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"content": "\u003cfigure id=\"attachment_21034\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/454076420.jpg\">\u003cimg class=\"size-large wp-image-21034\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/454076420-640x476.jpg\" alt=\"Police officers in Napa prop up a fallen door in front of a damaged building following Sunday's earthquake there. (Justin Sullivan/Getty Images)\" width=\"640\" height=\"476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Police officers in Napa prop up a fallen door in front of a damaged building following Sunday's earthquake there. (Justin Sullivan/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>I don't like earthquakes, yet I live in quake country. It's a paradox.\u003c/p>\n\u003cp>To mitigate my worry, I err on the side of preparedness. But this post is not to lecture you about creating an earthquake kit (\u003ca href=\"http://ww2.kqed.org/news/2014/08/24/how-to-prepare-for-an-earthquake/\" target=\"_blank\">although it's not hard to do\u003c/a>). It's to let you know what to do the moment the shaking starts.\u003c/p>\n\u003cp>And it's to tell you what not to do.\u003c/p>\n\u003cp>Folks, when the shaking starts, do not head to the nearest doorway. I cannot stress this enough: Do not stand in a doorway.\u003c!--more-->\u003c/p>\n\u003cp>I always thought the doorway was safe, too -- until I heard years ago that this is a myth. The idea of the safety of the doorway goes back to the 19th century. Back then in California, lots of homes were built of adobe. The only wood in the house was the wood-framed door. In a major quake, the adobe crumbled. The only thing left standing? The wood framing of the door.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>If you are presently living in a 19th century adobe home, you may stand in your doorway.\u003c/p>\n\u003cp>Otherwise, here's what you do:\u003c/p>\n\u003cp>\u003cstrong>1. Drop, cover and hold on.\u003c/strong>\u003c/p>\n\u003cp>In an earthquake, things fall over, move around and generally fling off shelves. These moving or falling objects can hurt you. Standing in a doorway does not protect you. In addition to stuff flying around, the door will swing back and forth, perhaps violently. The door may strike you, or your fingers may be pinched badly, if you have them jammed in the frame to brace yourself. The door could also fall down, as you see in the photo above.\u003c/p>\n\u003cp>Instead, if you are dropped, covered and holding on, those things flying around are less likely to hurt you. You drop to your knees, so the quake can't knock you down. You cover under a sturdy table or other piece of furniture to protect yourself from falling objects. You hold on, so your protection moves with you.\u003c/p>\n\u003cp style=\"text-align: center\">[\u003cstrong>Related:\u003c/strong> \u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/30/how-will-your-hospital-fare-in-the-next-earthquake/\" target=\"_blank\">How Will Your Hospital Fare in the Next Earthquake?\u003c/a>]\u003c/p>\n\u003cp>\u003cstrong>2. If you're inside, stay inside.\u003c/strong>\u003c/p>\n\u003cp>This is a hard one. But you don't want to go outside in the middle of the shaking -- because even more stuff is likely falling over outside, like bricks, power lines, all kinds of stuff that can really hurt you.\u003c/p>\n\u003cp>\u003cstrong>3. If you're in bed, stay in bed\u003c/strong> (unless you have a heavy light fixture or other heavy object over your bed). Protect yourself with your pillow.\u003c/p>\n\u003cp>\u003cstrong>4. If you're outside, try to move to the open.\u003c/strong> Move away from buildings and power lines.\u003c/p>\n\u003cp>\u003cstrong>5. If you're in your car, stop as quickly and safely as you can and stay in your vehicle.\u003c/strong> Do not stop under or on bridges, overpasses or trees.\u003c/p>\n\u003cp>There's much more I could say. But I'll leave it with this: Look around in your home and at work. Think where you could duck, cover and hold on.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>I compiled this post from my own earthquake obsessions, verified by information from \u003ca href=\"http://www.ready.gov/earthquakes\" target=\"_blank\">ready.gov \u003c/a>(brought to you by FEMA). If you visit\u003ca href=\"http://www.ready.gov/earthquakes\" target=\"_blank\"> the site\u003c/a>, scroll down to the helpful tabs that say \"before, during, after\" to learn more about being, well, ready. California's Department of Conservation also has a \u003ca href=\"http://www.consrv.ca.gov/index/earthquakes/Pages/qh_earthquakes_what.aspx\" target=\"_blank\">good fact sheet\u003c/a> on being prepared. The United States Geological Survey has a fun read about \u003ca href=\"http://earthquake.usgs.gov/learn/topics/megaqk_facts_fantasy.php\" target=\"_blank\">earthquake facts and earthquake fantasy.\u003c/a>\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_21034\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/454076420.jpg\">\u003cimg class=\"size-large wp-image-21034\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/454076420-640x476.jpg\" alt=\"Police officers in Napa prop up a fallen door in front of a damaged building following Sunday's earthquake there. (Justin Sullivan/Getty Images)\" width=\"640\" height=\"476\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Police officers in Napa prop up a fallen door in front of a damaged building following Sunday's earthquake there. (Justin Sullivan/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>I don't like earthquakes, yet I live in quake country. It's a paradox.\u003c/p>\n\u003cp>To mitigate my worry, I err on the side of preparedness. But this post is not to lecture you about creating an earthquake kit (\u003ca href=\"http://ww2.kqed.org/news/2014/08/24/how-to-prepare-for-an-earthquake/\" target=\"_blank\">although it's not hard to do\u003c/a>). It's to let you know what to do the moment the shaking starts.\u003c/p>\n\u003cp>And it's to tell you what not to do.\u003c/p>\n\u003cp>Folks, when the shaking starts, do not head to the nearest doorway. I cannot stress this enough: Do not stand in a doorway.\u003c!--more-->\u003c/p>\n\u003cp>I always thought the doorway was safe, too -- until I heard years ago that this is a myth. The idea of the safety of the doorway goes back to the 19th century. Back then in California, lots of homes were built of adobe. The only wood in the house was the wood-framed door. In a major quake, the adobe crumbled. The only thing left standing? The wood framing of the door.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>If you are presently living in a 19th century adobe home, you may stand in your doorway.\u003c/p>\n\u003cp>Otherwise, here's what you do:\u003c/p>\n\u003cp>\u003cstrong>1. Drop, cover and hold on.\u003c/strong>\u003c/p>\n\u003cp>In an earthquake, things fall over, move around and generally fling off shelves. These moving or falling objects can hurt you. Standing in a doorway does not protect you. In addition to stuff flying around, the door will swing back and forth, perhaps violently. The door may strike you, or your fingers may be pinched badly, if you have them jammed in the frame to brace yourself. The door could also fall down, as you see in the photo above.\u003c/p>\n\u003cp>Instead, if you are dropped, covered and holding on, those things flying around are less likely to hurt you. You drop to your knees, so the quake can't knock you down. You cover under a sturdy table or other piece of furniture to protect yourself from falling objects. You hold on, so your protection moves with you.\u003c/p>\n\u003cp style=\"text-align: center\">[\u003cstrong>Related:\u003c/strong> \u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/30/how-will-your-hospital-fare-in-the-next-earthquake/\" target=\"_blank\">How Will Your Hospital Fare in the Next Earthquake?\u003c/a>]\u003c/p>\n\u003cp>\u003cstrong>2. If you're inside, stay inside.\u003c/strong>\u003c/p>\n\u003cp>This is a hard one. But you don't want to go outside in the middle of the shaking -- because even more stuff is likely falling over outside, like bricks, power lines, all kinds of stuff that can really hurt you.\u003c/p>\n\u003cp>\u003cstrong>3. If you're in bed, stay in bed\u003c/strong> (unless you have a heavy light fixture or other heavy object over your bed). Protect yourself with your pillow.\u003c/p>\n\u003cp>\u003cstrong>4. If you're outside, try to move to the open.\u003c/strong> Move away from buildings and power lines.\u003c/p>\n\u003cp>\u003cstrong>5. If you're in your car, stop as quickly and safely as you can and stay in your vehicle.\u003c/strong> Do not stop under or on bridges, overpasses or trees.\u003c/p>\n\u003cp>There's much more I could say. But I'll leave it with this: Look around in your home and at work. Think where you could duck, cover and hold on.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>I compiled this post from my own earthquake obsessions, verified by information from \u003ca href=\"http://www.ready.gov/earthquakes\" target=\"_blank\">ready.gov \u003c/a>(brought to you by FEMA). If you visit\u003ca href=\"http://www.ready.gov/earthquakes\" target=\"_blank\"> the site\u003c/a>, scroll down to the helpful tabs that say \"before, during, after\" to learn more about being, well, ready. California's Department of Conservation also has a \u003ca href=\"http://www.consrv.ca.gov/index/earthquakes/Pages/qh_earthquakes_what.aspx\" target=\"_blank\">good fact sheet\u003c/a> on being prepared. The United States Geological Survey has a fun read about \u003ca href=\"http://earthquake.usgs.gov/learn/topics/megaqk_facts_fantasy.php\" target=\"_blank\">earthquake facts and earthquake fantasy.\u003c/a>\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "San Francisco Supervisors Put Soda Tax on Ballot",
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"content": "\u003cfigure id=\"attachment_20311\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/07/177844339.jpg\">\u003cimg class=\"size-large wp-image-20311\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/07/177844339-640x495.jpg\" alt=\"(Getty Images)\" width=\"640\" height=\"495\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">(Getty Images) \u003ccite>(Getty Images)\u003c/cite>\u003c/figcaption>\u003c/figure>\n\u003cp>The San Francisco Board of Supervisors approved a November ballot measure to tax soda and sugary drinks Tuesday afternoon, but not with the unanimous vote they were looking for.\u003c/p>\n\u003cp>If passed by a two-thirds majority of San Francisco voters, the new legislation will tax soda and other sugar-sweetened beverages at two cents per ounce and direct the revenue to the city's public health and recreation and parks departments and the school district.\u003c/p>\n\u003cp>The board voted 6-4 this afternoon to place the initiative by supervisors Scott Wiener and Eric Mar before voters, with supervisors Jane Kim, Katy Tang, Norman Yee and London Breed voting against it.\u003c!--more-->\u003c/p>\n\u003cp>Supervisor John Avalos, who has publicly supported the measure, was absent for today's meeting.\u003c/p>\n\u003cp>At a rally prior to the meeting, Mar said he thinks the tax will be an effective deterrent to selling sugary drinks, and that city economists have estimated it could reduce consumption 30 to 40 percent.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"It is a common sense measure that can put San Francisco on the map as the first city to fight for the health of our youth,\" Mar said.\u003c/p>\n\u003cp>Those health impacts, Mar argued, are huge. He said that of children today, one-third of them will develop type 2 diabetes, and for minorities that number is even higher, with as many as one-half likely to develop type 2 diabetes.\u003c/p>\n\u003cp>The disproportionate effect on minorities is one reason that Supervisor Malia Cohen called the measure \"crucial\" during the meeting.\u003c/p>\n\u003cp>\"Bullets are not the only thing that are killing African American males,\" Cohen said. \"You also have sugary beverages.\"\u003c/p>\n\u003cp>But Kim said today that she objected to the measure because of the disproportionate effect the tax will have on those same communities.\u003c/p>\n\u003cp>Calling it a regressive flat tax, Kim said that it \"unfairly burdens low-income communities\" similar to other sin taxes such as high taxes on cigarettes.\u003c/p>\n\u003cp>While agreeing with the policy goals of attempting to curb unhealthy habits, Kim suggested alternatives such as education, subsidizing healthier foods, policies to put healthier foods in corner liquor stores, and restricting sales with licenses like liquor licenses.\u003c/p>\n\u003cp>Mar sternly objected to Kim's objections, saying, \"Maybe you weren't listening.\"\u003c/p>\n\u003cp>\"It's very clear education isn't enough\" to improve health, he said.