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"content": "\u003cp>The San Francisco Giants, with the worst record in the National League, could probably use a shot of electricity about now.\u003c/p>\n\u003cp>Actually, they're already getting a shot of electricity\u003cspan style=\"font-weight: 400\">—\u003c/span>literally.\u003c/p>\n\u003caside class=\"pullquote alignright\">\u003c/aside>\n\u003cp>About a third of the major league roster, including \"some big-name players,\" are working out while using high-tech headgear that sends a weak electric current to the brain, says Geoff Head, the team's official sports scientist. The technology, called transcranial direct current stimulation, or tDCS, theoretically improves athletic performance.\u003c/p>\n\u003cp>So ... which players?\u003c/p>\n\u003cp>[audio src=\"http://www.kqed.org/.stream/anon/radio/science/2017/05/WebTDCS.mp3\" program=\"Listen to the radio version of this story by clicking below\" image=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/05/SciencePlayer_BG.jpeg\"]\u003c/p>\n\u003cp>Head wouldn't name names, but said if the technology showed results by the end of the season, some players would probably go public saying they used it.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Tyler Beede, at least, is a believer. Watching a promotional video in which the Giants' top pitching prospect hurls pitch after pitch while wearing a set of headphones, you'd think he was listening to tunes. But he's not -- instead, he's getting the juice, tDCS-style.\u003c/p>\n\u003cp>“It’s a very unique feeling,\" Beede explains in the video. \"You put it on, and it does have that kind of tickling, zapping feeling on your brain, but that’s kind of the reason you know its working.”\u003c/p>\n\u003cp>Beede, currently playing for the Giants' Sacramento AAA team, credits his \u003ca href=\"http://www.milb.com/player/index.jsp?player_id=595881#/career/R/pitching/2017/ALL\" target=\"_blank\" rel=\"noopener noreferrer\">improved pitching\u003c/a> in 2016 at least in part to the technology.\u003c/p>\n\u003cp>\u003cstrong>Tech Central\u003c/strong>\u003c/p>\n\u003cp>The headphones, from Halo Neuroscience, are just the latest health tech the team has sampled. Being in San Francisco, digital health startups frequently approach the club in hopes of getting a major league tryout, and Halo is located just blocks from the Giants' AT&T Park.\u003c/p>\n\u003cfigure id=\"attachment_385549\" class=\"wp-caption alignleft\" style=\"max-width: 320px\">\u003ca href=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/AustinSlaterCatching.jpg\">\u003cimg class=\"size-large wp-image-385549\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/AustinSlaterCatching-1020x1275.jpg\" alt=\"\" width=\"320\" height=\"400\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1020x1275.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-160x200.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-800x1000.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-768x960.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1920x2400.jpg 1920w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1180x1475.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-960x1200.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-240x300.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-375x469.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-520x650.jpg 520w\" sizes=\"(max-width: 320px) 100vw, 320px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Sacramento River Cats catcher Austin Slater giving his brain a little electrical juice. \u003ccite>(Halo Neuroscience)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Head says his role as sports scientist is to \"weed through\" a lot of the gadgets that companies send the team's way. Plenty of them, says Head, \"overpromise and underdeliver.\"\u003c/p>\n\u003cp>But Head decided to try the headset, called Halo Sport, during spring training last year\u003cspan style=\"font-weight: 400\">—he gave them to s\u003c/span>ome minor leaguers to wear as they sprinted 20-yard dashes. After two weeks, Head analyzed the results and found that the players who wore the equipment had\u003cstrong> \u003c/strong>shaved off a few one-hundredths of a second compared to a control group.\u003cstrong>\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>In the promotional video, Beede says, \"Your brain just becomes so in tune with what you’ve been doing that it can memorize your movements to help you go to that next level.\"\u003c/p>\n\u003cp>\u003cstrong>Targeting the Motor Cortex\u003c/strong>\u003c/p>\n\u003cp>Using Halo's headset is kind of like plugging your brain into a 9-volt battery\u003cstrong>,\u003c/strong> giving your neurons a little extra jolt and priming them for action.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Brain stimulation has been around since recorded history. They used to use electric fish to help migraines or gout or some other problems in ancient Egypt.’ \u003ccite>Theodore Zanto, UCSF neuroscientist\u003c/cite>\u003c/aside>\n\u003cp>The earphones are actually just for show, allowing the wearer to use the technology \"without necessarily displaying it to the world,\" a spokesperson for Halo said. The electrodes in the $750 headset are hidden inside the band that connects the earphones. The electrodes target the motor cortex, which is the region of the brain located across the top of your head, spanning ear to ear. The motor cortex sends electrical signals from your neurons to targeted groups of muscle fibers, causing them to contract.\u003c/p>\n\u003cp>“People like to say that electricity is the currency of the brain and that in many ways the brain is a circuit,\" says Marom Bikson, a professor of biomedical engineering at City College of New York. \"So when we apply electricity to the brain, we interact with that circuit, and we can change how that circuit works.\"\u003c/p>\n\u003cp>Theodore Zanto, director of the Neuroscape Neuroscience Research Program at UCSF, thinks applying electricity to the motor cortex enables it to \"trigger the 'execute movement' signal faster,\" he says.\u003c/p>\n\u003cp>Wiring the brain received a pretty bad rap last century when \u003ca href=\"http://www.mayoclinic.org/tests-procedures/electroconvulsive-therapy/basics/definition/prc-20014161\" target=\"_blank\" rel=\"noopener noreferrer\">electroconvulsive therapy \u003c/a>was used to deliberately induce brain seizures in order to treat mental illness.\u003c/p>\n\u003cp>But tDCS uses a very low-voltage electrical charge\u003cb>. \u003c/b>Researchers say the major concerns are minor burns, itching, fatigue and nausea. Most of the known injuries have occurred in the the do-it-yourself community, from people who constructed homemade tDCS headsets after watching YouTube tutorials.\u003cstrong> \u003c/strong>\u003c/p>\n\u003cp>\u003cstrong>Jury's Still Out\u003c/strong>\u003c/p>\n\u003cp>Even though companies like \u003ca href=\"https://www.haloneuro.com/\">Halo\u003c/a>, \u003ca href=\"http://www.thync.com/\">Thync\u003c/a> and \u003ca href=\"https://www.foc.us/edge-tdcs-headset\">Focus\u003c/a> promise their brain-boosting headsets will reduce fatigue, sharpen focus and improve muscle endurance, experts are cautious.\u003c/p>\n\u003cp>More than a thousand peer-reviewed studies have looked at how a mild brain jolt from electricity improves everything from \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/17614951\" target=\"_blank\" rel=\"noopener noreferrer\">physical actions\u003c/a> to \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004959\" target=\"_blank\" rel=\"noopener noreferrer\">memory\u003c/a> to \u003ca href=\"https://www.sciencedaily.com/releases/2016/04/160414095949.htm\" target=\"_blank\" rel=\"noopener noreferrer\">creativity\u003c/a>, and the results are highly inconsistent.\u003c/p>\n\u003cp>“One of the reasons why we believe the effects are highly variable is because everyone has slightly different thicknesses of scalp, thicknesses of skull, different amounts of cerebrospinal fluid, and that’s what the current has to travel through before it even gets to the brain,\" says Zanto. He also says age, gender, ethnicity and illness can influence results.\u003c/p>\n\u003cp>Bikson says marketing claims about tDCS often exaggerate the results from lab studies. For example, researchers may measure how fast someone can press a sensor with their finger before and after wearing a tDCS device.\u003c/p>\n\u003cp>\"And we may see a positive effect,\" says Bikson. \"But that is a world away, though, from a professional basketball player having a marginal improvement in their three-point success percentage after tDCS.\"\u003c/p>\n\u003cp>Even though a lot of the data is conflicting, the most positive results do support using tDCS to improve motor control. Hence the slew of startups targeting athletes.\u003c/p>\n\u003cp>The Giants' Head says even a tiny advantage can help win games at the major league level. An improvement of two-hundredths of a second can be \"the difference between safe and out sometimes,\" he says.\u003c/p>\n\u003cp>\u003cstrong>'This is My Brain on Fire'\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_383008\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-383008\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/IMG_1879-800x600.jpg\" alt=\"\" width=\"800\" height=\"600\">\u003cfigcaption class=\"wp-caption-text\">World record holding powerlifter Emily Hu wears Halo Sport headphones while she warms up at Boss Barbell gym in Mountain View. \u003ccite>(Lesley McClurg/ KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>At a Mountain View gym recently, Emily Hu, a world record holder in power lifting, tightened her silent black Halo headphones before sliding underneath a bar to bench press 220 pounds.\u003c/p>\n\u003cp>\"If I feel the tingling sensation I think, ‘OK. This is my brain on fire,\" says Hu. \"Let’s go!’”\u003c/p>\n\u003cp>About a year ago she tried stimulating her brain for the first time, while doing squats. Usually she adds just a few pounds to the bar between workouts, but the week she tried tDCS she was able to add nine, peaking at 295 pounds.\u003c/p>\n\u003cp>“Some people say, 'You know that could have been a fluke because that was only one data point,' \" says Hu. \" But for me it was a positive enough change that I thought, 'Well, I am going to stick with this device.' ”\u003c/p>\n\u003cp>Even though Hu hasn’t seen the same kind of improvement every week, she wears the headphones routinely while warming up. “I think it gives me a false sense of confidence to feel the device work,” she says, grinning.\u003c/p>\n\u003cp>\u003cstrong>Here to Stay?\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Neither Zanto nor Bikson, both academics, are popping tDCS devices onto their own heads -- not to improve athletic performance, anyway. But they both predict the technology is here to stay.\u003c/p>\n\u003cp>“Brain stimulation has been around since recorded history,\" says Zanto. \"They used to use electric fish to help migraines or gout or some other problems in ancient Egypt.\"\u003c/p>\n\u003cp>But the hype around tDCS inspires a lot of new questions. What are the long-term effects of wiring your brain daily? When you zap one part of the brain, are you influencing another region unknowingly, maybe even destructively?\u003c/p>\n\u003cp>And might using tDCS one day be considered a form of cheating?\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\"Maybe years from now we’ll look back at what we’re doing today and we’ll just say to ourselves we really were just feeling around in the dark,\" says Zanto.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Tyler Beede, at least, is a believer. Watching a promotional video in which the Giants' top pitching prospect hurls pitch after pitch while wearing a set of headphones, you'd think he was listening to tunes. But he's not -- instead, he's getting the juice, tDCS-style.\u003c/p>\n\u003cp>“It’s a very unique feeling,\" Beede explains in the video. \"You put it on, and it does have that kind of tickling, zapping feeling on your brain, but that’s kind of the reason you know its working.”\u003c/p>\n\u003cp>Beede, currently playing for the Giants' Sacramento AAA team, credits his \u003ca href=\"http://www.milb.com/player/index.jsp?player_id=595881#/career/R/pitching/2017/ALL\" target=\"_blank\" rel=\"noopener noreferrer\">improved pitching\u003c/a> in 2016 at least in part to the technology.\u003c/p>\n\u003cp>\u003cstrong>Tech Central\u003c/strong>\u003c/p>\n\u003cp>The headphones, from Halo Neuroscience, are just the latest health tech the team has sampled. Being in San Francisco, digital health startups frequently approach the club in hopes of getting a major league tryout, and Halo is located just blocks from the Giants' AT&T Park.\u003c/p>\n\u003cfigure id=\"attachment_385549\" class=\"wp-caption alignleft\" style=\"max-width: 320px\">\u003ca href=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/AustinSlaterCatching.jpg\">\u003cimg class=\"size-large wp-image-385549\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/AustinSlaterCatching-1020x1275.jpg\" alt=\"\" width=\"320\" height=\"400\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1020x1275.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-160x200.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-800x1000.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-768x960.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1920x2400.jpg 1920w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-1180x1475.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-960x1200.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-240x300.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-375x469.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/05/AustinSlaterCatching-520x650.jpg 520w\" sizes=\"(max-width: 320px) 100vw, 320px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Sacramento River Cats catcher Austin Slater giving his brain a little electrical juice. \u003ccite>(Halo Neuroscience)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Head says his role as sports scientist is to \"weed through\" a lot of the gadgets that companies send the team's way. Plenty of them, says Head, \"overpromise and underdeliver.\"\u003c/p>\n\u003cp>But Head decided to try the headset, called Halo Sport, during spring training last year\u003cspan style=\"font-weight: 400\">—he gave them to s\u003c/span>ome minor leaguers to wear as they sprinted 20-yard dashes. After two weeks, Head analyzed the results and found that the players who wore the equipment had\u003cstrong> \u003c/strong>shaved off a few one-hundredths of a second compared to a control group.\u003cstrong>\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>In the promotional video, Beede says, \"Your brain just becomes so in tune with what you’ve been doing that it can memorize your movements to help you go to that next level.\"\u003c/p>\n\u003cp>\u003cstrong>Targeting the Motor Cortex\u003c/strong>\u003c/p>\n\u003cp>Using Halo's headset is kind of like plugging your brain into a 9-volt battery\u003cstrong>,\u003c/strong> giving your neurons a little extra jolt and priming them for action.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Brain stimulation has been around since recorded history. They used to use electric fish to help migraines or gout or some other problems in ancient Egypt.’ \u003ccite>Theodore Zanto, UCSF neuroscientist\u003c/cite>\u003c/aside>\n\u003cp>The earphones are actually just for show, allowing the wearer to use the technology \"without necessarily displaying it to the world,\" a spokesperson for Halo said. The electrodes in the $750 headset are hidden inside the band that connects the earphones. The electrodes target the motor cortex, which is the region of the brain located across the top of your head, spanning ear to ear. The motor cortex sends electrical signals from your neurons to targeted groups of muscle fibers, causing them to contract.\u003c/p>\n\u003cp>“People like to say that electricity is the currency of the brain and that in many ways the brain is a circuit,\" says Marom Bikson, a professor of biomedical engineering at City College of New York. \"So when we apply electricity to the brain, we interact with that circuit, and we can change how that circuit works.\"\u003c/p>\n\u003cp>Theodore Zanto, director of the Neuroscape Neuroscience Research Program at UCSF, thinks applying electricity to the motor cortex enables it to \"trigger the 'execute movement' signal faster,\" he says.\u003c/p>\n\u003cp>Wiring the brain received a pretty bad rap last century when \u003ca href=\"http://www.mayoclinic.org/tests-procedures/electroconvulsive-therapy/basics/definition/prc-20014161\" target=\"_blank\" rel=\"noopener noreferrer\">electroconvulsive therapy \u003c/a>was used to deliberately induce brain seizures in order to treat mental illness.\u003c/p>\n\u003cp>But tDCS uses a very low-voltage electrical charge\u003cb>. \u003c/b>Researchers say the major concerns are minor burns, itching, fatigue and nausea. Most of the known injuries have occurred in the the do-it-yourself community, from people who constructed homemade tDCS headsets after watching YouTube tutorials.\u003cstrong> \u003c/strong>\u003c/p>\n\u003cp>\u003cstrong>Jury's Still Out\u003c/strong>\u003c/p>\n\u003cp>Even though companies like \u003ca href=\"https://www.haloneuro.com/\">Halo\u003c/a>, \u003ca href=\"http://www.thync.com/\">Thync\u003c/a> and \u003ca href=\"https://www.foc.us/edge-tdcs-headset\">Focus\u003c/a> promise their brain-boosting headsets will reduce fatigue, sharpen focus and improve muscle endurance, experts are cautious.\u003c/p>\n\u003cp>More than a thousand peer-reviewed studies have looked at how a mild brain jolt from electricity improves everything from \u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/17614951\" target=\"_blank\" rel=\"noopener noreferrer\">physical actions\u003c/a> to \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004959\" target=\"_blank\" rel=\"noopener noreferrer\">memory\u003c/a> to \u003ca href=\"https://www.sciencedaily.com/releases/2016/04/160414095949.htm\" target=\"_blank\" rel=\"noopener noreferrer\">creativity\u003c/a>, and the results are highly inconsistent.\u003c/p>\n\u003cp>“One of the reasons why we believe the effects are highly variable is because everyone has slightly different thicknesses of scalp, thicknesses of skull, different amounts of cerebrospinal fluid, and that’s what the current has to travel through before it even gets to the brain,\" says Zanto. He also says age, gender, ethnicity and illness can influence results.\u003c/p>\n\u003cp>Bikson says marketing claims about tDCS often exaggerate the results from lab studies. For example, researchers may measure how fast someone can press a sensor with their finger before and after wearing a tDCS device.\u003c/p>\n\u003cp>\"And we may see a positive effect,\" says Bikson. \"But that is a world away, though, from a professional basketball player having a marginal improvement in their three-point success percentage after tDCS.\"\u003c/p>\n\u003cp>Even though a lot of the data is conflicting, the most positive results do support using tDCS to improve motor control. Hence the slew of startups targeting athletes.\u003c/p>\n\u003cp>The Giants' Head says even a tiny advantage can help win games at the major league level. An improvement of two-hundredths of a second can be \"the difference between safe and out sometimes,\" he says.\u003c/p>\n\u003cp>\u003cstrong>'This is My Brain on Fire'\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_383008\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-383008\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/05/IMG_1879-800x600.jpg\" alt=\"\" width=\"800\" height=\"600\">\u003cfigcaption class=\"wp-caption-text\">World record holding powerlifter Emily Hu wears Halo Sport headphones while she warms up at Boss Barbell gym in Mountain View. \u003ccite>(Lesley McClurg/ KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>At a Mountain View gym recently, Emily Hu, a world record holder in power lifting, tightened her silent black Halo headphones before sliding underneath a bar to bench press 220 pounds.\u003c/p>\n\u003cp>\"If I feel the tingling sensation I think, ‘OK. This is my brain on fire,\" says Hu. \"Let’s go!’”\u003c/p>\n\u003cp>About a year ago she tried stimulating her brain for the first time, while doing squats. Usually she adds just a few pounds to the bar between workouts, but the week she tried tDCS she was able to add nine, peaking at 295 pounds.\u003c/p>\n\u003cp>“Some people say, 'You know that could have been a fluke because that was only one data point,' \" says Hu. \" But for me it was a positive enough change that I thought, 'Well, I am going to stick with this device.' ”\u003c/p>\n\u003cp>Even though Hu hasn’t seen the same kind of improvement every week, she wears the headphones routinely while warming up. “I think it gives me a false sense of confidence to feel the device work,” she says, grinning.\u003c/p>\n\u003cp>\u003cstrong>Here to Stay?\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Neither Zanto nor Bikson, both academics, are popping tDCS devices onto their own heads -- not to improve athletic performance, anyway. But they both predict the technology is here to stay.\u003c/p>\n\u003cp>“Brain stimulation has been around since recorded history,\" says Zanto. \"They used to use electric fish to help migraines or gout or some other problems in ancient Egypt.\"\u003c/p>\n\u003cp>But the hype around tDCS inspires a lot of new questions. What are the long-term effects of wiring your brain daily? When you zap one part of the brain, are you influencing another region unknowingly, maybe even destructively?\u003c/p>\n\u003cp>And might using tDCS one day be considered a form of cheating?\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"Maybe years from now we’ll look back at what we’re doing today and we’ll just say to ourselves we really were just feeling around in the dark,\" says Zanto.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>The San Francisco Giants, with the worst record in the National League, could probably use a shot of electricity about now.\u003c/p>\n\u003cp>Actually, they’re already getting a shot of electricity\u003cspan>—\u003c/span>literally.\u003c/p>\n\u003caside>The Giants’ official sports scientist says a third of the team is using tDCS headsets, which deliver an electrical current to the brain \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/05/05/san-francisco-giants-brain-electricity/\" target=\"_self\" rel=\"nofollow noopener\" id=\"rssmi_more\">Read More …\u003c/a> \n\u003cp>Source:: \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/05/05/san-francisco-giants-brain-electricity/\" target=\"_self\" title=\"The SF Giants Are Zapping Their Brains With Electricity. Will It Help?\" rel=\"nofollow noopener\">Future of You – tagged “kqedscience”\u003c/a>\u003c/p>\n\u003c/aside>\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n",
