, program the machine to find whatever it is you're looking for, and then it will spit out a little tube of just those cells alone. And the FACS gives you all kinds of information, too: how big the cells are and how much DNA they have inside.\u003c/p>\n\u003cp>The FACS was used to diagnose AIDS because the technology can quickly and easily sort out T cells. The FACS was used to find the first stem cells. When Len Herzenberg died, one colleague \u003ca href=\"http://www.nytimes.com/2013/11/11/us/leonard-herzenberg-immunologist-who-revolutionized-research-dies-at-81.html?_r=0\" target=\"_blank\">told\u003c/a> \u003cem>T\u003c/em>\u003cem>he New York Times\u003c/em> that \"without Len, tens of thousands of people now alive would not be.\"\u003c/p>\n\u003cp>But in the 1970s, the Herzenbergs were still proving the value of this machine. That's when they started thinking about using it to create a blood test for Down syndrome.\u003c/p>\n\u003cfigure id=\"attachment_177037\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-full wp-image-177037\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85.jpg\" alt=\"One of Michael's albums, with a photo of his birth parents, Lee and Len Herzenberg. \" width=\"800\" height=\"599\" srcset=\"https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85.jpg 800w, https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85-400x300.jpg 400w, https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85-768x575.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">One of Michael's albums, with a photo of his birth parents, Lee and Len Herzenberg. \u003ccite>(Mary Harris/WNYC)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Len had seen research from Finland claiming it was possible to see a fetus's cells in a mother's blood. It was hard to believe. But he figured that FACS, with its nearly magical sorting capabilities, could figure it out. So he took on a medical student named Diana Bianchi as a research associate and made sorting out these cells her project.\u003c/p>\n\u003cp>If they could isolate these cells, he could learn a lot about the developing fetus, including whether the fetus had chromosomal abnormalities.\u003c/p>\n\u003cp>\"They had a very personal reason for doing this, because of their son Michael,\" Bianchi says now. \"They wanted to have a test that could be offered to any pregnant woman — that would be noninvasive and would allow them to know if a child had Down syndrome. The first step, however, was to show that you could pull out fetal cells.\"\u003c/p>\n\u003cp>Scientists now estimate that for every 200 billion cells in a mother's bloodstream, about 10 of those are fetal cells. Bianchi was one of the first people to see them.\u003c/p>\n\u003cp>\u003cem>The New York Times\u003c/em> quoted Len saying the work was a \"first step\" toward a blood test for Down syndrome for all pregnant women. But it would take 30 years for a practical test to become a reality.\u003c/p>\n\u003cp>As it turned out, Len's FACS wasn't the right tool for prenatal diagnosis. There weren't very many fetal cells to be sorted, and if a pregnant woman already had children, scientists couldn't be sure if the cells in her blood came from the current fetus or one of her older kids.\u003c/p>\n\u003cp>But in 2008, Len helped ensure the right tool was found.\u003c/p>\n\u003cp>A researcher named Stephen Quake had discovered a way to sequence chunks of fetal DNA floating in expectant mothers' blood. As a member of the National Academy of Sciences, Len made sure the \u003ca href=\"http://www.pnas.org/content/early/2008/10/03/0808319105\" target=\"_blank\">paper was published\u003c/a> in the academy's journal. Another researcher, Dennis Lo, confirmed Quake's findings. Three years later, the tests were on the market.\u003c/p>\n\u003cp>Now, at just 10 weeks into a pregnancy, a whole range of things can be revealed with this test. Not just Down syndrome, but a host of other chromosomal abnormalities as well as the sex of the child to be.\u003c/p>\n\u003cp>Until this test, doctors had to rely on amniocentesis, an invasive procedure that involves inserting a needle in the womb to sample amniotic fluid, or biopsying the placenta, to tell them with any reliability whether a fetus had a chromosomal abnormality. These tests aren't just uncomfortable; they come with a risk of miscarriage. By some estimates, in the past five years the number of these procedures performed in this country \u003ca href=\"http://www.npr.org/sections/health-shots/2015/01/26/368449371/dna-blood-test-gives-women-a-new-option-for-prenatal-screening\" target=\"_blank\">has plummeted\u003c/a> by more than 50 percent.\u003c/p>\n\u003cp>To some parents, this knowledge can be alarming. Advocates in Ohio are trying to pass a law preventing abortions if Down syndrome is the reason (North Dakota and \u003ca href=\"http://www.npr.org/sections/thetwo-way/2016/03/25/471842196/indiana-governor-signs-new-abortion-restrictions-into-law\" target=\"_blank\">Indiana\u003c/a> have already passed similar laws).