\u003c/p>\n\u003cp>Cohen called it \"disingenuous\" to argue that the tax was regressive because the diseases caused by a high sugar diet so disproportionately affect low-income communities that the deterrent is most crucial there.\u003c/p>\n\u003cp>\"These diseases we are looking to solve are also regressive,\" she said.\u003c/p>\n\u003cp>Wiener said the comparison to a cigarette tax was apt, and that tobacco taxes are something he strongly supported. He said that he was disheartened that a recent statewide ballot measure to tax cigarettes failed but heartened that it received 73 percent support in San Francisco.\u003c/p>\n\u003cp>\"Tax policy is a critical part,\" he said. \"The cigarette tax is a great model.\"\u003c/p>\n\u003cp>Opponents who have formed a \"Stop Unfair Beverage Taxes\" coalition said today that singling out sugary drinks for taxation is unfair as sugar-sweetened beverage consumption is down while rates of diabetes and obesity have continued to rise.\u003c/p>\n\u003cp>But Campos and Mar argued that sugary beverages are a big part of the problem because it was easier to consume large quantities of sugar in a drink and metabolize larger quantities of sugar.\u003c/p>\n\u003cp>The Hispanic Chambers of Commerce of San Francisco also released a statement objecting to the initiative -- arguing that the new tax and increased prices will impact many already struggling businesses.\u003c/p>\n\u003cp>Supervisor David Campos, who ultimately voted yes today, echoed the comments that the measure would level a regressive tax on low-income communities.\u003c/p>\n\u003cp>\"I do believe in something like this I'm going to err on the side of giving voters a choice,\" he said, but said that he thought there was \"something Big Brother about this.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>He and Kim said that the citywide conversation about it leading to the November election will at least improve education about the health effects of sugary drinks.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"It is a common sense measure that can put San Francisco on the map as the first city to fight for the health of our youth,\" Mar said.\u003c/p>\n\u003cp>Those health impacts, Mar argued, are huge. He said that of children today, one-third of them will develop type 2 diabetes, and for minorities that number is even higher, with as many as one-half likely to develop type 2 diabetes.\u003c/p>\n\u003cp>The disproportionate effect on minorities is one reason that Supervisor Malia Cohen called the measure \"crucial\" during the meeting.\u003c/p>\n\u003cp>\"Bullets are not the only thing that are killing African American males,\" Cohen said. \"You also have sugary beverages.\"\u003c/p>\n\u003cp>But Kim said today that she objected to the measure because of the disproportionate effect the tax will have on those same communities.\u003c/p>\n\u003cp>Calling it a regressive flat tax, Kim said that it \"unfairly burdens low-income communities\" similar to other sin taxes such as high taxes on cigarettes.\u003c/p>\n\u003cp>While agreeing with the policy goals of attempting to curb unhealthy habits, Kim suggested alternatives such as education, subsidizing healthier foods, policies to put healthier foods in corner liquor stores, and restricting sales with licenses like liquor licenses.\u003c/p>\n\u003cp>Mar sternly objected to Kim's objections, saying, \"Maybe you weren't listening.\"\u003c/p>\n\u003cp>\"It's very clear education isn't enough\" to improve health, he said.\u003c/p>\n\u003cp>Cohen called it \"disingenuous\" to argue that the tax was regressive because the diseases caused by a high sugar diet so disproportionately affect low-income communities that the deterrent is most crucial there.\u003c/p>\n\u003cp>\"These diseases we are looking to solve are also regressive,\" she said.\u003c/p>\n\u003cp>Wiener said the comparison to a cigarette tax was apt, and that tobacco taxes are something he strongly supported. He said that he was disheartened that a recent statewide ballot measure to tax cigarettes failed but heartened that it received 73 percent support in San Francisco.\u003c/p>\n\u003cp>\"Tax policy is a critical part,\" he said. \"The cigarette tax is a great model.\"\u003c/p>\n\u003cp>Opponents who have formed a \"Stop Unfair Beverage Taxes\" coalition said today that singling out sugary drinks for taxation is unfair as sugar-sweetened beverage consumption is down while rates of diabetes and obesity have continued to rise.\u003c/p>\n\u003cp>But Campos and Mar argued that sugary beverages are a big part of the problem because it was easier to consume large quantities of sugar in a drink and metabolize larger quantities of sugar.\u003c/p>\n\u003cp>The Hispanic Chambers of Commerce of San Francisco also released a statement objecting to the initiative -- arguing that the new tax and increased prices will impact many already struggling businesses.\u003c/p>\n\u003cp>Supervisor David Campos, who ultimately voted yes today, echoed the comments that the measure would level a regressive tax on low-income communities.\u003c/p>\n\u003cp>\"I do believe in something like this I'm going to err on the side of giving voters a choice,\" he said, but said that he thought there was \"something Big Brother about this.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>He and Kim said that the citywide conversation about it leading to the November election will at least improve education about the health effects of sugary drinks.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Sacramento Patient Does Not Have Ebola, Officials Report",
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"content": "\u003cfigure id=\"attachment_20919\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-e1408556674718.jpg\">\u003cimg class=\"size-large wp-image-20919\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-640x426.jpg\" alt=\"Ebola virus magnified 108,000 times. (Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ebola virus magnified 108,000 times. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>A\u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\"> patient admitted to a Kaiser hospital\u003c/a> in South Sacramento has tested negative for the Ebola virus, said Dr. Ron Chapman, director of the California Department of Public Health (CDPH) in a brief press conference Thursday evening.\u003c/p>\n\u003cp>Chapman said the results came in from the Centers for Disease Control and Prevention earlier in the day. Chapman, Kaiser officials and Sacramento County health officials refused to answer other questions about the patient, citing privacy laws.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\">Earlier this week\u003c/a>, CDPH called the patient \"low risk\" and said the testing was occurring out of an \"abundance of caution.\" Chapman said CDPH and Kaiser made the determination that the patient was low risk by \u003ca href=\"http://www.cdc.gov/vhf/ebola/hcp/case-definition.html\" target=\"_blank\">following established CDC assessment tools\u003c/a>, available to any health care worker.\u003c/p>\n\u003cp>Chapman stressed that Ebola is \"a very difficult infection to spread.\" It does not spread through air, food or water. The virus can only be spread through direct physical contact with an infected person's bodily fluid, including blood and sweat.\u003c/p>\n\u003cp>There are no reported cases of Ebola in California. In West Africa, \u003ca href=\"http://www.cdc.gov/vhf/ebola/outbreaks/guinea/index.html\" target=\"_blank\">the disease has killed 1,350 people\u003c/a>.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_20919\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-e1408556674718.jpg\">\u003cimg class=\"size-large wp-image-20919\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-640x426.jpg\" alt=\"Ebola virus magnified 108,000 times. (Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ebola virus magnified 108,000 times. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>A\u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\"> patient admitted to a Kaiser hospital\u003c/a> in South Sacramento has tested negative for the Ebola virus, said Dr. Ron Chapman, director of the California Department of Public Health (CDPH) in a brief press conference Thursday evening.\u003c/p>\n\u003cp>Chapman said the results came in from the Centers for Disease Control and Prevention earlier in the day. Chapman, Kaiser officials and Sacramento County health officials refused to answer other questions about the patient, citing privacy laws.\u003c/p>\n\u003cp>\u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\">Earlier this week\u003c/a>, CDPH called the patient \"low risk\" and said the testing was occurring out of an \"abundance of caution.\" Chapman said CDPH and Kaiser made the determination that the patient was low risk by \u003ca href=\"http://www.cdc.gov/vhf/ebola/hcp/case-definition.html\" target=\"_blank\">following established CDC assessment tools\u003c/a>, available to any health care worker.\u003c/p>\n\u003cp>Chapman stressed that Ebola is \"a very difficult infection to spread.\" It does not spread through air, food or water. The virus can only be spread through direct physical contact with an infected person's bodily fluid, including blood and sweat.\u003c/p>\n\u003cp>There are no reported cases of Ebola in California. In West Africa, \u003ca href=\"http://www.cdc.gov/vhf/ebola/outbreaks/guinea/index.html\" target=\"_blank\">the disease has killed 1,350 people\u003c/a>.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"disqusTitle": "In Face of Ebola, California-Trained Doctor Treats Patients in Liberia",
"title": "In Face of Ebola, California-Trained Doctor Treats Patients in Liberia",
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"content": "\u003cfigure id=\"attachment_20959\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/453874026-e1408646792307.jpg\">\u003cimg class=\"size-large wp-image-20959\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/453874026-640x424.jpg\" alt=\"Shops remain closed in Monrovia's West Point slum as part of quarantine measures to contain the spread of Ebola. (ZOOM DOSSO/AFP/Getty Images) \" width=\"640\" height=\"424\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Shops remain closed in Monrovia's West Point slum as part of quarantine measures to contain the spread of Ebola in Liberia. A doctor trained in California traveled last week to staff a Monrovia hospital. (ZOOM DOSSO/AFP/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>While Californians worry about \u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\">a single possible case of Ebola\u003c/a>, considered low risk, the hot spot for this outbreak remains in West Africa where \u003ca href=\"http://www.cdc.gov/vhf/ebola/outbreaks/guinea/index.html\" target=\"_blank\">1,350 people have died\u003c/a>, and another 2,400 people are sick with the illness. But what happens to people who get sick with something that is not Ebola?\u003c/p>\n\u003cp>Dr. James Appel was trained in the Inland Empire, at the Loma Linda University School of Medicine. He's been working for Adventist Health International at hospitals in Chad for the last decade. Last week, Dr. Appel flew to Liberia to keep the doors open at \u003ca href=\"http://www.adventistdirectory.org/viewEntity.aspx?EntityID=13526\" target=\"_blank\">Cooper Adventist\u003c/a>, a small hospital in the capital, Monrovia, focusing on remaining available to patients with anything but Ebola. He \u003ca href=\"http://www.californiareport.org/archive/R201408210850/b\" target=\"_blank\">talked Thursday morning\u003c/a> with The California Report's Rachael Myrow.\u003c/p>\n\u003cp>Appel described Liberia as \"shutting down\" around him. \"There's a curfew that's been initiated. Many businesses are not open; all the schools are closed, government offices are closed,\" Appel told Myrow. \"So for example our hospital is not getting paid by the insurance companies, because insurance companies are closed. The whole economy is coming to a standstill.\"\u003c!--more-->\u003c/p>\n\u003cp>Appel said that people are starting to think there will be food shortages. There's a \"profound impact not just for those few patients effected by Ebola, but for the whole country,\" Appel said.\u003c/p>\n\u003cp>Many public hospitals in West Africa are closing their doors or refusing new patients, Myrow noted, and asked Appel why the General Conference of 7th Day Adventists wanted to keep Cooper Adventist open.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"Cooper has a history of not wanting to shut down during crisis situations,\" Appel said, adding that it stayed open during the Liberia's civil war. \"Staff feels that they have a mission, and that is to provide care to the Liberian people when no one else will.