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"content": "\u003cp>\u003cstrong>Update Thursday, 2:20 p.m.\u003c/strong>\u003c/p>\n\u003cp>\u003cem>Watch the winning presentation\u003c/em>\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=hey6Lzalx58\u003c/p>\n\u003cp>Some of the brightest -- or at least the most loquacious -- graduate students in the University of California system competed in the UC's third annual \u003ca href=\"https://gradslam.universityofcalifornia.edu/\" target=\"_blank\">Grad Slam\u003c/a> today.\u003c/p>\n\u003cp>At the downtown San Francisco offices of LinkedIn, 10 current graduate and Ph.D. students –- one from each UC school -- took the stage to present their research in the form of a three-minute elevator pitch. The jargon-free talks were succinct, but the ideas were far from simple.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Leslie Rith-Najarian, a Ph.D. student at UCLA, won the $6,000 grand prize for her presentation on building an online anxiety and depression prevention program for students.\u003c/p>\n\u003cp>Other topics ranged from curing blindness to sustainable surfboards.\u003c/p>\n\u003cp>“Cruz foam does exactly that – taking chitin from shrimp shells and transforming it into foam,\" said John Felts, the second-prize winner from UC Santa Cruz, in his talk. \"Our eco-friendly water-based process involves only water, salts and a foaming agent. There’s no toxic component.”\u003c/p>\n\u003cp>Third place went to Geoff Hollett, of UC San Diego, for his presentation on using geometry to create better birth control.\u003c/p>\n\u003cp>A people's choice award, voted on by people watching the event online, went to Leah Foltz of UC Santa Barbara, whose presentation was about using personalized medicine to cure blindness.\u003c/p>\n\u003cp>Students presented to an audience filled with UC alumni from companies like Google, Genentech and Illumina, and they all hung around afterward to network and -- dare we say it? -- perhaps discuss a little funding.\u003c/p>\n\u003cp>The hope is that these big ideas will translate to the real world rather than find their ultimate expression as an article in a scientific journal.\u003c/p>\n\u003cp>\u003cstrong>Communicating to Non-Academics\u003c/strong>\u003c/p>\n\u003cp>UC considers the contest a professional development opportunity, said Pamela Jennings, executive director of graduate studies for the system’s Office of the President.\u003c/p>\n\u003cp>“It used to be when people talked about getting a Ph.D. in particular, you thought about it only as a vehicle to pursue a professorship or teaching at a university or college level,” Jennings said. “And really our students come to graduate school with a mindset to do all sorts of careers. It’s particularly important that they have the ability to translate their [research] in a way that’s relatable to others. We’re seeing that’s very critical on the job market and for entrepreneurial opportunities.”\u003c/p>\n\u003cp>And — we might say, as we’ve seen around climate change — scientists are not always the best at communicating their research in a way that hits home with the general public.\u003c/p>\n\u003cp>“It’s very easy if your’e a researcher to speak to your own, because you do that quite often,” Jennings said. “What if you were just talking to someone down the street, you know your mom’s neighbor, your cousin’s best friend? How would you make them understand what you do and why it matters?”\u003c/p>\n\u003cp>As a side note on today's contest, the event was emceed by UC President Janet Napolitano, who is taking somewhat longer than three minutes to explain a \u003ca href=\"https://ww2.kqed.org/news/2017/05/03/uc-president-napolitano-apologizes-for-interfering-with-state-audit/\" target=\"_blank\">$175 million secret reserve \u003c/a>uncovered by a state audit. Napolitano did not look the worse for wear today after having to apologize in front of a joint legislative oversight committee Tuesday for what the state auditor says was interference of the investigation.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cstrong>Update Thursday, 2:20 p.m.\u003c/strong>\u003c/p>\n\u003cp>\u003cem>Watch the winning presentation\u003c/em>\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/hey6Lzalx58'\n title='//www.youtube.com/embed/hey6Lzalx58'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>Some of the brightest -- or at least the most loquacious -- graduate students in the University of California system competed in the UC's third annual \u003ca href=\"https://gradslam.universityofcalifornia.edu/\" target=\"_blank\">Grad Slam\u003c/a> today.\u003c/p>\n\u003cp>At the downtown San Francisco offices of LinkedIn, 10 current graduate and Ph.D. students –- one from each UC school -- took the stage to present their research in the form of a three-minute elevator pitch. The jargon-free talks were succinct, but the ideas were far from simple.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Leslie Rith-Najarian, a Ph.D. student at UCLA, won the $6,000 grand prize for her presentation on building an online anxiety and depression prevention program for students.\u003c/p>\n\u003cp>Other topics ranged from curing blindness to sustainable surfboards.\u003c/p>\n\u003cp>“Cruz foam does exactly that – taking chitin from shrimp shells and transforming it into foam,\" said John Felts, the second-prize winner from UC Santa Cruz, in his talk. \"Our eco-friendly water-based process involves only water, salts and a foaming agent. There’s no toxic component.”\u003c/p>\n\u003cp>Third place went to Geoff Hollett, of UC San Diego, for his presentation on using geometry to create better birth control.\u003c/p>\n\u003cp>A people's choice award, voted on by people watching the event online, went to Leah Foltz of UC Santa Barbara, whose presentation was about using personalized medicine to cure blindness.\u003c/p>\n\u003cp>Students presented to an audience filled with UC alumni from companies like Google, Genentech and Illumina, and they all hung around afterward to network and -- dare we say it? -- perhaps discuss a little funding.\u003c/p>\n\u003cp>The hope is that these big ideas will translate to the real world rather than find their ultimate expression as an article in a scientific journal.\u003c/p>\n\u003cp>\u003cstrong>Communicating to Non-Academics\u003c/strong>\u003c/p>\n\u003cp>UC considers the contest a professional development opportunity, said Pamela Jennings, executive director of graduate studies for the system’s Office of the President.\u003c/p>\n\u003cp>“It used to be when people talked about getting a Ph.D. in particular, you thought about it only as a vehicle to pursue a professorship or teaching at a university or college level,” Jennings said. “And really our students come to graduate school with a mindset to do all sorts of careers. It’s particularly important that they have the ability to translate their [research] in a way that’s relatable to others. We’re seeing that’s very critical on the job market and for entrepreneurial opportunities.”\u003c/p>\n\u003cp>And — we might say, as we’ve seen around climate change — scientists are not always the best at communicating their research in a way that hits home with the general public.\u003c/p>\n\u003cp>“It’s very easy if your’e a researcher to speak to your own, because you do that quite often,” Jennings said. “What if you were just talking to someone down the street, you know your mom’s neighbor, your cousin’s best friend? How would you make them understand what you do and why it matters?”\u003c/p>\n\u003cp>As a side note on today's contest, the event was emceed by UC President Janet Napolitano, who is taking somewhat longer than three minutes to explain a \u003ca href=\"https://ww2.kqed.org/news/2017/05/03/uc-president-napolitano-apologizes-for-interfering-with-state-audit/\" target=\"_blank\">$175 million secret reserve \u003c/a>uncovered by a state audit. Napolitano did not look the worse for wear today after having to apologize in front of a joint legislative oversight committee Tuesday for what the state auditor says was interference of the investigation.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp> \u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>\u003cem>This post was updated May 22 to include the radio version, which you can listen to by scrolling down.\u003c/em>\u003c/p>\n\u003cp>Last year, all of the accumulated data pointing to the poor mental health of medical students in general suddenly became more than just numbers at USC's Keck School of Medicine.\u003c/p>\n\u003cp>A Keck student, 25-year-old Sean Petro, had failed to show up for a clinical rotation. Eventually, campus police found his body in a closet of his apartment, where he had hung himself. In addition to attending medical school, Petro had just become an officer in the Navy Reserve, and had hopes of becoming a flight surgeon.\u003c/p>\n\u003cp>At Keck, he was just one year shy of graduating.\u003c/p>\n\u003cp>His suicide shocked Ranjita Raghavan, now in her third year at the medical school, a year behind Petro.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"It’s really scary,\" she says, speaking about medical school suicides in general. \"It’s one of those things that’s really alarming.\"\u003c/p>\n\u003cp>[audio src=\"http://www.kqed.org/.stream/anon/radio/science/2017/05/WEBSuicideDocsGorn170522.mp3\" title=\"Click on the play button below to listen to the radio story\" program=\"Future of You\" image=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/05/SciencePlayer_BG.jpeg\"]\u003c/p>\n\u003cp>Her own schedule illustrates how daunting a medical student's life can be. Six days a week, she rises at 4:30 a.m. and doesn't return home till 7 p.m. Whatever free time she has is used to study and eat.\u003c/p>\n\u003cp>\"No one said medical school’s going to be easy,\" she says. \"But you just don’t know from the outside. I come off as a happy person, but it was really tough for me the first two years.\"\u003c/p>\n\u003cp>She says although she is generally upbeat about her medical school experience, she still can't quite get her mind around all the data that shows so many students are exhibiting signs of burnout, not to mention thinking about suicide.\u003c/p>\n\u003cp>\u003cstrong>A Known Risk\u003c/strong>\u003c/p>\n\u003cp>After aspiring doctors receive a prized acceptance letter to medical school, they face a daunting reality.\u003c/p>\n\u003caside class=\"pullquote alignright\">'There is so much buzz in our circle right now, in the academic and physician circle, and now it’s reaching a level that can no longer be pushed under the rug. It’s becoming scandalous.'\u003ccite>Dr. Andres Sciolla, psychiatrist, UC Davis School of Medicine\u003c/cite>\u003c/aside>\n\u003cp>Get ready for 80-hour work weeks for the next seven years of med school and residency. Get ready for trying to commit a crush of information to sleep-deprived brain cells. Get ready for little time spent with family and friends. Oh, and by the way, get ready for making decisions resulting in life and death.\u003c/p>\n\u003cp>And get ready for, potentially, thoughts about ending your own life.\u003c/p>\n\u003cp>No one knows the exact number of medical students or residents who have killed themselves in the U.S.; there is no requirement to report suicide rates in medical school or residency programs. But multiple studies have shown these doctors-in-training are at risk for suicide, and the reality of poor mental health among the population is well-known.\u003c/p>\n\u003cp>Last year, a\u003ca href=\"http://jamanetwork.com/journals/jama/article-abstract/2589340\" target=\"_blank\" rel=\"noopener noreferrer\"> meta-study \u003c/a>published in the \u003cem>Journal of the American Medical Association\u003c/em> looked at 117,000 medical students around the world. The findings: 11 percent had considered ending their lives.\u003c/p>\n\u003cp>A 2008\u003ca href=\"https://www.med.upenn.edu/gastro/documents/Dyrbye.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"> study\u003c/a> of over 4,000 students at seven U.S. medical schools found as high as 13 percent having suicidal thoughts. For comparison, in the U.S., the rate of suicidal ideation among the general population is just 7 percent for 18 to-25 -year-olds, according to 2013 \u003ca href=\"https://www.cdc.gov/violenceprevention/pdf/suicide-datasheet-a.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">numbers\u003c/a> from the U.S. Centers for Disease Control and Prevention. For 26- to 49-year-olds, it is 4 percent.\u003c/p>\n\u003cp>And while a 2014 \u003ca href=\"http://journals.lww.com/academicmedicine/Fulltext/2014/03000/Burnout_Among_U_S__Medical_Students,_Residents,.25.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">study\u003c/a> found a slightly lower rate of suicidal ideation among medical students, residents and young doctors compared to others in their age group, it found significantly higher rates of depression and burnout.\u003c/p>\n\u003cp>\u003cstrong>Schools, Programs React\u003c/strong>\u003c/p>\n\u003cp>The data, combined with a number of actual suicides by medical students and residents, have prompted schools and residency programs across California and the country to initiate programs to reduce stress, require mental-health screenings and offer counseling.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I don’t know that we recognized the need. I think medicine traditionally has been a profession that says, ‘You just do it.’ ”\u003ccite>Donna Elliott, senior associate dean of student affairs, USC\u003c/cite>\u003c/aside>\n\u003cp>The programs have been instituted over just the last several years; traditionally, stress and mental health problems are not issues the institutions have specifically addressed, mental health experts say.\u003c/p>\n\u003cp>That's changing because Petro's death is only one of several recent suicides by medical students and residents around the country, says Andres Sciolla, a psychiatrist at the UC Davis School of Medicine.\u003c/p>\n\u003cp>Sciolla says the suicides of two doctors-in-training in New York City in 2014 galvanized the idea among the medical community that something needed to be done.\u003c/p>\n\u003cp>\"It’s a very big topic that the general public just doesn’t know about,” Sciolla says. “There is so much buzz in our circle right now, in the academic and physician circle, and now it’s reaching a level that can no longer be pushed under the rug. It’s becoming scandalous.”\u003c/p>\n\u003cp>Sciolla helped institute a mental health program at UC Davis to catch problems before they can turn into crises. Residents fill out an online confidential survey to help identify those who are dealing with high levels of stress. Those individuals are contacted and offered counseling and other resources so they don't have to suffer in silence.\u003c/p>\n\u003cp>At the Keck School of Medicine, administrators started to address student mental health even before Petro's death. That's partly because in 2014, the same year national attention focused on the resident suicides in New York, another medical student who was enrolled at USC disappeared and was never found. That same year, a faculty physician took his own life.\u003c/p>\n\u003cp>Donna Elliott, the senior associate dean of student affairs at USC, says those local and national incidents were a loud wake-up call.\u003c/p>\n\u003cp>“There's a strong need in medical schools now in supporting students’ mental health,\" Elliott says. A big first step in that direction, she says, is the need to change the culture of shame and stigma around burnout, depression and suicide.\u003c/p>\n\u003cp>USC has hired a director of medical student wellness, instituted mandatory \"Keck Check\" mental health\u003cem> \u003c/em>evaluation sessions and now requires students to take several mental-health days off every year.\u003c/p>\n\u003cp>\u003cstrong>'Slow Going'\u003c/strong>\u003c/p>\n\u003cp>In the past, Elliott says, \"I don’t know that we recognized the need. I think medicine traditionally has been a profession that says, ‘You just do it.’ ”\u003c/p>\n\u003cp>Indeed the stigma and shame of suicide is more pronounced in the medical community, says Christine Moutier, chief medical officer at the American Foundation for Suicide Prevention.\u003c/p>\n\u003cp>Moutier, while working at UC San Diego, was the driving force behind the first med school suicide prevention program in California, \u003ca href=\"https://healthsciences.ucsd.edu/som/hear/Documents/suicide-prevention-depression-awareness.pdf\">back in 2009\u003c/a>.\u003c/p>\n\u003cp>\"At the time, it felt like few were doing that work, and it felt like swimming upstream to get it done,\" Moutier says. \"And it became even more difficult when I would take ideas to the regional or national level. It was slow going.\"\u003c/p>\n\u003cp>Moutier points to the irony that those attending to people’s health are facing their own health crisis. “It’s such a disconnect that health professionals don’t take this seriously,” she says.\u003c/p>\n\u003cp>She calls the problem a public health crisis–not just for the medical providers, but for their patients as well.\u003c/p>\n\u003cp>“This is a major problem,” Moutier says. “I mean, if you’re looking at the fact that almost a \u003ca href=\"http://jamanetwork.com/journals/jamapsychiatry/fullarticle/2467822\" target=\"_blank\" rel=\"noopener noreferrer\">quarter of interns\u003c/a> are thinking of suicide, what kind of care are they giving patients?”\u003c/p>\n\u003cp>A national movement is now afoot to address the issue. The Accreditation Council for Graduate Medical Education last year \u003ca href=\"https://www.acgme.org/Portals/0/PDFs/JointReleaseFinal_Letterhead.pdf\">launched an initiative\u003c/a> to prevent medical school and residency suicides, and it hopes to require residency training programs to have wellness initiatives in place starting in July.\u003c/p>\n\u003cp>However, a \u003ca href=\"http://www.acgme.org/Portals/0/PDFs/Nasca-Community/Section-VI-Memo-3-10-17.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">recent ACGME decision\u003c/a> raised the\u003ca href=\"https://www.nytimes.com/2017/03/10/health/us-doctors-residents-24-hour-shifts.html\" target=\"_blank\" rel=\"noopener noreferrer\"> number of continuous hours\u003c/a> first-year residents can work, from 16 to 24.\u003c/p>\n\u003cp>Among other medical schools across the state, UCSF now requires third-year medical students, who typically spend up to 80 hours a week on hospital rotations, to attend check-in mental-health sessions. Stanford School of Medicine has a similar program to identify and help those who might be struggling with stress and burnout. One residency program at Stanford also offers stress-reduction perks like free delivery of groceries to residents' homes and time to exercise.\u003c/p>\n\u003cp>All of these efforts are a good start, but just a start, says Sidney Zisook, director of the psychiatry residency program at UC San Diego.\u003c/p>\n\u003cp>“There’s been a code of silence throughout the years. Places have tried to cover this up and hush it up, no question,\" Zisook says. “I do think things are moving in a positive direction now. But certainly institutions need to take a much more serious look at this.”\u003c/p>\n\u003cp>Raghavan, the third-year medical student from USC, says she recognizes the support she is getting from the school.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\"On your own, you never have enough time to sit and think about what you need. I mean, when do I have time to do that?\" she says with a laugh. \"So I appreciate the school thinking about that for you, and trying to do something about it.\"\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Her own schedule illustrates how daunting a medical student's life can be. Six days a week, she rises at 4:30 a.m. and doesn't return home till 7 p.m. Whatever free time she has is used to study and eat.\u003c/p>\n\u003cp>\"No one said medical school’s going to be easy,\" she says. \"But you just don’t know from the outside. I come off as a happy person, but it was really tough for me the first two years.\"\u003c/p>\n\u003cp>She says although she is generally upbeat about her medical school experience, she still can't quite get her mind around all the data that shows so many students are exhibiting signs of burnout, not to mention thinking about suicide.\u003c/p>\n\u003cp>\u003cstrong>A Known Risk\u003c/strong>\u003c/p>\n\u003cp>After aspiring doctors receive a prized acceptance letter to medical school, they face a daunting reality.\u003c/p>\n\u003caside class=\"pullquote alignright\">'There is so much buzz in our circle right now, in the academic and physician circle, and now it’s reaching a level that can no longer be pushed under the rug. It’s becoming scandalous.'\u003ccite>Dr. Andres Sciolla, psychiatrist, UC Davis School of Medicine\u003c/cite>\u003c/aside>\n\u003cp>Get ready for 80-hour work weeks for the next seven years of med school and residency. Get ready for trying to commit a crush of information to sleep-deprived brain cells. Get ready for little time spent with family and friends. Oh, and by the way, get ready for making decisions resulting in life and death.