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"content": "\u003cp>\"The X-Files\" revival has gotten some \u003ca href=\"http://www.nytimes.com/2016/01/27/arts/television/x-files-ratings-stay-strong.html\" target=\"_blank\">big ratings\u003c/a>. Clearly a lot of fans (if \u003ca href=\"http://variety.com/2016/tv/features/the-x-files-season-finale-review-my-struggle-ii-1201712181/\" target=\"_blank\">not\u003c/a> \u003ca href=\"http://www.vox.com/2016/2/24/11104426/the-x-files-finale-recap-bad\" target=\"_blank\">critics\u003c/a>) are over the moon at its return, as this Twitter search on \"\u003ca href=\"https://twitter.com/search?q=x-files%20best%20show%20ever&src=typd\" target=\"_blank\">X-Files Best Show Ever\u003c/a>\" will attest.\u003c/p>\n\u003cp>As much as we'd love to jump on the bandwagon and cover the infiltration of alien DNA in our genome, the funding isn't quite there, yet. Luckily, the inclusion of CRISPR/Cas9 as a major plot point in the season finale Monday does give us a convenient excuse to get in on the action.\u003c/p>\n\u003cp>CRISPR/Cas9, as we have been \u003ca href=\"http://ww2.kqed.org/futureofyou/tag/crispr/\" target=\"_blank\">writing about\u003c/a>, is a cutting-edge gene-editing technique that has been heralded as a \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough technology\u003c/a>, inspiring \u003ca href=\"http://ww2.kqed.org/futureofyou/2016/02/22/gene-editing-coming-to-a-kitchen-counter-near-you/\" target=\"_blank\">high expectations for\u003c/a> -- as well as \u003ca href=\"https://www.theguardian.com/science/2016/feb/12/rogue-scientists-could-exploit-gene-editing-technology-experts-warn\" target=\"_blank\">warnings about\u003c/a> -- potential uses.\u003c/p>\n\u003cfigure id=\"attachment_118123\" class=\"wp-caption alignright\" style=\"max-width: 338px\">\u003cimg class=\"wp-image-118123 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/02/duchovny-e1456426674504-338x600.jpg\" alt=\"X-Files science advisor Anne Simon and David Duchovny in Vancouver, August 2015.\" width=\"338\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-338x600.jpg 338w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-400x711.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-768x1365.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-664x1180.jpg 664w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-960x1707.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504.jpg 1080w\" sizes=\"(max-width: 338px) 100vw, 338px\">\u003cfigcaption class=\"wp-caption-text\">X-Files science advisor Anne Simon and David Duchovny in Vancouver, August 2015. \u003ccite>(Courtesy Anne Simon)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Anne Simon, a University of Maryland virologist who also happens to be a science advisor on \"The X-Files,\" has taken note. She co-wrote the finale's story, along with microbiologist Margaret Fearon and show creator Chris Carter. The plot involves humans who are stripped of their immune systems. This is accomplished via CRISPR/Cas9.\u003c/p>\n\u003cp>\"He asked me to come up with something that would kill off everybody,\" she said of Carter Wednesday. \"That took a lot of thought. It had to be something simple enough to get across to the public. I began thinking if you just got rid of the \u003ca href=\"http://ghr.nlm.nih.gov/gene/ADA\" target=\"_blank\">ADA gene\u003c/a> -- I teach this -- you would not have an immune system. That’s the \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">Boy in the Bubble syndrome\u003c/a>. The idea is that a long time ago [the aliens and human conspirators] must have put something in our genome that would get rid of the gene.\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>(In the show, the mechanism for introducing alien DNA into the human genome is the smallpox vaccine, which \"doubtless made \u003ca href=\"http://www.pbs.org/wgbh/frontline/article/jenny-mccarthy-were-not-an-anti-vaccine-movement-were-pro-safe-vaccine/\" target=\"_blank\">Jenny McCarthy\u003c/a> the happiest 'X-Files' viewer of the night,\" \u003ca href=\"https://www.yahoo.com/tv/x-files-finale-review-ep-6-my-struggle-141222649.html\" target=\"_blank\">wrote\u003c/a> a Yahoo! TV critic.)\u003c/p>\n\u003cp>Simon said she and co-writer Fearon had to do a lot of explaining to Carter as to how CRISPR works.\u003c/p>\n\u003cp>http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\u003c/p>\n\u003cp>\"Between the two of us we’re trying to explain it to him on the phone and showing him YouTube videos and stuff, and he \u003cem>kind\u003c/em> of gets it.\"\u003c/p>\n\u003cp>She said she looked at the script every day to check on the science. \"It really is accurate. I was happy at the end.\"\u003c/p>\n\u003cp>Accurate within the bounds of sci-fi/conspiracy theory, of course. Simon said she suggested the story have the mass gene deletion triggered by the increase in CO2 -- global warming. But Carter opted to make the triggering mechanism ... \u003ca href=\"http://thevane.gawker.com/why-i-write-about-and-debunk-the-chemtrail-conspiracy-1581896346\" target=\"_blank\">chemtrails\u003c/a>.\u003c/p>\n\u003cp>\"Chris wanted to use chemtrails, which is \u003ca href=\"http://thevane.gawker.com/why-i-write-about-and-debunk-the-chemtrail-conspiracy-1581896346\" target=\"_blank\">big in conspiracy theories\u003c/a>. I don’t even know what it is,\" Simon said.\u003c/p>\n\u003cp>She first connected with Carter, back in the day, through a family connection. \"He needed to talk to a biologist. I thought, 'We'll get the microscopes right.\"\u003c/p>\n\u003cp>At one point, Carter named a character after Simon, but her fictional self was short-lived. \"I had visions of her being Scully and Mulder’s partner, and helping them solve cases scientifically. And then I get killed off. \"\u003c/p>\n\u003cp>She thinks the character of Dana Scully has been great for encouraging female scientists.\u003c/p>\n\u003cp>\"She has been a wonderful draw for young people. I hear from so many people over Twitter who say they went into science because of 'The X-Files.'\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Whether the show comes back for more episodes is still an open question. But the signs are \u003ca href=\"http://www.ew.com/article/2016/01/29/x-files-ratings\" target=\"_blank\">encouraging\u003c/a>. FOX, no doubt, is suggesting we all stay tuned.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>\"The X-Files\" revival has gotten some \u003ca href=\"http://www.nytimes.com/2016/01/27/arts/television/x-files-ratings-stay-strong.html\" target=\"_blank\">big ratings\u003c/a>. Clearly a lot of fans (if \u003ca href=\"http://variety.com/2016/tv/features/the-x-files-season-finale-review-my-struggle-ii-1201712181/\" target=\"_blank\">not\u003c/a> \u003ca href=\"http://www.vox.com/2016/2/24/11104426/the-x-files-finale-recap-bad\" target=\"_blank\">critics\u003c/a>) are over the moon at its return, as this Twitter search on \"\u003ca href=\"https://twitter.com/search?q=x-files%20best%20show%20ever&src=typd\" target=\"_blank\">X-Files Best Show Ever\u003c/a>\" will attest.\u003c/p>\n\u003cp>As much as we'd love to jump on the bandwagon and cover the infiltration of alien DNA in our genome, the funding isn't quite there, yet. Luckily, the inclusion of CRISPR/Cas9 as a major plot point in the season finale Monday does give us a convenient excuse to get in on the action.\u003c/p>\n\u003cp>CRISPR/Cas9, as we have been \u003ca href=\"http://ww2.kqed.org/futureofyou/tag/crispr/\" target=\"_blank\">writing about\u003c/a>, is a cutting-edge gene-editing technique that has been heralded as a \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough technology\u003c/a>, inspiring \u003ca href=\"http://ww2.kqed.org/futureofyou/2016/02/22/gene-editing-coming-to-a-kitchen-counter-near-you/\" target=\"_blank\">high expectations for\u003c/a> -- as well as \u003ca href=\"https://www.theguardian.com/science/2016/feb/12/rogue-scientists-could-exploit-gene-editing-technology-experts-warn\" target=\"_blank\">warnings about\u003c/a> -- potential uses.\u003c/p>\n\u003cfigure id=\"attachment_118123\" class=\"wp-caption alignright\" style=\"max-width: 338px\">\u003cimg class=\"wp-image-118123 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2017/02/duchovny-e1456426674504-338x600.jpg\" alt=\"X-Files science advisor Anne Simon and David Duchovny in Vancouver, August 2015.\" width=\"338\" height=\"600\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-338x600.jpg 338w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-400x711.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-768x1365.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-664x1180.jpg 664w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504-960x1707.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2017/02/duchovny-e1456426674504.jpg 1080w\" sizes=\"(max-width: 338px) 100vw, 338px\">\u003cfigcaption class=\"wp-caption-text\">X-Files science advisor Anne Simon and David Duchovny in Vancouver, August 2015. \u003ccite>(Courtesy Anne Simon)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Anne Simon, a University of Maryland virologist who also happens to be a science advisor on \"The X-Files,\" has taken note. She co-wrote the finale's story, along with microbiologist Margaret Fearon and show creator Chris Carter. The plot involves humans who are stripped of their immune systems. This is accomplished via CRISPR/Cas9.\u003c/p>\n\u003cp>\"He asked me to come up with something that would kill off everybody,\" she said of Carter Wednesday. \"That took a lot of thought. It had to be something simple enough to get across to the public. I began thinking if you just got rid of the \u003ca href=\"http://ghr.nlm.nih.gov/gene/ADA\" target=\"_blank\">ADA gene\u003c/a> -- I teach this -- you would not have an immune system. That’s the \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">Boy in the Bubble syndrome\u003c/a>. The idea is that a long time ago [the aliens and human conspirators] must have put something in our genome that would get rid of the gene.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>(In the show, the mechanism for introducing alien DNA into the human genome is the smallpox vaccine, which \"doubtless made \u003ca href=\"http://www.pbs.org/wgbh/frontline/article/jenny-mccarthy-were-not-an-anti-vaccine-movement-were-pro-safe-vaccine/\" target=\"_blank\">Jenny McCarthy\u003c/a> the happiest 'X-Files' viewer of the night,\" \u003ca href=\"https://www.yahoo.com/tv/x-files-finale-review-ep-6-my-struggle-141222649.html\" target=\"_blank\">wrote\u003c/a> a Yahoo! TV critic.)\u003c/p>\n\u003cp>Simon said she and co-writer Fearon had to do a lot of explaining to Carter as to how CRISPR works.\u003c/p>\u003c/p>\u003c/div>",
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"content": "\u003cp>Yes, says one founder of a digital health company, on the birthday of the man who could eventually replace someone on Mount Rushmore if this \u003ca href=\"https://www.google.com/search?q=steve+jobs+hero+worship\" target=\"_blank\">hero worship\u003c/a> keeps up. (With a little creative chiseling and some black paint for the mock turtle, we're looking at you, \u003ca href=\"https://adventuresofacouchsurfer.files.wordpress.com/2011/08/img_8363-jefferson.jpg\" target=\"_blank\">Thomas Jefferson\u003c/a>.)\u003c/p>\n\u003cp>Dr. Damon Ramsey, in today's STAT, takes a potshot or two at the contemporary health care industry. He writes:\u003c/p>\n\u003cblockquote>\u003cp>\"With its labyrinths of regulation deeply entrenched and antiquated information systems, and monopolies built upon thrones of indifference to the consumer experience, the health care industry has chained itself to archaic and inefficient processes while resisting its own rescue.\"\u003c/p>\u003c/blockquote>\n\u003cp>Only Jobsian disruption can fix this beast, Ramsey concludes.\u003c/p>\n\u003cp>Of course, not all disruptors are created equal, one might keep in mind. In 2014, Theranos founder Elizabeth Holmes enjoyed the imprimatur of a\u003ca href=\"http://www.newyorker.com/magazine/2014/12/15/blood-simpler\" target=\"_blank\"> flattering profile\u003c/a> in The New Yorker. A year later, one tech \u003ca href=\"http://www.theverge.com/2015/12/29/10642070/2015-theranos-venture-capital-tech-bubble-disruption\" target=\"_blank\">headline\u003c/a> dubbed the company's secret blood-testing technology \"pseudoscience.\"\u003c/p>\n\u003cp>You can read Ramsey's commentary at STAT, below.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>http://www.statnews.com/2016/02/24/steve-jobs-health-care/\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Yes, says one founder of a digital health company, on the birthday of the man who could eventually replace someone on Mount Rushmore if this \u003ca href=\"https://www.google.com/search?q=steve+jobs+hero+worship\" target=\"_blank\">hero worship\u003c/a> keeps up. (With a little creative chiseling and some black paint for the mock turtle, we're looking at you, \u003ca href=\"https://adventuresofacouchsurfer.files.wordpress.com/2011/08/img_8363-jefferson.jpg\" target=\"_blank\">Thomas Jefferson\u003c/a>.)\u003c/p>\n\u003cp>Dr. Damon Ramsey, in today's STAT, takes a potshot or two at the contemporary health care industry. He writes:\u003c/p>\n\u003cblockquote>\u003cp>\"With its labyrinths of regulation deeply entrenched and antiquated information systems, and monopolies built upon thrones of indifference to the consumer experience, the health care industry has chained itself to archaic and inefficient processes while resisting its own rescue.\"\u003c/p>\u003c/blockquote>\n\u003cp>Only Jobsian disruption can fix this beast, Ramsey concludes.\u003c/p>\n\u003cp>Of course, not all disruptors are created equal, one might keep in mind. In 2014, Theranos founder Elizabeth Holmes enjoyed the imprimatur of a\u003ca href=\"http://www.newyorker.com/magazine/2014/12/15/blood-simpler\" target=\"_blank\"> flattering profile\u003c/a> in The New Yorker. A year later, one tech \u003ca href=\"http://www.theverge.com/2015/12/29/10642070/2015-theranos-venture-capital-tech-bubble-disruption\" target=\"_blank\">headline\u003c/a> dubbed the company's secret blood-testing technology \"pseudoscience.\"\u003c/p>\n\u003cp>You can read Ramsey's commentary at STAT, below.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cp>Whither wearables? Well...\u003c/p>\n\u003cp>Fitbit shares have \u003ca href=\"http://finance.yahoo.com/echarts?s=FIT+Interactive#%7B%22range%22:%226mo%22,%22allowChartStacking%22:true%7D\" target=\"_blank\">taken a spanking \u003c/a> and keep on tanking. Investors must have done some major panting today, weathering a \u003ca href=\"http://finance.yahoo.com/q?s=FIT\" target=\"_blank\">double-digit dip\u003c/a> due to diminished \u003ca href=\"http://blogs.barrons.com/techtraderdaily/2016/02/22/fitbit-cfo-blames-first-quarter-weakness-on-timing-the-confidence-is-very-high/?mod=yahoobarrons&ru=yahoo\" target=\"_blank\">first-quarter guidance\u003c/a>. And more bad press today from the \u003cstrong>\u003ca href=\"http://www.sfgate.com/business/article/Wearables-do-more-than-monitor-fitness-6844920.php\" target=\"_blank\">San Francisco Chronicle\u003c/a>\u003c/strong>: The paper reports the Fitbit Charge and other wearables have some 'splainin' to do when it comes to privacy, as the products can \"be used to surveil\" the wearer's movements. And what's worse for some of the major brands, \"Only the Apple Watch properly protected users against tracking,\" the Chron said.\u003c/p>\n\u003cp>Read here ...\u003c/p>\n\u003cp>http://www.sfgate.com/business/article/Wearables-do-more-than-monitor-fitness-6844920.php\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Whither wearables? Well...\u003c/p>\n\u003cp>Fitbit shares have \u003ca href=\"http://finance.yahoo.com/echarts?s=FIT+Interactive#%7B%22range%22:%226mo%22,%22allowChartStacking%22:true%7D\" target=\"_blank\">taken a spanking \u003c/a> and keep on tanking. Investors must have done some major panting today, weathering a \u003ca href=\"http://finance.yahoo.com/q?s=FIT\" target=\"_blank\">double-digit dip\u003c/a> due to diminished \u003ca href=\"http://blogs.barrons.com/techtraderdaily/2016/02/22/fitbit-cfo-blames-first-quarter-weakness-on-timing-the-confidence-is-very-high/?mod=yahoobarrons&ru=yahoo\" target=\"_blank\">first-quarter guidance\u003c/a>. And more bad press today from the \u003cstrong>\u003ca href=\"http://www.sfgate.com/business/article/Wearables-do-more-than-monitor-fitness-6844920.php\" target=\"_blank\">San Francisco Chronicle\u003c/a>\u003c/strong>: The paper reports the Fitbit Charge and other wearables have some 'splainin' to do when it comes to privacy, as the products can \"be used to surveil\" the wearer's movements. And what's worse for some of the major brands, \"Only the Apple Watch properly protected users against tracking,\" the Chron said.\u003c/p>\n\u003cp>Read here ...\u003c/p>\n\u003cp>http://www.sfgate.com/business/article/Wearables-do-more-than-monitor-fitness-6844920.php\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"disqusTitle": "Gene Editing: Coming to a Kitchen Counter Near You",