\"\u003c/p>\n\u003cp>\u003ciframe src=\"https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/164131162&color=ff5500&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false\" width=\"100%\" height=\"166\" frameborder=\"no\" scrolling=\"no\">\u003c/iframe>\u003c/p>\n\u003cp>\"While Ebola is dramatically killing people in a way that catches the imagination,\" Appel said, still more people are dying from malaria or complications from emergency c-sections. \"With all hospitals shut down because of the Ebola crisis, the death toll would soon far surpass anything that Ebola could do, just due to other normally treatable diseases,\" Appel noted.\u003c/p>\n\u003cp>The hospital is old and run down, he said, a very small, three story structure on a \"tiny parcel of land in the heart of the city.\"\u003c/p>\n\u003cp>Cooper Adventists cannot treat Ebola patients because they do not have the isolation facilities necessary. Appel said they refer any suspected Ebola patients to a bigger hospital. \"Anyone suspicious at all, we send them where they can get better care and where we will not be putting our other patients at risk,\"Appel said, adding there is only one lab in the country that can run tests for Ebola. All blood samples go there.\u003c/p>\n\u003cp>Appel acknowledged his own fears in treating patients during the ongoing crisis.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"I can't say I’m not afraid,\" he said. \"In all my medical training, there's only one thing that's ever scared me and that's Ebola -- because it is so lethal and happens so quickly and there's no known treatment.\" But he quickly added that Ebola is not as contagious as people might think. The virus is not airborne. Transmission requires \"direct physical contract with (a patient's) bodily fluids. If normal universal precautions are taken and you're very careful about screening patients and keeping yourself protected with gowns and gloves and masks, there's actually a low likelihood of you getting it.\"\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_20959\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/453874026-e1408646792307.jpg\">\u003cimg class=\"size-large wp-image-20959\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/453874026-640x424.jpg\" alt=\"Shops remain closed in Monrovia's West Point slum as part of quarantine measures to contain the spread of Ebola. (ZOOM DOSSO/AFP/Getty Images) \" width=\"640\" height=\"424\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Shops remain closed in Monrovia's West Point slum as part of quarantine measures to contain the spread of Ebola in Liberia. A doctor trained in California traveled last week to staff a Monrovia hospital. (ZOOM DOSSO/AFP/Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>While Californians worry about \u003ca href=\"http://ww2.kqed.org/stateofhealth/2014/08/20/kaiser-sacramento-patient-being-tested-for-possible-exposure-to-ebola/\" target=\"_blank\">a single possible case of Ebola\u003c/a>, considered low risk, the hot spot for this outbreak remains in West Africa where \u003ca href=\"http://www.cdc.gov/vhf/ebola/outbreaks/guinea/index.html\" target=\"_blank\">1,350 people have died\u003c/a>, and another 2,400 people are sick with the illness. But what happens to people who get sick with something that is not Ebola?\u003c/p>\n\u003cp>Dr. James Appel was trained in the Inland Empire, at the Loma Linda University School of Medicine. He's been working for Adventist Health International at hospitals in Chad for the last decade. Last week, Dr. Appel flew to Liberia to keep the doors open at \u003ca href=\"http://www.adventistdirectory.org/viewEntity.aspx?EntityID=13526\" target=\"_blank\">Cooper Adventist\u003c/a>, a small hospital in the capital, Monrovia, focusing on remaining available to patients with anything but Ebola. He \u003ca href=\"http://www.californiareport.org/archive/R201408210850/b\" target=\"_blank\">talked Thursday morning\u003c/a> with The California Report's Rachael Myrow.\u003c/p>\n\u003cp>Appel described Liberia as \"shutting down\" around him. \"There's a curfew that's been initiated. Many businesses are not open; all the schools are closed, government offices are closed,\" Appel told Myrow. \"So for example our hospital is not getting paid by the insurance companies, because insurance companies are closed. The whole economy is coming to a standstill.\"\u003c!--more-->\u003c/p>\n\u003cp>Appel said that people are starting to think there will be food shortages. There's a \"profound impact not just for those few patients effected by Ebola, but for the whole country,\" Appel said.\u003c/p>\n\u003cp>Many public hospitals in West Africa are closing their doors or refusing new patients, Myrow noted, and asked Appel why the General Conference of 7th Day Adventists wanted to keep Cooper Adventist open.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"Cooper has a history of not wanting to shut down during crisis situations,\" Appel said, adding that it stayed open during the Liberia's civil war. \"Staff feels that they have a mission, and that is to provide care to the Liberian people when no one else will.\"\u003c/p>\n\u003cp>\u003ciframe src=\"https://w.soundcloud.com/player/?url=https%3A//api.soundcloud.com/tracks/164131162&color=ff5500&auto_play=false&hide_related=false&show_comments=true&show_user=true&show_reposts=false\" width=\"100%\" height=\"166\" frameborder=\"no\" scrolling=\"no\">\u003c/iframe>\u003c/p>\n\u003cp>\"While Ebola is dramatically killing people in a way that catches the imagination,\" Appel said, still more people are dying from malaria or complications from emergency c-sections. \"With all hospitals shut down because of the Ebola crisis, the death toll would soon far surpass anything that Ebola could do, just due to other normally treatable diseases,\" Appel noted.\u003c/p>\n\u003cp>The hospital is old and run down, he said, a very small, three story structure on a \"tiny parcel of land in the heart of the city.\"\u003c/p>\n\u003cp>Cooper Adventists cannot treat Ebola patients because they do not have the isolation facilities necessary. Appel said they refer any suspected Ebola patients to a bigger hospital. \"Anyone suspicious at all, we send them where they can get better care and where we will not be putting our other patients at risk,\"Appel said, adding there is only one lab in the country that can run tests for Ebola. All blood samples go there.\u003c/p>\n\u003cp>Appel acknowledged his own fears in treating patients during the ongoing crisis.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"I can't say I’m not afraid,\" he said. \"In all my medical training, there's only one thing that's ever scared me and that's Ebola -- because it is so lethal and happens so quickly and there's no known treatment.\" But he quickly added that Ebola is not as contagious as people might think. The virus is not airborne. Transmission requires \"direct physical contract with (a patient's) bodily fluids. If normal universal precautions are taken and you're very careful about screening patients and keeping yourself protected with gowns and gloves and masks, there's actually a low likelihood of you getting it.\"\u003c/p>\n\n\u003c/div>\u003c/p>",
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"disqusTitle": "Sacramento Patient Being Tested for Possible Exposure to Ebola",
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"content": "\u003cfigure id=\"attachment_20919\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774.jpg\">\u003cimg class=\"size-large wp-image-20919\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-640x426.jpg\" alt=\"Ebola virus magnified 108,000 times. (Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ebola virus magnified 108,000 times. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>By Lisa Aliferis and April Dembosky\u003c/strong>\u003c/p>\n\u003cp>Don't panic, folks. Really.\u003c/p>\n\u003cp>A patient who \u003cem>may\u003c/em> have been exposed to the Ebola virus is being tested at Kaiser's South Sacramento Hospital.\u003c/p>\n\u003cp>The other key information here is that California Department of Public Health officials call the unidentified patient \u003ca href=\"http://www.cdph.ca.gov/Pages/NR14-073.aspx\" target=\"_blank\">\"low risk,\"\u003c/a> \u003cspan class=\"Apple-style-span\">\u003cspan style=\"color: #000000\">according to criteria established by the CDC that considers travel history, exposure to infection, and clinical features. \u003c/span>\u003c/span>\u003c/p>\n\u003cp>In a call with reporters Wednesday afternoon, CDPH deputy Dr. Gil Chavez said the state has received no reports of any high risk patients. CDPH said the patient is being tested out of an \"abundance of caution.\"\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003ca href=\"http://share.kaiserpermanente.org/article/kaiser-permanente-comments-on-patient-being-tested-for-ebola-virus/\" target=\"_blank\">In a statement\u003c/a>, Dr. Stephen Parodi, director of hospital operations for Kaiser Northern California, said the unidentified patient is being kept in a specially equipped negative pressure room, and staff working with the patient are using \"personal protective equipment.\"\u003c!--more-->\u003c/p>\n\u003cp>Samples from the patient are on their way to the Centers for Disease Control and Prevention for testing, and the results will take several days. No other information about the patient was readily available, including whether the person had recently traveled to any of the West African countries where an Ebola outbreak is ongoing.\u003c/p>\n\u003cp>The CDPH said there are no confirmed cases of Ebola in California. \u003ca href=\"http://www.abqjournal.com/447619/abqnewsseeker/health-department-cdc-testing-new-mexico-woman-for-ebola.html\" target=\"_blank\">One woman in New Mexico\u003c/a> who recently returned from Sierra Leone, one of the countries with an Ebola outbreak, is also in quarantine, awaiting results of testing for Ebola. Two patients who were flown in from West Africa are being treated in Atlanta.\u003c/p>\n\u003cp>While Ebola is very deadly, it is difficult to transmit. The virus is passed only through direct contact with bodily fluids, and a person is only infectious once they become very ill.\u003c/p>\n\u003cp>\"Those characteristics of the disease make it very unlikely that it would be something that would spread across the world,” said San Francisco public health officer Tomas Aragon. “We're not going to have a pandemic with Ebola.\"\u003c/p>\n\u003cp>He says any suspected cases that turn up in California will be quickly contained under American infectious disease protocols.\u003c/p>\n\u003cp>“It's not rocket science. It's not high tech,” Aragon said. “But it has to be very disciplined. In the U.S., people are very well trained, and they have the resources to be able to do this kind of work.”\u003c/p>\n\u003cp>Unlike the West African countries hard hit by Ebola, isolation units are widely available in hospitals throughout the state. Any patients would be cared for by specially trained health care workers. And the public has a greater trust of public health officials, so warnings to family members or any other people that may have come in contact with an infected person are much more likely to be heeded.\u003c/p>\n\u003cp>Chavez says the Sacramento case is an example of how quickly the system can identify and isolate potential infections.\u003c/p>\n\u003cp>“We knew it was a matter of time before we had a patient in California. California is a place with much international exposure and travel,” he said. “The case in Sacramento county really exemplifies how well our system is working.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This post has been updated with details from a press conference with the California Department of Public Health and an interview with the San Francisco Department of Public Health.\u003c/em>\u003c/strong>\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_20919\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774.jpg\">\u003cimg class=\"size-large wp-image-20919\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/08/79997774-640x426.jpg\" alt=\"Ebola virus magnified 108,000 times. (Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ebola virus magnified 108,000 times. (Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>By Lisa Aliferis and April Dembosky\u003c/strong>\u003c/p>\n\u003cp>Don't panic, folks. Really.\u003c/p>\n\u003cp>A patient who \u003cem>may\u003c/em> have been exposed to the Ebola virus is being tested at Kaiser's South Sacramento Hospital.