\u003c/p>\n\u003cp>And get ready for, potentially, thoughts about ending your own life.\u003c/p>\n\u003cp>No one knows the exact number of medical students or residents who have killed themselves in the U.S.; there is no requirement to report suicide rates in medical school or residency programs. But multiple studies have shown these doctors-in-training are at risk for suicide, and the reality of poor mental health among the population is well-known.\u003c/p>\n\u003cp>Last year, a\u003ca href=\"http://jamanetwork.com/journals/jama/article-abstract/2589340\" target=\"_blank\" rel=\"noopener noreferrer\"> meta-study \u003c/a>published in the \u003cem>Journal of the American Medical Association\u003c/em> looked at 117,000 medical students around the world. The findings: 11 percent had considered ending their lives.\u003c/p>\n\u003cp>A 2008\u003ca href=\"https://www.med.upenn.edu/gastro/documents/Dyrbye.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"> study\u003c/a> of over 4,000 students at seven U.S. medical schools found as high as 13 percent having suicidal thoughts. For comparison, in the U.S., the rate of suicidal ideation among the general population is just 7 percent for 18 to-25 -year-olds, according to 2013 \u003ca href=\"https://www.cdc.gov/violenceprevention/pdf/suicide-datasheet-a.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">numbers\u003c/a> from the U.S. Centers for Disease Control and Prevention. For 26- to 49-year-olds, it is 4 percent.\u003c/p>\n\u003cp>And while a 2014 \u003ca href=\"http://journals.lww.com/academicmedicine/Fulltext/2014/03000/Burnout_Among_U_S__Medical_Students,_Residents,.25.aspx\" target=\"_blank\" rel=\"noopener noreferrer\">study\u003c/a> found a slightly lower rate of suicidal ideation among medical students, residents and young doctors compared to others in their age group, it found significantly higher rates of depression and burnout.\u003c/p>\n\u003cp>\u003cstrong>Schools, Programs React\u003c/strong>\u003c/p>\n\u003cp>The data, combined with a number of actual suicides by medical students and residents, have prompted schools and residency programs across California and the country to initiate programs to reduce stress, require mental-health screenings and offer counseling.\u003c/p>\n\u003caside class=\"pullquote alignright\">'I don’t know that we recognized the need. I think medicine traditionally has been a profession that says, ‘You just do it.’ ”\u003ccite>Donna Elliott, senior associate dean of student affairs, USC\u003c/cite>\u003c/aside>\n\u003cp>The programs have been instituted over just the last several years; traditionally, stress and mental health problems are not issues the institutions have specifically addressed, mental health experts say.\u003c/p>\n\u003cp>That's changing because Petro's death is only one of several recent suicides by medical students and residents around the country, says Andres Sciolla, a psychiatrist at the UC Davis School of Medicine.\u003c/p>\n\u003cp>Sciolla says the suicides of two doctors-in-training in New York City in 2014 galvanized the idea among the medical community that something needed to be done.\u003c/p>\n\u003cp>\"It’s a very big topic that the general public just doesn’t know about,” Sciolla says. “There is so much buzz in our circle right now, in the academic and physician circle, and now it’s reaching a level that can no longer be pushed under the rug. It’s becoming scandalous.”\u003c/p>\n\u003cp>Sciolla helped institute a mental health program at UC Davis to catch problems before they can turn into crises. Residents fill out an online confidential survey to help identify those who are dealing with high levels of stress. Those individuals are contacted and offered counseling and other resources so they don't have to suffer in silence.\u003c/p>\n\u003cp>At the Keck School of Medicine, administrators started to address student mental health even before Petro's death. That's partly because in 2014, the same year national attention focused on the resident suicides in New York, another medical student who was enrolled at USC disappeared and was never found. That same year, a faculty physician took his own life.\u003c/p>\n\u003cp>Donna Elliott, the senior associate dean of student affairs at USC, says those local and national incidents were a loud wake-up call.\u003c/p>\n\u003cp>“There's a strong need in medical schools now in supporting students’ mental health,\" Elliott says. A big first step in that direction, she says, is the need to change the culture of shame and stigma around burnout, depression and suicide.\u003c/p>\n\u003cp>USC has hired a director of medical student wellness, instituted mandatory \"Keck Check\" mental health\u003cem> \u003c/em>evaluation sessions and now requires students to take several mental-health days off every year.\u003c/p>\n\u003cp>\u003cstrong>'Slow Going'\u003c/strong>\u003c/p>\n\u003cp>In the past, Elliott says, \"I don’t know that we recognized the need. I think medicine traditionally has been a profession that says, ‘You just do it.’ ”\u003c/p>\n\u003cp>Indeed the stigma and shame of suicide is more pronounced in the medical community, says Christine Moutier, chief medical officer at the American Foundation for Suicide Prevention.\u003c/p>\n\u003cp>Moutier, while working at UC San Diego, was the driving force behind the first med school suicide prevention program in California, \u003ca href=\"https://healthsciences.ucsd.edu/som/hear/Documents/suicide-prevention-depression-awareness.pdf\">back in 2009\u003c/a>.\u003c/p>\n\u003cp>\"At the time, it felt like few were doing that work, and it felt like swimming upstream to get it done,\" Moutier says. \"And it became even more difficult when I would take ideas to the regional or national level. It was slow going.\"\u003c/p>\n\u003cp>Moutier points to the irony that those attending to people’s health are facing their own health crisis. “It’s such a disconnect that health professionals don’t take this seriously,” she says.\u003c/p>\n\u003cp>She calls the problem a public health crisis–not just for the medical providers, but for their patients as well.\u003c/p>\n\u003cp>“This is a major problem,” Moutier says. “I mean, if you’re looking at the fact that almost a \u003ca href=\"http://jamanetwork.com/journals/jamapsychiatry/fullarticle/2467822\" target=\"_blank\" rel=\"noopener noreferrer\">quarter of interns\u003c/a> are thinking of suicide, what kind of care are they giving patients?”\u003c/p>\n\u003cp>A national movement is now afoot to address the issue. The Accreditation Council for Graduate Medical Education last year \u003ca href=\"https://www.acgme.org/Portals/0/PDFs/JointReleaseFinal_Letterhead.pdf\">launched an initiative\u003c/a> to prevent medical school and residency suicides, and it hopes to require residency training programs to have wellness initiatives in place starting in July.\u003c/p>\n\u003cp>However, a \u003ca href=\"http://www.acgme.org/Portals/0/PDFs/Nasca-Community/Section-VI-Memo-3-10-17.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">recent ACGME decision\u003c/a> raised the\u003ca href=\"https://www.nytimes.com/2017/03/10/health/us-doctors-residents-24-hour-shifts.html\" target=\"_blank\" rel=\"noopener noreferrer\"> number of continuous hours\u003c/a> first-year residents can work, from 16 to 24.\u003c/p>\n\u003cp>Among other medical schools across the state, UCSF now requires third-year medical students, who typically spend up to 80 hours a week on hospital rotations, to attend check-in mental-health sessions. Stanford School of Medicine has a similar program to identify and help those who might be struggling with stress and burnout. One residency program at Stanford also offers stress-reduction perks like free delivery of groceries to residents' homes and time to exercise.\u003c/p>\n\u003cp>All of these efforts are a good start, but just a start, says Sidney Zisook, director of the psychiatry residency program at UC San Diego.\u003c/p>\n\u003cp>“There’s been a code of silence throughout the years. Places have tried to cover this up and hush it up, no question,\" Zisook says. “I do think things are moving in a positive direction now. But certainly institutions need to take a much more serious look at this.”\u003c/p>\n\u003cp>Raghavan, the third-year medical student from USC, says she recognizes the support she is getting from the school.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"On your own, you never have enough time to sit and think about what you need. I mean, when do I have time to do that?\" she says with a laugh. \"So I appreciate the school thinking about that for you, and trying to do something about it.\"\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>People with a brain injury or dementia often struggle to remember simple things, like names or places. In research published recently in the journal \u003cem>Current Biology, \u003c/em>scientists have shown it may be possible to improve this sort of memory using tiny pulses of electricity — if they're properly timed.\u003c/p>\n\u003cp>A typical person's ability to remember things tends to vary a lot, says \u003ca href=\"http://memory.psych.upenn.edu/Michael_J._Kahana\">Michael Kahana,\u003c/a> who directs the computational memory lab at the University of Pennsylvania.\u003c/p>\n\u003cp>\"Some days we're at the top of our game,\" he says, \"and some days we're just off our game.\"\u003c/p>\n\u003cp>That's also true for people whose memory has been impaired — by a brain injury or disease. So Kahana wondered whether there might be some way to help these people perform at their peak level all the time.\u003c/p>\n\u003cp>\"If they could just move their game up so that every day was their best day, then it would really significantly change their quality of life,\" Kahana says.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>He and a team of researchers thought they might be able to do this by stimulating memory circuits in the brain. They tried the approach with a group of patients who had severe epilepsy.\u003c/p>\n\u003cp>These people already had electrodes temporarily implanted in their brains as part of their treatment. And that gave the scientists a way to deliver tiny pulses of electricity to areas deep in the brain.\u003c/p>\n\u003cp>Unfortunately, Kahana says, the stimulation made things worse.\u003c/p>\n\u003cp>\"Not only were we not able to enhance memory,\" he says, \"but we actually reliably and consistently \u003cem>impaired\u003c/em> memory in those patients.\"\u003c/p>\n\u003cp>So the team began studying more epilepsy patients to figure out why. This time, though, they used the electrodes to monitor brain activity as the volunteers did memory tasks — and the scientists were able to identify electrical patterns that predicted whether a person was going to remember something or not.\u003c/p>\n\u003cp>Then, the team tried another stimulation experiment, and this one yielded a breakthrough.\u003c/p>\n\u003cp>\"When memory was predicted to be poor,\" he explains, \"brain stimulation enhanced memory, and when it was predicted to be good, brain stimulation impaired memory.\"\u003c/p>\n\u003cp>In other words, on a bad memory day, stimulation helped. On a good day, it hurt.\u003c/p>\n\u003cp>When stimulation was delivered to the right place at the right time, the researchers found, it could improve memory performance among the patients by as much as 50 percent.\u003c/p>\n\u003cp>The research was funded by the Defense Advanced Research Projects Agency or \u003ca href=\"http://www.npr.org/2017/03/28/521779864/inside-darpa-the-pentagon-agency-whose-technology-has-changed-the-world\">DARPA\u003c/a>. Several years ago, DARPA launched an ambitious effort to help the troops who were returning from Iraq and Afghanistan with memory problems caused by \u003ca href=\"https://www.cdc.gov/traumaticbraininjury/\">traumatic brain injuries\u003c/a>.\u003c/p>\n\u003cp>\u003ca href=\"http://www.darpa.mil/staff/dr-justin-sanchez\">Justin Sanchez\u003c/a>, who is in charge of the program, says Kahana's work shows DARPA's investment is paying off.\u003c/p>\n\u003cp>\"When I first heard about these results, my mind was absolutely blown,\" Sanchez says. \"It's like the impossible happened.\"\u003c/p>\n\u003cp>A medical device based on this research could eventually do for an injured brain what a prosthetic limb does for an injured body, he says. There's a long research road ahead — brain stimulation still has way to go, before it can be proved useful as a memory aid. But it's a start.\u003c/p>\n\u003cp>\"Over 270,000 military personnel are living with traumatic brain injuries and the options for them are very few,\" Sanchez says. Now we can offer them some hope for the future.\"\u003c/p>\n\u003cp>And if the approach pans out, it might help people with a wide range of memory problems, Kahana suggests.\u003c/p>\n\u003cp>\"Traumatic brain injury is certainly high on our list,\" he says. \"But we're also thinking very much about Alzheimer's disease and the other dementias that affect memory.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Alzheimer's alone affects more than 5 million Americans.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Electrical+Stimulation+To+Boost+Memory%3A+Maybe+It%27s+All+In+The+Timing&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>People with a brain injury or dementia often struggle to remember simple things, like names or places. In research published recently in the journal \u003cem>Current Biology, \u003c/em>scientists have shown it may be possible to improve this sort of memory using tiny pulses of electricity — if they're properly timed.\u003c/p>\n\u003cp>A typical person's ability to remember things tends to vary a lot, says \u003ca href=\"http://memory.psych.upenn.edu/Michael_J._Kahana\">Michael Kahana,\u003c/a> who directs the computational memory lab at the University of Pennsylvania.\u003c/p>\n\u003cp>\"Some days we're at the top of our game,\" he says, \"and some days we're just off our game.\"\u003c/p>\n\u003cp>That's also true for people whose memory has been impaired — by a brain injury or disease. So Kahana wondered whether there might be some way to help these people perform at their peak level all the time.\u003c/p>\n\u003cp>\"If they could just move their game up so that every day was their best day, then it would really significantly change their quality of life,\" Kahana says.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>He and a team of researchers thought they might be able to do this by stimulating memory circuits in the brain. They tried the approach with a group of patients who had severe epilepsy.\u003c/p>\n\u003cp>These people already had electrodes temporarily implanted in their brains as part of their treatment. And that gave the scientists a way to deliver tiny pulses of electricity to areas deep in the brain.\u003c/p>\n\u003cp>Unfortunately, Kahana says, the stimulation made things worse.\u003c/p>\n\u003cp>\"Not only were we not able to enhance memory,\" he says, \"but we actually reliably and consistently \u003cem>impaired\u003c/em> memory in those patients.\"\u003c/p>\n\u003cp>So the team began studying more epilepsy patients to figure out why. This time, though, they used the electrodes to monitor brain activity as the volunteers did memory tasks — and the scientists were able to identify electrical patterns that predicted whether a person was going to remember something or not.\u003c/p>\n\u003cp>Then, the team tried another stimulation experiment, and this one yielded a breakthrough.\u003c/p>\n\u003cp>\"When memory was predicted to be poor,\" he explains, \"brain stimulation enhanced memory, and when it was predicted to be good, brain stimulation impaired memory.\"\u003c/p>\n\u003cp>In other words, on a bad memory day, stimulation helped. On a good day, it hurt.\u003c/p>\n\u003cp>When stimulation was delivered to the right place at the right time, the researchers found, it could improve memory performance among the patients by as much as 50 percent.\u003c/p>\n\u003cp>The research was funded by the Defense Advanced Research Projects Agency or \u003ca href=\"http://www.npr.org/2017/03/28/521779864/inside-darpa-the-pentagon-agency-whose-technology-has-changed-the-world\">DARPA\u003c/a>. Several years ago, DARPA launched an ambitious effort to help the troops who were returning from Iraq and Afghanistan with memory problems caused by \u003ca href=\"https://www.cdc.gov/traumaticbraininjury/\">traumatic brain injuries\u003c/a>.\u003c/p>\n\u003cp>\u003ca href=\"http://www.darpa.mil/staff/dr-justin-sanchez\">Justin Sanchez\u003c/a>, who is in charge of the program, says Kahana's work shows DARPA's investment is paying off.\u003c/p>\n\u003cp>\"When I first heard about these results, my mind was absolutely blown,\" Sanchez says. \"It's like the impossible happened.\"\u003c/p>\n\u003cp>A medical device based on this research could eventually do for an injured brain what a prosthetic limb does for an injured body, he says. There's a long research road ahead — brain stimulation still has way to go, before it can be proved useful as a memory aid. But it's a start.\u003c/p>\n\u003cp>\"Over 270,000 military personnel are living with traumatic brain injuries and the options for them are very few,\" Sanchez says. Now we can offer them some hope for the future.\"\u003c/p>\n\u003cp>And if the approach pans out, it might help people with a wide range of memory problems, Kahana suggests.\u003c/p>\n\u003cp>\"Traumatic brain injury is certainly high on our list,\" he says. \"But we're also thinking very much about Alzheimer's disease and the other dementias that affect memory.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Alzheimer's alone affects more than 5 million Americans.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2017 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"https://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Electrical+Stimulation+To+Boost+Memory%3A+Maybe+It%27s+All+In+The+Timing&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>\u003cem>Originally published April 10, 2017\u003c/em>\u003c/p>\n\u003cp>A recent trend in anti-aging research sounds straight out of an episode of \"The Twilight Zone\"—or, if you’re younger than 40, the \"Twilight\" series. Scientists are infusing blood from young people into elderly individuals to improve health and delay the afflictions of aging.\u003c/p>\n\u003cp>It may sound creepy, but the potential health benefits of the practice are grounded in more than a decade of research. According to numerous animal studies from Stanford, UC Berkeley and Harvard, young blood can \u003ca href=\"http://science.sciencemag.org/content/344/6184/649\">rejuvenate aging muscles\u003c/a>, \u003ca href=\"http://www.cell.com/cell/abstract/S0092-8674(13)00456-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286741300456X%3Fshowall%3Dtrue\">improve organ function\u003c/a>, help \u003ca href=\"http://www.nature.com/nature/journal/v477/n7362/full/nature10357.html\">generate new brain cells\u003c/a>, and even \u003ca href=\"http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html\">improve cognition\u003c/a>. So far, these benefits have only been seen in mice.\u003c/p>\n\u003caside class=\"pullquote alignright\">'We’re trying to avoid creating expectations of a Eureka moment that we’ll have people who have severe Alzheimer’s disease acting as though they’re adolescents again.' \u003ccite>Joe McCracken, Alkahest\u003c/cite>\u003c/aside>\n\u003cp>Now, two Northern California startups, \u003ca href=\"http://www.alkahest.com/\">Alkahest\u003c/a> and \u003ca href=\"https://www.ambrosiaplasma.com/\">Ambrosia LLC\u003c/a>, are conducting the first studies that attempt to recreate these anti-aging effects in humans. The two companies are running separate clinical trials to infuse plasma from people under the age of 25 into older adults, in an attempt to reverse some of the negative effects of aging and treat age-related diseases.\u003c/p>\n\u003cp>Scientists think certain proteins in the blood either increase or decrease with aging and are behind age-related diseases such as dementia, diabetes and heart disease. Infusions of young blood may replenish helpful proteins that are lost over the years or block the production of damaging ones that typically increase with age.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Although Alkahest and Ambrosia were inspired by the same studies, their goals and approaches to research are very different.\u003c/p>\n\u003cp>\u003cstrong>The Academic\u003c/strong>\u003c/p>\n\u003cp>Stanford professor Tony Wyss-Coray co-founded San Carlos-based Alkahest in 2014, based on his \u003ca href=\"http://www.nature.com/nm/journal/v20/n6/abs/nm.3569.html\">findings\u003c/a> that transfusions of young blood into old mice improve learning and memory and promote the growth of new connections between cells in the hippocampus. That’s a key memory center located in the middle of the brain. Alkahest is now working to translate these benefits to patients with Alzheimer’s disease.\u003c/p>\n\u003cfigure id=\"attachment_368258\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003ca href=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Wyss-Coray-2.jpg\">\u003cimg class=\"size-medium wp-image-368258\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Wyss-Coray-2-800x600.jpg\" alt=\"STANFORD. CA., MAY 2, 2014--Dr. Tony Wyss-Coray, Professor of Neurology at Stanford School of Medicine in lab on Friday, May 2, 2014. ( Norbert von der Groeben/Stanford School of Medicine )\" width=\"800\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-800x600.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-768x576.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-1020x765.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-1180x885.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-960x720.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-240x180.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-375x281.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-520x390.