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"content": "\u003cp>When you hear \"gene editing,\" do you think cancer cures? Designer babies? What about new fuel sources or drought-tolerant crops? Gene editing with a technique known as CRISPR/Cas9, hailed as a scientific \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough\u003c/a>, could mean all those things.\u003c/p>\n\u003cp>There's a possibility, of course, that CRISPR/Cas9 may not live up to expectations. That's happened before. Twenty-five years ago, recombinant DNA was supposed to transform society in a way that, well, didn't happen. But any past biotech disappointments are not stopping a slew of Bay Area CRISPR startups from taking the leap into the new world of DNA tinkering and synthetic biology. They are, in fact, everywhere, from biotech labs in Emeryville to kitchen counters in Burlingame.\u003c/p>\n\u003cp>\"It's something that people read about, it's something people see that's cutting edge,\" says Josiah Zayner, a former synthetic biologist at NASA. \"Yet it's so accessible, it's something that you can do in your home, on your kitchen table.\"\u003c/p>\n\u003cp>Zayner has considered himself a \"biohacker\" for a long time. Now it's his full-time job.\u003c/p>\n\u003cfigure id=\"attachment_114669\" class=\"wp-caption alignleft\" style=\"max-width: 360px\">\u003cimg class=\"size-full wp-image-114669\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/crispr-featureimage-e1455913319463.jpg\" alt='Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists.' width=\"360\" height=\"540\">\u003cfigcaption class=\"wp-caption-text\">Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>He's started a company called The Open Discovery Institute, or The ODIN (not coincidentally, the name of the Norse god connected with healing, knowledge and ... death). The point, he says, is to make science more accessible by providing low-cost supplies for people to practice gene editing at home. The first shipments from his \u003ca href=\"https://www.indiegogo.com/projects/diy-crispr-kits-learn-modern-science-by-doing#/\" target=\"_blank\">Indiegogo crowdfunding campaign\u003c/a> are expected this spring.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"You can learn about cutting-edge science by actually doing it,\" Zayner says. \"When I started experimenting with CRISPR I thought, 'That's pretty crazy!' I would definitely want that opportunity.\"\u003c/p>\n\u003cp>In Zayner's kitchen I get a crash course in how this new kind of gene editing works. Zayner's kits have three major parts: the Cas9 protein (other forms can use other proteins), the \"guide\" RNA and the donor DNA. The Cas9 protein makes precise cuts in the sections of the DNA to which it's led by the guide RNA. Sensing the cut, the cell's own repair mechanisms will try to repair it, by inserting a new piece of DNA. If all goes well, it will add a section of the donated DNA containing the desired gene or genes.\u003c/p>\n\u003cp>\"So you kind of trick the cell into using your new piece of DNA instead of some other piece of DNA it finds, or the original piece of DNA,\" says Zayner.\u003c/p>\n\u003cfigure id=\"attachment_115245\" class=\"wp-caption alignnone\" style=\"max-width: 1280px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\">\u003cimg class=\"wp-image-115245 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\" alt=\"CRISPR is Here\" width=\"1280\" height=\"850\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here.jpg 1280w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-800x531.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-768x510.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-960x638.jpg 960w\" sizes=\"(max-width: 1280px) 100vw, 1280px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\u003cem>Click on the image for a larger version\u003c/em>\u003c/figcaption>\u003c/figure>\n\u003cp>To see the process in action, we insert a yeast mutation that will change its color from milky white to rusty red. We mix a chemical solution called a buffer (which helps the cell accept the DNA into its wall), the Cas9 protein, the guide RNA and the donor DNA together in a small plastic test tube.\u003c/p>\n\u003cp>\"So we're going to try to get this inside the yeast cells,\" Zayner says, holding up the clear fluid.\u003c/p>\n\u003cp>Zayner has some yeast growing on an agar-filled culture plate in his fridge. We transfer the yeast with a thin plastic loop. We heat up the cells by putting the test tube in a warm bowl of water, then let them cool again and rest before spreading them on a plate to let them grow. The yeast only needs to grow a day or two to see if the experiment was successful. A few days later, Zayner says it was.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Why should we limit ourselves to what evolution has told us we should have based on natural selection?'\u003ccite>Josiah Zayner, The ODIN\u003c/cite>\u003c/aside>\n\u003cp>This is fairly simple stuff. Zayner's editing kits are more about fostering an interest in science than creating a new breed of super-humans -- not that he necessarily would have a problem with that.\u003c/p>\n\u003cp>\"Gene editing is the next step for humanity,\" Zayner says. \"Why should we limit ourselves to what evolution has told us we should have based on natural selection? When we can decide what works best for humanity?\"\u003c/p>\n\u003cp>Gene editing technology has made great strides in the three years since CRISPR/Cas9 burst onto the scientific scene. Despite the rapid pace of advances, many scientists are urging caution as the technology becomes easier to use and the experiments become more ambitious.\u003c/p>\n\u003cp>\"We haven't really had the conversation about humans and what's ethically appropriate or inappropriate,\" says \u003ca href=\"https://med.stanford.edu/profiles/mildred-cho\" target=\"_blank\">Mildred Cho, \u003c/a>a bioethicist at Stanford University. She sees a huge potential for breakthroughs in gene editing, but also the possibility of misuse. \"And we haven't really had the conversation about widespread release of organisms that we won't be able to get back once they're released into the environment.\" Cho, however, says it's not up to scientists to decide such things. \"So far, those discussions have not been very widespread outside of the expert communities.\"\u003c/p>\n\u003cfigure id=\"attachment_114670\" class=\"wp-caption alignright\" style=\"max-width: 240px\">\u003cimg class=\"size-full wp-image-114670\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/RS18524_IMG_8357-sfi.jpg\" alt=\"Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \" width=\"240\" height=\"360\">\u003cfigcaption class=\"wp-caption-text\">Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Yet Silicon Valley and the local biotech community are forging ahead. In San Francisco's Mission Bay neighborhood, \u003ca href=\"https://www.twistbioscience.com/\" target=\"_blank\">Twist Bioscience\u003c/a> is making the components of DNA and RNA that companies and academic researchers can use in their synthetic biology experiments.\u003c/p>\n\u003cp>\"We started Twist to disrupt the DNA-writing market,\" says Emily Leproust, one of the co-founders. \"There is a massive demand. A huge demand.\"\u003c/p>\n\u003cp>Leproust says many drugs, antibiotics and vaccines begin from DNA, with engineered microbes used to make them. And in the area of industrial chemicals, many researchers and companies are modifying algae, yeast and E. coli to turn them into bio-factories that make specialty chemicals.\u003c/p>\n\u003cp>Twist doesn't disclose the names of its clients. And in the interest of safety, Twist executives say, they restrict what sequences of DNA they'll sell, and to whom. But there are lots of local labs and companies using DNA in this way, and they're raising boatloads of money.\u003c/p>\n\u003cp>According to CrunchBase.com, \u003ca href=\"http://www.zymergen.com/\" target=\"_blank\">Zymergen\u003c/a> in Emeryville has raised $44 million, \u003ca href=\"http://cariboubio.com/\" target=\"_blank\">Caribou Bioscience\u003c/a> in Berkeley $14 million, \u003ca href=\"http://www.sangamo.com/index.html\" target=\"_blank\">Sangamo BioSciences\u003c/a> in Richmond about $74 million, and Twist itself more than $130 million.\u003c/p>\n\u003cp>That's why, Leproust says, it's good, today, to be in bio.\u003c/p>\n\u003cp>\"If you were in the '50s, you wanted to be in space and aeronautics and in the '90s you wanted to be in computers. And nowadays you want to be in biology because that's where the next big economic growth is going to come from.\"\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Time will tell. But local startups are betting and betting big on the new generation of gene editing.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>When you hear \"gene editing,\" do you think cancer cures? Designer babies? What about new fuel sources or drought-tolerant crops? Gene editing with a technique known as CRISPR/Cas9, hailed as a scientific \u003ca href=\"http://ww2.kqed.org/futureofyou/CRISPR%3A-What-You-Need-to-Know-About-the-Medical-Science-%27Breakthrough-of-the-Year%27\" target=\"_blank\">breakthrough\u003c/a>, could mean all those things.\u003c/p>\n\u003cp>There's a possibility, of course, that CRISPR/Cas9 may not live up to expectations. That's happened before. Twenty-five years ago, recombinant DNA was supposed to transform society in a way that, well, didn't happen. But any past biotech disappointments are not stopping a slew of Bay Area CRISPR startups from taking the leap into the new world of DNA tinkering and synthetic biology. They are, in fact, everywhere, from biotech labs in Emeryville to kitchen counters in Burlingame.\u003c/p>\n\u003cp>\"It's something that people read about, it's something people see that's cutting edge,\" says Josiah Zayner, a former synthetic biologist at NASA. \"Yet it's so accessible, it's something that you can do in your home, on your kitchen table.\"\u003c/p>\n\u003cp>Zayner has considered himself a \"biohacker\" for a long time. Now it's his full-time job.\u003c/p>\n\u003cfigure id=\"attachment_114669\" class=\"wp-caption alignleft\" style=\"max-width: 360px\">\u003cimg class=\"size-full wp-image-114669\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/crispr-featureimage-e1455913319463.jpg\" alt='Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists.' width=\"360\" height=\"540\">\u003cfigcaption class=\"wp-caption-text\">Biohacker Josiah Zayner conducts a gene editing experiment in his kitchen. Zayner has started \"The ODIN\" a company dedicated providing low cost lab supplies for DIY scientists. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>He's started a company called The Open Discovery Institute, or The ODIN (not coincidentally, the name of the Norse god connected with healing, knowledge and ... death). The point, he says, is to make science more accessible by providing low-cost supplies for people to practice gene editing at home. The first shipments from his \u003ca href=\"https://www.indiegogo.com/projects/diy-crispr-kits-learn-modern-science-by-doing#/\" target=\"_blank\">Indiegogo crowdfunding campaign\u003c/a> are expected this spring.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"You can learn about cutting-edge science by actually doing it,\" Zayner says. \"When I started experimenting with CRISPR I thought, 'That's pretty crazy!' I would definitely want that opportunity.\"\u003c/p>\n\u003cp>In Zayner's kitchen I get a crash course in how this new kind of gene editing works. Zayner's kits have three major parts: the Cas9 protein (other forms can use other proteins), the \"guide\" RNA and the donor DNA. The Cas9 protein makes precise cuts in the sections of the DNA to which it's led by the guide RNA. Sensing the cut, the cell's own repair mechanisms will try to repair it, by inserting a new piece of DNA. If all goes well, it will add a section of the donated DNA containing the desired gene or genes.\u003c/p>\n\u003cp>\"So you kind of trick the cell into using your new piece of DNA instead of some other piece of DNA it finds, or the original piece of DNA,\" says Zayner.\u003c/p>\n\u003cfigure id=\"attachment_115245\" class=\"wp-caption alignnone\" style=\"max-width: 1280px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\">\u003cimg class=\"wp-image-115245 size-full\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/CRISPR-is-Here.jpg\" alt=\"CRISPR is Here\" width=\"1280\" height=\"850\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here.jpg 1280w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-400x266.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-800x531.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-768x510.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-1180x784.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/CRISPR-is-Here-960x638.jpg 960w\" sizes=\"(max-width: 1280px) 100vw, 1280px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">\u003cem>Click on the image for a larger version\u003c/em>\u003c/figcaption>\u003c/figure>\n\u003cp>To see the process in action, we insert a yeast mutation that will change its color from milky white to rusty red. We mix a chemical solution called a buffer (which helps the cell accept the DNA into its wall), the Cas9 protein, the guide RNA and the donor DNA together in a small plastic test tube.\u003c/p>\n\u003cp>\"So we're going to try to get this inside the yeast cells,\" Zayner says, holding up the clear fluid.\u003c/p>\n\u003cp>Zayner has some yeast growing on an agar-filled culture plate in his fridge. We transfer the yeast with a thin plastic loop. We heat up the cells by putting the test tube in a warm bowl of water, then let them cool again and rest before spreading them on a plate to let them grow. The yeast only needs to grow a day or two to see if the experiment was successful. A few days later, Zayner says it was.\u003c/p>\n\u003caside class=\"pullquote alignright\">'Why should we limit ourselves to what evolution has told us we should have based on natural selection?'\u003ccite>Josiah Zayner, The ODIN\u003c/cite>\u003c/aside>\n\u003cp>This is fairly simple stuff. Zayner's editing kits are more about fostering an interest in science than creating a new breed of super-humans -- not that he necessarily would have a problem with that.\u003c/p>\n\u003cp>\"Gene editing is the next step for humanity,\" Zayner says. \"Why should we limit ourselves to what evolution has told us we should have based on natural selection? When we can decide what works best for humanity?\"\u003c/p>\n\u003cp>Gene editing technology has made great strides in the three years since CRISPR/Cas9 burst onto the scientific scene. Despite the rapid pace of advances, many scientists are urging caution as the technology becomes easier to use and the experiments become more ambitious.\u003c/p>\n\u003cp>\"We haven't really had the conversation about humans and what's ethically appropriate or inappropriate,\" says \u003ca href=\"https://med.stanford.edu/profiles/mildred-cho\" target=\"_blank\">Mildred Cho, \u003c/a>a bioethicist at Stanford University. She sees a huge potential for breakthroughs in gene editing, but also the possibility of misuse. \"And we haven't really had the conversation about widespread release of organisms that we won't be able to get back once they're released into the environment.\" Cho, however, says it's not up to scientists to decide such things. \"So far, those discussions have not been very widespread outside of the expert communities.\"\u003c/p>\n\u003cfigure id=\"attachment_114670\" class=\"wp-caption alignright\" style=\"max-width: 240px\">\u003cimg class=\"size-full wp-image-114670\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/RS18524_IMG_8357-sfi.jpg\" alt=\"Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \" width=\"240\" height=\"360\">\u003cfigcaption class=\"wp-caption-text\">Emily Leproust, co-founder of Twist Bioscience, holds one of the company's 10,000-well plates in her left hand. \u003ccite>(Danielle Venton/KQED)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Yet Silicon Valley and the local biotech community are forging ahead. In San Francisco's Mission Bay neighborhood, \u003ca href=\"https://www.twistbioscience.com/\" target=\"_blank\">Twist Bioscience\u003c/a> is making the components of DNA and RNA that companies and academic researchers can use in their synthetic biology experiments.\u003c/p>\n\u003cp>\"We started Twist to disrupt the DNA-writing market,\" says Emily Leproust, one of the co-founders. \"There is a massive demand. A huge demand.\"\u003c/p>\n\u003cp>Leproust says many drugs, antibiotics and vaccines begin from DNA, with engineered microbes used to make them. And in the area of industrial chemicals, many researchers and companies are modifying algae, yeast and E. coli to turn them into bio-factories that make specialty chemicals.\u003c/p>\n\u003cp>Twist doesn't disclose the names of its clients. And in the interest of safety, Twist executives say, they restrict what sequences of DNA they'll sell, and to whom. But there are lots of local labs and companies using DNA in this way, and they're raising boatloads of money.