\u003c/p>\n\u003cp>The other key information here is that California Department of Public Health officials call the unidentified patient \u003ca href=\"http://www.cdph.ca.gov/Pages/NR14-073.aspx\" target=\"_blank\">\"low risk,\"\u003c/a> \u003cspan class=\"Apple-style-span\">\u003cspan style=\"color: #000000\">according to criteria established by the CDC that considers travel history, exposure to infection, and clinical features. \u003c/span>\u003c/span>\u003c/p>\n\u003cp>In a call with reporters Wednesday afternoon, CDPH deputy Dr. Gil Chavez said the state has received no reports of any high risk patients. CDPH said the patient is being tested out of an \"abundance of caution.\"\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003ca href=\"http://share.kaiserpermanente.org/article/kaiser-permanente-comments-on-patient-being-tested-for-ebola-virus/\" target=\"_blank\">In a statement\u003c/a>, Dr. Stephen Parodi, director of hospital operations for Kaiser Northern California, said the unidentified patient is being kept in a specially equipped negative pressure room, and staff working with the patient are using \"personal protective equipment.\"\u003c!--more-->\u003c/p>\n\u003cp>Samples from the patient are on their way to the Centers for Disease Control and Prevention for testing, and the results will take several days. No other information about the patient was readily available, including whether the person had recently traveled to any of the West African countries where an Ebola outbreak is ongoing.\u003c/p>\n\u003cp>The CDPH said there are no confirmed cases of Ebola in California. \u003ca href=\"http://www.abqjournal.com/447619/abqnewsseeker/health-department-cdc-testing-new-mexico-woman-for-ebola.html\" target=\"_blank\">One woman in New Mexico\u003c/a> who recently returned from Sierra Leone, one of the countries with an Ebola outbreak, is also in quarantine, awaiting results of testing for Ebola. Two patients who were flown in from West Africa are being treated in Atlanta.\u003c/p>\n\u003cp>While Ebola is very deadly, it is difficult to transmit. The virus is passed only through direct contact with bodily fluids, and a person is only infectious once they become very ill.\u003c/p>\n\u003cp>\"Those characteristics of the disease make it very unlikely that it would be something that would spread across the world,” said San Francisco public health officer Tomas Aragon. “We're not going to have a pandemic with Ebola.\"\u003c/p>\n\u003cp>He says any suspected cases that turn up in California will be quickly contained under American infectious disease protocols.\u003c/p>\n\u003cp>“It's not rocket science. It's not high tech,” Aragon said. “But it has to be very disciplined. In the U.S., people are very well trained, and they have the resources to be able to do this kind of work.”\u003c/p>\n\u003cp>Unlike the West African countries hard hit by Ebola, isolation units are widely available in hospitals throughout the state. Any patients would be cared for by specially trained health care workers. And the public has a greater trust of public health officials, so warnings to family members or any other people that may have come in contact with an infected person are much more likely to be heeded.\u003c/p>\n\u003cp>Chavez says the Sacramento case is an example of how quickly the system can identify and isolate potential infections.\u003c/p>\n\u003cp>“We knew it was a matter of time before we had a patient in California. California is a place with much international exposure and travel,” he said. “The case in Sacramento county really exemplifies how well our system is working.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cstrong>\u003cem>This post has been updated with details from a press conference with the California Department of Public Health and an interview with the San Francisco Department of Public Health.\u003c/em>\u003c/strong>\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cfigure id=\"attachment_20113\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Joggers.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20113\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Joggers.jpg\" alt=\"Liking to exercise may be in their genes. Maybe one day everyone will like to exercise as much. (Wikimedia Commons)\" width=\"640\" height=\"358\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Liking to exercise may be in their genes. Maybe one day everyone will like to exercise as much. (\u003ca class=\"nofancybox\" href=\"http://commons.wikimedia.org/wiki/File:Female_joggers_on_foggy_Morro_Strand_State_Beach.jpg\">Wikimedia Commons\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>Here in the U.S., we are bombarded with an almost constant barrage of information about the benefits of exercise. And those benefits are real. For example, exercise may help \u003ca href=\"http://jap.physiology.org/cgi/pmidlookup?view=long&pmid=21836048\">prevent at least 35 chronic unhealthy conditions and premature death\u003c/a>.\u003c/p>\n\u003cp>Despite all of this, something like \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/18091006\">90% of us over the age of 12 fail to get as much exercise as we should\u003c/a>. This is almost certainly not because we don’t believe in those benefits. Instead, it looks like at least part of the reason may be that some of us are genetically programmed to hate exercise.\u003c/p>\n\u003cp>The evidence that genes play a big role in people’s interest in exercise comes mostly from twin and family studies. For example, a \u003ca href=\"http://ajcn.nutrition.org/cgi/pmidlookup?view=long&pmid=24047914\">recent report\u003c/a> found that genetics explained 47% of the behavior of people who like to exercise and 31% of the behavior of those who avoid exercise whenever they can. The rest of the reluctance to or enthusiasm for exercise can be chalked up to environmental factors like already being overweight or coming from a family that doesn’t exercise or about a thousand other possibilities.\u003c/p>\n\u003cp>What makes the obviousness of exercise motivation genes interesting is that if there is a biological link to lack of enthusiasm for exercise, then there is a chance that we might one day be able to tweak things to make exercise enjoyable for everyone. With a gentle prod from these new meds, people who get no thrill from exercise might now be able to love it. The health benefits of such a treatment would be staggering.\u003c/p>\n\u003cp>The best chance in the short term for finding the biological reason behind why some people like exercise more than others is probably in rats. Studies on rats have shown that not wanting to exercise is a trait that can be passed down generation after generation. And scientists have even started to figure out the differences between the brains of rats that love to exercise and those with better things to do.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003cstrong>Breeding Rats That Hate to Exercise\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_20118\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/RatWithMelon.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20118\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/RatWithMelon.jpg\" alt=\"With a few more mature neurons, this rat might choose exercising over eating. (Wikimedia Commons) \" width=\"300\" height=\"238\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">With a few more mature neurons, this rat might choose exercising over eating. (\u003ca class=\"nofancybox\" href=\"http://commons.wikimedia.org/wiki/File:Rat_melon.jpg\">Wikimedia Commons\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>The rat story starts a few years ago when scientists noticed that some rats loved to run around on their wheel all night while others liked doing that a whole lot less. These scientists then took the most enthusiastic exercisers and put them together so they would breed. They did the same thing with the least enthusiastic rats. They repeated this for each group for ten generations.\u003c/p>\n\u003cp>In the end, the researchers found that \u003ca href=\"http://ajpregu.physiology.org/content/304/11/R1024\">a huge gap had developed\u003c/a> between these two groups in terms of their desire to exercise. These scientists had selectively bred two groups of rats that could now be compared so as to identify the biological reasons for their differences in behavior.\u003c/p>\n\u003cp>Previous work had pointed to a part of the brain called the \u003ca href=\"http://thebrain.mcgill.ca/flash/i/i_03/i_03_cr/i_03_cr_par/i_03_cr_par.html\">nucleus accumbens\u003c/a> (NAc) as being important in exercise motivation in rats. This make sense as this is the part of the brain that acts as a reward center for voluntary sorts of actions.\u003c/p>\n\u003cp>Using a variety of techniques, researchers in a \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24665095\">recent study\u003c/a> not only confirmed that a key difference between the two rat groups was in the NAc part of the brain, but they were also able to make an educated guess about what that difference might be. It turns out that rats that don’t like to exercise have more immature neurons in this part of the brain. And conversely, those that really liked to exercise had more mature neurons. Liking exercise has to do with maturity!\u003c/p>\n\u003cp>This finding in no way explains everything about exercise motivation in rats. But it is a great start that points scientists in the right direction to learn even more.\u003c/p>\n\u003cp>If these sorts of findings translate to people, then we may one day find a way to help more people get motivated to get some exercise. Then we can finally shut all those people up who keep badgering us about exercising.\u003c/p>\n\u003cp>http://www.youtube.com/watch?v=gd44cDtMzug\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003cem>We can learn a lot from rats that like to exercise.\u003c/em>\u003c/p>\n\n",
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"excerpt": "About 90% of us over the age of 12 fail to get as much exercise as we should. This is almost certainly not because we don’t believe in those benefits. Instead, it looks like at least part of the reason may be that some of us are genetically programmed to hate exercise.",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_20113\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Joggers.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20113\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Joggers.jpg\" alt=\"Liking to exercise may be in their genes. Maybe one day everyone will like to exercise as much. (Wikimedia Commons)\" width=\"640\" height=\"358\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Liking to exercise may be in their genes. Maybe one day everyone will like to exercise as much. (\u003ca class=\"nofancybox\" href=\"http://commons.wikimedia.org/wiki/File:Female_joggers_on_foggy_Morro_Strand_State_Beach.jpg\">Wikimedia Commons\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>Here in the U.S., we are bombarded with an almost constant barrage of information about the benefits of exercise. And those benefits are real. For example, exercise may help \u003ca href=\"http://jap.physiology.org/cgi/pmidlookup?view=long&pmid=21836048\">prevent at least 35 chronic unhealthy conditions and premature death\u003c/a>.\u003c/p>\n\u003cp>Despite all of this, something like \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/18091006\">90% of us over the age of 12 fail to get as much exercise as we should\u003c/a>. This is almost certainly not because we don’t believe in those benefits. Instead, it looks like at least part of the reason may be that some of us are genetically programmed to hate exercise.\u003c/p>\n\u003cp>The evidence that genes play a big role in people’s interest in exercise comes mostly from twin and family studies. For example, a \u003ca href=\"http://ajcn.nutrition.org/cgi/pmidlookup?view=long&pmid=24047914\">recent report\u003c/a> found that genetics explained 47% of the behavior of people who like to exercise and 31% of the behavior of those who avoid exercise whenever they can. The rest of the reluctance to or enthusiasm for exercise can be chalked up to environmental factors like already being overweight or coming from a family that doesn’t exercise or about a thousand other possibilities.\u003c/p>\n\u003cp>What makes the obviousness of exercise motivation genes interesting is that if there is a biological link to lack of enthusiasm for exercise, then there is a chance that we might one day be able to tweak things to make exercise enjoyable for everyone. With a gentle prod from these new meds, people who get no thrill from exercise might now be able to love it. The health benefits of such a treatment would be staggering.\u003c/p>\n\u003cp>The best chance in the short term for finding the biological reason behind why some people like exercise more than others is probably in rats. Studies on rats have shown that not wanting to exercise is a trait that can be passed down generation after generation. And scientists have even started to figure out the differences between the brains of rats that love to exercise and those with better things to do.