\u003c/p>\n\u003cp>Lee Herzenberg is honest about what she would have done if she'd known early on in her pregnancy that Michael had Down syndrome.\u003c/p>\n\u003cp>\"I'd say if I had the choice of not pushing Michael into this life — if I at that time would know I was carrying a Down syndrome child — I would have aborted the child,\" she says. \"I see no reason Michael has to live the life he leads. The fact that we've made it very happy for him or that he's made it very happy for us — all of that is adapting to a situation, but I don't think it's fair or proper.\"\u003c/p>\n\u003cp>But Lee is alarmed that these tests are now being used to determine the sex of unborn babies. She worries about parents choosing to abort girls.\u003c/p>\n\u003cp>Diana Bianchi, that medical student from the Herzenberg lab, is now a professor at Tufts, where she founded the \u003ca href=\"https://www.tuftsmedicalcenter.org/Research-Clinical-Trials/Institutes-Centers-Labs/Mother-Infant-Research-Institute/Laboratories/Bianchi-Laboratory.aspx\" target=\"_blank\">Mother Infant Research Institute\u003c/a>. She's still working in prenatal testing. In fact, perfecting these tests has become her life's work.\u003c/p>\n\u003cp>But her focus has shifted. Now that she can detect Down syndrome so early, she wants to treat it early, too — in the womb. Because finding this chromosomal abnormality at 10 weeks means there's a window of opportunity: The brain changes associated with Down syndrome don't occur until a month or so later. Theoretically, you could treat a fetus before some brain changes occur at all.\u003c/p>\n\u003cp>Bianchi's work is still early. She's experimenting with mice, giving them existing drugs in utero to see if she can forestall brain damage.\u003c/p>\n\u003cp>There's an often-quoted statistic, that 90 percent of parents who find out that their fetus has Down syndrome will abort. But that statistic is from a study done in the United Kingdom. In the U.S., far fewer women terminate.\u003c/p>\n\u003cp>\"We have to unpack this connection between prenatal testing and abortion,\" she says. \"We have good data to suggest that approximately 40 plus percent of women who know their fetus has Down syndrome continue their pregnancy. There are many women who speak very highly of the fact that this allows them to prepare.\"\u003c/p>\n\u003cp>The Down syndrome baby who kicked off the search for this blood test is now a 54-year-old man. He lives in a squat house in Redwood City, Calif., just a 30-minute drive from his birth mother's home.\u003c/p>\n\u003cp>For years, Michael lived with a local woman named Barbara Jennings, who raised a number of children with developmental challenges. The Herzenbergs' pediatrician helped them find her when Michael was a newborn. The Herzenbergs would visit Michael every month or so, but they never felt they should bring him home. When Barbara died, Michael moved to this group home.\u003c/p>\n\u003cp>It's hard to know how much Michael understands when I speak to him, though he has learned to read and use a cellphone. And he's stubborn. A lot like his mother, actually. \"Michael has the hardest head in the whole world,\" says Janet Thomas, the caretaker who runs this house. \"He does whatever he wants to do. He does not care whatever you say. He's going to do whatever it is he wants to do — that's Michael.\"\u003c/p>\n\u003cp>I asked Lee if she ever regretted not raising Michael, and she said no. \"It was a decision that was selfish, if you like, because we had things we wanted to do. In retrospect, a lot of things would never have gotten done. There would be no FACS had we decided to do this. Because it would have been a very intensive kind of upbringing.\"\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>As for Michael, he clearly loves his mother, no matter what she decided. In Michael's room, there are photos on almost every surface, with snapshots of his biological and adopted families. In the corner is a huge poster of his father, celebrating when \u003ca href=\"//www.the-scientist.com/?articles.view/articleNo/24076/title/Herzenberg-wins-Kyoto-Prize/\" target=\"_blank\">he won the Kyoto Prize\u003c/a> for his contributions to biotechnology. And deep in one album, there's a picture of Len and Lee together. The caption reads: \"Michael's Other Mom + Dad.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 WNYC Radio. To see more, visit \u003ca href=\"http://www.wnyc.org/\" target=\"_blank\">WNYC Radio\u003c/a>.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Only+Human%3A+A+Birth+That+Launched+The+Search+For+A+Down+Syndrome+Test&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>This story comes to us via\u003c/em> Only Human, \u003cem>a new podcast from WNYC Studios. Hosted by Mary Harris, \u003c/em>\u003ca href=\"http://www.wnyc.org/shows/onlyhuman/\" target=\"_blank\">Only Human\u003c/a>\u003cem> tells stories we all can relate to. Because every body has a story. Subscribe to \u003c/em>Only Human\u003cem> on iTunes or wherever you like to get your podcasts. \u003c/em>\u003c/p>\n\u003chr>\n\u003cp>When Lee Herzenberg remembers the day her son Michael was born, she laughs and calls it a \"cool birth.