\u003c/p>\n\u003cp>According to CrunchBase.com, \u003ca href=\"http://www.zymergen.com/\" target=\"_blank\">Zymergen\u003c/a> in Emeryville has raised $44 million, \u003ca href=\"http://cariboubio.com/\" target=\"_blank\">Caribou Bioscience\u003c/a> in Berkeley $14 million, \u003ca href=\"http://www.sangamo.com/index.html\" target=\"_blank\">Sangamo BioSciences\u003c/a> in Richmond about $74 million, and Twist itself more than $130 million.\u003c/p>\n\u003cp>That's why, Leproust says, it's good, today, to be in bio.\u003c/p>\n\u003cp>\"If you were in the '50s, you wanted to be in space and aeronautics and in the '90s you wanted to be in computers. And nowadays you want to be in biology because that's where the next big economic growth is going to come from.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cp>A large Los Angeles hospital chose to pay hackers who were holding its computer network hostage, a move its CEO said was in its best interest and the most efficient way to end the problem.\u003c/p>\n\u003cp>Hollywood Presbyterian Medical Center showed uncommon transparency in saying Wednesday that it paid the 40 bitcoins — or about $17,000 — demanded when it fell victim to what's commonly called \"ransomware.\"\u003c/p>\n\u003cp>The hacking tactic is growing fast against both individuals and institutions, but it's difficult to say exactly how fast, and even tougher to say how many pay up.\u003c/p>\n\u003cp>\"Unfortunately, a lot of companies don't tell anybody if they had fallen victim to ransomware and especially if they have paid the criminals,\" said Adam Kujawa, Head of Malware Intelligence for Malwarebytes, a San Jose-based company that recently released anti-ransomware software. \"I know from the experiences I hear about from various industry professionals that it's a pretty common practice to just hand over the cash.\"\u003c/p>\n\u003cp>Computer security experts normally recommend people not pay the ransom, though at times law enforcement agencies suggest they do, Kujawa said.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The FBI said it is investigating the ransomware attack, but have provided no details beyond that.\u003c/p>\n\u003cp>During 2013, the number of attacks each month rose from 100,000 in January to 600,000 in December, according to a 2014 report by Symantec, the maker of antivirus software.\u003c/p>\n\u003cp>A report from Intel Corp.'s McAfee Labs released in November said the number of ransomware attacks is expected to grow even more in 2016 because of increased sophistication in the software used to do it. The company estimates that on average, 3 percent of users with infected machines pay a ransom.\u003c/p>\n\u003cp>The infiltration at Hollywood Presbyterian was first noticed on Feb. 5, CEO Allen Stefanek said in a statement. Its system was fully functioning again by Monday, 10 days later.\u003c/p>\n\u003cp>The hospital did not say whether anyone in law enforcement or the technology business had recommended it pay off the hackers and quickly obtain the digital key used to be able to access its data again.\u003c/p>\n\u003cp>\"The quickest and most efficient way to restore our systems and administrative functions was to pay the ransom and obtain the decryption key,\" Stefanek said. \"In the best interest of restoring normal operations, we did this.\"\u003c/p>\n\u003cp>Neither law enforcement nor the hospital gave any indication of who might have been behind the attack or whether there are any suspects.\u003c/p>\n\u003cp>Bitcoins, the online currency that is hard to trace, is becoming the preferred way for hackers collect a ransom, FBI Special Agent Thomas Grasso, who is part of the government's efforts to fight malicious software including ransomware, told The Associated Press last year.\u003c/p>\n\u003cp>Patient care at Hollywood Presbyterian was not affected by the hacking, and there is no evidence any patient data was compromised, Stefanek said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The 434-bed hospital in the Los Feliz area of Los Angeles was founded in 1924. It was sold to CHA Medical Center of South Korea in 2004. It offers a range of services including emergency care, maternity services, cancer care, physical therapy, and specialized operations such as fetal and orthopedic surgeries.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>A large Los Angeles hospital chose to pay hackers who were holding its computer network hostage, a move its CEO said was in its best interest and the most efficient way to end the problem.\u003c/p>\n\u003cp>Hollywood Presbyterian Medical Center showed uncommon transparency in saying Wednesday that it paid the 40 bitcoins — or about $17,000 — demanded when it fell victim to what's commonly called \"ransomware.\"\u003c/p>\n\u003cp>The hacking tactic is growing fast against both individuals and institutions, but it's difficult to say exactly how fast, and even tougher to say how many pay up.\u003c/p>\n\u003cp>\"Unfortunately, a lot of companies don't tell anybody if they had fallen victim to ransomware and especially if they have paid the criminals,\" said Adam Kujawa, Head of Malware Intelligence for Malwarebytes, a San Jose-based company that recently released anti-ransomware software. \"I know from the experiences I hear about from various industry professionals that it's a pretty common practice to just hand over the cash.\"\u003c/p>\n\u003cp>Computer security experts normally recommend people not pay the ransom, though at times law enforcement agencies suggest they do, Kujawa said.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The FBI said it is investigating the ransomware attack, but have provided no details beyond that.\u003c/p>\n\u003cp>During 2013, the number of attacks each month rose from 100,000 in January to 600,000 in December, according to a 2014 report by Symantec, the maker of antivirus software.\u003c/p>\n\u003cp>A report from Intel Corp.'s McAfee Labs released in November said the number of ransomware attacks is expected to grow even more in 2016 because of increased sophistication in the software used to do it. The company estimates that on average, 3 percent of users with infected machines pay a ransom.\u003c/p>\n\u003cp>The infiltration at Hollywood Presbyterian was first noticed on Feb. 5, CEO Allen Stefanek said in a statement. Its system was fully functioning again by Monday, 10 days later.\u003c/p>\n\u003cp>The hospital did not say whether anyone in law enforcement or the technology business had recommended it pay off the hackers and quickly obtain the digital key used to be able to access its data again.\u003c/p>\n\u003cp>\"The quickest and most efficient way to restore our systems and administrative functions was to pay the ransom and obtain the decryption key,\" Stefanek said. \"In the best interest of restoring normal operations, we did this.\"\u003c/p>\n\u003cp>Neither law enforcement nor the hospital gave any indication of who might have been behind the attack or whether there are any suspects.\u003c/p>\n\u003cp>Bitcoins, the online currency that is hard to trace, is becoming the preferred way for hackers collect a ransom, FBI Special Agent Thomas Grasso, who is part of the government's efforts to fight malicious software including ransomware, told The Associated Press last year.\u003c/p>\n\u003cp>Patient care at Hollywood Presbyterian was not affected by the hacking, and there is no evidence any patient data was compromised, Stefanek said.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The 434-bed hospital in the Los Feliz area of Los Angeles was founded in 1924. It was sold to CHA Medical Center of South Korea in 2004. It offers a range of services including emergency care, maternity services, cancer care, physical therapy, and specialized operations such as fetal and orthopedic surgeries.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>In the sci-fi romp, Men in Black, top-secret agents used what Will Smith called a \"\u003ca href=\"https://www.youtube.com/watch?v=PnEWvBsRjBo\">flashy-thing\u003c/a>\" to erase memories of trespassing space aliens.\u003c/p>\n\u003cp>While that \"neuralyzer\" technology was strictly fictional (as far as we've been told), real men and women in white have come up with a flashy-thing to erase jet lag.\u003c/p>\n\u003caside class=\"pullquote alignright\">'People are becoming more aware that sleep is one of the pillars of health.'\u003ccite>LumosTech CEO Vanessa Burns\u003cbr>\n\u003c/cite>\u003c/aside>\n\u003cp>Stanford behavioral scientist Jamie Zeitzer says his team has figured out how to stave off the annoying travel fatigue with flashing lights during sleep.\u003c/p>\n\u003cp>Zeitzer, whose study appears in the \u003ci>\u003ca href=\"http://www.jci.org/articles/view/82306\" target=\"_blank\">Journal of Clinical Investigation\u003c/a> \u003c/i>this week, found that short flashes of 2 miliseconds each, delivered 10 seconds apart for two hours the day before a trip can help the change circadian rhythms, which act as the body's internal clock.\u003c/p>\n\u003cp>That bio-clock is based on a 24-hour cycle and takes cues from the outside world, like the sunrise. It's the reason you often feel tired at night and why you can wake up at the same time everyday without an alarm.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Zeitzer and his team exposed study participants to flashing light while they were asleep, using a xenon flash bulb in a Ganzfeld dome. Zeitzer says to think of the dome as \"a giant ping pong ball that you put your head into. Wherever you look inside this 'ping pong ball,' the light is the same in terms of intensity.\"\u003c/p>\n\u003cfigure id=\"attachment_110854\" class=\"wp-caption aligncenter\" style=\"max-width: 620px\">\u003cimg class=\"size-full wp-image-110854\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/Zeitzer.jpg\" alt=\"Stanford University assistant professor Jamie Zeitzer sets up a flashing light in his lab. His research shows that exposure to short flashes of light during sleep can help prevent jet lag. \" width=\"620\" height=\"443\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/Zeitzer.jpg 620w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/Zeitzer-400x286.jpg 400w\" sizes=\"(max-width: 620px) 100vw, 620px\">\u003cfigcaption class=\"wp-caption-text\">Stanford University assistant professor Jamie Zeitzer sets up a flashing light in his lab. His research shows that exposure to short flashes of light during sleep can help prevent jet lag. \u003ccite>(Norbert von der Groeben)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Even though their eyes were closed, participants still had light pass through their eyelids, which interacted with the brain.\u003c/p>\n\u003cp>The brain perceives the light, which essentially \"tricks the brain into thinking the sun is still up,\" Zeitzer says.\u003c/p>\n\u003cp>The light is administered at night because the body's circadian clock is the most sensitive at night during sleep. Zeitzer says the timing of the treatment is important.\u003c/p>\n\u003cp>If the light starts flashing right after you go to bed, the body thinks the day is longer than it is. Those flashing lights are perceived as daylight and thus the body perceives an extended day. Which is what you want if you're traveling from, say, New York to California.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">If you're traveling back to New York, you'd want to administer the light during the last few hours you're sleeping so the brain perceives an early sunrise.\u003c/span>\u003c/p>\n\u003cp>Because sticking your head inside a high-tech 'ping pong ball' isn't practical for most of us, some of Zeitzer's students have started a company to bring light therapy to consumers.\u003c/p>\n\u003cfigure id=\"attachment_110816\" class=\"wp-caption aligncenter\" style=\"max-width: 1232px\">\u003cimg class=\"size-full wp-image-110816\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/lumostech_jpeg.jpg\" alt=\"More than 100 people have beta tested LumosTech's flashing light mask and CEO Vanessa Burns says it'll be commercially available late this summer.\" width=\"1232\" height=\"622\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg.jpg 1232w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-400x202.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-800x404.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-768x388.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-1180x596.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-960x485.jpg 960w\" sizes=\"(max-width: 1232px) 100vw, 1232px\">\u003cfigcaption class=\"wp-caption-text\">Palo Alto's LumosTech says more than 100 people have beta-tested its flashing light mask and CEO Vanessa Burns says it'll be commercially available late this summer. \u003ccite>(LumosTech)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Palo Alto-based \u003ca href=\"http://lumostech.co/\">LumosTech\u003c/a> has created an eye mask that has flashing internal lights and is controlled by data entered into a smartphone app.\u003c/p>\n\u003cp>In the app, you enter your gender, age, bedtime and whether you're a night owl or an early bird. Then the app tells LED lights in the mask when to start flashing.\u003c/p>\n\u003cp>\"There’s been a growing interest in sleep with the rise of sleep tracking apps,\" says CEO Vanessa Burns. \"People are becoming more aware that sleep is one of the pillars of health.\"\u003c/p>\n\u003cp>Fitful sleep isn't just a problem for travelers, it also affects shift workers, teenagers and astronauts. LumosTech has a contract with the NASA-funded \u003ca href=\"http://www.nsbri.org/\">National Space Biomedical Research Institute\u003c/a> to provide eye masks for astronauts to test.\u003c/p>\n\u003cfigure id=\"attachment_110851\" class=\"wp-caption alignright\" style=\"max-width: 400px\">\u003cimg class=\"size-full wp-image-110851\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/LumosTech-1.jpg\" alt=\"Commander Ken Bowersox (left) tries on a LumosTech mask at NSBRI headquarters in Houston.\" width=\"400\" height=\"267\">\u003cfigcaption class=\"wp-caption-text\">Commander Ken Bowersox (left) tries on a LumosTech mask at NSBRI headquarters in Houston. \u003ccite>(NSBRI)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“They were very excited about the potential use,” says Burns. “Astronauts experience multiple sunrises over the course of 24 hours and frequently need assistance to optimize their sleep cycles.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>By the end of the summer, masks will also be available for Earthbound travelers. The final price is yet to be determined but the company is currently taking pre-orders at $175. The last time we checked, a strong cup of espresso was still cheaper.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>In the sci-fi romp, Men in Black, top-secret agents used what Will Smith called a \"\u003ca href=\"https://www.youtube.com/watch?v=PnEWvBsRjBo\">flashy-thing\u003c/a>\" to erase memories of trespassing space aliens.\u003c/p>\n\u003cp>While that \"neuralyzer\" technology was strictly fictional (as far as we've been told), real men and women in white have come up with a flashy-thing to erase jet lag.\u003c/p>\n\u003caside class=\"pullquote alignright\">'People are becoming more aware that sleep is one of the pillars of health.'\u003ccite>LumosTech CEO Vanessa Burns\u003cbr>\n\u003c/cite>\u003c/aside>\n\u003cp>Stanford behavioral scientist Jamie Zeitzer says his team has figured out how to stave off the annoying travel fatigue with flashing lights during sleep.\u003c/p>\n\u003cp>Zeitzer, whose study appears in the \u003ci>\u003ca href=\"http://www.jci.org/articles/view/82306\" target=\"_blank\">Journal of Clinical Investigation\u003c/a> \u003c/i>this week, found that short flashes of 2 miliseconds each, delivered 10 seconds apart for two hours the day before a trip can help the change circadian rhythms, which act as the body's internal clock.\u003c/p>\n\u003cp>That bio-clock is based on a 24-hour cycle and takes cues from the outside world, like the sunrise. It's the reason you often feel tired at night and why you can wake up at the same time everyday without an alarm.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Zeitzer and his team exposed study participants to flashing light while they were asleep, using a xenon flash bulb in a Ganzfeld dome. Zeitzer says to think of the dome as \"a giant ping pong ball that you put your head into. Wherever you look inside this 'ping pong ball,' the light is the same in terms of intensity.\"\u003c/p>\n\u003cfigure id=\"attachment_110854\" class=\"wp-caption aligncenter\" style=\"max-width: 620px\">\u003cimg class=\"size-full wp-image-110854\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/Zeitzer.jpg\" alt=\"Stanford University assistant professor Jamie Zeitzer sets up a flashing light in his lab. His research shows that exposure to short flashes of light during sleep can help prevent jet lag. \" width=\"620\" height=\"443\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/Zeitzer.jpg 620w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/Zeitzer-400x286.jpg 400w\" sizes=\"(max-width: 620px) 100vw, 620px\">\u003cfigcaption class=\"wp-caption-text\">Stanford University assistant professor Jamie Zeitzer sets up a flashing light in his lab. His research shows that exposure to short flashes of light during sleep can help prevent jet lag. \u003ccite>(Norbert von der Groeben)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Even though their eyes were closed, participants still had light pass through their eyelids, which interacted with the brain.