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tony Wyss-Coray's clinical trial tested whether infusions of young blood are safe for patients with Alzheimer's disease; future trials may test whether the treatment would be beneficial. \u003ccite>(Norbert von der Groeben/Stanford School of Medicine)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In 2014, Alkahest sponsored an FDA-approved \u003ca href=\"https://clinicaltrials.gov/ct2/show/NCT02256306\">clinical trial\u003c/a> at Stanford to give Alzheimer’s patients between the ages of 50 and 90 four small, weekly transfusions of plasma. The plasma is obtained from the \u003ca href=\"https://bloodcenter.stanford.edu/research/\">Stanford Blood Center\u003c/a>, which has a dedicated research arm that accepts blood donations specifically for Stanford clinical trials.\u003c/p>\n\u003cp>Joe McCracken, vice president of business development at Alkahest, says that for now, the study is focused on safety and feasibility rather than the efficacy of the treatment.\u003c/p>\n\u003cp>“We’re trying to avoid creating expectations of a Eureka moment that we’ll have people who have severe Alzheimer’s disease acting as though they’re adolescents again,” he says. “The expectation we have is that we will demonstrate that administration of young plasma to elderly patients with Alzheimer’s disease is safe.”\u003c/p>\n\u003cp>The patients are also undergoing memory assessments, brain scans and blood tests to detect any potential changes in disease symptoms. The trial has completed testing on all 18 patients, and McCracken hopes to publish the results by the end of the year. If all goes well, Alkahest plans to conduct a second, larger study to test for efficacy.\u003c/p>\n\u003cp>The company’s long-term goal is to identify the proteins in the blood that change with age, and then synthesize these factors into pharmaceutical drugs.\u003c/p>\n\u003cp>\u003cstrong>The Entrepreneur\u003c/strong>\u003c/p>\n\u003cp>Jesse Karmazin, CEO of Ambrosia, is taking an unconventional—and more controversial—approach to anti-aging research. Ambrosia, which has clinics in Monterey, California and Tampa, Florida, acts as a “pay-to-play” \u003ca href=\"https://clinicaltrials.gov/ct2/show/NCT02803554\">clinical trial\u003c/a>, giving one large plasma transfusion to anyone over the age of 35 for a fee of $8,000. The plasma is purchased from local blood banks, which often have a surplus of the material because hospitals typically only require red blood cells for medical procedures.\u003c/p>\n\u003cp>[contextly_sidebar id=\"Ge8xrkWvdt1iNqxT39StX0C8FxMNPAxq\"]Karmazin, who graduated from Stanford medical school, has gotten some heat for the price his participants are paying. He says his company has no investors, and without the fee the clinic and the study would be impossible. In contrast, Alkahest received a \u003ca href=\"http://www.grifols.com/en/web/international/view-news/-/new/grifols-to-make-a-major-equity-investment-in-alkahest\">$37.5 million investment in 2015 from Grifols\u003c/a>, a Spanish-based company that is the leading producer of blood- and plasma-based products.\u003c/p>\n\u003cp>“You don’t think about it, but you—or your insurance company—ultimately pay for the clinical trial over 20 years after the drug has been approved,” Karmazin says. “Companies patent the drug, they pay up front tens or even hundreds of millions of dollars [for a clinical trial], and then they hope to make a billion dollars over the next 20 years.”\u003c/p>\n\u003cp>Karmazin also justifies the cost of his study by saying that what people choose to do with their money is their decision.\u003c/p>\n\u003cp>“This amount of money for some people is nothing,” he says. “Not for me, I have $200,000 in loans.”\u003c/p>\n\u003cp>Ambrosia is analyzing data from its first 60 participants to look for changes in biomarkers of aging in the blood taken one month after treatment. The company doesn’t have any conclusive results yet.\u003c/p>\n\u003cp>It’s difficult to say whether Ambrosia’s study, as designed, is capable of producing conclusive results. Karmazin is accepting people with a vast range of ages and with different diseases or reasons for wanting the injection. That means the amount of data he gathers on any one condition will likely be limited and may not be useful.\u003c/p>\n\u003cp>\u003cstrong>The Question of Ethics\u003c/strong>\u003c/p>\n\u003cp>Neither company would comment on the work of the other, although Wyss-Coray took some shots in an article in \u003ca href=\"http://www.sciencemag.org/news/2016/08/young-blood-antiaging-trial-raises-questions\">\u003cem>Science\u003c/em>\u003c/a> last year, saying that Karmazin was “basically abusing people’s trust and the public excitement around” the research.\u003c/p>\n\u003cp>Bioethicist Karen Maschke from The Hastings Center, a research institute in New York, says the payment model of the Ambrosia trial “raises a lot of a red flags,” and that the design of the study sounds “very suspect.” She is particularly concerned that participants will think they are paying for a known therapy when in fact they are paying for an experimental and unproven procedure.\u003c/p>\n\u003cp>For his part, Karmazin says that he is \"totally transparent that it is experimental.” Consent documents for the trial do describe the procedure as experimental and do not guarantee any improvements.\u003c/p>\n\u003cp>There have been no serious adverse events from the transfusions reported by either company, and both researchers are optimistic the treatment will provide real benefits to patients.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>Dana Smith is a freelance writer focusing on health and science, with a special interest in the brain. Her work has been featured in The Atlantic, The Guardian, Fast Company, Scientific American, Discover Magazine, and others. In a previous life, she received a Ph.D. in experimental psychology from the University of Cambridge. Find her on Twitter @smithdanag\u003c/em>\u003c/p>\n\n",
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"excerpt": "Remember that study where scientists put blood from young mice into old mice and it reversed aging? Research has begun on humans.",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cem>Originally published April 10, 2017\u003c/em>\u003c/p>\n\u003cp>A recent trend in anti-aging research sounds straight out of an episode of \"The Twilight Zone\"—or, if you’re younger than 40, the \"Twilight\" series. Scientists are infusing blood from young people into elderly individuals to improve health and delay the afflictions of aging.\u003c/p>\n\u003cp>It may sound creepy, but the potential health benefits of the practice are grounded in more than a decade of research. According to numerous animal studies from Stanford, UC Berkeley and Harvard, young blood can \u003ca href=\"http://science.sciencemag.org/content/344/6184/649\">rejuvenate aging muscles\u003c/a>, \u003ca href=\"http://www.cell.com/cell/abstract/S0092-8674(13)00456-X?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS009286741300456X%3Fshowall%3Dtrue\">improve organ function\u003c/a>, help \u003ca href=\"http://www.nature.com/nature/journal/v477/n7362/full/nature10357.html\">generate new brain cells\u003c/a>, and even \u003ca href=\"http://www.nature.com/nm/journal/v20/n6/full/nm.3569.html\">improve cognition\u003c/a>. So far, these benefits have only been seen in mice.\u003c/p>\n\u003caside class=\"pullquote alignright\">'We’re trying to avoid creating expectations of a Eureka moment that we’ll have people who have severe Alzheimer’s disease acting as though they’re adolescents again.' \u003ccite>Joe McCracken, Alkahest\u003c/cite>\u003c/aside>\n\u003cp>Now, two Northern California startups, \u003ca href=\"http://www.alkahest.com/\">Alkahest\u003c/a> and \u003ca href=\"https://www.ambrosiaplasma.com/\">Ambrosia LLC\u003c/a>, are conducting the first studies that attempt to recreate these anti-aging effects in humans. The two companies are running separate clinical trials to infuse plasma from people under the age of 25 into older adults, in an attempt to reverse some of the negative effects of aging and treat age-related diseases.\u003c/p>\n\u003cp>Scientists think certain proteins in the blood either increase or decrease with aging and are behind age-related diseases such as dementia, diabetes and heart disease. Infusions of young blood may replenish helpful proteins that are lost over the years or block the production of damaging ones that typically increase with age.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Although Alkahest and Ambrosia were inspired by the same studies, their goals and approaches to research are very different.\u003c/p>\n\u003cp>\u003cstrong>The Academic\u003c/strong>\u003c/p>\n\u003cp>Stanford professor Tony Wyss-Coray co-founded San Carlos-based Alkahest in 2014, based on his \u003ca href=\"http://www.nature.com/nm/journal/v20/n6/abs/nm.3569.html\">findings\u003c/a> that transfusions of young blood into old mice improve learning and memory and promote the growth of new connections between cells in the hippocampus. That’s a key memory center located in the middle of the brain. Alkahest is now working to translate these benefits to patients with Alzheimer’s disease.\u003c/p>\n\u003cfigure id=\"attachment_368258\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003ca href=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Wyss-Coray-2.jpg\">\u003cimg class=\"size-medium wp-image-368258\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Wyss-Coray-2-800x600.jpg\" alt=\"STANFORD. CA., MAY 2, 2014--Dr. Tony Wyss-Coray, Professor of Neurology at Stanford School of Medicine in lab on Friday, May 2, 2014. ( Norbert von der Groeben/Stanford School of Medicine )\" width=\"800\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-800x600.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-160x120.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-768x576.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-1020x765.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-1180x885.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-960x720.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-240x180.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-375x281.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2-520x390.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Wyss-Coray-2.jpg 1200w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Tony Wyss-Coray's clinical trial tested whether infusions of young blood are safe for patients with Alzheimer's disease; future trials may test whether the treatment would be beneficial. \u003ccite>(Norbert von der Groeben/Stanford School of Medicine)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In 2014, Alkahest sponsored an FDA-approved \u003ca href=\"https://clinicaltrials.gov/ct2/show/NCT02256306\">clinical trial\u003c/a> at Stanford to give Alzheimer’s patients between the ages of 50 and 90 four small, weekly transfusions of plasma. The plasma is obtained from the \u003ca href=\"https://bloodcenter.stanford.edu/research/\">Stanford Blood Center\u003c/a>, which has a dedicated research arm that accepts blood donations specifically for Stanford clinical trials.\u003c/p>\n\u003cp>Joe McCracken, vice president of business development at Alkahest, says that for now, the study is focused on safety and feasibility rather than the efficacy of the treatment.\u003c/p>\n\u003cp>“We’re trying to avoid creating expectations of a Eureka moment that we’ll have people who have severe Alzheimer’s disease acting as though they’re adolescents again,” he says. “The expectation we have is that we will demonstrate that administration of young plasma to elderly patients with Alzheimer’s disease is safe.”\u003c/p>\n\u003cp>The patients are also undergoing memory assessments, brain scans and blood tests to detect any potential changes in disease symptoms. The trial has completed testing on all 18 patients, and McCracken hopes to publish the results by the end of the year. If all goes well, Alkahest plans to conduct a second, larger study to test for efficacy.\u003c/p>\n\u003cp>The company’s long-term goal is to identify the proteins in the blood that change with age, and then synthesize these factors into pharmaceutical drugs.\u003c/p>\n\u003cp>\u003cstrong>The Entrepreneur\u003c/strong>\u003c/p>\n\u003cp>Jesse Karmazin, CEO of Ambrosia, is taking an unconventional—and more controversial—approach to anti-aging research. Ambrosia, which has clinics in Monterey, California and Tampa, Florida, acts as a “pay-to-play” \u003ca href=\"https://clinicaltrials.gov/ct2/show/NCT02803554\">clinical trial\u003c/a>, giving one large plasma transfusion to anyone over the age of 35 for a fee of $8,000. The plasma is purchased from local blood banks, which often have a surplus of the material because hospitals typically only require red blood cells for medical procedures.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>Karmazin, who graduated from Stanford medical school, has gotten some heat for the price his participants are paying. He says his company has no investors, and without the fee the clinic and the study would be impossible. In contrast, Alkahest received a \u003ca href=\"http://www.grifols.com/en/web/international/view-news/-/new/grifols-to-make-a-major-equity-investment-in-alkahest\">$37.5 million investment in 2015 from Grifols\u003c/a>, a Spanish-based company that is the leading producer of blood- and plasma-based products.\u003c/p>\n\u003cp>“You don’t think about it, but you—or your insurance company—ultimately pay for the clinical trial over 20 years after the drug has been approved,” Karmazin says. “Companies patent the drug, they pay up front tens or even hundreds of millions of dollars [for a clinical trial], and then they hope to make a billion dollars over the next 20 years.”\u003c/p>\n\u003cp>Karmazin also justifies the cost of his study by saying that what people choose to do with their money is their decision.\u003c/p>\n\u003cp>“This amount of money for some people is nothing,” he says. “Not for me, I have $200,000 in loans.”\u003c/p>\n\u003cp>Ambrosia is analyzing data from its first 60 participants to look for changes in biomarkers of aging in the blood taken one month after treatment. The company doesn’t have any conclusive results yet.\u003c/p>\n\u003cp>It’s difficult to say whether Ambrosia’s study, as designed, is capable of producing conclusive results. Karmazin is accepting people with a vast range of ages and with different diseases or reasons for wanting the injection. That means the amount of data he gathers on any one condition will likely be limited and may not be useful.\u003c/p>\n\u003cp>\u003cstrong>The Question of Ethics\u003c/strong>\u003c/p>\n\u003cp>Neither company would comment on the work of the other, although Wyss-Coray took some shots in an article in \u003ca href=\"http://www.sciencemag.org/news/2016/08/young-blood-antiaging-trial-raises-questions\">\u003cem>Science\u003c/em>\u003c/a> last year, saying that Karmazin was “basically abusing people’s trust and the public excitement around” the research.\u003c/p>\n\u003cp>Bioethicist Karen Maschke from The Hastings Center, a research institute in New York, says the payment model of the Ambrosia trial “raises a lot of a red flags,” and that the design of the study sounds “very suspect.” She is particularly concerned that participants will think they are paying for a known therapy when in fact they are paying for an experimental and unproven procedure.\u003c/p>\n\u003cp>For his part, Karmazin says that he is \"totally transparent that it is experimental.” Consent documents for the trial do describe the procedure as experimental and do not guarantee any improvements.\u003c/p>\n\u003cp>There have been no serious adverse events from the transfusions reported by either company, and both researchers are optimistic the treatment will provide real benefits to patients.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cem>Dana Smith is a freelance writer focusing on health and science, with a special interest in the brain. Her work has been featured in The Atlantic, The Guardian, Fast Company, Scientific American, Discover Magazine, and others. In a previous life, she received a Ph.D. in experimental psychology from the University of Cambridge. Find her on Twitter @smithdanag\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp class=\"danger-zone\">The genetic testing company 23andMe received \u003ca href=\"https://www.statnews.com/2017/04/06/genetic-test-alzheimers/\">approval\u003c/a> this week from regulators to sell genetic reports on an individual’s risk for 10 diseases, most prominently Alzheimer’s and Parkinson’s. Before you send in your saliva sample and $199, here’s what you should know:\u003c/p>\n\u003ch2 class=\"danger-zone\">What will a genetic test actually tell me?\u003c/h2>\n\u003cp class=\"danger-zone\">At most, that you carry a DNA variant that, according to research, is associated with a higher risk of a disease. For the rare clotting disorder hereditary thrombophilia, for instance, the report will say that you do or do not carry a variant called Factor V Leiden in the F5 gene and a variant called Prothrombin G20210A in the F2 gene.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s important for people to know that even if they have a mutation in the genes [associated with Parkinson’s that 23andMe will test for], by and large they won’t get Parkinson’s disease.'\u003c/aside>\n\u003cp>23and me is still fine-tuning the reports, but its tests will also tell you how the presence (or absence) of variants affects risk. If there’s enough science to quantify that, the report will specify a percentage, like “your risk is 3 percent.” If not, it will just say there’s an (unspecified) increased risk. Of course, you can also look it up. For Alzheimer’s, carrying two copies of the Apoe4 variant (one from each parent), as \u003ca href=\"https://science.education.nih.gov/supplements/nih9/bioethics/guide/pdf/Master_4-2.pdf\">1 to 2 percent\u003c/a> of the population does, raises the risk of the disease to as much as 87 percent, for instance, compared to about \u003ca href=\"https://www.statnews.com/2016/11/21/dementia-rate-decline/\">9 percent\u003c/a> in the general population.\u003c/p>\n\u003ch2 class=\"danger-zone\">What diseases can 23andMe tell me about?\u003c/h2>\n\u003cp class=\"danger-zone\">This month, late-onset Alzheimer’s disease, Parkinson’s disease, the clotting disorder alpha-1 antitrypsin deficiency, and Gaucher disease. Soon — the company hasn’t said exactly when — it will also test for genetic variants linked to factor XI deficiency (excessive bleeding), celiac disease, anemia-causing G6PD deficiency, the movement disorder early-onset primary dystonia, and the blood illness hereditary hemochromatosis.\u003c/p>\n\u003ch2>Will the test tell me if I’m doomed to get one of these terrible disorders?\u003c/h2>\n\u003cp>No. None of the genetic variants that 23andMe tests for is what’s called “fully penetrant,” meaning that 100 percent of those who carry the variant develop the disease. By not “fully,” we mean \u003cem>really\u003c/em> not fully, as in the risk might be measured in the single-digit percentages. “It’s important for people to know that even if they have a mutation in the genes [associated with Parkinson’s that 23andMe will test for], by and large they won’t get Parkinson’s disease,” said James Beck, chief scientific officer of the Parkinson’s Foundation. The N370S variant in the GBA gene, for instance, triples the risk of Parkinson’s, Beck said, but with a baseline risk of 0.3 percent that means about a 1 percent risk.\u003c/p>\n\u003ch2>Do these tests work better for some ethnic groups than others?\u003c/h2>\n\u003cp>Geneticists have studied more people of European descent than other groups, so they have more data on white people. 23andMe knows this, so its reports will include warnings such as that the test results are “most relevant for people of European descent” (for Alzheimer’s), “. . . for people of European, Ashkenazi Jewish, and North African Berber descent” (for Parkinson’s), and “. . . for people of Ashkenazi Jewish descent” (Factor XI Deficiency). With Alzheimer’s, the effect of the ApoE4 variant is weaker in African-Americans, for instance.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>\u003cspan style=\"font-weight: 400\">This \u003ca href=\"https://www.statnews.com/2017/04/07/genetic-analysis-need-to-know/\" target=\"_blank\">story\u003c/a> was originally published by STAT, an online publication of Boston Globe Media that covers health, medicine, and scientific discovery.\u003c/span>\u003c/em>\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp class=\"danger-zone\">The genetic testing company 23andMe received \u003ca href=\"https://www.statnews.com/2017/04/06/genetic-test-alzheimers/\">approval\u003c/a> this week from regulators to sell genetic reports on an individual’s risk for 10 diseases, most prominently Alzheimer’s and Parkinson’s. Before you send in your saliva sample and $199, here’s what you should know:\u003c/p>\n\u003ch2 class=\"danger-zone\">What will a genetic test actually tell me?\u003c/h2>\n\u003cp class=\"danger-zone\">At most, that you carry a DNA variant that, according to research, is associated with a higher risk of a disease. For the rare clotting disorder hereditary thrombophilia, for instance, the report will say that you do or do not carry a variant called Factor V Leiden in the F5 gene and a variant called Prothrombin G20210A in the F2 gene.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s important for people to know that even if they have a mutation in the genes [associated with Parkinson’s that 23andMe will test for], by and large they won’t get Parkinson’s disease.'\u003c/aside>\n\u003cp>23and me is still fine-tuning the reports, but its tests will also tell you how the presence (or absence) of variants affects risk. If there’s enough science to quantify that, the report will specify a percentage, like “your risk is 3 percent.” If not, it will just say there’s an (unspecified) increased risk. Of course, you can also look it up. For Alzheimer’s, carrying two copies of the Apoe4 variant (one from each parent), as \u003ca href=\"https://science.education.nih.gov/supplements/nih9/bioethics/guide/pdf/Master_4-2.pdf\">1 to 2 percent\u003c/a> of the population does, raises the risk of the disease to as much as 87 percent, for instance, compared to about \u003ca href=\"https://www.statnews.com/2016/11/21/dementia-rate-decline/\">9 percent\u003c/a> in the general population.