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cstrong>Breeding Rats That Hate to Exercise\u003c/strong>\u003c/p>\n\u003cfigure id=\"attachment_20118\" class=\"wp-caption alignright\" style=\"max-width: 300px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/RatWithMelon.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20118\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/RatWithMelon.jpg\" alt=\"With a few more mature neurons, this rat might choose exercising over eating. (Wikimedia Commons) \" width=\"300\" height=\"238\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">With a few more mature neurons, this rat might choose exercising over eating. (\u003ca class=\"nofancybox\" href=\"http://commons.wikimedia.org/wiki/File:Rat_melon.jpg\">Wikimedia Commons\u003c/a>)\u003c/figcaption>\u003c/figure>\n\u003cp>The rat story starts a few years ago when scientists noticed that some rats loved to run around on their wheel all night while others liked doing that a whole lot less. These scientists then took the most enthusiastic exercisers and put them together so they would breed. They did the same thing with the least enthusiastic rats. They repeated this for each group for ten generations.\u003c/p>\n\u003cp>In the end, the researchers found that \u003ca href=\"http://ajpregu.physiology.org/content/304/11/R1024\">a huge gap had developed\u003c/a> between these two groups in terms of their desire to exercise. These scientists had selectively bred two groups of rats that could now be compared so as to identify the biological reasons for their differences in behavior.\u003c/p>\n\u003cp>Previous work had pointed to a part of the brain called the \u003ca href=\"http://thebrain.mcgill.ca/flash/i/i_03/i_03_cr/i_03_cr_par/i_03_cr_par.html\">nucleus accumbens\u003c/a> (NAc) as being important in exercise motivation in rats. This make sense as this is the part of the brain that acts as a reward center for voluntary sorts of actions.\u003c/p>\n\u003cp>Using a variety of techniques, researchers in a \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24665095\">recent study\u003c/a> not only confirmed that a key difference between the two rat groups was in the NAc part of the brain, but they were also able to make an educated guess about what that difference might be. It turns out that rats that don’t like to exercise have more immature neurons in this part of the brain. And conversely, those that really liked to exercise had more mature neurons. Liking exercise has to do with maturity!\u003c/p>\n\u003cp>This finding in no way explains everything about exercise motivation in rats. But it is a great start that points scientists in the right direction to learn even more.\u003c/p>\n\u003cp>If these sorts of findings translate to people, then we may one day find a way to help more people get motivated to get some exercise. Then we can finally shut all those people up who keep badgering us about exercising.\u003c/p>\u003c/p>\u003cp>\u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutube'>\n \u003cspan class='utils-parseShortcode-shortcodes-__youtubeShortcode__embedYoutubeInside'>\n \u003ciframe\n loading='lazy'\n class='utils-parseShortcode-shortcodes-__youtubeShortcode__youtubePlayer'\n type='text/html'\n src='//www.youtube.com/embed/gd44cDtMzug'\n title='//www.youtube.com/embed/gd44cDtMzug'\n allowfullscreen='true'\n style='border:0;'>\u003c/iframe>\n \u003c/span>\n \u003c/span>\u003c/p>\u003cp>\u003cp>\u003c/p>\n\u003cp>\u003cem>We can learn a lot from rats that like to exercise.\u003c/em>\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cdiv class=\"audio-wrap\">\n\u003ch2>Listen:\u003c/h2>\n\u003cp>http://www.kqed.org/.stream/anon/radio/science/2014/08/20140811science.mp3\u003c/p>\n\u003c/div>\n\u003cp>People with schizophrenia often have a hard time explaining what it’s like to hear voices. “There’s a huge range of voice hearing experiences,” says Nev Jones, postdoctoral fellow in anthropology at Stanford University who was treated for her psychotic symptoms in 2007.\u003c/p>\n\u003caside class=\"pullquote alignright\">“It’s not like wearing an iPod”, says the Stanford anthropologist Tanya Luhrman. “It’s like being surrounded by a gang of bullies.”\u003c/aside>\n\u003cp>There can be “voices that are more thought-like,” says Jones, “voices that sound like non-human entities, voices that are perceived as the direct communication of a message, rather than something you’re actually hearing.” Voices aren’t always voices, either. They can sound more like a murmur, a rustle or a beeping. But when a voice is a recognizable voice, more than often, it’s not very nice. “It’s not like wearing an iPod”, says the Stanford anthropologist Tanya Luhrman. “It’s like being surrounded by a gang of bullies.”\u003c/p>\n\u003cp>Here are a few of the people I’ve met over the last few months I’ve spent reporting on young people who have been diagnosed with schizophrenia, or experienced symptoms that seemed, possibly, pre-schizophrenic.\u003c/p>\n\u003cp>\u003cstrong>EFRAIN PACHECO\u003cbr>\n\u003c/strong>Efrain Pacheco is 21 and lives in San Diego. He can’t remember exactly when the voices began, in part because he thought everyone heard them.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/162033993″]\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments \u003c/strong>This is the third story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part One: \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">New Clinics in California Seek to Stop Schizophrenia Before it Starts\u003c/a>\u003c/li>\n\u003cli>Part Two: \u003ca href=\"http://ww2.kqed.org/science/audio/what-is-schizophrenia-scientists-call-for-new-thinking/\">What Is Schizophrenia? Scientists Call for New Thinking\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Today he takes an anti-psychotic drug, Risperdal, which has mostly quieted them. Sometimes he misses them, he says.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003cstrong>FRANKIE MORENO\u003cbr>\n\u003c/strong>Frankie Moreno is 25, and also lives in San Diego. About four years ago, his reality started to shift. At first, he heard “random noises,” like the sound of running on the roof. The sounds evolved into two voices, speaking just out of range of hearing.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/162034446″] Over time, the voices got louder and more threatening, until one night, they told him to hurt himself.\u003c/p>\n\u003cp>\u003cstrong>REAGAN\u003c/strong>\u003cbr>\nWe profiled Reagan in the \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">first story in this series\u003c/a>. She’s 23 and lives in Simi Valley. Her hallucinations were visual, not auditory.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/162034827″] She knew they couldn’t be real, but they still terrified her.\u003c/p>\n\u003cp>\u003cstrong>WILL HALL\u003c/strong>\u003c/p>\n\u003cp>Will Hall was in his 20s when the film \u003cem>The Matrix\u003c/em> came out. He was obsessed with it, and thought it had been written for him, specifically. He heard voices telling him that he had caused the Columbine massacre.\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/162181136″] \u003c/p>\n\u003caside class=\"alignright\">In California, \u003ca href=\"http://prepwellness.org/prep-san-francisco/\">PREP\u003c/a> offers mental health services to young people and their families. Schizophrenia.com offers a \u003ca href=\"http://www.schizophrenia.com/earlypsychosis.htm\">resource page\u003c/a> that includes other states. \u003ca href=\"http://www.nami.org/\">The National Alliance on Mental Illness\u003c/a> has \u003ca href=\"http://www.nami.org/Template.cfm?Section=Your_Local_NAMI&Template=/CustomSource/AffiliateFinder.cfm\">chapters\u003c/a> in every state and offers support to families. The young people in this story received help at \u003ca href=\"http://www.kickstartsd.org/\">Kickstart\u003c/a>, in San Diego.\u003c/aside>\n\u003cp>He found that as he listened to the voices, and tried to understand where they were coming from, the voices became kinder and more supportive.\u003c/p>\n\u003cp>\u003cstrong>ANDREA VALLEJO\u003c/strong>\u003cbr>\nThis last one is Andrea Vallejo, who works for a program in San Diego called Kickstart, which treats kids in the very earliest stages of schizophrenia. I met her when she and other Kickstart staff had taken a bunch of clients, between 10 and 25 years old, to fly kites at San Diego’s Seaport Village.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>[soundcloud url=”https://api.soundcloud.com/tracks/162033392″] Vallejo’s job is to help kids stay in school, connected to friends and family. The slide into isolation can make everything, including auditory and visual hallucinations, much worse.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/div>\n\u003cp>People with schizophrenia often have a hard time explaining what it’s like to hear voices. “There’s a huge range of voice hearing experiences,” says Nev Jones, postdoctoral fellow in anthropology at Stanford University who was treated for her psychotic symptoms in 2007.\u003c/p>\n\u003caside class=\"pullquote alignright\">“It’s not like wearing an iPod”, says the Stanford anthropologist Tanya Luhrman. “It’s like being surrounded by a gang of bullies.”\u003c/aside>\n\u003cp>There can be “voices that are more thought-like,” says Jones, “voices that sound like non-human entities, voices that are perceived as the direct communication of a message, rather than something you’re actually hearing.” Voices aren’t always voices, either. They can sound more like a murmur, a rustle or a beeping. But when a voice is a recognizable voice, more than often, it’s not very nice. “It’s not like wearing an iPod”, says the Stanford anthropologist Tanya Luhrman. “It’s like being surrounded by a gang of bullies.”\u003c/p>\n\u003cp>Here are a few of the people I’ve met over the last few months I’ve spent reporting on young people who have been diagnosed with schizophrenia, or experienced symptoms that seemed, possibly, pre-schizophrenic.\u003c/p>\n\u003cp>\u003cstrong>EFRAIN PACHECO\u003cbr>\n\u003c/strong>Efrain Pacheco is 21 and lives in San Diego. He can’t remember exactly when the voices began, in part because he thought everyone heard them.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='undefined' height='undefined'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/162033993″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/162033993″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp>\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments \u003c/strong>This is the third story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part One: \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">New Clinics in California Seek to Stop Schizophrenia Before it Starts\u003c/a>\u003c/li>\n\u003cli>Part Two: \u003ca href=\"http://ww2.kqed.org/science/audio/what-is-schizophrenia-scientists-call-for-new-thinking/\">What Is Schizophrenia? Scientists Call for New Thinking\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Today he takes an anti-psychotic drug, Risperdal, which has mostly quieted them. Sometimes he misses them, he says.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003cstrong>FRANKIE MORENO\u003cbr>\n\u003c/strong>Frankie Moreno is 25, and also lives in San Diego. About four years ago, his reality started to shift. At first, he heard “random noises,” like the sound of running on the roof. The sounds evolved into two voices, speaking just out of range of hearing.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='undefined' height='undefined'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/162034446″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/162034446″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp> Over time, the voices got louder and more threatening, until one night, they told him to hurt himself.\u003c/p>\n\u003cp>\u003cstrong>REAGAN\u003c/strong>\u003cbr>\nWe profiled Reagan in the \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">first story in this series\u003c/a>. She’s 23 and lives in Simi Valley. Her hallucinations were visual, not auditory.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='undefined' height='undefined'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/162034827″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/162034827″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp> She knew they couldn’t be real, but they still terrified her.\u003c/p>\n\u003cp>\u003cstrong>WILL HALL\u003c/strong>\u003c/p>\n\u003cp>Will Hall was in his 20s when the film \u003cem>The Matrix\u003c/em> came out. He was obsessed with it, and thought it had been written for him, specifically. He heard voices telling him that he had caused the Columbine massacre.