\u003c/p>\n\u003cp>The brain perceives the light, which essentially \"tricks the brain into thinking the sun is still up,\" Zeitzer says.\u003c/p>\n\u003cp>The light is administered at night because the body's circadian clock is the most sensitive at night during sleep. Zeitzer says the timing of the treatment is important.\u003c/p>\n\u003cp>If the light starts flashing right after you go to bed, the body thinks the day is longer than it is. Those flashing lights are perceived as daylight and thus the body perceives an extended day. Which is what you want if you're traveling from, say, New York to California.\u003c/p>\n\u003cp>\u003cspan style=\"font-weight: 400\">If you're traveling back to New York, you'd want to administer the light during the last few hours you're sleeping so the brain perceives an early sunrise.\u003c/span>\u003c/p>\n\u003cp>Because sticking your head inside a high-tech 'ping pong ball' isn't practical for most of us, some of Zeitzer's students have started a company to bring light therapy to consumers.\u003c/p>\n\u003cfigure id=\"attachment_110816\" class=\"wp-caption aligncenter\" style=\"max-width: 1232px\">\u003cimg class=\"size-full wp-image-110816\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/lumostech_jpeg.jpg\" alt=\"More than 100 people have beta tested LumosTech's flashing light mask and CEO Vanessa Burns says it'll be commercially available late this summer.\" width=\"1232\" height=\"622\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg.jpg 1232w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-400x202.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-800x404.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-768x388.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-1180x596.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/lumostech_jpeg-960x485.jpg 960w\" sizes=\"(max-width: 1232px) 100vw, 1232px\">\u003cfigcaption class=\"wp-caption-text\">Palo Alto's LumosTech says more than 100 people have beta-tested its flashing light mask and CEO Vanessa Burns says it'll be commercially available late this summer. \u003ccite>(LumosTech)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>Palo Alto-based \u003ca href=\"http://lumostech.co/\">LumosTech\u003c/a> has created an eye mask that has flashing internal lights and is controlled by data entered into a smartphone app.\u003c/p>\n\u003cp>In the app, you enter your gender, age, bedtime and whether you're a night owl or an early bird. Then the app tells LED lights in the mask when to start flashing.\u003c/p>\n\u003cp>\"There’s been a growing interest in sleep with the rise of sleep tracking apps,\" says CEO Vanessa Burns. \"People are becoming more aware that sleep is one of the pillars of health.\"\u003c/p>\n\u003cp>Fitful sleep isn't just a problem for travelers, it also affects shift workers, teenagers and astronauts. LumosTech has a contract with the NASA-funded \u003ca href=\"http://www.nsbri.org/\">National Space Biomedical Research Institute\u003c/a> to provide eye masks for astronauts to test.\u003c/p>\n\u003cfigure id=\"attachment_110851\" class=\"wp-caption alignright\" style=\"max-width: 400px\">\u003cimg class=\"size-full wp-image-110851\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/LumosTech-1.jpg\" alt=\"Commander Ken Bowersox (left) tries on a LumosTech mask at NSBRI headquarters in Houston.\" width=\"400\" height=\"267\">\u003cfigcaption class=\"wp-caption-text\">Commander Ken Bowersox (left) tries on a LumosTech mask at NSBRI headquarters in Houston. \u003ccite>(NSBRI)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>“They were very excited about the potential use,” says Burns. “Astronauts experience multiple sunrises over the course of 24 hours and frequently need assistance to optimize their sleep cycles.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>By the end of the summer, masks will also be available for Earthbound travelers. The final price is yet to be determined but the company is currently taking pre-orders at $175. The last time we checked, a strong cup of espresso was still cheaper.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Palo Alto Student Was Asked to Leave School Because of His DNA",
"title": "Palo Alto Student Was Asked to Leave School Because of His DNA",
"headTitle": "Future of You | KQED Future of You | KQED Science",
"content": "\u003cp>To find a society where a student is forced to leave school because of his genes, you might think you’d need to watch \"\u003ca href=\"https://en.wikipedia.org/wiki/Gattaca\">Gattaca\u003c/a>\" or pick up a dystopian novel.\u003c/p>\n\u003cp>As it turns out, you wouldn't need to immerse yourself in fiction. This exact scenario occurred at a middle school in Palo Alto, California.\u003c/p>\n\u003caside class=\"pullquote alignright\">Unless something is done to strengthen legal protections, anyone who is genetically tested could be discriminated against.\u003c/aside>\n\u003cp>And unless something is done to strengthen our legal protections, it could be just the tip of the iceberg. Any of us who learns about our DNA through direct-to-consumer tests like 23andMe, newborn genetic testing or gene sequencing at the doctor’s office could be genetically discriminated against too.\u003c/p>\n\u003cp>\u003cstrong>School Boots Out Sixth Grader Over Predisposition to Disease\u003c/strong>\u003c/p>\n\u003cp>In 2012, Jordan Middle School tried to force 11-year-old Colman Chadam to transfer to another school, not because he did something wrong or had a contagious disease, but because of his DNA.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>[contextly_sidebar id=\"RWAfIZvPfGk0QXWSsjL020T1kdGZFuZd\"]Colman had been born with a heart condition. To try to figure out what was wrong, the doctors had performed a lot of genetic tests, one of which found an increased risk for cystic fibrosis, a very severe genetic condition.\u003c/p>\n\u003cp>Twelve years later, Colman's parents, as a simple precaution, filled out a medical form telling the school about his genetic results even though he had none of the symptoms of CF. He did not have the disease.\u003c/p>\n\u003cp>But the student population at Jordan Middle School included two siblings who had CF. Because there is a high risk for people with the disease to give each other lung infections, it is important to always keep them at least 6 feet away from each other.\u003c/p>\n\u003cp>After teachers at the school told the parents of these students about Colman's genetics, the district ordered Colman's transfer, despite the fact that he did not have the disease.\u003c/p>\n\u003cp>His parents took the district to court. After Colman missed 11 days of school, a settlement was reached to \u003ca href=\"http://www.sfgate.com/bayarea/article/6th-grader-back-in-school-despite-genes-4010983.php\" target=\"_blank\">let him return\u003c/a>.\u003c/p>\n\u003cp>But the Chadams filed a suit in federal court, alleging unlawful disclosure of Colman's private medical information. The case was dismissed, but last month the Chadams filed an \u003ca href=\"https://assets.documentcloud.org/documents/2701506/Opening-Brief.pdf\" target=\"_blank\">appeal to the Ninth Circuit Court\u003c/a>.\u003c/p>\n\u003cp>All of this brouhaha occurred even though Colman did not have CF and posed no risk to anyone. The specific genetic differences he had are in a gray area of genetics known as \u003ca href=\"http://ghr.nlm.nih.gov/glossary=penetrance\">variable penetrance\u003c/a>.\u003c/p>\n\u003cp>Some people with his DNA end up with CF and some don't. Up to that time, Colman had not developed any symptoms.\u003c/p>\n\u003cp>Perhaps it's not surprising that well-meaning people at Jordan Middle School did not understand these subtleties and misinterpreted Colman's results. What is surprising is that there is so little legal protection against this sort of misunderstanding.\u003c/p>\n\u003cfigure id=\"attachment_108371\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-108371\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/BushSignsGINA2008-800x510.jpg\" alt=\"In 2008 President Bush signed the Genetics Information Nondiscrimination Act (GINA) . It did not protect a middle school student from being asked to transfer to a new school because of his DNA. \" width=\"800\" height=\"510\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-800x510.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-400x255.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-768x489.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-1180x752.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-960x612.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008.jpg 1400w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">In 2008 President Bush signed the Genetics Information Nondiscrimination Act (GINA) . It did not protect a middle school student from being asked to transfer to a new school because of his DNA. \u003ccite>(NHGRI)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>Surprisingly Weak Protections\u003c/strong>\u003c/p>\n\u003cp>Back in 2008 President Bush signed the \u003ca href=\"http://ginahelp.org/\" target=\"_blank\">Genetics Information Nondiscrimination Act\u003c/a> (GINA). Unfortunately for the Chadams, it only covers employment and health insurance discrimination.\u003c/p>\n\u003cp>This oversight needs to be addressed sooner rather than later.\u003c/p>\n\u003cp>Every day more and more people learn about potential disease risks from their DNA. Many people will have results similar to Colman's that could be used against them.\u003c/p>\n\u003cp>\u003cstrong>The Perils of Testing\u003c/strong>\u003c/p>\n\u003cp>DNA is more complicated than a lot of people think. For example, scientists have found over 2000 DNA variants or differences in CFTR, the key gene involved in cystic fibrosis.\u003c/p>\n\u003cp>Without additional protections in place, CF screening programs like the one described \u003ca href=\"http://ww2.kqed.org/futureofyou/2016/02/01/stanford-develops-fast-affordable-genetic-test-for-newborns/\">here\u003c/a> could place many more people in Colman Chadam's situation.\u003c/p>\n\u003cp>Multiply these risks by 10, 100, 1000 or even 10,000 for some of the proposed screens where \u003ca href=\"http://genomemag.com/a-newborn-challenge/#.Vrj3vfkrKM8\">every gene of a newborn might be looked at\u003c/a> (exome sequencing), and you begin to see what we're up against. People will be flooded with a lot of hard-to-understand information that is easy to misinterpret.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>This doesn't mean genetic testing, which can have many benefits, shouldn't be done. We just need to ensure it isn't used to discriminate, as we head toward a world where everyone knows their DNA but doesn’t necessarily understand genetics.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>To find a society where a student is forced to leave school because of his genes, you might think you’d need to watch \"\u003ca href=\"https://en.wikipedia.org/wiki/Gattaca\">Gattaca\u003c/a>\" or pick up a dystopian novel.\u003c/p>\n\u003cp>As it turns out, you wouldn't need to immerse yourself in fiction. This exact scenario occurred at a middle school in Palo Alto, California.\u003c/p>\n\u003caside class=\"pullquote alignright\">Unless something is done to strengthen legal protections, anyone who is genetically tested could be discriminated against.\u003c/aside>\n\u003cp>And unless something is done to strengthen our legal protections, it could be just the tip of the iceberg. Any of us who learns about our DNA through direct-to-consumer tests like 23andMe, newborn genetic testing or gene sequencing at the doctor’s office could be genetically discriminated against too.\u003c/p>\n\u003cp>\u003cstrong>School Boots Out Sixth Grader Over Predisposition to Disease\u003c/strong>\u003c/p>\n\u003cp>In 2012, Jordan Middle School tried to force 11-year-old Colman Chadam to transfer to another school, not because he did something wrong or had a contagious disease, but because of his DNA.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003c/p>\u003cp>Colman had been born with a heart condition. To try to figure out what was wrong, the doctors had performed a lot of genetic tests, one of which found an increased risk for cystic fibrosis, a very severe genetic condition.\u003c/p>\n\u003cp>Twelve years later, Colman's parents, as a simple precaution, filled out a medical form telling the school about his genetic results even though he had none of the symptoms of CF. He did not have the disease.\u003c/p>\n\u003cp>But the student population at Jordan Middle School included two siblings who had CF. Because there is a high risk for people with the disease to give each other lung infections, it is important to always keep them at least 6 feet away from each other.\u003c/p>\n\u003cp>After teachers at the school told the parents of these students about Colman's genetics, the district ordered Colman's transfer, despite the fact that he did not have the disease.\u003c/p>\n\u003cp>His parents took the district to court. After Colman missed 11 days of school, a settlement was reached to \u003ca href=\"http://www.sfgate.com/bayarea/article/6th-grader-back-in-school-despite-genes-4010983.php\" target=\"_blank\">let him return\u003c/a>.\u003c/p>\n\u003cp>But the Chadams filed a suit in federal court, alleging unlawful disclosure of Colman's private medical information. The case was dismissed, but last month the Chadams filed an \u003ca href=\"https://assets.documentcloud.org/documents/2701506/Opening-Brief.pdf\" target=\"_blank\">appeal to the Ninth Circuit Court\u003c/a>.\u003c/p>\n\u003cp>All of this brouhaha occurred even though Colman did not have CF and posed no risk to anyone. The specific genetic differences he had are in a gray area of genetics known as \u003ca href=\"http://ghr.nlm.nih.gov/glossary=penetrance\">variable penetrance\u003c/a>.\u003c/p>\n\u003cp>Some people with his DNA end up with CF and some don't. Up to that time, Colman had not developed any symptoms.\u003c/p>\n\u003cp>Perhaps it's not surprising that well-meaning people at Jordan Middle School did not understand these subtleties and misinterpreted Colman's results. What is surprising is that there is so little legal protection against this sort of misunderstanding.\u003c/p>\n\u003cfigure id=\"attachment_108371\" class=\"wp-caption alignnone\" style=\"max-width: 800px\">\u003cimg class=\"size-medium wp-image-108371\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2016/02/BushSignsGINA2008-800x510.jpg\" alt=\"In 2008 President Bush signed the Genetics Information Nondiscrimination Act (GINA) . It did not protect a middle school student from being asked to transfer to a new school because of his DNA. \" width=\"800\" height=\"510\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-800x510.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-400x255.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-768x489.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-1180x752.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008-960x612.jpg 960w, https://ww2.kqed.org/app/uploads/sites/13/2016/02/BushSignsGINA2008.jpg 1400w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003cfigcaption class=\"wp-caption-text\">In 2008 President Bush signed the Genetics Information Nondiscrimination Act (GINA) . It did not protect a middle school student from being asked to transfer to a new school because of his DNA. \u003ccite>(NHGRI)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>Surprisingly Weak Protections\u003c/strong>\u003c/p>\n\u003cp>Back in 2008 President Bush signed the \u003ca href=\"http://ginahelp.org/\" target=\"_blank\">Genetics Information Nondiscrimination Act\u003c/a> (GINA). Unfortunately for the Chadams, it only covers employment and health insurance discrimination.\u003c/p>\n\u003cp>This oversight needs to be addressed sooner rather than later.\u003c/p>\n\u003cp>Every day more and more people learn about potential disease risks from their DNA. Many people will have results similar to Colman's that could be used against them.\u003c/p>\n\u003cp>\u003cstrong>The Perils of Testing\u003c/strong>\u003c/p>\n\u003cp>DNA is more complicated than a lot of people think. For example, scientists have found over 2000 DNA variants or differences in CFTR, the key gene involved in cystic fibrosis.\u003c/p>\n\u003cp>Without additional protections in place, CF screening programs like the one described \u003ca href=\"http://ww2.kqed.org/futureofyou/2016/02/01/stanford-develops-fast-affordable-genetic-test-for-newborns/\">here\u003c/a> could place many more people in Colman Chadam's situation.\u003c/p>\n\u003cp>Multiply these risks by 10, 100, 1000 or even 10,000 for some of the proposed screens where \u003ca href=\"http://genomemag.com/a-newborn-challenge/#.Vrj3vfkrKM8\">every gene of a newborn might be looked at\u003c/a> (exome sequencing), and you begin to see what we're up against. People will be flooded with a lot of hard-to-understand information that is easy to misinterpret.