\u003c/p>\n\u003ch2 class=\"danger-zone\">What diseases can 23andMe tell me about?\u003c/h2>\n\u003cp class=\"danger-zone\">This month, late-onset Alzheimer’s disease, Parkinson’s disease, the clotting disorder alpha-1 antitrypsin deficiency, and Gaucher disease. Soon — the company hasn’t said exactly when — it will also test for genetic variants linked to factor XI deficiency (excessive bleeding), celiac disease, anemia-causing G6PD deficiency, the movement disorder early-onset primary dystonia, and the blood illness hereditary hemochromatosis.\u003c/p>\n\u003ch2>Will the test tell me if I’m doomed to get one of these terrible disorders?\u003c/h2>\n\u003cp>No. None of the genetic variants that 23andMe tests for is what’s called “fully penetrant,” meaning that 100 percent of those who carry the variant develop the disease. By not “fully,” we mean \u003cem>really\u003c/em> not fully, as in the risk might be measured in the single-digit percentages. “It’s important for people to know that even if they have a mutation in the genes [associated with Parkinson’s that 23andMe will test for], by and large they won’t get Parkinson’s disease,” said James Beck, chief scientific officer of the Parkinson’s Foundation. The N370S variant in the GBA gene, for instance, triples the risk of Parkinson’s, Beck said, but with a baseline risk of 0.3 percent that means about a 1 percent risk.\u003c/p>\n\u003ch2>Do these tests work better for some ethnic groups than others?\u003c/h2>\n\u003cp>Geneticists have studied more people of European descent than other groups, so they have more data on white people. 23andMe knows this, so its reports will include warnings such as that the test results are “most relevant for people of European descent” (for Alzheimer’s), “. . . for people of European, Ashkenazi Jewish, and North African Berber descent” (for Parkinson’s), and “. . . for people of Ashkenazi Jewish descent” (Factor XI Deficiency). With Alzheimer’s, the effect of the ApoE4 variant is weaker in African-Americans, for instance.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cp>Katherine Stevenson was 8 when she joined a UCSF study to test the effects of a video game on kids like her with \u003ca href=\"https://www.spdstar.org/basic/about-spd\" target=\"_blank\">sensory processing dysfunction\u003c/a>, or SPD, a collection of symptoms where the brain has trouble filtering incoming information -- like sounds and instructions -- in organized, focused ways.\u003c/p>\n\u003cp>Katherine is a happy, outgoing child with a high overall IQ, but her cognitive speed (relating to response and performance) is low in comparison to her critical thinking. Her main challenge is an auditory processing disorder that makes it hard for her to screen out certain sounds, because she hears them all at once.\u003c/p>\n\u003cp>\"It's almost like having a 500 horsepower engine that gets flooded,\" says her mom, Kori Stevenson.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s almost like having a 500 horsepower engine that gets flooded.'\u003ccite>Parent Kori Stevenson on her daughter's sensory processing dysfunction, or SPD\u003c/cite>\u003c/aside>\n\u003cp>The UCSF study, spearheaded in 2014 by two Department of Neurology professors, brought Katherine and 62 other elementary school kids (38 with SPD and 25 with typical development patterns) into a lab where an EEG machine tracked their brain activity while they followed computer prompts designed to measure their ability to focus and multitask.\u003c/p>\n\u003cp>Then the real work began. The kids brought home iPads loaded with a special software designed to target and improve problems with thinking, reacting, and performing tasks. Twice a day, five days a week for a month, the kids spent 30 minutes maneuvering a cartoonish 3-D figure along a moving pathway without hitting the walls -- tilting, swiping and jabbing the iPad as the game made all kinds of sounds and other potential distractions.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"There were times that it was really hard to for her,\" says Stevenson. \"There were some days when she breezed through and other days, she was in tears.\"\u003c/p>\n\u003cp>But when the month was over, and the kids were retested, Katherine's performance had improved.\u003c/p>\n\u003cp>\"Her ability to focus was a little bit better. And she wasn’t as fatigued at the end of the day. Her ability to multitask improved,\" says Stevenson.\u003c/p>\n\u003cp>Katherine's experience was not unique. The UCSF study, \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172616\" target=\"_blank\">published \u003c/a>Wednesday in the journal PLOS ONE, showed that while the iPad home training program benefited all the kids who participated to some extent, the results were even better for seven children (including Katherine), a subset of the 38 SPD children with symptoms of ADHD. This group dramatically overcame these issues, at least temporarily, after just a month of video play. Nine months later, those children had so improved (based on their parents' feedback) that they would no longer meet the clinical standard for symptoms of ADHD.\u003c/p>\n\u003cp>\u003cstrong>An Underserved Group\u003c/strong>\u003c/p>\n\u003cp>Video games designed for kids with ADHD have received the most press. But for this study, UCSF Neurology professors Joaquin Anguera and Elyse Marco wanted to focus on an underserved group that doesn't get as much attention.\u003c/p>\n\u003cp>Some brain training studies specifically target people with ADHD with \u003ca href=\"http://www.cnbc.com/2015/05/21/a-tech-start-up-making-a-play-for-billions-in-adhd-drug-market.html\">gaming products\u003c/a> -- a market ripe for profit, if it can be shown that such products really work. But \u003ca href=\"http://profiles.ucsf.edu/joaquin.anguera\">Anguera\u003c/a> and \u003ca href=\"http://anp.ucsf.edu/aboutus/faculty/emarco\">Marco\u003c/a> wanted to work with children with sensory processing dysfunction, a group Marco got to know through her pediatric clinical practice at UCSF. If you're not familiar with SPD, you're not alone. The disorder is thought to affect 5 percent of all U.S. children, but it's a poorly studied group. Symptoms vary widely, from children like Katherine Stevenson with auditory processing issues to something closer to autism spectrum disorder and ADHD. As such, it is often misdiagnosed.\u003c/p>\n\u003cfigure id=\"attachment_366979\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-366979\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Project-EVO-800x564.jpg\" alt=\"A child plays with Project: EVO, a video game software.\" width=\"800\" height=\"564\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-800x564.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-160x113.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-768x541.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-1020x719.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-960x677.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-240x169.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-375x264.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-520x366.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO.jpg 1084w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">A child plays with Project: EVO, a video game software. \u003ccite>(Akili Interactive Labs)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>The results\u003cem> \u003c/em>of the UCSF study challenge the notion that prolonged exposure to video games, iPads and other interactive technology turns toddlers into strung-out youngsters with an \u003ca href=\"http://www.psychiatrictimes.com/adhd/adhd-associated-video-game-addiction\">ADHD-like inability to focus on tasks\u003c/a> and get things done to completion.\u003c/p>\n\u003cp>A preponderance of studies suggest that all that screen time \u003ca href=\"http://www.npr.org/sections/health-shots/2016/11/19/502610055/heavy-screen-time-rewires-young-brains-for-better-and-worse\">\u003cem>does\u003c/em> re-wire the brain\u003c/a>. But that may not be a bad thing -- especially for kids like Katherine, who can benefit from learning how to focus on a single goal-based task and block out any other distractions.\u003c/p>\n\u003cp>\"The fact that these parents reported persistent amounts of improvement for nine months – I think that’s really remarkable,\" says Anguera, lead author of the study. The results showed some parallels to his\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/24005416\"> much-publicized 2013 \u003c/a>study where a different 3-D video game called Neuroracer trained seniors to multitask better than a group of 20-year-olds.\u003c/p>\n\u003cp>\u003cstrong>Beyond the Hype\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Since the new study only included 63 kids, it was meant as more of a proof of concept experiment than a study meant to offer clinical conclusions.\u003c/p>\n\u003cp>Cognitive scientists bristle at suggestions that any of the newfangled cognitive training programs on the market can work for everyone. \u003ca href=\"http://www.cogmed.com/who-is-cogmed-for\">Cogmed \u003c/a>and \u003ca href=\"https://www.lumosity.com/\">Lumosity\u003c/a>, for example, target both children and adults with claims of improving attention and processing speed. The most common word experts use to describe them is \"exaggerated.\"\u003c/p>\n\u003cp>Dr. Laura Carstensen, founding director of the \u003ca href=\"http://longevity3.stanford.edu/\" target=\"_blank\">Stanford Center on Longevity\u003c/a>, is one of the skeptics. “Can you improve your brain so that it’s faster, more adept, more vital?,\" she told KQED in 2010. \"That’s what the claims are, and I don’t think there’s really any evidence for that.\" In 2014, 73 experts signed an open letter (since taken offline) \u003ca href=\"https://www.theguardian.com/science/2014/oct/23/brain-games-memory-loss-open-letter\">warning about\u003c/a> companies exploiting consumers with such claims.\u003c/p>\n\u003cp>Anguera is the first to agree. \"You have all these problematic 'brain training' things, and it's fraught with snake oil,\" he says. \"There haven’t been very many studies that have shown any kind of difference, that it does work.\" [contextly_sidebar id=\"8fVx8JR3VjF4j4i929dImiQCARfor4l2\"]\u003c/p>\n\u003cp>The main takeaway from this study, according to Anguera, is how well it demonstrates the need for personalized assessment before offering kids the brain-training programs of tomorrow. One size does not fit all; look at the fact that only a small subset of the study participants with SPD -- the cohort of SPD kids with hyperactivity or attention struggles -- showed long-term benefit from the video game training.\u003c/p>\n\u003cp>\"It really gives us a perspective. If you’re going to use these types of technologies to improve people's attention, you need to be putting thought into it. Not everyone needs the same type of intervention, and the same types of intervention won't work for everyone.\"\u003c/p>\n\u003cp>That said, Anguera has confidence that the improvements his team observed were genuine, based on the fact that they were assessed with three different metrics: behavioral testing in the lab, parent surveys, and the use of EEG devices to measure brain waves.\u003c/p>\n\u003cp>Anguera's team was particularly intrigued to watch a part of the pre-frontal lobe \"light up\" during EEG scans. It's the part of the brain that drives goal-directed activities, and researchers saw how much more responsive it became after kids had spent a month playing with the iPad. Scientists suspect that in kids with ADHD-like symptoms, the cognitive circuits at the front of the brain are not firing at the right time or they’re not firing enough, according to Anguera.\u003c/p>\n\u003cp>Researchers don't know exactly how, but it appears that \"pushing\" on, or repeatedly using, these circuits of attention strengthens them, like bicep training at the gym.\u003c/p>\n\u003cp>\"There’s very few of these cognitive training studies – maybe none – that show a signature that correlates with behavior on some test of attention and shows what’s happening,\" says Anguera. \"That's what makes this unique.\"\u003c/p>\n\u003caside class=\"pullquote alignright\">'The fact that these parents reported persistent amounts of improvement for nine months – I think that’s really remarkable.'\u003ccite>Dr. Joaquin Anguera, UCSF\u003c/cite>\u003c/aside>\n\u003cp>The UCSF study used an iPad game called Project: EVO. In 2015, \u003ca href=\"http://www.akiliinteractive.com/\">Akili Interactive Labs\u003c/a>, the software developer, used it to \u003ca href=\"https://well.blogs.nytimes.com/2015/11/23/video-game-is-built-to-be-prescribed-to-children-with-a-d-h-d/?_r=0\">measure the effects on a small group of children\u003c/a> with ADHD and a control group. The study found that, after playing the game five days a week for a month, the children with ADHD showed significant improvement and the control group did not.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Akili Interactive is now \u003ca href=\"http://nationaladhdstudy.com/\">testing their software \u003c/a>on hundreds of ADHD children at 13 study sites across the U.S. and aims to be first FDA-approved ADHD videogame\u003ca href=\"http://www.npr.org/sections/health-shots/2015/08/10/430149726/will-doctors-soon-be-prescribing-video-games-for-mental-health\"> doctors prescribe to parents\u003c/a>.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Katherine Stevenson was 8 when she joined a UCSF study to test the effects of a video game on kids like her with \u003ca href=\"https://www.spdstar.org/basic/about-spd\" target=\"_blank\">sensory processing dysfunction\u003c/a>, or SPD, a collection of symptoms where the brain has trouble filtering incoming information -- like sounds and instructions -- in organized, focused ways.\u003c/p>\n\u003cp>Katherine is a happy, outgoing child with a high overall IQ, but her cognitive speed (relating to response and performance) is low in comparison to her critical thinking. Her main challenge is an auditory processing disorder that makes it hard for her to screen out certain sounds, because she hears them all at once.\u003c/p>\n\u003cp>\"It's almost like having a 500 horsepower engine that gets flooded,\" says her mom, Kori Stevenson.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s almost like having a 500 horsepower engine that gets flooded.'\u003ccite>Parent Kori Stevenson on her daughter's sensory processing dysfunction, or SPD\u003c/cite>\u003c/aside>\n\u003cp>The UCSF study, spearheaded in 2014 by two Department of Neurology professors, brought Katherine and 62 other elementary school kids (38 with SPD and 25 with typical development patterns) into a lab where an EEG machine tracked their brain activity while they followed computer prompts designed to measure their ability to focus and multitask.\u003c/p>\n\u003cp>Then the real work began. The kids brought home iPads loaded with a special software designed to target and improve problems with thinking, reacting, and performing tasks. Twice a day, five days a week for a month, the kids spent 30 minutes maneuvering a cartoonish 3-D figure along a moving pathway without hitting the walls -- tilting, swiping and jabbing the iPad as the game made all kinds of sounds and other potential distractions.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"There were times that it was really hard to for her,\" says Stevenson. \"There were some days when she breezed through and other days, she was in tears.\"\u003c/p>\n\u003cp>But when the month was over, and the kids were retested, Katherine's performance had improved.\u003c/p>\n\u003cp>\"Her ability to focus was a little bit better. And she wasn’t as fatigued at the end of the day. Her ability to multitask improved,\" says Stevenson.\u003c/p>\n\u003cp>Katherine's experience was not unique. The UCSF study, \u003ca href=\"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172616\" target=\"_blank\">published \u003c/a>Wednesday in the journal PLOS ONE, showed that while the iPad home training program benefited all the kids who participated to some extent, the results were even better for seven children (including Katherine), a subset of the 38 SPD children with symptoms of ADHD. This group dramatically overcame these issues, at least temporarily, after just a month of video play. Nine months later, those children had so improved (based on their parents' feedback) that they would no longer meet the clinical standard for symptoms of ADHD.\u003c/p>\n\u003cp>\u003cstrong>An Underserved Group\u003c/strong>\u003c/p>\n\u003cp>Video games designed for kids with ADHD have received the most press. But for this study, UCSF Neurology professors Joaquin Anguera and Elyse Marco wanted to focus on an underserved group that doesn't get as much attention.\u003c/p>\n\u003cp>Some brain training studies specifically target people with ADHD with \u003ca href=\"http://www.cnbc.com/2015/05/21/a-tech-start-up-making-a-play-for-billions-in-adhd-drug-market.html\">gaming products\u003c/a> -- a market ripe for profit, if it can be shown that such products really work. But \u003ca href=\"http://profiles.ucsf.edu/joaquin.anguera\">Anguera\u003c/a> and \u003ca href=\"http://anp.ucsf.edu/aboutus/faculty/emarco\">Marco\u003c/a> wanted to work with children with sensory processing dysfunction, a group Marco got to know through her pediatric clinical practice at UCSF. If you're not familiar with SPD, you're not alone. The disorder is thought to affect 5 percent of all U.S. children, but it's a poorly studied group. Symptoms vary widely, from children like Katherine Stevenson with auditory processing issues to something closer to autism spectrum disorder and ADHD. As such, it is often misdiagnosed.\u003c/p>\n\u003cfigure id=\"attachment_366979\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-366979\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/04/Project-EVO-800x564.jpg\" alt=\"A child plays with Project: EVO, a video game software.\" width=\"800\" height=\"564\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-800x564.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-160x113.jpg 160w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-768x541.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-1020x719.jpg 1020w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-960x677.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-240x169.jpg 240w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-375x264.jpg 375w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO-520x366.jpg 520w, https://ww2.kqed.org/app/uploads/sites/13/2017/04/Project-EVO.jpg 1084w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">A child plays with Project: EVO, a video game software. \u003ccite>(Akili Interactive Labs)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>The results\u003cem> \u003c/em>of the UCSF study challenge the notion that prolonged exposure to video games, iPads and other interactive technology turns toddlers into strung-out youngsters with an \u003ca href=\"http://www.psychiatrictimes.com/adhd/adhd-associated-video-game-addiction\">ADHD-like inability to focus on tasks\u003c/a> and get things done to completion.\u003c/p>\n\u003cp>A preponderance of studies suggest that all that screen time \u003ca href=\"http://www.npr.org/sections/health-shots/2016/11/19/502610055/heavy-screen-time-rewires-young-brains-for-better-and-worse\">\u003cem>does\u003c/em> re-wire the brain\u003c/a>. But that may not be a bad thing -- especially for kids like Katherine, who can benefit from learning how to focus on a single goal-based task and block out any other distractions.\u003c/p>\n\u003cp>\"The fact that these parents reported persistent amounts of improvement for nine months – I think that’s really remarkable,\" says Anguera, lead author of the study. The results showed some parallels to his\u003ca href=\"https://www.ncbi.nlm.nih.gov/pubmed/24005416\"> much-publicized 2013 \u003c/a>study where a different 3-D video game called Neuroracer trained seniors to multitask better than a group of 20-year-olds.\u003c/p>\n\u003cp>\u003cstrong>Beyond the Hype\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Since the new study only included 63 kids, it was meant as more of a proof of concept experiment than a study meant to offer clinical conclusions.\u003c/p>\n\u003cp>Cognitive scientists bristle at suggestions that any of the newfangled cognitive training programs on the market can work for everyone. \u003ca href=\"http://www.cogmed.com/who-is-cogmed-for\">Cogmed \u003c/a>and \u003ca href=\"https://www.lumosity.com/\">Lumosity\u003c/a>, for example, target both children and adults with claims of improving attention and processing speed. The most common word experts use to describe them is \"exaggerated.\"\u003c/p>\n\u003cp>Dr. Laura Carstensen, founding director of the \u003ca href=\"http://longevity3.stanford.edu/\" target=\"_blank\">Stanford Center on Longevity\u003c/a>, is one of the skeptics. “Can you improve your brain so that it’s faster, more adept, more vital?,\" she told KQED in 2010. \"That’s what the claims are, and I don’t think there’s really any evidence for that.\" In 2014, 73 experts signed an open letter (since taken offline) \u003ca href=\"https://www.theguardian.com/science/2014/oct/23/brain-games-memory-loss-open-letter\">warning about\u003c/a> companies exploiting consumers with such claims.\u003c/p>\n\u003cp>Anguera is the first to agree. \"You have all these problematic 'brain training' things, and it's fraught with snake oil,\" he says. \"There haven’t been very many studies that have shown any kind of difference, that it does work.\" \u003c/p>\u003cp>\u003c/p>\u003cp>\u003c/p>\n\u003cp>The main takeaway from this study, according to Anguera, is how well it demonstrates the need for personalized assessment before offering kids the brain-training programs of tomorrow. One size does not fit all; look at the fact that only a small subset of the study participants with SPD -- the cohort of SPD kids with hyperactivity or attention struggles -- showed long-term benefit from the video game training.\u003c/p>\n\u003cp>\"It really gives us a perspective. If you’re going to use these types of technologies to improve people's attention, you need to be putting thought into it. Not everyone needs the same type of intervention, and the same types of intervention won't work for everyone.\"\u003c/p>\n\u003cp>That said, Anguera has confidence that the improvements his team observed were genuine, based on the fact that they were assessed with three different metrics: behavioral testing in the lab, parent surveys, and the use of EEG devices to measure brain waves.\u003c/p>\n\u003cp>Anguera's team was particularly intrigued to watch a part of the pre-frontal lobe \"light up\" during EEG scans. It's the part of the brain that drives goal-directed activities, and researchers saw how much more responsive it became after kids had spent a month playing with the iPad. Scientists suspect that in kids with ADHD-like symptoms, the cognitive circuits at the front of the brain are not firing at the right time or they’re not firing enough, according to Anguera.\u003c/p>\n\u003cp>Researchers don't know exactly how, but it appears that \"pushing\" on, or repeatedly using, these circuits of attention strengthens them, like bicep training at the gym.\u003c/p>\n\u003cp>\"There’s very few of these cognitive training studies – maybe none – that show a signature that correlates with behavior on some test of attention and shows what’s happening,\" says Anguera. \"That's what makes this unique.\"\u003c/p>\n\u003caside class=\"pullquote alignright\">'The fact that these parents reported persistent amounts of improvement for nine months – I think that’s really remarkable.'\u003ccite>Dr. Joaquin Anguera, UCSF\u003c/cite>\u003c/aside>\n\u003cp>The UCSF study used an iPad game called Project: EVO. In 2015, \u003ca href=\"http://www.akiliinteractive.com/\">Akili Interactive Labs\u003c/a>, the software developer, used it to \u003ca href=\"https://well.blogs.nytimes.com/2015/11/23/video-game-is-built-to-be-prescribed-to-children-with-a-d-h-d/?_r=0\">measure the effects on a small group of children\u003c/a> with ADHD and a control group. The study found that, after playing the game five days a week for a month, the children with ADHD showed significant improvement and the control group did not.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Akili Interactive is now \u003ca href=\"http://nationaladhdstudy.com/\">testing their software \u003c/a>on hundreds of ADHD children at 13 study sites across the U.S. and aims to be first FDA-approved ADHD videogame\u003ca href=\"http://www.npr.org/sections/health-shots/2015/08/10/430149726/will-doctors-soon-be-prescribing-video-games-for-mental-health\"> doctors prescribe to parents\u003c/a>.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"title": "These Fighting Fruit Flies Are Superheroes of Brain Science",