\" Her obstetrician was a friend, and she describes it almost like a party — \"a little bit painful, but that you forget very quickly.\" Lee even got a kick out of the fact that a resident learned to do an episiotomy on her.\u003c/p>\n\u003cp>It was November 1961, and she was at the newly christened Palo Alto-Stanford Hospital Center; her husband, Len, was a biology professor on campus. Like most fathers at the time, he didn't attend the birth, which meant he wasn't there when Michael started turning blue.\u003c/p>\n\u003cp>The nurses whisked the newborn off to the nursery without telling Lee anything was wrong.\u003c/p>\n\u003cp>It was then that a doctor noticed the characteristic features of Down syndrome: floppy muscles, eyes that slanted upward. They got Michael breathing again, but doctors thought his prognosis was grim. They gave Michael just a few months to live. A daisy chain of physicians was called, and Lee says it was a pediatrics professor who told her husband what had happened. Then Len was dispatched to tell Lee.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>She remembers the moment with uncharacteristic emotion. \"We hugged each other, and it was a terrible conversation to realize that you'd lost the baby, but the baby was lost,\" Lee says now. \"We knew immediately what we'd do. We had already made the decision that it was not a good thing to take the baby home, and so we didn't.\"\u003c/p>\n\u003cp>In the 1960s — an era before neurodiversity movements and early intervention programs — many people still called people with Down syndrome \"mongoloids.\" Playwright Arthur Miller institutionalized his son, Daniel, in 1966. A few years later, \u003ca href=\"https://repository.library.georgetown.edu/handle/10822/1031271\" target=\"_blank\">an article\u003c/a> in \u003cem>The Atlantic Monthly\u003c/em> argued that \"a Down's is not a person.\"\u003c/p>\n\u003cp>Lee and Len Herzenberg had seen friends struggle with the birth of a child with Down syndrome and had even gone with a colleague to an institution, where he dropped off his own infant daughter.\u003c/p>\n\u003cp>So, they decided Michael would never come home.\u003c/p>\n\u003cp>But Michael wasn't absolutely lost to them. Michael's birth sparked their search for a blood test that has revolutionized prenatal care in this country.\u003c/p>\n\u003cp>I made the mistake of telling one scientist I was reporting about \"Len Herzenberg's lab.\" He corrected me instantly: \"Len \u003cem>and Lee's\u003c/em> lab.\" Because Lee Herzenberg was \"leaning in\" decades before Sheryl Sandberg coined the phrase. At 81, Lee, a professor of genetics, is still running the lab she and her husband founded more than 50 years ago. Len died in 2013.\u003c/p>\n\u003cp>The lab is a quirky place, even by Stanford standards. Lee rarely sits on chairs, preferring cushions on the floor. She's often accompanied by her bichon frise, Gigi. Researchers can often be found working in this basement office well into the night.\u003c/p>\n\u003cp>But Lee Herzenberg isn't just quirky. She is one of the few professors at Stanford — possibly the only one — never to have officially graduated from college. Instead, she trained by her husband's side, auditing courses while he got his Ph.D. at Caltech (women weren't allowed to attend at the time) and working at his labs at the Pasteur Institute in Paris and the National Institutes of Health.\u003c/p>\n\u003cp>And the science that's been done here has changed the course of medicine.\u003c/p>\n\u003cp>The Herzenbergs are best known as the creators of the modern-day \u003ca href=\"http://www.bio.umass.edu/micro/immunology/facs542/facswhat.htm\" target=\"_blank\">fluorescence-activated flow cytometer\u003c/a>, or FACS. It was a machine born out of frustration: Len couldn't stand squinting down a microscope looking at cells.\u003c/p>\n\u003cp>Before the FACS, a biologist peering at slides could feel like he was playing a really intense round of \"Where's Waldo,\" staring at crowds of all kinds of cells, trying to pinpoint the exact ones he was looking for. Not only was it annoying — Len Herzenberg worried it wasn't particularly scientific. He wanted a way to find and describe cells that didn't rely on his worn-out eyes.\u003c/p>\n\u003cp>The FACS allows you to pour cells in, program the machine to find whatever it is you're looking for, and then it will spit out a little tube of just those cells alone. And the FACS gives you all kinds of information, too: how big the cells are and how much DNA they have inside.