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>This doesn't mean genetic testing, which can have many benefits, shouldn't be done. We just need to ensure it isn't used to discriminate, as we head toward a world where everyone knows their DNA but doesn’t necessarily understand genetics.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>The blood testing startup Theranos got a little more time, Friday.\u003c/p>\n\u003cp>The Centers for Medicare & Medicaid Services sent this statement today:\u003c/p>\n\u003cp>\"At the request of the laboratory’s director, Theranos was granted an extension until February 12 to submit their response to the CMS inspection report. This is a routine procedure in oversight of clinical labs.\"\u003c/p>\n\u003caside class=\"“pullquote alignright\">\"The idea that you should not let your customers rely on test results you have reason to think had a good chance of being inaccurate is not [complicated].\"\u003cbr>\n--\u003ccite>Hank Greely, director of Stanford's Center for Law and the Biosciences \u003c/cite>\u003c/aside>\n\u003cp>A CMS inspection of the lab, in Newark, California, had found deficiencies that “pose immediate jeopardy to patient health and safety,” according to a CMS letter sent to Theranos.\u003c/p>\n\u003cp>Immediate jeopardy, as defined by CMS, means “a situation in which immediate corrective action is necessary because the laboratory’s non-compliance … has already caused, is causing, or is likely to cause, at any time, serious injury or harm, or death, to individuals served by the laboratory or to the health and safety of the general public.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Originally, Theranos had been given 10 days from receipt of the letter to correct the deficiencies. That deadline was today.\u003c/p>\n\u003cp>CMS also directed the company to take \"corrective action\" for affected patients.\u003c/p>\n\u003cp>Theranos sent this statement about the extension:\u003c/p>\n\u003cp>“We are working to submit our plan of correction to CMS, addressing every issue raised in the audit report regarding the Newark, CA lab and will continue to actively work with them. CMS has granted an extension to February 12 for submission of our plan of correction, to allow our new Lab Director, Dr. Das, additional time to review our comprehensive response.”\u003c/p>\n\u003cp>So ... what should people whose blood has been tested by Theranos do in the meantime?\u003c/p>\n\u003cp>I asked a CMS spokesperson if the agency had any advice for those folks; she declined to respond.\u003c/p>\n\u003cp>Theranos did not respond to two queries asking the same question.\u003c/p>\n\u003cp>\u003cstrong>Medical Ethicist Weighs In\u003c/strong>\u003c/p>\n\u003cp>What does an expert in medical ethics think?\u003c/p>\n\u003cp>Hank Greely is the director of Stanford's Center for Law and the Biosciences. He said in an email that \"it wouldn't shock\" him if CMS' assertion of potential fatal consequences wasn't literal.\u003c/p>\n\u003cp>He said the language \"is enough to \u003cstrong>at least \u003c/strong>raise serious questions about getting customers/patients to get new tests.\"\u003c/p>\n\u003cp>Greely said the haste in which Theranos should be obligated to contact potentially affected patients would be determined by the substance and frequency of the errors CMS found.\u003c/p>\n\u003cp>\"If they got substantial error rates on a particular kind of test (I don’t know - total cholesterol), I would think they need to tell the customers who got that test. If instead they had a relatively low error rate (though still too high) scattered across all their testing, figuring out who to tell what is trickier. And some kinds of lab tests are going to be more critical than others.\"\u003c/p>\n\u003cp>Greely said he thought it would behoove Theranos to offer affected patients or even every patient a free retest, if it was able to do so.\u003c/p>\n\u003cp>\"Good PR, good for the patients (if the retests are accurate), and, if their tests are as cheap as they say they are, not expensive.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Greely said though the details of disclosure are complicated and depend on many factors, \"the idea that you should not let your customers rely on test results you have reason to think had a good chance of being inaccurate is not [complicated].\"\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>The blood testing startup Theranos got a little more time, Friday.\u003c/p>\n\u003cp>The Centers for Medicare & Medicaid Services sent this statement today:\u003c/p>\n\u003cp>\"At the request of the laboratory’s director, Theranos was granted an extension until February 12 to submit their response to the CMS inspection report. This is a routine procedure in oversight of clinical labs.\"\u003c/p>\n\u003caside class=\"“pullquote alignright\">\"The idea that you should not let your customers rely on test results you have reason to think had a good chance of being inaccurate is not [complicated].\"\u003cbr>\n--\u003ccite>Hank Greely, director of Stanford's Center for Law and the Biosciences \u003c/cite>\u003c/aside>\n\u003cp>A CMS inspection of the lab, in Newark, California, had found deficiencies that “pose immediate jeopardy to patient health and safety,” according to a CMS letter sent to Theranos.\u003c/p>\n\u003cp>Immediate jeopardy, as defined by CMS, means “a situation in which immediate corrective action is necessary because the laboratory’s non-compliance … has already caused, is causing, or is likely to cause, at any time, serious injury or harm, or death, to individuals served by the laboratory or to the health and safety of the general public.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Originally, Theranos had been given 10 days from receipt of the letter to correct the deficiencies. That deadline was today.\u003c/p>\n\u003cp>CMS also directed the company to take \"corrective action\" for affected patients.\u003c/p>\n\u003cp>Theranos sent this statement about the extension:\u003c/p>\n\u003cp>“We are working to submit our plan of correction to CMS, addressing every issue raised in the audit report regarding the Newark, CA lab and will continue to actively work with them. CMS has granted an extension to February 12 for submission of our plan of correction, to allow our new Lab Director, Dr. Das, additional time to review our comprehensive response.”\u003c/p>\n\u003cp>So ... what should people whose blood has been tested by Theranos do in the meantime?\u003c/p>\n\u003cp>I asked a CMS spokesperson if the agency had any advice for those folks; she declined to respond.\u003c/p>\n\u003cp>Theranos did not respond to two queries asking the same question.\u003c/p>\n\u003cp>\u003cstrong>Medical Ethicist Weighs In\u003c/strong>\u003c/p>\n\u003cp>What does an expert in medical ethics think?\u003c/p>\n\u003cp>Hank Greely is the director of Stanford's Center for Law and the Biosciences. He said in an email that \"it wouldn't shock\" him if CMS' assertion of potential fatal consequences wasn't literal.\u003c/p>\n\u003cp>He said the language \"is enough to \u003cstrong>at least \u003c/strong>raise serious questions about getting customers/patients to get new tests.\"\u003c/p>\n\u003cp>Greely said the haste in which Theranos should be obligated to contact potentially affected patients would be determined by the substance and frequency of the errors CMS found.\u003c/p>\n\u003cp>\"If they got substantial error rates on a particular kind of test (I don’t know - total cholesterol), I would think they need to tell the customers who got that test. If instead they had a relatively low error rate (though still too high) scattered across all their testing, figuring out who to tell what is trickier. And some kinds of lab tests are going to be more critical than others.\"\u003c/p>\n\u003cp>Greely said he thought it would behoove Theranos to offer affected patients or even every patient a free retest, if it was able to do so.\u003c/p>\n\u003cp>\"Good PR, good for the patients (if the retests are accurate), and, if their tests are as cheap as they say they are, not expensive.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Greely said though the details of disclosure are complicated and depend on many factors, \"the idea that you should not let your customers rely on test results you have reason to think had a good chance of being inaccurate is not [complicated].\"\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Is it Ethical to Create Babies With Genes From Three People? Panel Says Yes",
"title": "Is it Ethical to Create Babies With Genes From Three People? Panel Says Yes",
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"content": "\u003cp>Would it be ethical for scientists to try to create babies that have genetic material from three different people? An influential panel of experts has concluded the answer could be yes.\u003c/p>\n\u003cp>The 12-member panel, assembled by the National Academies of Sciences, Engineering and Medicine, released a 164-page \u003ca href=\"http://www.nap.edu/catalog/21871/mitochondrial-replacement-techniques-ethical-social-and-policy-considerations\">report\u003c/a> Wednesday outlining a plan for how scientists could ethically pursue the controversial research.\u003c/p>\n\u003cp>\"The committee concludes that it is ethically permissible\" to conduct such experiments, the report says, but then goes on to detail a long list of conditions that would have to be met first.\u003c/p>\n\u003cp>For example, scientists would have to perform extensive preliminary research in the laboratory and with animals to try to make sure it is safe. And then researchers should initially try to make only male babies, because they would be incapable of passing their unusual amalgamation of DNA on to future generations.\u003c/p>\n\u003cp>\"Minimizing risk to future children should be of highest priority,\" the committee writes.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>The report was \u003ca href=\"http://www.npr.org/sections/health-shots/2013/10/09/229167219/proposed-treatment-to-fix-genetic-diseases-raising-ethics-issues\">requested \u003c/a>by the Food and Drug Administration in response to applications by two groups of scientists in New York and Oregon to conduct the experiments. Their goal is to help women have healthy babies even though they come from families plagued by genetic disorders.\u003c/p>\n\u003cp>A statement issued by the FDA immediately after the report's release raised questions about whether the FDA would permit the research to move forward.\u003c/p>\n\u003cp>The FDA email praised the \"thoughtful work\" of the panel and said the agency would be \"reviewing\" the recommendations. But it noted that the latest federal budget \"prevents the FDA from using funds to review applications in which a human embryo is intentionally created or modified to include\" changes that could be passed down to future generations. As a result, the email says, any such research \"cannot be performed in the United States\" at this time.\u003c/p>\n\u003cp>The researchers pursuing these experiments welcomed the panel's conclusions.\u003c/p>\n\u003cp>\"I think it's a great step in the right direction,\" \u003ca href=\"http://www.columbiaobgyn.org/doctor/mark-v-sauer#.VrFk2bIrLIU\">Mark Sauer\u003c/a>, a professor of obstetrics and gynecology at Columbia University who is a member of one of the teams, said of the National Academies report in an interview before the FDA issued its statement\u003cem>.\u003c/em>\u003c/p>\n\u003cp>Sauer called the report more of a \"yellow light\" than a \"green light,\" because of the long list of caveats and cautions. But that is \"better than a red light,\" he says.\u003c/p>\n\u003cp>\"Most importantly to us is that it allows the work to continue to hopefully produce children without these disorders,\" Sauer says.\u003c/p>\n\u003cp>But Sauer said he was disappointed when he learned of the FDA's response.\u003c/p>\n\u003cp>\"Politics as usual often gets in way of progress,\" Sauer said in a subsequent email. While the FDA statement would cause \"undue delays\" in his research, he added that he hoped it wouldn't permanently \"necessarily halt the efforts.\"\u003c/p>\n\u003cp>Critics of the research, meanwhile, say the number of women who could benefit from the experiments is so small that it's not worth crossing a line that's long been considered off-limits — making genetic changes that could be passed down for generations.\u003c/p>\n\u003cp>\"The possibility of what you could call 'mission creep' is very real,\" says \u003ca href=\"http://www.geneticsandsociety.org/article.php?id=2081\">Marcy Darnovsky\u003c/a>, executive director of the Center for Genetics and Society, a watchdog group based in Berkeley, Calif. \"People are talking about going forward not just with this but with the kind of genetic engineering that will produce outright genetically modified human beings.\"\u003c/p>\n\u003cp>Once that happens, Darnovsky says, \"I think you get into a situation of where some people are genetically enhanced and other people are the regular old variety of human being. And I don't think that's a world we want to live in.\"\u003c/p>\n\u003cp>The goal of the research is to help women carrying diseases known as \u003ca href=\"http://mitochondrialdiseases.org/mitochondrial-disease/\">mitochondrial disorders\u003c/a>, which are only passed down by women through defects in the genetic material in their eggs.\u003c/p>\n\u003cp>Specifically, the defects are in a type of genetic material known as \u003ca href=\"http://www.umdf.org/site/pp.aspx?c=8qKOJ0MvF7LUG&b=7934627\">mitochondrial DNA\u003c/a>.\u003c/p>\n\u003cp>Unlike the DNA that most people are familiar with — the 23 pairs of human chromosomes that program most of our body processes and traits — mitochondrial DNA consists of just 37 genes inside mitochondria, which are structures inside cells that provide their energy.\u003c/p>\n\u003cp>Mitochondrial disorders range from mild to severe. In many cases there is no treatment, and the affected child dies early in life after suffering progressive, debilitating symptoms.\u003c/p>\n\u003cp>Scientists want to create eggs free of mitochondrial defects by removing the defective mitochondrial DNA. It would be replaced with healthy mitochondrial DNA from eggs donated by other women.\u003c/p>\n\u003cp>The British government recently \u003ca href=\"http://www.npr.org/2015/02/03/383578221/u-k-lawmakers-allow-scientists-to-attempt-dna-transplants\">approved\u003c/a> such experiments in that country.\u003c/p>\n\u003cp>But this remains \u003ca href=\"http://www.npr.org/sections/health-shots/2014/11/10/360342623/combining-the-dna-of-three-people-raises-ethical-questions\">controversial\u003c/a>, not only due to the fact that the resulting children would have DNA from three people. Because the transplanted DNA could be passed down for generations, critics fear it could accidentally introduce errors into the human gene pool that could create new diseases.\u003c/p>\n\u003cp>They also worry it would set a precedent that could open the door to creating designer babies, in which parents can pick and chose the traits of their children.\u003c/p>\n\u003cp>Because of such concerns, making any change in DNA that could be passed down for generations has long been considered off-limits.\u003c/p>\n\u003cp>The committee report acknowledged that making babies with DNA from three different people could have \"psychological and social effects\" on the offspring, including issues about their \"conception of identity.\"\u003c/p>\n\u003cp>In addition, the committee acknowledged the possibility that it could lead to attempts at genetic \"enhancements.\"\u003c/p>\n\u003cp>Such work would raise thorny regulatory issues, the committee noted. For example, the federal government is prohibited from funding research that involves destroying human embryos. As a result, \"even an agency request\" for data from such research in support of FDA approval \"could well be controversial,\" the report says.\u003c/p>\n\u003cp>Nevertheless, the committee says the potential benefits make the work worth pursuing with careful oversight.\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Moreover, the FDA could at some point even consider letting experiments proceed to try to create female babies if certain criteria are met, the report said, including the production of \"clear evidence of safety and efficacy from male\" experiments and signs that it would be publicly acceptable.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Babies+With+Genes+From+3+People+Could+Be+Ethical%2C+Panel+Says&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/div>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Would it be ethical for scientists to try to create babies that have genetic material from three different people? An influential panel of experts has concluded the answer could be yes.\u003c/p>\n\u003cp>The 12-member panel, assembled by the National Academies of Sciences, Engineering and Medicine, released a 164-page \u003ca href=\"http://www.nap.edu/catalog/21871/mitochondrial-replacement-techniques-ethical-social-and-policy-considerations\">report\u003c/a> Wednesday outlining a plan for how scientists could ethically pursue the controversial research.