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"headTitle": "These Fighting Fruit Flies Are Superheroes of Brain Science | KQED",
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"content": "\u003cp>[dl_subscribe]Neuroscientist Eric Hoopfer likes to watch animals fight. But these aren’t the kind of fights that could get him arrested – no roosters or pit bulls are involved.\u003c/p>\n\u003cp>Hoopfer watches fruit flies. Very close up.\u003c/p>\n\u003cp>The tiny insects are the size of a pinhead, with big red eyes, golden translucent bodies and iridescent wings. For flies, they’re quite handsome. But you probably have only ever seen them flying around an overripe piece of fruit.\u003c/p>\n\u003cp>In the “Fly Behavior” room at the California Institute of Technology, in Pasadena, Hoopfer places pairs of male fruit flies in tiny glass chambers. When they start fighting, they look like martial arts practitioners: They stand face to face and tip each other over; they lunge, roll around and even toss each other, sumo-wrestler style.\u003c/p>\n\u003cfigure id=\"attachment_1502413\" class=\"wp-caption aligncenter\" style=\"max-width: 720px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_TOSS_720.gif\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1502413\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_TOSS_720.gif\" alt=\"These fighting fruit flies are helping researchers at the California Institute of Technology, in Pasadena, understand what nerve cells are activated in the brain during bouts of aggression.\" width=\"720\" height=\"405\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">These fighting fruit flies are helping researchers at the California Institute of Technology, in Pasadena, understand what nerve cells are activated in the brain during bouts of aggression. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>But this isn’t about entertainment. Hoopfer is trying to understand how the brain works.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Scientists have regularly used fruit flies as research subjects since 1910, when Columbia University biologist Thomas Hunt Morgan discovered a mutant white-eyed fly among his normal red-eyed flies and used the discovery to describe how genes get passed on from generation to generation.\u003c/p>\n\u003cfigure id=\"attachment_1502417\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502417\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1020x574.jpg\" alt=\"A mutant white-eyed fruit fly like the one on the left helped biologist Thomas Hunt Morgan in 1910 figure out how genes get passed on from generation to generation. Normally, fruit flies have red eyes.\" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A mutant white-eyed fruit fly like the one on the left helped biologist Thomas Hunt Morgan in 1910 figure out how genes get passed on from generation to generation. Normally, fruit flies have red eyes. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>More recently, fruit flies are helping scientists understand human diseases like cancer, Parkinson’s and Alzheimer’s. They can do this because they’re a simpler version of us. They have about the same number of genes: 20,000 or so. About 75 percent of the genes that make humans sick are found, in a very similar form, in fruit flies. These insects reproduce quickly and are cheap to keep in the lab.\u003c/p>\n\u003cp>Now, they’re helping scientists create a map of the brain that shows what groups of neurons control social behaviors.\u003c/p>\n\u003cp>“The fruit fly is a compact system,” said neuroscientist David Anderson, who oversees the lab in which Hoopfer works. “It’s simpler in that the number of neurons it has is a lot smaller. We take advantage that there are only about 100,000 neurons in a fly’s brain, compared to 100 billion neurons in a human brain.”\u003c/p>\n\u003cp>When the aggressive fruit flies at Caltech fight, Hoopfer and his colleagues monitor which parts of their brains the flies are using. The researchers can see clusters of neurons lighting up. In the future, they hope this can help our understanding of conditions that tap into human emotional states, like depression or addiction.\u003c/p>\n\u003cp>“Flies when they fight, they fight at different intensities. And once they start fighting they continue fighting for a while; this state persists. These are all things that are similar to (human) emotional states,” said Hoopfer. “For example, there’s this scale of emotions where you can be a little bit annoyed and that can scale up to being very angry. If somebody cuts you off in traffic you might get angry and that lasts for a little while. So your emotion lasts longer than the initial stimulus.”\u003c/p>\n\u003cp>Circuits in our brains that make us stay mad, for example, could hold the key to developing better treatments for mental illness.\u003c/p>\n\u003cp>“All these neuropsychiatric disorders, like depression, addiction, schizophrenia, the drugs that we have to treat them, we don’t really understand exactly how they are acting at the level of circuits in the brain,” said Hoopfer. “They help in some cases the symptoms that you want to treat. But they also cause a lot of side effects. So what we’d ideally like are drugs that can act on the specific neurons and circuits in the brain that are responsible for depression and for the symptoms of depression that we want to treat, and not ones that control other things.”\u003c/p>\n\u003cfigure id=\"attachment_1502534\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502534\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1020x574.jpg\" alt=\"At Caltech, neuroscientist Eric Hoopfer puts on special glasses to protect his eyes from the red light he will flash on his research fruit flies. \" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At Caltech, neuroscientist Eric Hoopfer puts on special glasses to protect his eyes from the red light he will flash on his research fruit flies. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cfigure id=\"attachment_1502307\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502307\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1020x574.jpg\" alt=\"Neuroscientist Eric Hoopfer, at Caltech, flashes a red light at a pair of male fruit flies housed in a tiny glass chamber. The light activates a cluster of neurons in the flies’ brains and they start to fight.\" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Neuroscientist Eric Hoopfer, at Caltech, flashes a red light at a pair of male fruit flies housed in a tiny glass chamber. The light activates a cluster of neurons in the flies’ brains and they start to fight. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In the fly room, Hoopfer flashes a pair of male fruit flies with a red light. He has genetically altered them to be sensitive to the light. It activates a cluster of neurons in the flies’ brains and they start to fight almost immediately.\u003c/p>\n\u003cp>But when he changes the intensity of the red light, they do something very different. They lift and vibrate just one wing, a sign that they’re courting the other fly.\u003c/p>\n\u003cp>“When we activate the neurons a lot, they’ll do courtship behavior,” said Hoopfer, “whereas when we activate the neurons weakly, they get aggressive.”\u003c/p>\n\u003cfigure id=\"attachment_1502306\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502306\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1020x574.jpg\" alt=\"To flirt, fruit flies lift and vibrate one wing. Researchers at Caltech discovered that the same group of neurons controls both flirting and fighting. \" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">To flirt, fruit flies lift and vibrate one wing. Researchers at Caltech discovered that the same group of neurons controls both flirting and fighting. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>The researchers were surprised to see that the same neurons controlled such different behaviors. What do fighting and flirting have in common? In both, flies are pretty hot and bothered; these neurons control something like emotional arousal. Hoopfer and his colleagues are interested precisely in circuits like these that control a constellation of social behaviors.\u003c/p>\n\u003cp>There’s evidence that mice brains have neurons that do something similar.\u003c/p>\n\u003cp>“In the mouse, when you activate them a lot, the mouse will fight,” said Hoopfer. “They’ll attack a rubber glove. It’s interesting, the parallel.”\u003c/p>\n\u003cp>So even though a fly – or a mouse, for that matter – isn’t the same as a human, this tiny insect could help pinpoint circuits in the human brain that work in a similar way as the fly’s circuits do.\u003c/p>\n\u003cp>“Maybe there are certain ways that evolution has solved these basic problems of how to control behavior and internal states that are associated with behaviors,” said Hoopfer.\u003c/p>\n\u003cfigure id=\"attachment_1502416\" class=\"wp-caption aligncenter\" style=\"max-width: 720px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_ROLL_720-1.gif\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1502416\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_ROLL_720-1.gif\" alt=\"Fruit flies fight as part of brain research at Caltech.\" width=\"720\" height=\"405\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Fruit flies fight as part of brain research at Caltech. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Researchers hope that a more precise knowledge of the human brain – brought on by an understanding of the fruit fly’s brain – could one day lead to the development of better drugs to treat depression and other mental illnesses. But disorders like depression are complex, cautions Anderson, and nobody should expect new treatments anytime soon.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>And yet, clues are coming from some of the most simple organisms. So the next time you find a fruit fly on your piece of banana, you might want to think twice before swatting it.\u003c/p>\n\n",
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"title": "These Fighting Fruit Flies Are Superheroes of Brain Science | KQED",
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"headline": "These Fighting Fruit Flies Are Superheroes of Brain Science",
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"content": "\u003cdiv class=\"post-body\">\u003cp>Neuroscientist Eric Hoopfer likes to watch animals fight. But these aren’t the kind of fights that could get him arrested – no roosters or pit bulls are involved.\u003c/p>\n\u003cp>Hoopfer watches fruit flies. Very close up.\u003c/p>\n\u003cp>The tiny insects are the size of a pinhead, with big red eyes, golden translucent bodies and iridescent wings. For flies, they’re quite handsome. But you probably have only ever seen them flying around an overripe piece of fruit.\u003c/p>\n\u003cp>In the “Fly Behavior” room at the California Institute of Technology, in Pasadena, Hoopfer places pairs of male fruit flies in tiny glass chambers. When they start fighting, they look like martial arts practitioners: They stand face to face and tip each other over; they lunge, roll around and even toss each other, sumo-wrestler style.\u003c/p>\n\u003cfigure id=\"attachment_1502413\" class=\"wp-caption aligncenter\" style=\"max-width: 720px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_TOSS_720.gif\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1502413\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_TOSS_720.gif\" alt=\"These fighting fruit flies are helping researchers at the California Institute of Technology, in Pasadena, understand what nerve cells are activated in the brain during bouts of aggression.\" width=\"720\" height=\"405\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">These fighting fruit flies are helping researchers at the California Institute of Technology, in Pasadena, understand what nerve cells are activated in the brain during bouts of aggression. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>But this isn’t about entertainment. Hoopfer is trying to understand how the brain works.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Scientists have regularly used fruit flies as research subjects since 1910, when Columbia University biologist Thomas Hunt Morgan discovered a mutant white-eyed fly among his normal red-eyed flies and used the discovery to describe how genes get passed on from generation to generation.\u003c/p>\n\u003cfigure id=\"attachment_1502417\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502417\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1020x574.jpg\" alt=\"A mutant white-eyed fruit fly like the one on the left helped biologist Thomas Hunt Morgan in 1910 figure out how genes get passed on from generation to generation. Normally, fruit flies have red eyes.\" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_MUTANT_AND_NORMAL_FRUIT_FLIES-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">A mutant white-eyed fruit fly like the one on the left helped biologist Thomas Hunt Morgan in 1910 figure out how genes get passed on from generation to generation. Normally, fruit flies have red eyes. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>More recently, fruit flies are helping scientists understand human diseases like cancer, Parkinson’s and Alzheimer’s. They can do this because they’re a simpler version of us. They have about the same number of genes: 20,000 or so. About 75 percent of the genes that make humans sick are found, in a very similar form, in fruit flies. These insects reproduce quickly and are cheap to keep in the lab.\u003c/p>\n\u003cp>Now, they’re helping scientists create a map of the brain that shows what groups of neurons control social behaviors.\u003c/p>\n\u003cp>“The fruit fly is a compact system,” said neuroscientist David Anderson, who oversees the lab in which Hoopfer works. “It’s simpler in that the number of neurons it has is a lot smaller. We take advantage that there are only about 100,000 neurons in a fly’s brain, compared to 100 billion neurons in a human brain.”\u003c/p>\n\u003cp>When the aggressive fruit flies at Caltech fight, Hoopfer and his colleagues monitor which parts of their brains the flies are using. The researchers can see clusters of neurons lighting up. In the future, they hope this can help our understanding of conditions that tap into human emotional states, like depression or addiction.\u003c/p>\n\u003cp>“Flies when they fight, they fight at different intensities. And once they start fighting they continue fighting for a while; this state persists. These are all things that are similar to (human) emotional states,” said Hoopfer. “For example, there’s this scale of emotions where you can be a little bit annoyed and that can scale up to being very angry. If somebody cuts you off in traffic you might get angry and that lasts for a little while. So your emotion lasts longer than the initial stimulus.”\u003c/p>\n\u003cp>Circuits in our brains that make us stay mad, for example, could hold the key to developing better treatments for mental illness.\u003c/p>\n\u003cp>“All these neuropsychiatric disorders, like depression, addiction, schizophrenia, the drugs that we have to treat them, we don’t really understand exactly how they are acting at the level of circuits in the brain,” said Hoopfer. “They help in some cases the symptoms that you want to treat. But they also cause a lot of side effects. So what we’d ideally like are drugs that can act on the specific neurons and circuits in the brain that are responsible for depression and for the symptoms of depression that we want to treat, and not ones that control other things.”\u003c/p>\n\u003cfigure id=\"attachment_1502534\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502534\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1020x574.jpg\" alt=\"At Caltech, neuroscientist Eric Hoopfer puts on special glasses to protect his eyes from the red light he will flash on his research fruit flies. \" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_Eric_Hoopfer-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At Caltech, neuroscientist Eric Hoopfer puts on special glasses to protect his eyes from the red light he will flash on his research fruit flies. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cfigure id=\"attachment_1502307\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502307\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1020x574.jpg\" alt=\"Neuroscientist Eric Hoopfer, at Caltech, flashes a red light at a pair of male fruit flies housed in a tiny glass chamber. The light activates a cluster of neurons in the flies’ brains and they start to fight.\" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLIES_UNDER_RED_LIGHT03-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Neuroscientist Eric Hoopfer, at Caltech, flashes a red light at a pair of male fruit flies housed in a tiny glass chamber. The light activates a cluster of neurons in the flies’ brains and they start to fight. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>In the fly room, Hoopfer flashes a pair of male fruit flies with a red light. He has genetically altered them to be sensitive to the light. It activates a cluster of neurons in the flies’ brains and they start to fight almost immediately.\u003c/p>\n\u003cp>But when he changes the intensity of the red light, they do something very different. They lift and vibrate just one wing, a sign that they’re courting the other fly.\u003c/p>\n\u003cp>“When we activate the neurons a lot, they’ll do courtship behavior,” said Hoopfer, “whereas when we activate the neurons weakly, they get aggressive.”\u003c/p>\n\u003cfigure id=\"attachment_1502306\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-1502306\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1020x574.jpg\" alt=\"To flirt, fruit flies lift and vibrate one wing. Researchers at Caltech discovered that the same group of neurons controls both flirting and fighting. \" width=\"640\" height=\"360\" srcset=\"https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1020x574.jpg 1020w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-160x90.jpg 160w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-800x450.jpg 800w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-768x432.jpg 768w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS.jpg 1920w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-1180x664.jpg 1180w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-960x540.jpg 960w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-240x135.jpg 240w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-375x211.jpg 375w, https://cdn.kqed.org/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_FRUIT_FLY_FLIRTS-520x293.jpg 520w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">To flirt, fruit flies lift and vibrate one wing. Researchers at Caltech discovered that the same group of neurons controls both flirting and fighting. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>The researchers were surprised to see that the same neurons controlled such different behaviors. What do fighting and flirting have in common? In both, flies are pretty hot and bothered; these neurons control something like emotional arousal. Hoopfer and his colleagues are interested precisely in circuits like these that control a constellation of social behaviors.\u003c/p>\n\u003cp>There’s evidence that mice brains have neurons that do something similar.\u003c/p>\n\u003cp>“In the mouse, when you activate them a lot, the mouse will fight,” said Hoopfer. “They’ll attack a rubber glove. It’s interesting, the parallel.”\u003c/p>\n\u003cp>So even though a fly – or a mouse, for that matter – isn’t the same as a human, this tiny insect could help pinpoint circuits in the human brain that work in a similar way as the fly’s circuits do.\u003c/p>\n\u003cp>“Maybe there are certain ways that evolution has solved these basic problems of how to control behavior and internal states that are associated with behaviors,” said Hoopfer.\u003c/p>\n\u003cfigure id=\"attachment_1502416\" class=\"wp-caption aligncenter\" style=\"max-width: 720px\">\u003ca href=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_ROLL_720-1.gif\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1502416\" src=\"https://ww2.kqed.org/science/wp-content/uploads/sites/35/2017/03/DL_407FruitFlies_ROLL_720-1.gif\" alt=\"Fruit flies fight as part of brain research at Caltech.\" width=\"720\" height=\"405\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Fruit flies fight as part of brain research at Caltech. \u003ccite>(Josh Cassidy/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Researchers hope that a more precise knowledge of the human brain – brought on by an understanding of the fruit fly’s brain – could one day lead to the development of better drugs to treat depression and other mental illnesses. But disorders like depression are complex, cautions Anderson, and nobody should expect new treatments anytime soon.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>And yet, clues are coming from some of the most simple organisms. So the next time you find a fruit fly on your piece of banana, you might want to think twice before swatting it.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Strong Progress for Paralyzed Patients After Stem Cell Therapy, Company Says",