\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='undefined' height='undefined'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/162181136″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/162181136″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp> \u003c/p>\n\u003caside class=\"alignright\">In California, \u003ca href=\"http://prepwellness.org/prep-san-francisco/\">PREP\u003c/a> offers mental health services to young people and their families. Schizophrenia.com offers a \u003ca href=\"http://www.schizophrenia.com/earlypsychosis.htm\">resource page\u003c/a> that includes other states. \u003ca href=\"http://www.nami.org/\">The National Alliance on Mental Illness\u003c/a> has \u003ca href=\"http://www.nami.org/Template.cfm?Section=Your_Local_NAMI&Template=/CustomSource/AffiliateFinder.cfm\">chapters\u003c/a> in every state and offers support to families. The young people in this story received help at \u003ca href=\"http://www.kickstartsd.org/\">Kickstart\u003c/a>, in San Diego.\u003c/aside>\n\u003cp>He found that as he listened to the voices, and tried to understand where they were coming from, the voices became kinder and more supportive.\u003c/p>\n\u003cp>\u003cstrong>ANDREA VALLEJO\u003c/strong>\u003cbr>\nThis last one is Andrea Vallejo, who works for a program in San Diego called Kickstart, which treats kids in the very earliest stages of schizophrenia. I met her when she and other Kickstart staff had taken a bunch of clients, between 10 and 25 years old, to fly kites at San Diego’s Seaport Village.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\u003c/p>\u003cp>\u003cdiv class='utils-parseShortcode-shortcodes-__shortcodes__shortcodeWrapper'>\n \u003ciframe width='undefined' height='undefined'\n scrolling='no' frameborder='no'\n src='https://w.soundcloud.com/player/?url=”https://api.soundcloud.com/tracks/162033392″&visual=true&undefined'\n title='”https://api.soundcloud.com/tracks/162033392″'>\n \u003c/iframe>\n \u003c/div>\u003c/p>\u003cp> Vallejo’s job is to help kids stay in school, connected to friends and family. The slide into isolation can make everything, including auditory and visual hallucinations, much worse.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"title": "Stanford Scientists Use Fruit Flies to Study Diabetes",
"headTitle": "Stanford Scientists Use Fruit Flies to Study Diabetes | KQED",
"content": "\u003cfigure id=\"attachment_20356\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-FEATURE-Dahanukar-Lab-UC-Riverside.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-20356 size-full\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-FEATURE-Dahanukar-Lab-UC-Riverside.jpg\" alt=\"Tiny fruit flies will help Stanford scientists study the complicated genetics of type 2 diabetes. (Dahanukar Lab/UC Riverside)\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The tiny fruit fly will help Stanford scientists study the complicated genetics of type 2 diabetes. (Dahanukar Lab/UC Riverside)\u003c/figcaption>\u003c/figure>\n\u003cp>An unusual patient is helping scientists study diabetes.\u003c/p>\n\u003cp>In a paper published today, Stanford researchers report a new way to use fruit flies to sort through the complicated genetics of Type 2 diabetes.\u003c/p>\n\u003cp>Type 2 diabetes, once known as adult-onset diabetes, is the most common form of diabetes and affects millions of Americans. The condition is partly genetic, and past studies have uncovered many possible risk genes associated with the disease.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘There are scores of these genes that have been linked but not proven to have a causative role in diabetes. No one really knows what most of those [genes] do.’\u003ccite>— Seung Kim, Stanford\u003c/cite>\u003c/aside>\n\u003cp>Problem is, scientists don’t understand enough about these genes to know which ones are the real culprits.\u003c/p>\n\u003cp>“There are scores of these genes that have been linked but not proven to have a causative role in diabetes,” said Seung Kim, a professor at the Stanford School of Medicine and the senior author of the study. “No one really knows what most of those [genes] do.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Although it’s possible to study the genes in mice or in human cells, Kim says it’s extremely laborious and expensive. He thinks fruit flies will offer researchers an easier, faster and cheaper way to study the genes.\u003c/p>\n\u003cp>Type 2 diabetes is characterized by the body’s inability to properly create or respond to insulin, a molecule that regulates blood sugar. Practically all animals, including fruit flies, use insulin to control how they metabolize sugar. And while flies may seem a far cry from humans, Kim says they are a reasonable experimental stand-in for studying the disease.\u003c/p>\n\u003cp>To study diabetes in flies, Kim first needed a way to monitor the insulin in the tiny creatures’ blood.\u003c/p>\n\u003cp>“Because the size of a fruit fly is obviously very small, it doesn’t have much blood,” Kim explained. “Measuring insulin in fruit flies has been a real challenge in the field, and something we’ve been trying to overcome for several years.”\u003c/p>\n\u003cfigure id=\"attachment_20355\" class=\"wp-caption alignleft\" style=\"max-width: 340px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-Dime-University-of-Missouri-e1407359205217.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-20355\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-Dime-University-of-Missouri-e1407359205217.jpg\" alt=\"The small size of fruit flies makes it difficult to measure insulin levels in their blood. (University of Missouri)\" width=\"340\" height=\"290\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The small size of fruit flies makes it particularly difficult to measure insulin levels in their blood. (University of Missouri)\u003c/figcaption>\u003c/figure>\n\u003cp>Kim and his team figured out how to add a molecular label to fruit fly insulin that allowed them to reliably measure very low levels of insulin in extremely small samples of fly blood.\u003c/p>\n\u003cp>They are now using this technique to study different risk genes associated with Type 2 diabetes. In the current study, they examined two such genes. One gene controlled how much insulin was produced in the fly, while the other regulated the amount of insulin circulating in the fly’s blood. These results provide useful information about how each gene could uniquely relate to diabetes.\u003c/p>\n\u003cp>“I think this a very nice example of using the power of \u003cem>Drosophila\u003c/em> [fruit fly] genetics to try to gain insights into human disease,” said Michael German. German is the Clinical Director of the UCSF Diabetes Center and was not involved in the study.\u003c/p>\n\u003cp>German points out that fruit flies are just the first step toward figuring out how diabetes works in humans. “Ultimately anything that you find out from flies you then have to confirm in mammals and in humans,” he said.\u003c/p>\n\u003cp>But using flies as an experimental model is a good starting point.\u003c/p>\n\u003cp>“I think that sometimes people undervalue these kinds of models,” says German. “They really are remarkably powerful, and we can find things in these models that we would never find if we just tried to study humans, or if we just tried to study mice.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Moving forward, Kim will use his fruit fly system to study the many human genes associated with Type 2 diabetes. His experiments will help researchers prioritize which genes to focus on in more challenging experimental systems — such as mouse and human cells — to ultimately develop new approaches to treating diabetes.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_20356\" class=\"wp-caption alignnone\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-FEATURE-Dahanukar-Lab-UC-Riverside.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-20356 size-full\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-FEATURE-Dahanukar-Lab-UC-Riverside.jpg\" alt=\"Tiny fruit flies will help Stanford scientists study the complicated genetics of type 2 diabetes. (Dahanukar Lab/UC Riverside)\" width=\"640\" height=\"360\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The tiny fruit fly will help Stanford scientists study the complicated genetics of type 2 diabetes. (Dahanukar Lab/UC Riverside)\u003c/figcaption>\u003c/figure>\n\u003cp>An unusual patient is helping scientists study diabetes.\u003c/p>\n\u003cp>In a paper published today, Stanford researchers report a new way to use fruit flies to sort through the complicated genetics of Type 2 diabetes.\u003c/p>\n\u003cp>Type 2 diabetes, once known as adult-onset diabetes, is the most common form of diabetes and affects millions of Americans. The condition is partly genetic, and past studies have uncovered many possible risk genes associated with the disease.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘There are scores of these genes that have been linked but not proven to have a causative role in diabetes. No one really knows what most of those [genes] do.’\u003ccite>— Seung Kim, Stanford\u003c/cite>\u003c/aside>\n\u003cp>Problem is, scientists don’t understand enough about these genes to know which ones are the real culprits.\u003c/p>\n\u003cp>“There are scores of these genes that have been linked but not proven to have a causative role in diabetes,” said Seung Kim, a professor at the Stanford School of Medicine and the senior author of the study. “No one really knows what most of those [genes] do.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Although it’s possible to study the genes in mice or in human cells, Kim says it’s extremely laborious and expensive. He thinks fruit flies will offer researchers an easier, faster and cheaper way to study the genes.\u003c/p>\n\u003cp>Type 2 diabetes is characterized by the body’s inability to properly create or respond to insulin, a molecule that regulates blood sugar. Practically all animals, including fruit flies, use insulin to control how they metabolize sugar. And while flies may seem a far cry from humans, Kim says they are a reasonable experimental stand-in for studying the disease.\u003c/p>\n\u003cp>To study diabetes in flies, Kim first needed a way to monitor the insulin in the tiny creatures’ blood.\u003c/p>\n\u003cp>“Because the size of a fruit fly is obviously very small, it doesn’t have much blood,” Kim explained. “Measuring insulin in fruit flies has been a real challenge in the field, and something we’ve been trying to overcome for several years.”\u003c/p>\n\u003cfigure id=\"attachment_20355\" class=\"wp-caption alignleft\" style=\"max-width: 340px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-Dime-University-of-Missouri-e1407359205217.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"wp-image-20355\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/Drosophila-Dime-University-of-Missouri-e1407359205217.jpg\" alt=\"The small size of fruit flies makes it difficult to measure insulin levels in their blood. (University of Missouri)\" width=\"340\" height=\"290\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The small size of fruit flies makes it particularly difficult to measure insulin levels in their blood. (University of Missouri)\u003c/figcaption>\u003c/figure>\n\u003cp>Kim and his team figured out how to add a molecular label to fruit fly insulin that allowed them to reliably measure very low levels of insulin in extremely small samples of fly blood.\u003c/p>\n\u003cp>They are now using this technique to study different risk genes associated with Type 2 diabetes. In the current study, they examined two such genes. One gene controlled how much insulin was produced in the fly, while the other regulated the amount of insulin circulating in the fly’s blood. These results provide useful information about how each gene could uniquely relate to diabetes.\u003c/p>\n\u003cp>“I think this a very nice example of using the power of \u003cem>Drosophila\u003c/em> [fruit fly] genetics to try to gain insights into human disease,” said Michael German. German is the Clinical Director of the UCSF Diabetes Center and was not involved in the study.\u003c/p>\n\u003cp>German points out that fruit flies are just the first step toward figuring out how diabetes works in humans. “Ultimately anything that you find out from flies you then have to confirm in mammals and in humans,” he said.\u003c/p>\n\u003cp>But using flies as an experimental model is a good starting point.\u003c/p>\n\u003cp>“I think that sometimes people undervalue these kinds of models,” says German. “They really are remarkably powerful, and we can find things in these models that we would never find if we just tried to study humans, or if we just tried to study mice.”