\u003c/p>\n\u003cp>\"The committee concludes that it is ethically permissible\" to conduct such experiments, the report says, but then goes on to detail a long list of conditions that would have to be met first.\u003c/p>\n\u003cp>For example, scientists would have to perform extensive preliminary research in the laboratory and with animals to try to make sure it is safe. And then researchers should initially try to make only male babies, because they would be incapable of passing their unusual amalgamation of DNA on to future generations.\u003c/p>\n\u003cp>\"Minimizing risk to future children should be of highest priority,\" the committee writes.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>The report was \u003ca href=\"http://www.npr.org/sections/health-shots/2013/10/09/229167219/proposed-treatment-to-fix-genetic-diseases-raising-ethics-issues\">requested \u003c/a>by the Food and Drug Administration in response to applications by two groups of scientists in New York and Oregon to conduct the experiments. Their goal is to help women have healthy babies even though they come from families plagued by genetic disorders.\u003c/p>\n\u003cp>A statement issued by the FDA immediately after the report's release raised questions about whether the FDA would permit the research to move forward.\u003c/p>\n\u003cp>The FDA email praised the \"thoughtful work\" of the panel and said the agency would be \"reviewing\" the recommendations. But it noted that the latest federal budget \"prevents the FDA from using funds to review applications in which a human embryo is intentionally created or modified to include\" changes that could be passed down to future generations. As a result, the email says, any such research \"cannot be performed in the United States\" at this time.\u003c/p>\n\u003cp>The researchers pursuing these experiments welcomed the panel's conclusions.\u003c/p>\n\u003cp>\"I think it's a great step in the right direction,\" \u003ca href=\"http://www.columbiaobgyn.org/doctor/mark-v-sauer#.VrFk2bIrLIU\">Mark Sauer\u003c/a>, a professor of obstetrics and gynecology at Columbia University who is a member of one of the teams, said of the National Academies report in an interview before the FDA issued its statement\u003cem>.\u003c/em>\u003c/p>\n\u003cp>Sauer called the report more of a \"yellow light\" than a \"green light,\" because of the long list of caveats and cautions. But that is \"better than a red light,\" he says.\u003c/p>\n\u003cp>\"Most importantly to us is that it allows the work to continue to hopefully produce children without these disorders,\" Sauer says.\u003c/p>\n\u003cp>But Sauer said he was disappointed when he learned of the FDA's response.\u003c/p>\n\u003cp>\"Politics as usual often gets in way of progress,\" Sauer said in a subsequent email. While the FDA statement would cause \"undue delays\" in his research, he added that he hoped it wouldn't permanently \"necessarily halt the efforts.\"\u003c/p>\n\u003cp>Critics of the research, meanwhile, say the number of women who could benefit from the experiments is so small that it's not worth crossing a line that's long been considered off-limits — making genetic changes that could be passed down for generations.\u003c/p>\n\u003cp>\"The possibility of what you could call 'mission creep' is very real,\" says \u003ca href=\"http://www.geneticsandsociety.org/article.php?id=2081\">Marcy Darnovsky\u003c/a>, executive director of the Center for Genetics and Society, a watchdog group based in Berkeley, Calif. \"People are talking about going forward not just with this but with the kind of genetic engineering that will produce outright genetically modified human beings.\"\u003c/p>\n\u003cp>Once that happens, Darnovsky says, \"I think you get into a situation of where some people are genetically enhanced and other people are the regular old variety of human being. And I don't think that's a world we want to live in.\"\u003c/p>\n\u003cp>The goal of the research is to help women carrying diseases known as \u003ca href=\"http://mitochondrialdiseases.org/mitochondrial-disease/\">mitochondrial disorders\u003c/a>, which are only passed down by women through defects in the genetic material in their eggs.\u003c/p>\n\u003cp>Specifically, the defects are in a type of genetic material known as \u003ca href=\"http://www.umdf.org/site/pp.aspx?c=8qKOJ0MvF7LUG&b=7934627\">mitochondrial DNA\u003c/a>.\u003c/p>\n\u003cp>Unlike the DNA that most people are familiar with — the 23 pairs of human chromosomes that program most of our body processes and traits — mitochondrial DNA consists of just 37 genes inside mitochondria, which are structures inside cells that provide their energy.\u003c/p>\n\u003cp>Mitochondrial disorders range from mild to severe. In many cases there is no treatment, and the affected child dies early in life after suffering progressive, debilitating symptoms.\u003c/p>\n\u003cp>Scientists want to create eggs free of mitochondrial defects by removing the defective mitochondrial DNA. It would be replaced with healthy mitochondrial DNA from eggs donated by other women.\u003c/p>\n\u003cp>The British government recently \u003ca href=\"http://www.npr.org/2015/02/03/383578221/u-k-lawmakers-allow-scientists-to-attempt-dna-transplants\">approved\u003c/a> such experiments in that country.\u003c/p>\n\u003cp>But this remains \u003ca href=\"http://www.npr.org/sections/health-shots/2014/11/10/360342623/combining-the-dna-of-three-people-raises-ethical-questions\">controversial\u003c/a>, not only due to the fact that the resulting children would have DNA from three people. Because the transplanted DNA could be passed down for generations, critics fear it could accidentally introduce errors into the human gene pool that could create new diseases.\u003c/p>\n\u003cp>They also worry it would set a precedent that could open the door to creating designer babies, in which parents can pick and chose the traits of their children.\u003c/p>\n\u003cp>Because of such concerns, making any change in DNA that could be passed down for generations has long been considered off-limits.\u003c/p>\n\u003cp>The committee report acknowledged that making babies with DNA from three different people could have \"psychological and social effects\" on the offspring, including issues about their \"conception of identity.\"\u003c/p>\n\u003cp>In addition, the committee acknowledged the possibility that it could lead to attempts at genetic \"enhancements.\"\u003c/p>\n\u003cp>Such work would raise thorny regulatory issues, the committee noted. For example, the federal government is prohibited from funding research that involves destroying human embryos. As a result, \"even an agency request\" for data from such research in support of FDA approval \"could well be controversial,\" the report says.\u003c/p>\n\u003cp>Nevertheless, the committee says the potential benefits make the work worth pursuing with careful oversight.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Moreover, the FDA could at some point even consider letting experiments proceed to try to create female babies if certain criteria are met, the report said, including the production of \"clear evidence of safety and efficacy from male\" experiments and signs that it would be publicly acceptable.\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2016 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=Babies+With+Genes+From+3+People+Could+Be+Ethical%2C+Panel+Says&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>https://www.youtube.com/watch?v=zSgwJA-GOlg\u003c/p>\n\u003cp>The blood-testing firm Theranos has pushed back fiercely on The Wall Street Journal's reporting on a host of irregularities it found with the company's cheaper, less-intrusive blood-tests. In one \u003ca href=\"https://www.theranos.com/news/posts/statement-from-theranos-5\" target=\"_blank\">statement\u003c/a>, Theranos called a particular story \"inaccurate, misleading and defamatory.\"\u003c/p>\n\u003cp>So we thought this long interview with the Journal reporter who's written those stories was interesting. John Carreyrou appeared last week on the video podcast \"This Week in Startups,\" hosted by investor and entrepreneur Jason Calicanis. In the interview, Carreyrou defends his reporting and recaps some of his findings. He also says he repeatedly \u003ca href=\"https://www.youtube.com/watch?v=LqEmGEKFMxY&ab_channel=ThisWeekInStartups\" target=\"_blank\">tried to interview Theranos founder Elizabeth Holmes\u003c/a> but was rebuffed. You can see \u003ca href=\"https://www.youtube.com/user/ThisWeekIn/videos?&ab_channel=ThisWeekInStartups\" target=\"_blank\">selected clips from the interview here\u003c/a>, including one in which he talks about the \u003ca href=\"https://www.youtube.com/watch?v=RPwj4WJMbFg&ab_channel=ThisWeekInStartups\" target=\"_blank\">Journal's vetting process\u003c/a>.\u003c/p>\n\u003cp>Keep in mind Calicanis himself is a big critic of Theranos. He is not the most objective interviewer. (And you'll also have to sit through some ads.) Also keep in mind, again, that Theranos denies the claims made in the reports, which include allegations that the company hid test results and data that cast doubt on the accuracy of its technology.\u003c/p>\n\u003cp>\u003cstrong>To Recap...\u003c/strong>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>For those unfamiliar with the story:\u003c/p>\n\u003cp>Last year, Theranos was valued at $9 billion, making then 31-year-old founder Elizabeth Holmes the world's youngest female billionaire, according to \u003ca href=\"http://www.forbes.com/sites/matthewherper/2015/07/15/giving-theranos-a-few-tests/#1448085d1721\" target=\"_blank\">Forbes\u003c/a>. Driving the investor rush: The company's claim that it could provide cheaper, less-intrusive blood tests.\u003c/p>\n\u003cp>But in a foreshadowing of what was to come, Forbes science and medicine reporter Matthew Herper wrote: \"How much is real and how much is hype? ... I still have no idea how Theranos’ technology works.\"\u003c/p>\n\u003cp>Nobody outside the company knew either. Now, the consensus leans more toward \"hype\" than \"real,\" thanks to Carryrou's \u003ca href=\"https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=wall+street+journal+theranos\" target=\"_blank\">stories \u003c/a>and a federal government's inspection finding that the company's Newark, California lab posed \"immediate jeopardy\" to patients.\u003c/p>\n\u003cp>Theranos says the lab is under new management and that it's remediated problems there. It has until Friday to respond to the Centers for Medicare & Medicaid Services with a plan to correct deficiencies at the lab. CMS says a report will be released after that plan is reviewed and accepted, but it doesn't have a timeframe for when that will be.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Theranos has declined to say if it will make its plan public.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/zSgwJA-GOlg'\n title='//www.youtube.com/embed/zSgwJA-GOlg'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>The blood-testing firm Theranos has pushed back fiercely on The Wall Street Journal's reporting on a host of irregularities it found with the company's cheaper, less-intrusive blood-tests. In one \u003ca href=\"https://www.theranos.com/news/posts/statement-from-theranos-5\" target=\"_blank\">statement\u003c/a>, Theranos called a particular story \"inaccurate, misleading and defamatory.\"\u003c/p>\n\u003cp>So we thought this long interview with the Journal reporter who's written those stories was interesting. John Carreyrou appeared last week on the video podcast \"This Week in Startups,\" hosted by investor and entrepreneur Jason Calicanis. In the interview, Carreyrou defends his reporting and recaps some of his findings. He also says he repeatedly \u003ca href=\"https://www.youtube.com/watch?v=LqEmGEKFMxY&ab_channel=ThisWeekInStartups\" target=\"_blank\">tried to interview Theranos founder Elizabeth Holmes\u003c/a> but was rebuffed. You can see \u003ca href=\"https://www.youtube.com/user/ThisWeekIn/videos?&ab_channel=ThisWeekInStartups\" target=\"_blank\">selected clips from the interview here\u003c/a>, including one in which he talks about the \u003ca href=\"https://www.youtube.com/watch?v=RPwj4WJMbFg&ab_channel=ThisWeekInStartups\" target=\"_blank\">Journal's vetting process\u003c/a>.\u003c/p>\n\u003cp>Keep in mind Calicanis himself is a big critic of Theranos. He is not the most objective interviewer. (And you'll also have to sit through some ads.) Also keep in mind, again, that Theranos denies the claims made in the reports, which include allegations that the company hid test results and data that cast doubt on the accuracy of its technology.\u003c/p>\n\u003cp>\u003cstrong>To Recap...\u003c/strong>\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>For those unfamiliar with the story:\u003c/p>\n\u003cp>Last year, Theranos was valued at $9 billion, making then 31-year-old founder Elizabeth Holmes the world's youngest female billionaire, according to \u003ca href=\"http://www.forbes.com/sites/matthewherper/2015/07/15/giving-theranos-a-few-tests/#1448085d1721\" target=\"_blank\">Forbes\u003c/a>. Driving the investor rush: The company's claim that it could provide cheaper, less-intrusive blood tests.\u003c/p>\n\u003cp>But in a foreshadowing of what was to come, Forbes science and medicine reporter Matthew Herper wrote: \"How much is real and how much is hype? ... I still have no idea how Theranos’ technology works.\"\u003c/p>\n\u003cp>Nobody outside the company knew either. Now, the consensus leans more toward \"hype\" than \"real,\" thanks to Carryrou's \u003ca href=\"https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=wall+street+journal+theranos\" target=\"_blank\">stories \u003c/a>and a federal government's inspection finding that the company's Newark, California lab posed \"immediate jeopardy\" to patients.\u003c/p>\n\u003cp>Theranos says the lab is under new management and that it's remediated problems there. It has until Friday to respond to the Centers for Medicare & Medicaid Services with a plan to correct deficiencies at the lab. CMS says a report will be released after that plan is reviewed and accepted, but it doesn't have a timeframe for when that will be.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Theranos has declined to say if it will make its plan public.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Would You See a Holographic Doctor?",
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"content": "\u003cp>Imagine if instead of schlepping across town to your physician's office, spending a half-hour in the waiting room leafing through a year-old National Geographic, and spending just long enough with the doc to get a prescription, you could instead request a personal house call in the form of a hologram. Or talk to an artificial representation not only possessing your doctor's knowledge, but all the research contained in medical databases.\u003c/p>\n\u003caside class=\"“pullquote alignright\">\"We can take care of more and more patients virtually and save the brick and mortar visits for those that really need it.”\u003c/aside>\n\u003cp>Well, if the “virtual care clinic,” now in the works at the University of Southern California, opens for business sometime later this year, we're going to find out.\u003c/p>\n\u003cp>The plan is to combine real physicians, their visual representations, and artificial intelligence into one badass caregiver, providing patients access to not only a wealth of routine and specialized information, but also to virtual doctors who don’t get cranky when you ask, “So can I, like, die from this?\" Patients will transmit information about their physical condition through body sensors.\u003c/p>\n\u003cp>What will this look like? Well, take a look at the videos below, where you'll see patients who want more information about their condition or treatment as they connect with electronic versions of their physicians.\u003c/p>\n\u003cp>In the first demo, a video version of a real doctor asks the patient which treatment outcomes concern him the most. When he chooses “survival mortality,” the \"doctor\" searches its database and pulls studies of patients with a similar profile. She then reports that a new medication for his condition reduced mortality 9 percent more than an older treatment. That, coupled with a reduced risk of stroke, leads the virtual physician to recommend the newer medication.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=1YOX9Bh3jR8\u003c/p>\n\u003cp>In this demo, an avatar with a computer-generated voice gives a patient with prostate cancer the mortality rate for radical prostatectomy as compared to the rate for active surveillance.\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=Mt8Hfy9A8zg\u003c/p>\n\u003cp>And apparently holograms are also on the table ...