\u003c/p>\n\u003cp>The FACS was used to diagnose AIDS because the technology can quickly and easily sort out T cells. The FACS was used to find the first stem cells. When Len Herzenberg died, one colleague \u003ca href=\"http://www.nytimes.com/2013/11/11/us/leonard-herzenberg-immunologist-who-revolutionized-research-dies-at-81.html?_r=0\" target=\"_blank\">told\u003c/a> \u003cem>T\u003c/em>\u003cem>he New York Times\u003c/em> that \"without Len, tens of thousands of people now alive would not be.\"\u003c/p>\n\u003cp>But in the 1970s, the Herzenbergs were still proving the value of this machine. That's when they started thinking about using it to create a blood test for Down syndrome.\u003c/p>\n\u003cfigure id=\"attachment_177037\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-full wp-image-177037\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85.jpg\" alt=\"One of Michael's albums, with a photo of his birth parents, Lee and Len Herzenberg. \" width=\"800\" height=\"599\" srcset=\"https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85.jpg 800w, https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85-400x300.jpg 400w, https://ww2.kqed.org/app/uploads/sites/27/2016/04/herzenberg-2-8b2c93f342bef3820866b27fb8d5fb69f300d149-s800-c85-768x575.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">One of Michael's albums, with a photo of his birth parents, Lee and Len Herzenberg. \u003ccite>(Mary Harris/WNYC)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Len had seen research from Finland claiming it was possible to see a fetus's cells in a mother's blood. It was hard to believe. But he figured that FACS, with its nearly magical sorting capabilities, could figure it out. So he took on a medical student named Diana Bianchi as a research associate and made sorting out these cells her project.\u003c/p>\n\u003cp>If they could isolate these cells, he could learn a lot about the developing fetus, including whether the fetus had chromosomal abnormalities.\u003c/p>\n\u003cp>\"They had a very personal reason for doing this, because of their son Michael,\" Bianchi says now. \"They wanted to have a test that could be offered to any pregnant woman — that would be noninvasive and would allow them to know if a child had Down syndrome. The first step, however, was to show that you could pull out fetal cells.\"\u003c/p>\n\u003cp>Scientists now estimate that for every 200 billion cells in a mother's bloodstream, about 10 of those are fetal cells. Bianchi was one of the first people to see them.\u003c/p>\n\u003cp>\u003cem>The New York Times\u003c/em> quoted Len saying the work was a \"first step\" toward a blood test for Down syndrome for all pregnant women. But it would take 30 years for a practical test to become a reality.\u003c/p>\n\u003cp>As it turned out, Len's FACS wasn't the right tool for prenatal diagnosis. There weren't very many fetal cells to be sorted, and if a pregnant woman already had children, scientists couldn't be sure if the cells in her blood came from the current fetus or one of her older kids.\u003c/p>\n\u003cp>But in 2008, Len helped ensure the right tool was found.\u003c/p>\n\u003cp>A researcher named Stephen Quake had discovered a way to sequence chunks of fetal DNA floating in expectant mothers' blood. As a member of the National Academy of Sciences, Len made sure the \u003ca href=\"http://www.pnas.org/content/early/2008/10/03/0808319105\" target=\"_blank\">paper was published\u003c/a> in the academy's journal. Another researcher, Dennis Lo, confirmed Quake's findings. Three years later, the tests were on the market.\u003c/p>\n\u003cp>Now, at just 10 weeks into a pregnancy, a whole range of things can be revealed with this test. Not just Down syndrome, but a host of other chromosomal abnormalities as well as the sex of the child to be.\u003c/p>\n\u003cp>Until this test, doctors had to rely on amniocentesis, an invasive procedure that involves inserting a needle in the womb to sample amniotic fluid, or biopsying the placenta, to tell them with any reliability whether a fetus had a chromosomal abnormality. These tests aren't just uncomfortable; they come with a risk of miscarriage. By some estimates, in the past five years the number of these procedures performed in this country \u003ca href=\"http://www.npr.org/sections/health-shots/2015/01/26/368449371/dna-blood-test-gives-women-a-new-option-for-prenatal-screening\" target=\"_blank\">has plummeted\u003c/a> by more than 50 percent.\u003c/p>\n\u003cp>To some parents, this knowledge can be alarming. Advocates in Ohio are trying to pass a law preventing abortions if Down syndrome is the reason (North Dakota and \u003ca href=\"http://www.npr.org/sections/thetwo-way/2016/03/25/471842196/indiana-governor-signs-new-abortion-restrictions-into-law\" target=\"_blank\">Indiana\u003c/a> have already passed similar laws).\u003c/p>\n\u003cp>Lee Herzenberg is honest about what she would have done if she'd known early on in her pregnancy that Michael had Down syndrome.