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>Moving forward, Kim will use his fruit fly system to study the many human genes associated with Type 2 diabetes. His experiments will help researchers prioritize which genes to focus on in more challenging experimental systems — such as mouse and human cells — to ultimately develop new approaches to treating diabetes.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cdiv class=\"audio-wrap\">\n\u003ch2>Listen:\u003c/h2>\n\u003cp>http://www.kqed.org/.stream/anon/radio/science/2014/08/20140804science.mp3\u003c/p>\n\u003c/div>\n\u003cp>The first sign of trouble, says Veronica, was when her daughter’s grades started to slip. At 15, Jasmin had been an honor roll student in her San Diego middle school. Suddenly, it was a strain even to sit through class.\u003c/p>\n\u003cp>“She would come home from school exhausted,” Veronica recalls. “She’d go to a corner in the living room and just sit there, away from everybody.” (Veronica asked us not to use her family’s last name, because Jasmin is still a minor.)\u003c/p>\n\u003cfigure id=\"attachment_20190\" class=\"wp-caption aligncenter\" style=\"max-width: 2721px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1068-e1406926256788.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20190\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1068-e1406926256788.jpg\" alt=\"Jasmin heads out to the beach in San Diego on a windy day, to fly a kite. (Marvi Lacar/KQED)\" width=\"2721\" height=\"2617\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At 15, Jasmin was intensely sensitive to noise and light; her grades dropped. Some psychiatrists believe she was experiencing early symptoms of psychosis. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>What Jasmin remembers from that time is an acute sensitivity to sound and light. She wore dark sunglasses around the house and asked her family to turn the music down.\u003c/p>\n\u003cp>“It wasn’t a headache or anything, it would just bother me,” Jasmin recalls.\u003c/p>\n\u003cp>Within months, she had declined to the point where she couldn’t go to school, couldn’t eat without assistance.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘It feels like your child is not there. She’s looking at you, but she’s not comprehending who you are, where she is.’\u003c/aside>\n\u003cp>“It feels like your child is not there,” Veronica says. “She’s looking at you, but she’s not comprehending who you are, where she is.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>Eventually, Jasmin recovered from her catatonic state, but only after things got much worse: a diagnosis of psychosis, a brief hospitalization and powerful anti-psychotic drugs that caused a 40-pound weight gain over three months.\u003c/p>\n\u003cp>Could the worst of it have been avoided had doctors paid closer attention to Jasmin’s earliest symptoms, particularly her sudden problems with schoolwork and her sensitivity to noise and bright lights?\u003c/p>\n\u003cp>A new generation of schizophrenia researchers believes these struggles may be some of the earliest symptoms of schizophrenia, symptoms of a cognitive decline that may precede, even cause the delusions and hallucinations the disease is famous for. \u003c/p>\n\u003cp>\u003cstrong>A Mysterious Disease\u003c/strong>\u003c/p>\n\u003cp>Schizophrenia is twice as common as Alzheimer’s disease, but almost nothing is known about how it works in the body. As with most other mental illnesses, there’s no blood test for schizophrenia, no scan that can diagnose it.\u003c/p>\n\u003cp>Instead, schizophrenia is defined by symptoms patients describe about themselves, particularly a blurring of the boundaries of reality.\u003c/p>\n\u003cp>A patient may hear strange, often threatening voices that no one else can hear. She may believe she is being spied on through her television, that she is telepathic, or that newspaper articles contain hidden messages directed at her alone.\u003c/p>\n\u003cp>These strange behaviors – hallucinations and delusions — have defined the disease since it was first formally described in 1950. The word “schizophrenia” means, literally, “split mind”: a division between what the patient believes is real and what most other people would agree is real.\u003c/p>\n\u003cp>Society’s preoccupation with hallucinations and delusions is easy to understand, says Sophia Vinogradov, a psychiatrist and researcher at the San Francisco VA hospital.\u003c/p>\n\u003cfigure id=\"attachment_20239\" class=\"wp-caption alignright\" style=\"max-width: 369px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/schiz-graphic.png\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\" wp-image-20239\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/schiz-graphic.png\" alt=\"(David Pierce/KQED)\" width=\"369\" height=\"790\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">(David Pierce/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>“They’re right there, in your face,” Vinogradov says. “And they’re frightening. They’re frightening for the person who has them and they’re frightening for society.”\u003c/p>\n\u003cp>She says that’s why anti-psychotic drugs, which were developed in the 1960s, seemed like such a breakthrough. Until then, nothing else had worked to help people with schizophrenia.“Up until that point we had wrapping them in wet towels, locking them in a padded cell,” Vinogradov says. “Frontal lobotomies if the behavior was really out of control. I mean, what did we have? So when antipsychotic medications did evolve, and they did reduce psychotic symptoms, it was like the heavens had opened.”\u003c/p>\n\u003cp>But the drugs came with powerful side effects. They left some people virtually comatose. Even the modern versions can cause serious weight gain. That’s one reason people with schizophrenia are at least twice as likely to die of cardiovascular disease.\u003c/p>\n\u003cp>And in recent years, scientists have begun asking whether the voices are better viewed as a symptom of something else, says Vikaas Sohal, a researcher at UCSF.\u003c/p>\n\u003cp>“If someone came to you with cancer and said, ‘My back is hurting, my gums bleed, I’m tired, I have headaches,'” Sohal says, “okay, there’s all these things, but that’s not what cancer is. Cancer is this group of cells that are dividing uncontrollably.”\u003c/p>\n\u003cp>In other words, giving antipsychotics to a person with schizophrenia may be like giving painkillers to someone with cancer. It might help, but it’s not getting at the cause.\u003c/p>\n\u003cp>\u003cstrong>Cognitive Decline as the First Sign of Disease \u003c/strong>\u003c/p>\n\u003cp>Basic cognitive problems may precede hallucinations and delusions by a decade or more.\u003c/p>\n\u003cp>Elaine Walker, a professor of psychology and neuroscience at Emory University, studied home movies of young children and \u003ca href=\"http://www.psycontent.com/content/9181225j68206743/\">noticed\u003c/a> that children who would later develop schizophrenia seemed to walk differently than the control group. Their gait seemed particularly abnormal on the left side of their bodies.\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments\u003c/strong>This is the second story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part One: \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">New Clinics in California Seek to Stop Schizophrenia Before it Starts\u003c/a>\u003c/li>\n\u003cli>Part Three: \u003ca href=\"http://ww2.kqed.org/science/audio/schizophrenia-what-its-like-to-hear-voices/\">Schizophrenia: What It’s Like to Hear Voices\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Other studies point to a \u003ca href=\"http://www.schizophreniaforum.org/new/detail.asp?id=1950\">decline in IQ\u003c/a> that happens over the time the disease develops.\u003c/p>\n\u003cp>People in the early stages of schizophrenia “seem to have problems focusing attention, planning, trouble with encoding and storing memories,” says Daniel Mathalon, a neuroscientist at UCSF. “Patients sometimes say they used to be able to read books, now they can’t read books. They can’t sustain focus. They used to build models, now they don’t. They used to be able to play the guitar well, now that’s deteriorated.”\u003c/p>\n\u003cp>Parents hope, he says, that the problems are “just a phase that an adolescent is going through. Sometimes it is, but sometimes it’s the predecessor to a full-blown psychotic illness.”\u003c/p>\n\u003cp>\u003cstrong>A Problem of Information Overload\u003c/strong>\u003c/p>\n\u003cp>In recent years, scientists have begun to talk about schizophrenia as a disease of “\u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/12505794\">salience\u003c/a>,” in which the brain loses the ability to tune out information that isn’t useful or relevant.\u003c/p>\n\u003cp>“They are walking down the street trying to have a conversation and their brain is being flooded with the sound of the door slamming, the airplane going overhead,” says Vinogradov, of the San Francisco VA hospital. “The brain is starting to process all of that information as if it has meaning, and is something the brain needs to pay attention to and needs to do something about.”\u003c/p>\n\u003cp>Maybe, the theory goes, that’s what gives rise to hallucinations and delusions. The mind seeks explanations for the extra data coming in.\u003c/p>\n\u003cp>“If you pay attention to everything,” says UCSF’s Sohal, “you might start paying attention to coincidences, and you might get paranoid. Or you might pay even more attention to your own thoughts and start thinking, ‘These are other peoples thoughts.’”\u003c/p>\n\u003cfigure id=\"attachment_20217\" class=\"wp-caption aligncenter\" style=\"max-width: 3456px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1025.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20217\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1025.jpg\" alt=\"Young people taking part in a mental illness prevention program called Kickstart fly kites at San Diego's Seaport Village. Marvi/KQED)\" width=\"3456\" height=\"3456\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Young people taking part in a mental illness prevention program called Kickstart fly kites at San Diego’s Seaport Village. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>New Treatments Emerge\u003c/strong>\u003c/p>\n\u003cp>When you change how you define a disease, you begin to change how you treat it.\u003c/p>\n\u003cp>Increasingly people in the early stages of schizophrenia are prescribed fish oil and exercise, to support basic brain functioning. Drug companies are \u003ca href=\"http://schizophrenia.com/?p=110\">working\u003c/a> on new medicines that could do the same.\u003c/p>\n\u003cp>At the Citywide Mental Health Center in San Francisco’s Tenderloin neighborhood, Vinogradov is leading \u003ca href=\"http://vinogradovlab.com/#/sectpage/4560739020\">a study\u003c/a> to see whether the brain can be, essentially, re-taught.\u003c/p>\n\u003cp>A middle-aged man named George, wearing a crisp short-sleeved shirt, sits at a computer. He’s wearing plastic gloves.\u003c/p>\n\u003cp>“Why the gloves?” I ask him. “Gloves?” he says. “So the cosmic dust doesn’t get on my hands.”\u003c/p>\n\u003cp>George can see my voice, he tells me. It looks “yellow, with light pinkish color.” He wants to know whether I’ve ever seen voices, or would like to.\u003c/p>\n\u003cp>“I don’t know,” I tell him. “Is it a good thing?”\u003c/p>\n\u003caside class=\"pullquote alignleft\">Giving antipsychotics to a person with schizophrenia may be like giving painkillers to someone with cancer. It might help, but it’s not getting at the cause.\u003c/aside>\n\u003cp>“Yes,” he answers. “You can understand life in general better.”\u003c/p>\n\u003cp>“You feel like you understand things other people don’t?” I ask.\u003c/p>\n\u003cp>“Of course,” George says. “It makes you superior.”\u003c/p>\n\u003cp>As we talk, George drags his cursor across the screen, following directions from a cognitive training exercise designed by the San Francisco software company Posit Science.\u003c/p>\n\u003cp>“Move the boy to the school,” the voice intones. George complies. He supplies his own commentary.\u003c/p>\n\u003cp>“OK, he’s going to school, see? Cutting, smoking cigarettes in the back.”\u003c/p>\n\u003cp>Researchers tend to avoid the term “video games.” These exercises are about as much fun as brushing your teeth. The idea here is to train George to tune out distractions and focus on simple instructions.\u003c/p>\n\u003cp>Another exercise repeats a word, like asking the user to click on the emotion that best describes how the word is said. They’re given four choices: happy, angry, sad and neutral.