\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=61xd07vxev8\u003c/p>\n\u003cp>“By allowing people to access doctors on their own time, it can create an interaction that’s been missing from medicine,” said Dr. Leslie Saxon, the executive director of the University of Southern California's Center for Body Computing, which is creating the clinic in partnership with the USC Institute for Creative Technologies and Keck Medicine of USC. In addition, there are eight “\u003ca href=\"http://www.prnewswire.com/news-releases/the-next-level-of-on-demand-expert-medical-care-is-here-usc-center-for-body-computing-announces-its-virtual-care-clinic-vcc-in-collaboration-with-eight-strategic-partners-for-an-anytime-anywhere-disruptive-health-care-model--300210442.html\" target=\"_blank\">foundational partners\u003c/a>,\" which the clinic announced last week.\u003c/p>\n\u003cp>Saxon believes this sort of remote, virtual care will become the \"dominant global health care solution\" because of the benefits it will provide for physicians, patients and the bottom line.\u003c/p>\n\u003cp>By “virtualizing” the knowledge set of experts, she said, “we can provide access to [them] at a fraction of the cost. We can take care of more and more patients virtually and save the brick and mortar visits for those that really need it.”\u003c/p>\n\u003cp>Saxon also thinks enabling appointments from anywhere patients can use a smartphone will relieve many of the burdens involved in traditional encounters, including having to leave work to travel to the doctor and the inability to have all concerns addressed in a time-sensitive, sometimes intimidating environment.\u003c/p>\n\u003cp>Then there's the democratizing aspect.\u003c/p>\n\u003cp>“There are only so many medical experts in the world,” Saxon told the Voice of America in an \u003ca href=\"http://www.voanews.com/content/virtual-medical-clinic-equalize-health-care/3168894.html\" target=\"_blank\">interview\u003c/a>, \"and we're never going to have enough to supply the need of the entire world. So we can clone, if you will, many of the experts to provide care anywhere anytime, without borders.\"\u003c/p>\n\u003cp>\u003cstrong>What About The Human Element?\u003c/strong>\u003c/p>\n\u003cp>All right. Do I really want a computer to compel me to “say ahh”?\u003c/p>\n\u003cp>“We’re not saying you don’t need [human interaction],” Saxon said. “But you don’t need it for everything. What people like is convenience and continuous access.”\u003c/p>\n\u003cp>Saxon said the early data shows patients have responded well to this type of interaction.\u003c/p>\n\u003cp>One of the reasons, perhaps: a virtual doctor doesn’t get annoyed.\u003c/p>\n\u003cp>“I’m a cardiologist,\" Saxon says \"I see 30 patients at a clinic, I’m describing the same information a lot. Do you think I’m as fresh at 4 p.m. as I am at 8 a.m.? I like the idea of being able to standardize my behavior and conduct. \"\u003c/p>\n\u003cp>\u003cstrong>What About Privacy?\u003c/strong>\u003c/p>\n\u003cp>Considering that all these interactions would take place online, I asked Saxon how the clinic could ensure privacy.\u003c/p>\n\u003cp>“We work only with HIPAA compliant partners that have a high level of security required for the transfer and storage of digital health data,” she said\u003c/p>\n\u003cp>\u003cb>What Do Doctors Think About \"Being Virtualized?\"\u003c/b>\u003c/p>\n\u003cp>When I described the virtual clinic to the AMA, it seemed a bit like, \"that's a new one on us.\" But I sent some info and they emailed me back a response, \"While the AMA has not reviewed the virtual health service that you describe, we would be interested in how this health care delivery model is addressing some of the challenges that occur in telehealth: no serious history-taking, no patient evaluation to guide a proper diagnosis, no counseling, no monitoring or assessment of a treatment, and no semblance of a true patient-physician relationship.\"\u003c/p>\n\u003cp>I also wondered how a regular doctor, not particularly connected to the tech world and who has seen a ton of patients, would react to the ideas in play here. My pal Dan O’Connell, an assistant professor of family medicine at Montefiore Medical Center in the Bronx, New York, fit the bill. He sees about 25 patients per week and supervises residents who treat about 45 more patients. Most of this clientele is low-income.\u003c/p>\n\u003cp>He wasn’t particularly impressed by the demonstration videos. One of the main tasks of any medical interaction, he said, is to see if the patient actually understands what you are talking about.\u003c/p>\n\u003cp>“The virtual doctors are only some pre-set scripts with no interaction or intelligence at all,” he said. “Most effective education is an interactive conversation.\"\u003c/p>\n\u003cp>He thought the demonstration of the doctor providing the respective mortality rates for Coumadin and New Oral Anticoagulants showed the system’s limitations.\u003c/p>\n\u003cp>“Because the \u003cem>conversation\u003c/em> is so central to the doctor-patient relationship, this particular example is useless -- it spends a lot of time and clicks to basically say, ‘the very expensive one is slightly better’ without individualizing.”\u003c/p>\n\u003cp>“I'm sure they will get better at this,” he said, “but the early basic assumptions -- that patients want an avatar to translate epidemiology into high school math -- misses what people want from their health provider.”\u003c/p>\n\u003cp>I guess we'll have to see how patients respond. If enough like this model of care, well ...\u003c/p>\n\u003cp>Remember this guy from Star Trek Voyager?\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>https://www.youtube.com/watch?v=vr0OHhA6rGs\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>Imagine if instead of schlepping across town to your physician's office, spending a half-hour in the waiting room leafing through a year-old National Geographic, and spending just long enough with the doc to get a prescription, you could instead request a personal house call in the form of a hologram. Or talk to an artificial representation not only possessing your doctor's knowledge, but all the research contained in medical databases.\u003c/p>\n\u003caside class=\"“pullquote alignright\">\"We can take care of more and more patients virtually and save the brick and mortar visits for those that really need it.”\u003c/aside>\n\u003cp>Well, if the “virtual care clinic,” now in the works at the University of Southern California, opens for business sometime later this year, we're going to find out.\u003c/p>\n\u003cp>The plan is to combine real physicians, their visual representations, and artificial intelligence into one badass caregiver, providing patients access to not only a wealth of routine and specialized information, but also to virtual doctors who don’t get cranky when you ask, “So can I, like, die from this?\" Patients will transmit information about their physical condition through body sensors.\u003c/p>\n\u003cp>What will this look like? Well, take a look at the videos below, where you'll see patients who want more information about their condition or treatment as they connect with electronic versions of their physicians.\u003c/p>\n\u003cp>In the first demo, a video version of a real doctor asks the patient which treatment outcomes concern him the most. When he chooses “survival mortality,” the \"doctor\" searches its database and pulls studies of patients with a similar profile. She then reports that a new medication for his condition reduced mortality 9 percent more than an older treatment. That, coupled with a reduced risk of stroke, leads the virtual physician to recommend the newer medication.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/1YOX9Bh3jR8'\n title='//www.youtube.com/embed/1YOX9Bh3jR8'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>In this demo, an avatar with a computer-generated voice gives a patient with prostate cancer the mortality rate for radical prostatectomy as compared to the rate for active surveillance.\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/Mt8Hfy9A8zg'\n title='//www.youtube.com/embed/Mt8Hfy9A8zg'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>And apparently holograms are also on the table ...\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/61xd07vxev8'\n title='//www.youtube.com/embed/61xd07vxev8'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>“By allowing people to access doctors on their own time, it can create an interaction that’s been missing from medicine,” said Dr. Leslie Saxon, the executive director of the University of Southern California's Center for Body Computing, which is creating the clinic in partnership with the USC Institute for Creative Technologies and Keck Medicine of USC. In addition, there are eight “\u003ca href=\"http://www.prnewswire.com/news-releases/the-next-level-of-on-demand-expert-medical-care-is-here-usc-center-for-body-computing-announces-its-virtual-care-clinic-vcc-in-collaboration-with-eight-strategic-partners-for-an-anytime-anywhere-disruptive-health-care-model--300210442.html\" target=\"_blank\">foundational partners\u003c/a>,\" which the clinic announced last week.\u003c/p>\n\u003cp>Saxon believes this sort of remote, virtual care will become the \"dominant global health care solution\" because of the benefits it will provide for physicians, patients and the bottom line.\u003c/p>\n\u003cp>By “virtualizing” the knowledge set of experts, she said, “we can provide access to [them] at a fraction of the cost. We can take care of more and more patients virtually and save the brick and mortar visits for those that really need it.”\u003c/p>\n\u003cp>Saxon also thinks enabling appointments from anywhere patients can use a smartphone will relieve many of the burdens involved in traditional encounters, including having to leave work to travel to the doctor and the inability to have all concerns addressed in a time-sensitive, sometimes intimidating environment.\u003c/p>\n\u003cp>Then there's the democratizing aspect.\u003c/p>\n\u003cp>“There are only so many medical experts in the world,” Saxon told the Voice of America in an \u003ca href=\"http://www.voanews.com/content/virtual-medical-clinic-equalize-health-care/3168894.html\" target=\"_blank\">interview\u003c/a>, \"and we're never going to have enough to supply the need of the entire world. So we can clone, if you will, many of the experts to provide care anywhere anytime, without borders.\"\u003c/p>\n\u003cp>\u003cstrong>What About The Human Element?\u003c/strong>\u003c/p>\n\u003cp>All right. Do I really want a computer to compel me to “say ahh”?\u003c/p>\n\u003cp>“We’re not saying you don’t need [human interaction],” Saxon said. “But you don’t need it for everything. What people like is convenience and continuous access.”\u003c/p>\n\u003cp>Saxon said the early data shows patients have responded well to this type of interaction.\u003c/p>\n\u003cp>One of the reasons, perhaps: a virtual doctor doesn’t get annoyed.\u003c/p>\n\u003cp>“I’m a cardiologist,\" Saxon says \"I see 30 patients at a clinic, I’m describing the same information a lot. Do you think I’m as fresh at 4 p.m. as I am at 8 a.m.? I like the idea of being able to standardize my behavior and conduct. \"\u003c/p>\n\u003cp>\u003cstrong>What About Privacy?\u003c/strong>\u003c/p>\n\u003cp>Considering that all these interactions would take place online, I asked Saxon how the clinic could ensure privacy.\u003c/p>\n\u003cp>“We work only with HIPAA compliant partners that have a high level of security required for the transfer and storage of digital health data,” she said\u003c/p>\n\u003cp>\u003cb>What Do Doctors Think About \"Being Virtualized?\"\u003c/b>\u003c/p>\n\u003cp>When I described the virtual clinic to the AMA, it seemed a bit like, \"that's a new one on us.\" But I sent some info and they emailed me back a response, \"While the AMA has not reviewed the virtual health service that you describe, we would be interested in how this health care delivery model is addressing some of the challenges that occur in telehealth: no serious history-taking, no patient evaluation to guide a proper diagnosis, no counseling, no monitoring or assessment of a treatment, and no semblance of a true patient-physician relationship.\"\u003c/p>\n\u003cp>I also wondered how a regular doctor, not particularly connected to the tech world and who has seen a ton of patients, would react to the ideas in play here. My pal Dan O’Connell, an assistant professor of family medicine at Montefiore Medical Center in the Bronx, New York, fit the bill. He sees about 25 patients per week and supervises residents who treat about 45 more patients. Most of this clientele is low-income.\u003c/p>\n\u003cp>He wasn’t particularly impressed by the demonstration videos. One of the main tasks of any medical interaction, he said, is to see if the patient actually understands what you are talking about.\u003c/p>\n\u003cp>“The virtual doctors are only some pre-set scripts with no interaction or intelligence at all,” he said. “Most effective education is an interactive conversation.\"\u003c/p>\n\u003cp>He thought the demonstration of the doctor providing the respective mortality rates for Coumadin and New Oral Anticoagulants showed the system’s limitations.\u003c/p>\n\u003cp>“Because the \u003cem>conversation\u003c/em> is so central to the doctor-patient relationship, this particular example is useless -- it spends a lot of time and clicks to basically say, ‘the very expensive one is slightly better’ without individualizing.”\u003c/p>\n\u003cp>“I'm sure they will get better at this,” he said, “but the early basic assumptions -- that patients want an avatar to translate epidemiology into high school math -- misses what people want from their health provider.”\u003c/p>\n\u003cp>I guess we'll have to see how patients respond. If enough like this model of care, well ...\u003c/p>\n\u003cp>Remember this guy from Star Trek Voyager?\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"disqusTitle": "Can Automating Physician Empathy Work?",
"title": "Can Automating Physician Empathy Work?",
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"content": "\u003cp>A health care startup made a wild pitch to Cara Waller, CEO of the Newport Orthopedic Institute. The company said it could get patients more engaged with their care by automating physician empathy.\u003c/p>\n\u003cp>It \"almost made me nauseous,\" she said. How can you automate something as deeply personal as empathy?\u003c/p>\n\u003caside class=\"pullquote alignright\">A patient might receive this automated email: “How are you? Let me know so I can make sure you’re okay.\"\u003c/aside>\n\u003cp>But Waller needed help. Her physicians in Orange County, Calif., perform as many as 500 surgeries a year, manage large numbers of patients at various stages of treatment and recovery. The doctors needed a better way to communicate with patients and track their progress.\u003c/p>\n\u003cp>The California startup, HealthLoop, told Waller its messaging technology would improve patient satisfaction and help keep them out of the hospital. High satisfaction scores and low readmission rates mean higher reimbursements from Medicare. Waller was intrigued and decided to give the technology a try.\u003c/p>\n\u003cp>So far, she's been surprised at patients' enthusiasm for the personalized – but automated — daily emails they receive from their doctors.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"There's a limited number of resources in health care. If you do 500 joint replacements in a year, how do you follow up all of those patients every day?\" Waller said. The technology \"allows you to direct your energy to people who need the hand-holding.\"\u003c/p>\n\u003cp>Though it may sound like an oxymoron, \"automating empathy\" is becoming a catchphrase in health care. The goal is to help doctors stay in touch with patients cheaply and with minimal effort.\u003c/p>\n\u003cp>Automated empathy is a powerful draw for hospitals and other health care providers scrambling to adjust to sweeping changes in how they're paid.\u003c/p>\n\u003cp>Whether the emails actually trigger an empathetic connection or not, the idea of tailoring regular electronic communications to patients counts as an innovation in health care — one that has the potential to save money and improve quality.\u003c/p>\n\u003cp>Companies like HealthLoop are promising that their technologies will help patients stick to treatment and recovery regimens, avoid repeat hospital stays and be more satisfied with their care. Similar companies that aim to improve patient engagement include Wellframe, Curaspan, and Infield Health.\u003c/p>\n\u003cp>HealthLoop's technology is being tested at medical centers that include the Cleveland Clinic, Kaiser Permanente-Southern California and the University of California, San Francisco.\u003c/p>\n\u003cp>How does it work? Doctors can send daily emails with information timed to milestones in surgery prep and recovery. The emails can ask patients or caregivers for feedback on specific issues that come up during recovery.\u003c/p>\n\u003cp>The doctors may write their own email scripts, as Newport Orthopedics' physicians did, or use the company's suggestions. An online dashboard helps doctors and administrators keep track of which patients are doing well and who might need more follow-up care.\u003c/p>\n\u003cp>A patient might see this message: \"How are you? Let me know so I can make sure you're OK. I have four questions for you today.