"title": "Strong Progress for Paralyzed Patients After Stem Cell Therapy, Company Says",
"headTitle": "KQED Future of You | KQED Science",
"content": "\u003cp>A small stem cell trial in which patients with severe spinal injuries appeared to make remarkable progress is still showing excellent results, according to the company conducting the research.\u003c/p>\n\u003caside class=\"pullquote alignright\">'This is as good as you could hope at this point.' \u003ccite>Charles Liu, director of the USC Neurorestoration Center\u003c/cite>\u003c/aside>\n\u003cp>\u003cspan style=\"font-weight: 400\">One of the patients in the trial is 21-year-old Kris Boesen, from Bakersfield, California, whose \u003ca href=\"https://ww2.kqed.org/futureofyou/2016/09/12/stem-cells-may-have-restored-use-of-hands-and-arms-in-paralyzed-man/\" target=\"_blank\" rel=\"noopener\">story \u003c/a>we reported on last year. A car crash had left the Bakersfield, California native with \u003c/span>\u003cspan style=\"font-weight: 400\">three crushed vertebrae, almost no feeling below his neck, and a grim\u003c/span>\u003cspan style=\"font-weight: 400\"> prognosis. Doctors believed he would live the rest of his life as a paraplegic.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">Enter stem cell therapy. Most treatments for serious spinal injuries concentrate on physical therapy to expand the range of the patient's remaining motor skills and to limit further injury, not to reverse the actual damage. But last April, as part of an experimental phase 2 clinical trial called \u003c/span>\u003ca href=\"http://www.scistar-study.com/\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">SCiStar\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">, researchers injected Boesen with 10 million stem cells. By July, he had recovered use of his hands to the point where he could use a wheelchair, a computer and a cellphone, and could take care of most of his daily living needs.\u003c/span> In recent months his progress has continued, says his father.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s certainly interesting, but it’s still early.'\u003ccite>Paul Knoepfler, UC Davis stem cell researcher\u003c/cite>\u003c/aside>\n\u003cp>Boesen is not the only patient to have improved in the trial, according to Asterias Biotherapeutics, which is conducting the research. Boesen is part of a cohort of six patients who were experiencing various levels of paralysis and were injected with the 10 million stem cell dose. In a Jan. 24 \u003ca href=\"http://asteriasbiotherapeutics.com/presentations/Asterias-Biotherapeutics_Investor_Presentation_January-2017.pdf\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">update\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">, the company said\u003c/span>\u003cspan style=\"font-weight: 400\"> five of those patients had improved either one or two levels on a widely used scale to measure \u003c/span>motor function in spinal injury patients.\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">On Tuesday, Asterias issued a new \u003c/span>\u003ca href=\"https://finance.yahoo.com/news/full-six-patient-cohort-confirms-110000936.html\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">update\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">,\u003c/span> \u003cspan style=\"font-weight: 400\">announcing\u003c/span> \u003cspan style=\"font-weight: 400\"> that the sixth patient in the cohort has experienced a similar improvement. \u003c/span>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp class=\"p1\">While spontaneous recovery for spinal injury patients does occur, the likelihood of all six patients recovering to the degree they have is less likely, researchers say.\u003c/p>\n\u003cp class=\"p1\">“This is as good as you could hope at this point,” said Charles Liu, Boesen’s neurosurgeon and director of the USC Neurorestoration Center. “So far all the evidence is pointing in the right direction.”\u003c/p>\n\u003cp class=\"p1\">To measure improvement in spinal injury patients, researchers use two yardsticks: the Upper Extremity Motor Scale, or UEMS, and the International Standards for Neurological Classification of Spinal Cord Injury, or ISNCSCI. On the UEMS scale, patients are scored from 0 to 5 on their ability to use \u003ca href=\"http://www.nature.com/sc/journal/v45/n3/fig_tab/3102008t1.html\" target=\"_blank\" rel=\"noopener\">five key muscles\u003c/a> in the wrists, elbows and fingers. The \u003ca href=\"http://www.hopkinsmedicine.org/healthlibrary/conditions/physical_medicine_and_rehabilitation/spinal_cord_injury_85,P01180/\" target=\"_blank\" rel=\"noopener\">ISNCSCI scale\u003c/a> assesses where damage has occurred along the different levels of the cervical vertebrae, which generally determines the scope of impairment to the body and the\u003ca href=\"http://www.spinalinjury101.org/details/levels-of-injury\" target=\"_blank\" rel=\"noopener\"> level of care needed\u003c/a>.\u003c/p>\n\u003cp>For instance, if a patient has sustained damage at the fourth cervical vertebra down, known as C-4, at the base of the neck, it generally means that person is paralyzed from the neck down, requiring round-the-clock care and a ventilator to breathe. A patient with a C-5 injury may not be able to move her arms or hands, requiring about 6 to 12 hours per day of assisted care; and at the C-6 level, better motor function may allow a patient to take care of most of her daily living needs on her own.\u003c/p>\n\u003cfigure id=\"attachment_243385\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003cimg class=\"wp-image-243385 size-medium\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/09/Neurosurgery-Stem-Cell-spine-patient-Kris-Boesen_04-800x526.jpg\" alt=\"Lifting weights is part of Kris Boesen’s regular program of physical therapy. \" width=\"800\" height=\"526\">\u003cfigcaption class=\"wp-caption-text\">Lifting weights is part of Kris Boesen’s regular program of physical therapy. \u003ccite>(Greg Iger/Keck Medicine of USC))\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Which is all to say that even one level of recovery could substantially improve the daily life of a spinal injury patient.\u003c/p>\n\u003cp class=\"p1\">According to Asterias, all six patients in the 10 million-cell cohort have improved their general UEMS scores, and jumped at least one motor level on the ISNCSCI scale on one or both sides of their body.\u003c/p>\n\u003cp class=\"p1\">Two patients have improved two motor levels on one side; and one patient, Boesen, has improved two motor levels on both sides\u003cb>. \u003c/b>\u003c/p>\n\u003cp>Steve Cartt, president and CEO of Asterias, said another patient, Jake Javier of Danville, California, has gone from partial paralysis to being able to use his hands well enough to consider pursuing a computer science career.\u003c/p>\n\u003cp>\u003cstrong>'Throws Like a Regular Throw'\u003c/strong>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">In September, Boesen’s father, Rod Boesen, told us how excited he was that his son had regained some feeling in one of his feet. Last week, at 11 months post-injection, the elder Boesen said Kris has continued to improve.\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">“Now he can move his toe and his knee together at the same time,” Boesen said. “They’re about to give him a manual wheelchair now [instead of a motorized one]. He can grip with his hands enough to use a manual one.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">Boesen said the movement in his son’s arms and hands has greatly improved since September. \u003c/span>\u003cspan style=\"font-weight: 400\">Kris, a former high school pitcher, had been flinging a ball to his dog “like people throw hand grenades,” Boesen said. “They kind of cradle them – and that’s how Kris would do it. … But now he throws like a regular throw, tosses that ball down the hall, has that release point down, and just wings it.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">Asterias is currently recruiting patients for a trial in which they'll receive 20 million stem cells, the optimal dose, according to company researchers. T\u003c/span>\u003cspan style=\"font-weight: 400\">wo patients have already started the 20 million stem cell therapy, and six-month results from those patients will be released in the fall, Cartt said.\u003c/span>\u003c/p>\n\u003cp>Patients who received 2 million stem cells in an earlier phase of the study have not shown much change in their condition, according to the Jan. 24 update.\u003c/p>\n\u003cp>\u003cstrong>Guarded Optimism\u003c/strong>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">While Boesen’s father is impressed with the results, the optimism of researchers inside and outside the study has been guarded. \u003c/span>The trial is still in its early stages, and the sample size is small, said Paul Knoepfler, a cell biology professor and stem cell researcher at UC Davis, who is not involved in the SCiStar study.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">\"As a scientist, I still would want to wait for more data,” Knoepfler said. “It’s certainly interesting, but it’s still early. It’s a phase 2 trial.”\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">To address the issue of small sample size, Asterias is looking at historical data to determine the level of improvement for patients in similar circumstances who did not receive stem cell therapy. The company has said it found \"a meaningful difference\" in the recovery of its study patients compared to the norm. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">Liu said one of the most important results is the lack of significant side effects or other negative outcomes resulting from the treatment to date.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">\"That’s very significant to me,” Liu said. “That’s the first thing you look for, is anyone hurt from this therapy.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">There was also a concern, he said, that some patients might regress over time, once the initial injection of stem cells wore off. That has yet to occur.\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">“No one has lost anything they’ve gained,” Liu said. “We were very happy to see that. This is all very promising.\"\u003c/span>\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">The next step for the SCiStar trial will be to establish a control group, Cartt said.\u003c/span>\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>A small stem cell trial in which patients with severe spinal injuries appeared to make remarkable progress is still showing excellent results, according to the company conducting the research.\u003c/p>\n\u003caside class=\"pullquote alignright\">'This is as good as you could hope at this point.' \u003ccite>Charles Liu, director of the USC Neurorestoration Center\u003c/cite>\u003c/aside>\n\u003cp>\u003cspan style=\"font-weight: 400\">One of the patients in the trial is 21-year-old Kris Boesen, from Bakersfield, California, whose \u003ca href=\"https://ww2.kqed.org/futureofyou/2016/09/12/stem-cells-may-have-restored-use-of-hands-and-arms-in-paralyzed-man/\" target=\"_blank\" rel=\"noopener\">story \u003c/a>we reported on last year. A car crash had left the Bakersfield, California native with \u003c/span>\u003cspan style=\"font-weight: 400\">three crushed vertebrae, almost no feeling below his neck, and a grim\u003c/span>\u003cspan style=\"font-weight: 400\"> prognosis. Doctors believed he would live the rest of his life as a paraplegic.\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">Enter stem cell therapy. Most treatments for serious spinal injuries concentrate on physical therapy to expand the range of the patient's remaining motor skills and to limit further injury, not to reverse the actual damage. But last April, as part of an experimental phase 2 clinical trial called \u003c/span>\u003ca href=\"http://www.scistar-study.com/\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">SCiStar\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">, researchers injected Boesen with 10 million stem cells. By July, he had recovered use of his hands to the point where he could use a wheelchair, a computer and a cellphone, and could take care of most of his daily living needs.\u003c/span> In recent months his progress has continued, says his father.\u003c/p>\n\u003caside class=\"pullquote alignright\">'It’s certainly interesting, but it’s still early.'\u003ccite>Paul Knoepfler, UC Davis stem cell researcher\u003c/cite>\u003c/aside>\n\u003cp>Boesen is not the only patient to have improved in the trial, according to Asterias Biotherapeutics, which is conducting the research. Boesen is part of a cohort of six patients who were experiencing various levels of paralysis and were injected with the 10 million stem cell dose. In a Jan. 24 \u003ca href=\"http://asteriasbiotherapeutics.com/presentations/Asterias-Biotherapeutics_Investor_Presentation_January-2017.pdf\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">update\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">, the company said\u003c/span>\u003cspan style=\"font-weight: 400\"> five of those patients had improved either one or two levels on a widely used scale to measure \u003c/span>motor function in spinal injury patients.\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">On Tuesday, Asterias issued a new \u003c/span>\u003ca href=\"https://finance.yahoo.com/news/full-six-patient-cohort-confirms-110000936.html\" target=\"_blank\" rel=\"noopener\">\u003cspan style=\"font-weight: 400\">update\u003c/span>\u003c/a>\u003cspan style=\"font-weight: 400\">,\u003c/span> \u003cspan style=\"font-weight: 400\">announcing\u003c/span> \u003cspan style=\"font-weight: 400\"> that the sixth patient in the cohort has experienced a similar improvement. \u003c/span>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp class=\"p1\">While spontaneous recovery for spinal injury patients does occur, the likelihood of all six patients recovering to the degree they have is less likely, researchers say.\u003c/p>\n\u003cp class=\"p1\">“This is as good as you could hope at this point,” said Charles Liu, Boesen’s neurosurgeon and director of the USC Neurorestoration Center. “So far all the evidence is pointing in the right direction.”\u003c/p>\n\u003cp class=\"p1\">To measure improvement in spinal injury patients, researchers use two yardsticks: the Upper Extremity Motor Scale, or UEMS, and the International Standards for Neurological Classification of Spinal Cord Injury, or ISNCSCI. On the UEMS scale, patients are scored from 0 to 5 on their ability to use \u003ca href=\"http://www.nature.com/sc/journal/v45/n3/fig_tab/3102008t1.html\" target=\"_blank\" rel=\"noopener\">five key muscles\u003c/a> in the wrists, elbows and fingers. The \u003ca href=\"http://www.hopkinsmedicine.org/healthlibrary/conditions/physical_medicine_and_rehabilitation/spinal_cord_injury_85,P01180/\" target=\"_blank\" rel=\"noopener\">ISNCSCI scale\u003c/a> assesses where damage has occurred along the different levels of the cervical vertebrae, which generally determines the scope of impairment to the body and the\u003ca href=\"http://www.spinalinjury101.org/details/levels-of-injury\" target=\"_blank\" rel=\"noopener\"> level of care needed\u003c/a>.\u003c/p>\n\u003cp>For instance, if a patient has sustained damage at the fourth cervical vertebra down, known as C-4, at the base of the neck, it generally means that person is paralyzed from the neck down, requiring round-the-clock care and a ventilator to breathe. A patient with a C-5 injury may not be able to move her arms or hands, requiring about 6 to 12 hours per day of assisted care; and at the C-6 level, better motor function may allow a patient to take care of most of her daily living needs on her own.\u003c/p>\n\u003cfigure id=\"attachment_243385\" class=\"wp-caption alignright\" style=\"max-width: 800px\">\u003cimg class=\"wp-image-243385 size-medium\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/09/Neurosurgery-Stem-Cell-spine-patient-Kris-Boesen_04-800x526.jpg\" alt=\"Lifting weights is part of Kris Boesen’s regular program of physical therapy. \" width=\"800\" height=\"526\">\u003cfigcaption class=\"wp-caption-text\">Lifting weights is part of Kris Boesen’s regular program of physical therapy. \u003ccite>(Greg Iger/Keck Medicine of USC))\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Which is all to say that even one level of recovery could substantially improve the daily life of a spinal injury patient.\u003c/p>\n\u003cp class=\"p1\">According to Asterias, all six patients in the 10 million-cell cohort have improved their general UEMS scores, and jumped at least one motor level on the ISNCSCI scale on one or both sides of their body.\u003c/p>\n\u003cp class=\"p1\">Two patients have improved two motor levels on one side; and one patient, Boesen, has improved two motor levels on both sides\u003cb>. \u003c/b>\u003c/p>\n\u003cp>Steve Cartt, president and CEO of Asterias, said another patient, Jake Javier of Danville, California, has gone from partial paralysis to being able to use his hands well enough to consider pursuing a computer science career.\u003c/p>\n\u003cp>\u003cstrong>'Throws Like a Regular Throw'\u003c/strong>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">In September, Boesen’s father, Rod Boesen, told us how excited he was that his son had regained some feeling in one of his feet. Last week, at 11 months post-injection, the elder Boesen said Kris has continued to improve.\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">“Now he can move his toe and his knee together at the same time,” Boesen said. “They’re about to give him a manual wheelchair now [instead of a motorized one]. He can grip with his hands enough to use a manual one.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">Boesen said the movement in his son’s arms and hands has greatly improved since September. \u003c/span>\u003cspan style=\"font-weight: 400\">Kris, a former high school pitcher, had been flinging a ball to his dog “like people throw hand grenades,” Boesen said. “They kind of cradle them – and that’s how Kris would do it. … But now he throws like a regular throw, tosses that ball down the hall, has that release point down, and just wings it.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">Asterias is currently recruiting patients for a trial in which they'll receive 20 million stem cells, the optimal dose, according to company researchers. T\u003c/span>\u003cspan style=\"font-weight: 400\">wo patients have already started the 20 million stem cell therapy, and six-month results from those patients will be released in the fall, Cartt said.\u003c/span>\u003c/p>\n\u003cp>Patients who received 2 million stem cells in an earlier phase of the study have not shown much change in their condition, according to the Jan. 24 update.\u003c/p>\n\u003cp>\u003cstrong>Guarded Optimism\u003c/strong>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">While Boesen’s father is impressed with the results, the optimism of researchers inside and outside the study has been guarded. \u003c/span>The trial is still in its early stages, and the sample size is small, said Paul Knoepfler, a cell biology professor and stem cell researcher at UC Davis, who is not involved in the SCiStar study.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">\"As a scientist, I still would want to wait for more data,” Knoepfler said. “It’s certainly interesting, but it’s still early. It’s a phase 2 trial.”\u003c/span>\u003c/p>\n\u003cp class=\"p1\">\u003cspan style=\"font-weight: 400\">To address the issue of small sample size, Asterias is looking at historical data to determine the level of improvement for patients in similar circumstances who did not receive stem cell therapy. The company has said it found \"a meaningful difference\" in the recovery of its study patients compared to the norm. \u003c/span>\u003c/p>\n\u003cp class=\"p1\">Liu said one of the most important results is the lack of significant side effects or other negative outcomes resulting from the treatment to date.