\u003c/p>\n\u003cp>\"I'd say if I had the choice of not pushing Michael into this life — if I at that time would know I was carrying a Down syndrome child — I would have aborted the child,\" she says. \"I see no reason Michael has to live the life he leads. The fact that we've made it very happy for him or that he's made it very happy for us — all of that is adapting to a situation, but I don't think it's fair or proper.\"\u003c/p>\n\u003cp>But Lee is alarmed that these tests are now being used to determine the sex of unborn babies. She worries about parents choosing to abort girls.\u003c/p>\n\u003cp>Diana Bianchi, that medical student from the Herzenberg lab, is now a professor at Tufts, where she founded the \u003ca href=\"https://www.tuftsmedicalcenter.org/Research-Clinical-Trials/Institutes-Centers-Labs/Mother-Infant-Research-Institute/Laboratories/Bianchi-Laboratory.aspx\" target=\"_blank\">Mother Infant Research Institute\u003c/a>. She's still working in prenatal testing. In fact, perfecting these tests has become her life's work.\u003c/p>\n\u003cp>But her focus has shifted. Now that she can detect Down syndrome so early, she wants to treat it early, too — in the womb. Because finding this chromosomal abnormality at 10 weeks means there's a window of opportunity: The brain changes associated with Down syndrome don't occur until a month or so later. Theoretically, you could treat a fetus before some brain changes occur at all.\u003c/p>\n\u003cp>Bianchi's work is still early. She's experimenting with mice, giving them existing drugs in utero to see if she can forestall brain damage.\u003c/p>\n\u003cp>There's an often-quoted statistic, that 90 percent of parents who find out that their fetus has Down syndrome will abort. But that statistic is from a study done in the United Kingdom. In the U.S., far fewer women terminate.\u003c/p>\n\u003cp>\"We have to unpack this connection between prenatal testing and abortion,\" she says. \"We have good data to suggest that approximately 40 plus percent of women who know their fetus has Down syndrome continue their pregnancy. There are many women who speak very highly of the fact that this allows them to prepare.\"\u003c/p>\n\u003cp>The Down syndrome baby who kicked off the search for this blood test is now a 54-year-old man. He lives in a squat house in Redwood City, Calif., just a 30-minute drive from his birth mother's home.\u003c/p>\n\u003cp>For years, Michael lived with a local woman named Barbara Jennings, who raised a number of children with developmental challenges. The Herzenbergs' pediatrician helped them find her when Michael was a newborn. The Herzenbergs would visit Michael every month or so, but they never felt they should bring him home. When Barbara died, Michael moved to this group home.\u003c/p>\n\u003cp>It's hard to know how much Michael understands when I speak to him, though he has learned to read and use a cellphone. And he's stubborn. A lot like his mother, actually. \"Michael has the hardest head in the whole world,\" says Janet Thomas, the caretaker who runs this house. \"He does whatever he wants to do. He does not care whatever you say. He's going to do whatever it is he wants to do — that's Michael.\"\u003c/p>\n\u003cp>I asked Lee if she ever regretted not raising Michael, and she said no. \"It was a decision that was selfish, if you like, because we had things we wanted to do. In retrospect, a lot of things would never have gotten done. There would be no FACS had we decided to do this. Because it would have been a very intensive kind of upbringing.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>As for Michael, he clearly loves his mother, no matter what she decided. In Michael's room, there are photos on almost every surface, with snapshots of his biological and adopted families. In the corner is a huge poster of his father, celebrating when \u003ca href=\"//www.the-scientist.com/?articles.view/articleNo/24076/title/Herzenberg-wins-Kyoto-Prize/\" target=\"_blank\">he won the Kyoto Prize\u003c/a> for his contributions to biotechnology. And deep in one album, there's a picture of Len and Lee together. The caption reads: \"Michael's Other Mom + Dad.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 WNYC Radio. To see more, visit \u003ca href=\"http://www.wnyc.org/\" target=\"_blank\">WNYC Radio\u003c/a>.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Only+Human%3A+A+Birth+That+Launched+The+Search+For+A+Down+Syndrome+Test&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"title": "American Suburb: The Podcast",
"tagline": "The flip side of gentrification, told through one town",
"info": "Gentrification is changing cities across America, forcing people from neighborhoods they have long called home. Call them the displaced. Now those priced out of the Bay Area are looking for a better life in an unlikely place. American Suburb follows this migration to one California town along the Delta, 45 miles from San Francisco. But is this once sleepy suburb ready for them?",
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"tagline": "Exploring the Bay Area, one question at a time",