\" The answers to those questions can trigger a call from the doctor's office.\u003c/p>\n\u003cp>One of those calls may have been a lifesaver for David Larson, a Huntington Beach retiree. After Larson responded \"yes\" to an email that asked if he had calf pain after knee surgery, he got a call from his doctor's office telling him to come in immediately. An ultrasound confirmed he had a blood clot that could have landed him in the hospital — or worse. With treatment, the blood clot dissolved.\u003c/p>\n\u003cp>\"There were times when it was like, 'Oh brother, they're contacting me again,' but none of this would have been caught if it wasn't for the email,\" said Larson, 66. \"So it was more than worth it to me. Now I'm back to walking the dog, surfing, riding a bike.\"\u003c/p>\n\u003cp>How to keep patients like Larson from being readmitted to the hospital because of avoidable complications after a hospital stay has long been a vexing and expensive challenge.\u003c/p>\n\u003cp>Almost 1 in 5 Medicare patients discharged from a hospital — approximately 2.6 million seniors a year – must be readmitted within 30 days, at an annual cost of more than $26 billion, according to the Centers for Medicare and Medicaid Services.\u003c/p>\n\u003cp>For decades, hospitals had no financial incentive to keep patients out of the hospital after they were discharged. But under the Affordable Care Act, penalties were established for hospitals with readmission rates higher than the national average for certain conditions.\u003c/p>\n\u003cp>Also under the ACA, hospitals are financially rewarded for high scores on patient satisfaction scores and good performance on other quality measures.\u003c/p>\n\u003cp>The sea change is affecting doctors' groups, either because they are part-owners in hospitals, as Newport Orthopedics is with Hoag Hospital in Newport Beach, Calif., or because they participate in risk-sharing financial partnerships with them.\u003c/p>\n\u003cp>With money on the line, hospitals and other health care providers may be willing to pay for programs like HealthLoop, if the tryouts prove successful. And you could see your own relationship with your physician change as a result, whether you're on Medicare or not: HealthLoop is aimed at all patients, whatever the payment source.\u003c/p>\n\u003cp>Some experts worry that health care providers will come to rely too heavily on electronic communication as a cheap substitute for the hard work of improving the doctor-patient relationship and the quality of care that patients get.\u003c/p>\n\u003cp>\"Automating personalized messages isn't a terrible thing; we all get some of that in our everyday lives,\" said Michael Millenson, a health industry consultant. \"The real question is whether this kind of automated messaging is in conjunction with a cultural change in how doctors think about their patients or not.\"\u003c/p>\n\u003cp>Health care providers have experimented, with varying success, with ways to prevent complications that can lead to re-admissions, said Kristin Carman, vice president of health policy research at the American Institutes for Research.\u003c/p>\n\u003cp>Robocalls reminding you to take your medicine, for example, don't seem to be very effective. And the new technologies don't always address demographic, cultural and language barriers that can prevent patients from communicating with their doctors. For now, HealthLoop is only available in English.\u003c/p>\n\u003cp>Dr. Jordan Shlain, a San Francisco internist, said he founded HealthLoop because he wanted a simple way to keep track of his patients' progress after a hospital visit or procedure.\u003c/p>\n\u003cp>\"Every human has the same kind of trajectory of concerns and anxieties with regard to medical situations,\" Shlain said. \"You know your doctor can't email you every day; you know your doctor usually will not call you. Now you're in a world where your doctor says I'd like to use this system to stay in touch with you and guide you through your recovery.\"\u003c/p>\n\u003cp>Dr. Thomas Vail, professor and chairman of the department of orthopedic surgery at the University of California, San Francisco would agree – up to a point.\u003c/p>\n\u003cp>With his UCSF colleagues, Vail is testing HealthLoop's system with his patients, and the university will be evaluating whether patients who use it experience fewer problems.\u003c/p>\n\u003cp>UCSF helped create some of the language for the automated emails and has a financial relationship with the company, said Dr. Aenor Sawyer, who directs UCSF's Skeletal Health Service and is a leader at the university's Center for Digital Health Innovation.\u003c/p>\n\u003cp>While Vail thinks HealthLoop is potentially promising, he's cautious about its role in his practice. \"I don't think it substitutes for face-to-face communication,\" Vail said, \"but it does help us collectively to not overlook something that might be important.\"\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>\u003cem>This story was produced by Kaiser Health News, which publishes California Healthline, a service of the California HealthCare Foundation.\u003c/em>\u003c/p>\n\n",
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"nprByline": "Barbara Feder Ostrov\u003cbr />California Healthline",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>A health care startup made a wild pitch to Cara Waller, CEO of the Newport Orthopedic Institute. The company said it could get patients more engaged with their care by automating physician empathy.\u003c/p>\n\u003cp>It \"almost made me nauseous,\" she said. How can you automate something as deeply personal as empathy?\u003c/p>\n\u003caside class=\"pullquote alignright\">A patient might receive this automated email: “How are you? Let me know so I can make sure you’re okay.\"\u003c/aside>\n\u003cp>But Waller needed help. Her physicians in Orange County, Calif., perform as many as 500 surgeries a year, manage large numbers of patients at various stages of treatment and recovery. The doctors needed a better way to communicate with patients and track their progress.\u003c/p>\n\u003cp>The California startup, HealthLoop, told Waller its messaging technology would improve patient satisfaction and help keep them out of the hospital. High satisfaction scores and low readmission rates mean higher reimbursements from Medicare. Waller was intrigued and decided to give the technology a try.\u003c/p>\n\u003cp>So far, she's been surprised at patients' enthusiasm for the personalized – but automated — daily emails they receive from their doctors.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"There's a limited number of resources in health care. If you do 500 joint replacements in a year, how do you follow up all of those patients every day?\" Waller said. The technology \"allows you to direct your energy to people who need the hand-holding.\"\u003c/p>\n\u003cp>Though it may sound like an oxymoron, \"automating empathy\" is becoming a catchphrase in health care. The goal is to help doctors stay in touch with patients cheaply and with minimal effort.\u003c/p>\n\u003cp>Automated empathy is a powerful draw for hospitals and other health care providers scrambling to adjust to sweeping changes in how they're paid.\u003c/p>\n\u003cp>Whether the emails actually trigger an empathetic connection or not, the idea of tailoring regular electronic communications to patients counts as an innovation in health care — one that has the potential to save money and improve quality.\u003c/p>\n\u003cp>Companies like HealthLoop are promising that their technologies will help patients stick to treatment and recovery regimens, avoid repeat hospital stays and be more satisfied with their care. Similar companies that aim to improve patient engagement include Wellframe, Curaspan, and Infield Health.\u003c/p>\n\u003cp>HealthLoop's technology is being tested at medical centers that include the Cleveland Clinic, Kaiser Permanente-Southern California and the University of California, San Francisco.\u003c/p>\n\u003cp>How does it work? Doctors can send daily emails with information timed to milestones in surgery prep and recovery. The emails can ask patients or caregivers for feedback on specific issues that come up during recovery.\u003c/p>\n\u003cp>The doctors may write their own email scripts, as Newport Orthopedics' physicians did, or use the company's suggestions. An online dashboard helps doctors and administrators keep track of which patients are doing well and who might need more follow-up care.\u003c/p>\n\u003cp>A patient might see this message: \"How are you? Let me know so I can make sure you're OK. I have four questions for you today.\" The answers to those questions can trigger a call from the doctor's office.\u003c/p>\n\u003cp>One of those calls may have been a lifesaver for David Larson, a Huntington Beach retiree. After Larson responded \"yes\" to an email that asked if he had calf pain after knee surgery, he got a call from his doctor's office telling him to come in immediately. An ultrasound confirmed he had a blood clot that could have landed him in the hospital — or worse. With treatment, the blood clot dissolved.\u003c/p>\n\u003cp>\"There were times when it was like, 'Oh brother, they're contacting me again,' but none of this would have been caught if it wasn't for the email,\" said Larson, 66. \"So it was more than worth it to me. Now I'm back to walking the dog, surfing, riding a bike.\"\u003c/p>\n\u003cp>How to keep patients like Larson from being readmitted to the hospital because of avoidable complications after a hospital stay has long been a vexing and expensive challenge.\u003c/p>\n\u003cp>Almost 1 in 5 Medicare patients discharged from a hospital — approximately 2.6 million seniors a year – must be readmitted within 30 days, at an annual cost of more than $26 billion, according to the Centers for Medicare and Medicaid Services.\u003c/p>\n\u003cp>For decades, hospitals had no financial incentive to keep patients out of the hospital after they were discharged. But under the Affordable Care Act, penalties were established for hospitals with readmission rates higher than the national average for certain conditions.\u003c/p>\n\u003cp>Also under the ACA, hospitals are financially rewarded for high scores on patient satisfaction scores and good performance on other quality measures.\u003c/p>\n\u003cp>The sea change is affecting doctors' groups, either because they are part-owners in hospitals, as Newport Orthopedics is with Hoag Hospital in Newport Beach, Calif., or because they participate in risk-sharing financial partnerships with them.\u003c/p>\n\u003cp>With money on the line, hospitals and other health care providers may be willing to pay for programs like HealthLoop, if the tryouts prove successful. And you could see your own relationship with your physician change as a result, whether you're on Medicare or not: HealthLoop is aimed at all patients, whatever the payment source.\u003c/p>\n\u003cp>Some experts worry that health care providers will come to rely too heavily on electronic communication as a cheap substitute for the hard work of improving the doctor-patient relationship and the quality of care that patients get.\u003c/p>\n\u003cp>\"Automating personalized messages isn't a terrible thing; we all get some of that in our everyday lives,\" said Michael Millenson, a health industry consultant. \"The real question is whether this kind of automated messaging is in conjunction with a cultural change in how doctors think about their patients or not.\"\u003c/p>\n\u003cp>Health care providers have experimented, with varying success, with ways to prevent complications that can lead to re-admissions, said Kristin Carman, vice president of health policy research at the American Institutes for Research.\u003c/p>\n\u003cp>Robocalls reminding you to take your medicine, for example, don't seem to be very effective. And the new technologies don't always address demographic, cultural and language barriers that can prevent patients from communicating with their doctors. For now, HealthLoop is only available in English.\u003c/p>\n\u003cp>Dr. Jordan Shlain, a San Francisco internist, said he founded HealthLoop because he wanted a simple way to keep track of his patients' progress after a hospital visit or procedure.\u003c/p>\n\u003cp>\"Every human has the same kind of trajectory of concerns and anxieties with regard to medical situations,\" Shlain said. \"You know your doctor can't email you every day; you know your doctor usually will not call you. Now you're in a world where your doctor says I'd like to use this system to stay in touch with you and guide you through your recovery.\"\u003c/p>\n\u003cp>Dr. Thomas Vail, professor and chairman of the department of orthopedic surgery at the University of California, San Francisco would agree – up to a point.\u003c/p>\n\u003cp>With his UCSF colleagues, Vail is testing HealthLoop's system with his patients, and the university will be evaluating whether patients who use it experience fewer problems.\u003c/p>\n\u003cp>UCSF helped create some of the language for the automated emails and has a financial relationship with the company, said Dr. Aenor Sawyer, who directs UCSF's Skeletal Health Service and is a leader at the university's Center for Digital Health Innovation.\u003c/p>\n\u003cp>While Vail thinks HealthLoop is potentially promising, he's cautious about its role in his practice. \"I don't think it substitutes for face-to-face communication,\" Vail said, \"but it does help us collectively to not overlook something that might be important.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
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"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
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"tagline": "Politics from a personal perspective",
"info": "Political Breakdown is a new series that explores the political intersection of California and the nation. Each week hosts Scott Shafer and Marisa Lagos are joined with a new special guest to unpack politics -- with personality — and offer an insider’s glimpse at how politics happens.",
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"possible": {
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"title": "Possible",
"info": "Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.",
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"pri-the-world": {
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"info": "Each weekday, host Marco Werman and his team of producers bring you the world's most interesting stories in an hour of radio that reminds us just how small our planet really is.",
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"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-World-Podcast-Tile-360x360-1.jpg",
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},
"radiolab": {
"id": "radiolab",
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"info": "A two-time Peabody Award-winner, Radiolab is an investigation told through sounds and stories, and centered around one big idea. In the Radiolab world, information sounds like music and science and culture collide. Hosted by Jad Abumrad and Robert Krulwich, the show is designed for listeners who demand skepticism, but appreciate wonder. WNYC Studios is the producer of other leading podcasts including Freakonomics Radio, Death, Sex & Money, On the Media and many more.",
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},
"reveal": {
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"title": "Reveal",
"info": "Created by The Center for Investigative Reporting and PRX, Reveal is public radios first one-hour weekly radio show and podcast dedicated to investigative reporting. Credible, fact based and without a partisan agenda, Reveal combines the power and artistry of driveway moment storytelling with data-rich reporting on critically important issues. The result is stories that inform and inspire, arming our listeners with information to right injustices, hold the powerful accountable and improve lives.Reveal is hosted by Al Letson and showcases the award-winning work of CIR and newsrooms large and small across the nation. In a radio and podcast market crowded with choices, Reveal focuses on important and often surprising stories that illuminate the world for our listeners.",
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"officialWebsiteLink": "https://www.revealnews.org/episodes/",
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},
"rightnowish": {
"id": "rightnowish",
"title": "Rightnowish",
"tagline": "Art is where you find it",
"info": "Rightnowish digs into life in the Bay Area right now… ish. Journalist Pendarvis Harshaw takes us to galleries painted on the sides of liquor stores in West Oakland. We'll dance in warehouses in the Bayview, make smoothies with kids in South Berkeley, and listen to classical music in a 1984 Cutlass Supreme in Richmond. Every week, Pen talks to movers and shakers about how the Bay Area shapes what they create, and how they shape the place we call home.",
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"order": 16
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},
"science-friday": {
"id": "science-friday",
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