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">\"That’s very significant to me,” Liu said. “That’s the first thing you look for, is anyone hurt from this therapy.”\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">There was also a concern, he said, that some patients might regress over time, once the initial injection of stem cells wore off. That has yet to occur.\u003c/span>\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">“No one has lost anything they’ve gained,” Liu said. “We were very happy to see that. This is all very promising.\"\u003c/span>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cp>Okay, we thought big data folks had really turned it \u003ca href=\"https://en.wikipedia.org/wiki/Up_to_eleven\" target=\"_blank\">up to 11\u003c/a> with the Institute for Health Metrics and Evaluation's comprehensive \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/01/31/find-life-expectancy-map/\" target=\"_blank\">U.S. Health Map\u003c/a>, which categorizes each and every U.S. death by each and every U.S. county. The map can tell you which areas of the country have the lowest life expectancy (parts of Appalachia and the South don't look good); which suffer the highest rates of binge drinking (Wisconsin, Montana, North Dakota) and suicide (the Kusilvak Census Area in Alaska; South Dakota Native American reservations); and lots of other information that will satisfy even the most voracious consumer of death and morbidity data.\u003c/p>\n\u003cp>But when it comes to urban areas, the Centers for Disease Control and Prevention may have gone the IHME's tool one better \u003cspan style=\"font-weight: 400\">— \u003c/span>turned it up to 12, if you will \u003cspan style=\"font-weight: 400\">— \u003c/span>with its recently introduced health data map, part of its \u003ca href=\"https://chronicdata.cdc.gov/health-area/500-cities\" target=\"_blank\">500 Cities\u003c/a> project.\u003c/p>\n\u003cp>\"The project identifies, analyzes, and reports on 27 chronic disease measures focusing on conditions, behaviors, and risk factors that have a substantial effect on people’s health,\" according to the CDC, which launched the map in partnership with the CDC Foundation and the Robert Woods Johnson Foundation.\u003c/p>\n\u003cdiv class=\"show-for-small-only\">\n\u003cp>\u003cem>Click on the image to be taken to the map.\u003c/em>\u003c/p>\n\u003cp>\u003ca href=\"https://www.cdc.gov/500cities/\">\u003cimg class=\"aligncenter size-full wp-image-346557\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/03/cdcmap-1.jpg\" alt=\"cdcmap\" width=\"713\" height=\"507\">\u003c/a>\u003c/p>\n\u003c/div>\n\u003cdiv align=\"center\">\n\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe width=\"850\" height=\"1000\" src=\"https://nccd.cdc.gov/500_Cities/rdPage.aspx?rdReport=DPH_500_Cities.InteractiveMap&islCategories=HLTHOUT&islMeasures=ARTHRITIS&islStates=59\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\n\u003c/div>\n\u003cp> \u003c/p>\n\u003cp>But wait, there's more\u003cb> \u003c/b> \u003cspan style=\"font-weight: 400\">— \u003c/span> the map doesn't just drill down to the city level; it homes in on each census tract, which is, \u003cspan style=\"font-weight: 400\">basically, \u003c/span>your neighborhood.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>We clicked ourselves down to the city level for San Francisco, where KQED is based, then all the way into different patches of blocks, checking out health outcomes like asthma, diabetes and cancer. The prevention data displays rates for dental visits, annual checkups and lack of health insurance, among other measures, and the stats for \"unhealthy behaviors\" include the numbers on smoking, obesity and lack of sleep. (View the \u003ca href=\"https://www.cdc.gov/500cities/measure-definitions.htm\" target=\"_blank\">definitions of each measure here\u003c/a>.)\u003c/p>\n\u003cp>Some of these are self-reported, we're relieved to find out. (Still, what's next -- unhealthy behaviors broken out by each room in your apartment?)\u003c/p>\n\u003cp>The data, from as recently as 2014, comes from the Behavioral Risk Factor Surveillance System (which is collected through telephone surveys, despite its high-tech and ominous-sounding name), U.S. Census Bureau \u003ca href=\"https://www.census.gov/topics/population/data.html\" target=\"_blank\">population data\u003c/a>, and the bureau's \u003ca href=\"https://www.census.gov/programs-surveys/acs/\" target=\"_blank\">American Community Survey\u003c/a>.\u003c/p>\n\u003cp>Keep in mind these numbers represent estimates, derived from \"small area estimation techniques.\" These statistical methods use data from big surveys pertaining to larger geographical areas, then apply that data to smaller areas, said James Holt, the CDC's team leader for analytic methods in the Division of Population Health.\u003c/p>\n\u003cp>All well and good. But we did notice one thing: The residents in San Francisco's Golden Gate Park do a relatively heavy amount of binge drinking, according to the map. What, do the the squirrels have an alcohol problem?\u003c/p>\n\u003cp>\"The area that contains Golden Gate Park is census tract 060759803,\" wrote a CDC spokesperson, in response to a question that didn't mention squirrels. \"According to the 2010 US Census, this census tract had a 2010 resident population of 171. We did suppress estimates for census tracts that had fewer than 50 residents, to avoid the issue of interpretation, but Golden Gate Park is in a tract that exceeds that threshold.\"\u003c/p>\n\u003cp>Okay, then.\u003c/p>\n\u003cp>The CDC anticipates this trove of data will be used by local health officials, to help them \"target health interventions to areas within their cities at highest need,\" Holt said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Enjoy, data nerds, enjoy.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Okay, we thought big data folks had really turned it \u003ca href=\"https://en.wikipedia.org/wiki/Up_to_eleven\" target=\"_blank\">up to 11\u003c/a> with the Institute for Health Metrics and Evaluation's comprehensive \u003ca href=\"https://ww2.kqed.org/futureofyou/2017/01/31/find-life-expectancy-map/\" target=\"_blank\">U.S. Health Map\u003c/a>, which categorizes each and every U.S. death by each and every U.S. county. The map can tell you which areas of the country have the lowest life expectancy (parts of Appalachia and the South don't look good); which suffer the highest rates of binge drinking (Wisconsin, Montana, North Dakota) and suicide (the Kusilvak Census Area in Alaska; South Dakota Native American reservations); and lots of other information that will satisfy even the most voracious consumer of death and morbidity data.\u003c/p>\n\u003cp>But when it comes to urban areas, the Centers for Disease Control and Prevention may have gone the IHME's tool one better \u003cspan style=\"font-weight: 400\">— \u003c/span>turned it up to 12, if you will \u003cspan style=\"font-weight: 400\">— \u003c/span>with its recently introduced health data map, part of its \u003ca href=\"https://chronicdata.cdc.gov/health-area/500-cities\" target=\"_blank\">500 Cities\u003c/a> project.\u003c/p>\n\u003cp>\"The project identifies, analyzes, and reports on 27 chronic disease measures focusing on conditions, behaviors, and risk factors that have a substantial effect on people’s health,\" according to the CDC, which launched the map in partnership with the CDC Foundation and the Robert Woods Johnson Foundation.\u003c/p>\n\u003cdiv class=\"show-for-small-only\">\n\u003cp>\u003cem>Click on the image to be taken to the map.\u003c/em>\u003c/p>\n\u003cp>\u003ca href=\"https://www.cdc.gov/500cities/\">\u003cimg class=\"aligncenter size-full wp-image-346557\" src=\"https://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/03/cdcmap-1.jpg\" alt=\"cdcmap\" width=\"713\" height=\"507\">\u003c/a>\u003c/p>\n\u003c/div>\n\u003cdiv align=\"center\">\n\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe width=\"850\" height=\"1000\" src=\"https://nccd.cdc.gov/500_Cities/rdPage.aspx?rdReport=DPH_500_Cities.InteractiveMap&islCategories=HLTHOUT&islMeasures=ARTHRITIS&islStates=59\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\n\u003c/div>\n\u003cp> \u003c/p>\n\u003cp>But wait, there's more\u003cb> \u003c/b> \u003cspan style=\"font-weight: 400\">— \u003c/span> the map doesn't just drill down to the city level; it homes in on each census tract, which is, \u003cspan style=\"font-weight: 400\">basically, \u003c/span>your neighborhood.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>We clicked ourselves down to the city level for San Francisco, where KQED is based, then all the way into different patches of blocks, checking out health outcomes like asthma, diabetes and cancer. The prevention data displays rates for dental visits, annual checkups and lack of health insurance, among other measures, and the stats for \"unhealthy behaviors\" include the numbers on smoking, obesity and lack of sleep. (View the \u003ca href=\"https://www.cdc.gov/500cities/measure-definitions.htm\" target=\"_blank\">definitions of each measure here\u003c/a>.)\u003c/p>\n\u003cp>Some of these are self-reported, we're relieved to find out. (Still, what's next -- unhealthy behaviors broken out by each room in your apartment?)\u003c/p>\n\u003cp>The data, from as recently as 2014, comes from the Behavioral Risk Factor Surveillance System (which is collected through telephone surveys, despite its high-tech and ominous-sounding name), U.S. Census Bureau \u003ca href=\"https://www.census.gov/topics/population/data.html\" target=\"_blank\">population data\u003c/a>, and the bureau's \u003ca href=\"https://www.census.gov/programs-surveys/acs/\" target=\"_blank\">American Community Survey\u003c/a>.\u003c/p>\n\u003cp>Keep in mind these numbers represent estimates, derived from \"small area estimation techniques.\" These statistical methods use data from big surveys pertaining to larger geographical areas, then apply that data to smaller areas, said James Holt, the CDC's team leader for analytic methods in the Division of Population Health.\u003c/p>\n\u003cp>All well and good. But we did notice one thing: The residents in San Francisco's Golden Gate Park do a relatively heavy amount of binge drinking, according to the map. What, do the the squirrels have an alcohol problem?\u003c/p>\n\u003cp>\"The area that contains Golden Gate Park is census tract 060759803,\" wrote a CDC spokesperson, in response to a question that didn't mention squirrels. \"According to the 2010 US Census, this census tract had a 2010 resident population of 171. We did suppress estimates for census tracts that had fewer than 50 residents, to avoid the issue of interpretation, but Golden Gate Park is in a tract that exceeds that threshold.\"\u003c/p>\n\u003cp>Okay, then.\u003c/p>\n\u003cp>The CDC anticipates this trove of data will be used by local health officials, to help them \"target health interventions to areas within their cities at highest need,\" Holt said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Enjoy, data nerds, enjoy.\u003c/p>\n\n\u003c/div>\u003c/p>",
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}
},
"city-arts": {
"id": "city-arts",
"title": "City Arts & Lectures",
"info": "A one-hour radio program to hear celebrated writers, artists and thinkers address contemporary ideas and values, often discussing the creative process. Please note: tapes or transcripts are not available",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/05/cityartsandlecture-300x300.jpg",
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"airtime": "SUN 1pm-2pm, TUE 10pm, WED 1am",
"meta": {
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"source": "City Arts & Lectures"
},
"link": "https://www.cityarts.net",
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"rss": "https://www.cityarts.net/feed/"
}
},
"closealltabs": {
"id": "closealltabs",
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"officialWebsiteLink": "/podcasts/closealltabs",
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"order": 1
},
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"id": "code-switch-life-kit",
"title": "Code Switch / Life Kit",
"info": "\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />",
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"meta": {
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"id": "commonwealth-club",
"title": "Commonwealth Club of California Podcast",
"info": "The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.",
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"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg",
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"meta": {
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"source": "Commonwealth Club of California"
},
"link": "/radio/program/commonwealth-club",
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"google": "https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw",
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"id": "forum",
"title": "Forum",
"tagline": "The conversation starts here",
"info": "KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.",
"airtime": "MON-FRI 9am-11am, 10pm-11pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED Forum with Mina Kim and Alexis Madrigal",
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"source": "kqed",
"order": 9
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz",
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"officialWebsiteLink": "http://freakonomics.com/",
"airtime": "SUN 1am-2am, SAT 3pm-4pm",
"meta": {
"site": "radio",
"source": "WNYC"
},
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"subscribe": {
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"apple": "https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519",
"tuneIn": "https://tunein.com/podcasts/WNYC-Podcasts/Freakonomics-Radio-p272293/",
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},
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"id": "fresh-air",
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"apple": "https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=214089682&at=11l79Y&ct=nprdirectory",
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"info": "A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.",
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},
"hidden-brain": {
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"info": "Shankar Vedantam uses science and storytelling to reveal the unconscious patterns that drive human behavior, shape our choices and direct our relationships.",
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"airtime": "SUN 7pm-8pm",
"meta": {
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"source": "NPR"
},
"link": "/radio/program/hidden-brain",
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},
"how-i-built-this": {
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"title": "How I Built This with Guy Raz",
"info": "Guy Raz dives into the stories behind some of the world's best known companies. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists—and the movements they built.",
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"airtime": "SUN 7:30pm-8pm",
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},
"link": "/radio/program/how-i-built-this",
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"npr": "https://rpb3r.app.goo.gl/3zxy",
"apple": "https://itunes.apple.com/us/podcast/how-i-built-this-with-guy-raz/id1150510297?mt=2",
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"hyphenacion": {
"id": "hyphenacion",
"title": "Hyphenación",
"tagline": "Where conversation and cultura meet",
"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2025/03/Hyphenacion_FinalAssets_PodcastTile.png",
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"officialWebsiteLink": "/podcasts/hyphenacion",
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"order": 15
},
"link": "/podcasts/hyphenacion",
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"spotify": "https://open.spotify.com/show/2p3Fifq96nw9BPcmFdIq0o?si=39209f7b25774f38",
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},
"jerrybrown": {
"id": "jerrybrown",
"title": "The Political Mind of Jerry Brown",
"tagline": "Lessons from a lifetime in politics",
"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game – and Brown has some lessons he'd like to share. ",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-Political-Mind-of-Jerry-Brown-Podcast-Tile-703x703-1.jpg",
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"officialWebsiteLink": "/podcasts/jerrybrown",
"meta": {
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"order": 18
},
"link": "/podcasts/jerrybrown",
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}
},
"latino-usa": {
"id": "latino-usa",
"title": "Latino USA",
"airtime": "MON 1am-2am, SUN 6pm-7pm",
"info": "Latino USA, the radio journal of news and culture, is the only national, English-language radio program produced from a Latino perspective.",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/latinoUsa.jpg",
"officialWebsiteLink": "http://latinousa.org/",
"meta": {
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},
"link": "/radio/program/latino-usa",
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"apple": "https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=79681317&at=11l79Y&ct=nprdirectory",
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"rss": "https://feeds.npr.org/510016/podcast.xml"
}
},
"marketplace": {
"id": "marketplace",
"title": "Marketplace",
"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
"airtime": "MON-FRI 4pm-4:30pm, MON-WED 6:30pm-7pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Marketplace-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.marketplace.org/",
"meta": {
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"source": "American Public Media"
},
"link": "/radio/program/marketplace",
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},
"masters-of-scale": {
"id": "masters-of-scale",
"title": "Masters of Scale",
"info": "Masters of Scale is an original podcast in which LinkedIn co-founder and Greylock Partner Reid Hoffman sets out to describe and prove theories that explain how great entrepreneurs take their companies from zero to a gazillion in ingenious fashion.",
"airtime": "Every other Wednesday June 12 through October 16 at 8pm (repeats Thursdays at 2am)",
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"officialWebsiteLink": "https://mastersofscale.com/",
"meta": {
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"source": "WaitWhat"
},
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"rss": "https://rss.art19.com/masters-of-scale"
}
},
"mindshift": {
"id": "mindshift",
"title": "MindShift",
"tagline": "A podcast about the future of learning and how we raise our kids",
"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED MindShift: How We Will Learn",
"officialWebsiteLink": "/mindshift/",
"meta": {
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"source": "kqed",
"order": 12
},
"link": "/podcasts/mindshift",
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5",
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}
},
"morning-edition": {
"id": "morning-edition",
"title": "Morning Edition",
"info": "\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.",
"airtime": "MON-FRI 3am-9am",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.npr.org/programs/morning-edition/",
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"link": "/radio/program/morning-edition"
},
"onourwatch": {
"id": "onourwatch",
"title": "On Our Watch",
"tagline": "Deeply-reported investigative journalism",
"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg",
"imageAlt": "On Our Watch from NPR and KQED",
"officialWebsiteLink": "/podcasts/onourwatch",
"meta": {
"site": "news",
"source": "kqed",
"order": 11
},
"link": "/podcasts/onourwatch",
"subscribe": {
"apple": "https://podcasts.apple.com/podcast/id1567098962",
"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw",
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}
},
"on-the-media": {
"id": "on-the-media",
"title": "On The Media",
"info": "Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us",
"airtime": "SUN 2pm-3pm, MON 12am-1am",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png",
"officialWebsiteLink": "https://www.wnycstudios.org/shows/otm",
"meta": {
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"source": "wnyc"
},
"link": "/radio/program/on-the-media",
"subscribe": {
"apple": "https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2",
"tuneIn": "https://tunein.com/radio/On-the-Media-p69/",
"rss": "http://feeds.wnyc.org/onthemedia"
}
},
"pbs-newshour": {
"id": "pbs-newshour",
"title": "PBS NewsHour",
"info": "Analysis, background reports and updates from the PBS NewsHour putting today's news in context.",
"airtime": "MON-FRI 3pm-4pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.pbs.org/newshour/",
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"source": "pbs"
},
"link": "/radio/program/pbs-newshour",
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"apple": "https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2",
"tuneIn": "https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/",
"rss": "https://www.pbs.org/newshour/feeds/rss/podcasts/show"
}
},
"perspectives": {
"id": "perspectives",
"title": "Perspectives",
"tagline": "KQED's series of daily listener commentaries since 1991",
"info": "KQED's series of daily listener commentaries since 1991.",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2025/01/Perspectives_Tile_Final.jpg",
"imageAlt": "KQED Perspectives",
"officialWebsiteLink": "/perspectives/",
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"source": "kqed",
"order": 14
},
"link": "/perspectives",
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