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"title": "Code Switch / Life Kit",
"info": "\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />",
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"order": 10
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"meta": {
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},
"link": "/radio/program/freakonomics-radio",
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"apple": "https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519",
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"info": "A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.",
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"airtime": "SUN 7:30pm-8pm",
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"info": "Inside Europe, a one-hour weekly news magazine hosted by Helen Seeney and Keith Walker, explores the topical issues shaping the continent. No other part of the globe has experienced such dynamic political and social change in recent years.",
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"title": "Latino USA",
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"info": "Latino USA, the radio journal of news and culture, is the only national, English-language radio program produced from a Latino perspective.",
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"live-from-here-highlights": {
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"title": "Live from Here Highlights",
"info": "Chris Thile steps to the mic as the host of Live from Here (formerly A Prairie Home Companion), a live public radio variety show. Download Chris’s Song of the Week plus other highlights from the broadcast. Produced by American Public Media.",
"airtime": "SAT 6pm-8pm, SUN 11am-1pm",
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"meta": {
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"link": "/radio/program/live-from-here-highlights",
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"rss": "https://feeds.publicradio.org/public_feeds/a-prairie-home-companion-highlights/rss/rss"
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"marketplace": {
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"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
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"officialWebsiteLink": "https://www.marketplace.org/",
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"source": "American Public Media"
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"mindshift": {
"id": "mindshift",
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"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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"officialWebsiteLink": "/mindshift/",
"meta": {
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"order": 13
},
"link": "/podcasts/mindshift",
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"info": "\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.",
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"tagline": "Deeply-reported investigative journalism",
"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg",
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"order": 12
},
"link": "/podcasts/onourwatch",
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"title": "On The Media",
"info": "Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us",
"airtime": "SUN 2pm-3pm, MON 12am-1am",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png",
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"link": "/radio/program/on-the-media",
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},
"our-body-politic": {
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"title": "Our Body Politic",
"info": "Presented by KQED, KCRW and KPCC, and created and hosted by award-winning journalist Farai Chideya, Our Body Politic is unapologetically centered on reporting on not just how women of color experience the major political events of today, but how they’re impacting those very issues.",
"airtime": "SAT 6pm-7pm, SUN 1am-2am",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Our-Body-Politic-Podcast-Tile-360x360-1.jpg",
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},
"link": "/radio/program/our-body-politic",
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5zaW1wbGVjYXN0LmNvbS9feGFQaHMxcw",
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"info": "Analysis, background reports and updates from the PBS NewsHour putting today's news in context.",
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},
"perspectives": {
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"tagline": "KQED's series of daily listener commentaries since 1991",
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"officialWebsiteLink": "/perspectives/",
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"order": 15
},
"link": "/perspectives",
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