\u003c/p>\n\u003cp>\u003cstrong>For Some People, Not All. \u003c/strong>\u003c/p>\n\u003cp>The idea here isn’t to replace anti-psychotic drugs, at least not for everyone. Vinogradov says there are some people whose voices or delusions are so destructive, so violent, that they need to be turned off.\u003c/p>\n\u003cp>But for another group of people, doctors might be able to focus on a different set of questions, Vinogradov says.\u003c/p>\n\u003cp>“Is this person able to have the kind of life they want? Are they able to have friends, to have people who they can love, who can love them back? Are they able to keep food and shelter?”\u003c/p>\n\u003cp>Vinogradov, Mathalon and others point to studies showing that delusions and hallucinations aren’t always the factors that interfere with a person’s ability to lead a fulfilling life.\u003c/p>\n\u003cp>By focusing on cognitive problems, says Mathalon, “we might have greater impact on outcomes for patients. We might have a greater impact on whether they can successfully work, have relationships, than if we just quell their psychotic symptoms, keep the voices from intruding.”\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Silencing the voices with big doses of anti-psychotic drugs may, in some cases, do more harm than good.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/div>\n\u003cp>The first sign of trouble, says Veronica, was when her daughter’s grades started to slip. At 15, Jasmin had been an honor roll student in her San Diego middle school. Suddenly, it was a strain even to sit through class.\u003c/p>\n\u003cp>“She would come home from school exhausted,” Veronica recalls. “She’d go to a corner in the living room and just sit there, away from everybody.” (Veronica asked us not to use her family’s last name, because Jasmin is still a minor.)\u003c/p>\n\u003cfigure id=\"attachment_20190\" class=\"wp-caption aligncenter\" style=\"max-width: 2721px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1068-e1406926256788.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20190\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1068-e1406926256788.jpg\" alt=\"Jasmin heads out to the beach in San Diego on a windy day, to fly a kite. (Marvi Lacar/KQED)\" width=\"2721\" height=\"2617\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">At 15, Jasmin was intensely sensitive to noise and light; her grades dropped. Some psychiatrists believe she was experiencing early symptoms of psychosis. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>What Jasmin remembers from that time is an acute sensitivity to sound and light. She wore dark sunglasses around the house and asked her family to turn the music down.\u003c/p>\n\u003cp>“It wasn’t a headache or anything, it would just bother me,” Jasmin recalls.\u003c/p>\n\u003cp>Within months, she had declined to the point where she couldn’t go to school, couldn’t eat without assistance.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘It feels like your child is not there. She’s looking at you, but she’s not comprehending who you are, where she is.’\u003c/aside>\n\u003cp>“It feels like your child is not there,” Veronica says. “She’s looking at you, but she’s not comprehending who you are, where she is.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Eventually, Jasmin recovered from her catatonic state, but only after things got much worse: a diagnosis of psychosis, a brief hospitalization and powerful anti-psychotic drugs that caused a 40-pound weight gain over three months.\u003c/p>\n\u003cp>Could the worst of it have been avoided had doctors paid closer attention to Jasmin’s earliest symptoms, particularly her sudden problems with schoolwork and her sensitivity to noise and bright lights?\u003c/p>\n\u003cp>A new generation of schizophrenia researchers believes these struggles may be some of the earliest symptoms of schizophrenia, symptoms of a cognitive decline that may precede, even cause the delusions and hallucinations the disease is famous for. \u003c/p>\n\u003cp>\u003cstrong>A Mysterious Disease\u003c/strong>\u003c/p>\n\u003cp>Schizophrenia is twice as common as Alzheimer’s disease, but almost nothing is known about how it works in the body. As with most other mental illnesses, there’s no blood test for schizophrenia, no scan that can diagnose it.\u003c/p>\n\u003cp>Instead, schizophrenia is defined by symptoms patients describe about themselves, particularly a blurring of the boundaries of reality.\u003c/p>\n\u003cp>A patient may hear strange, often threatening voices that no one else can hear. She may believe she is being spied on through her television, that she is telepathic, or that newspaper articles contain hidden messages directed at her alone.\u003c/p>\n\u003cp>These strange behaviors – hallucinations and delusions — have defined the disease since it was first formally described in 1950. The word “schizophrenia” means, literally, “split mind”: a division between what the patient believes is real and what most other people would agree is real.\u003c/p>\n\u003cp>Society’s preoccupation with hallucinations and delusions is easy to understand, says Sophia Vinogradov, a psychiatrist and researcher at the San Francisco VA hospital.\u003c/p>\n\u003cfigure id=\"attachment_20239\" class=\"wp-caption alignright\" style=\"max-width: 369px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/schiz-graphic.png\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\" wp-image-20239\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/schiz-graphic.png\" alt=\"(David Pierce/KQED)\" width=\"369\" height=\"790\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">(David Pierce/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>“They’re right there, in your face,” Vinogradov says. “And they’re frightening. They’re frightening for the person who has them and they’re frightening for society.”\u003c/p>\n\u003cp>She says that’s why anti-psychotic drugs, which were developed in the 1960s, seemed like such a breakthrough. Until then, nothing else had worked to help people with schizophrenia.“Up until that point we had wrapping them in wet towels, locking them in a padded cell,” Vinogradov says. “Frontal lobotomies if the behavior was really out of control. I mean, what did we have? So when antipsychotic medications did evolve, and they did reduce psychotic symptoms, it was like the heavens had opened.”\u003c/p>\n\u003cp>But the drugs came with powerful side effects. They left some people virtually comatose. Even the modern versions can cause serious weight gain. That’s one reason people with schizophrenia are at least twice as likely to die of cardiovascular disease.\u003c/p>\n\u003cp>And in recent years, scientists have begun asking whether the voices are better viewed as a symptom of something else, says Vikaas Sohal, a researcher at UCSF.\u003c/p>\n\u003cp>“If someone came to you with cancer and said, ‘My back is hurting, my gums bleed, I’m tired, I have headaches,'” Sohal says, “okay, there’s all these things, but that’s not what cancer is. Cancer is this group of cells that are dividing uncontrollably.”\u003c/p>\n\u003cp>In other words, giving antipsychotics to a person with schizophrenia may be like giving painkillers to someone with cancer. It might help, but it’s not getting at the cause.\u003c/p>\n\u003cp>\u003cstrong>Cognitive Decline as the First Sign of Disease \u003c/strong>\u003c/p>\n\u003cp>Basic cognitive problems may precede hallucinations and delusions by a decade or more.\u003c/p>\n\u003cp>Elaine Walker, a professor of psychology and neuroscience at Emory University, studied home movies of young children and \u003ca href=\"http://www.psycontent.com/content/9181225j68206743/\">noticed\u003c/a> that children who would later develop schizophrenia seemed to walk differently than the control group. Their gait seemed particularly abnormal on the left side of their bodies.\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments\u003c/strong>This is the second story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part One: \u003ca href=\"http://ww2.kqed.org/science/audio/new-clinics-in-california-seek-to-stop-schizophrenia-before-it-starts/\">New Clinics in California Seek to Stop Schizophrenia Before it Starts\u003c/a>\u003c/li>\n\u003cli>Part Three: \u003ca href=\"http://ww2.kqed.org/science/audio/schizophrenia-what-its-like-to-hear-voices/\">Schizophrenia: What It’s Like to Hear Voices\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Other studies point to a \u003ca href=\"http://www.schizophreniaforum.org/new/detail.asp?id=1950\">decline in IQ\u003c/a> that happens over the time the disease develops.\u003c/p>\n\u003cp>People in the early stages of schizophrenia “seem to have problems focusing attention, planning, trouble with encoding and storing memories,” says Daniel Mathalon, a neuroscientist at UCSF. “Patients sometimes say they used to be able to read books, now they can’t read books. They can’t sustain focus. They used to build models, now they don’t. They used to be able to play the guitar well, now that’s deteriorated.”\u003c/p>\n\u003cp>Parents hope, he says, that the problems are “just a phase that an adolescent is going through. Sometimes it is, but sometimes it’s the predecessor to a full-blown psychotic illness.”\u003c/p>\n\u003cp>\u003cstrong>A Problem of Information Overload\u003c/strong>\u003c/p>\n\u003cp>In recent years, scientists have begun to talk about schizophrenia as a disease of “\u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/12505794\">salience\u003c/a>,” in which the brain loses the ability to tune out information that isn’t useful or relevant.\u003c/p>\n\u003cp>“They are walking down the street trying to have a conversation and their brain is being flooded with the sound of the door slamming, the airplane going overhead,” says Vinogradov, of the San Francisco VA hospital. “The brain is starting to process all of that information as if it has meaning, and is something the brain needs to pay attention to and needs to do something about.”\u003c/p>\n\u003cp>Maybe, the theory goes, that’s what gives rise to hallucinations and delusions. The mind seeks explanations for the extra data coming in.\u003c/p>\n\u003cp>“If you pay attention to everything,” says UCSF’s Sohal, “you might start paying attention to coincidences, and you might get paranoid. Or you might pay even more attention to your own thoughts and start thinking, ‘These are other peoples thoughts.’”\u003c/p>\n\u003cfigure id=\"attachment_20217\" class=\"wp-caption aligncenter\" style=\"max-width: 3456px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1025.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-20217\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/08/20140618_Schizo_1025.jpg\" alt=\"Young people taking part in a mental illness prevention program called Kickstart fly kites at San Diego's Seaport Village. Marvi/KQED)\" width=\"3456\" height=\"3456\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Young people taking part in a mental illness prevention program called Kickstart fly kites at San Diego’s Seaport Village. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>New Treatments Emerge\u003c/strong>\u003c/p>\n\u003cp>When you change how you define a disease, you begin to change how you treat it.\u003c/p>\n\u003cp>Increasingly people in the early stages of schizophrenia are prescribed fish oil and exercise, to support basic brain functioning. Drug companies are \u003ca href=\"http://schizophrenia.com/?p=110\">working\u003c/a> on new medicines that could do the same.\u003c/p>\n\u003cp>At the Citywide Mental Health Center in San Francisco’s Tenderloin neighborhood, Vinogradov is leading \u003ca href=\"http://vinogradovlab.com/#/sectpage/4560739020\">a study\u003c/a> to see whether the brain can be, essentially, re-taught.\u003c/p>\n\u003cp>A middle-aged man named George, wearing a crisp short-sleeved shirt, sits at a computer. He’s wearing plastic gloves.\u003c/p>\n\u003cp>“Why the gloves?” I ask him. “Gloves?” he says. “So the cosmic dust doesn’t get on my hands.”\u003c/p>\n\u003cp>George can see my voice, he tells me. It looks “yellow, with light pinkish color.” He wants to know whether I’ve ever seen voices, or would like to.\u003c/p>\n\u003cp>“I don’t know,” I tell him. “Is it a good thing?”\u003c/p>\n\u003caside class=\"pullquote alignleft\">Giving antipsychotics to a person with schizophrenia may be like giving painkillers to someone with cancer. It might help, but it’s not getting at the cause.\u003c/aside>\n\u003cp>“Yes,” he answers. “You can understand life in general better.”\u003c/p>\n\u003cp>“You feel like you understand things other people don’t?” I ask.\u003c/p>\n\u003cp>“Of course,” George says. “It makes you superior.”\u003c/p>\n\u003cp>As we talk, George drags his cursor across the screen, following directions from a cognitive training exercise designed by the San Francisco software company Posit Science.\u003c/p>\n\u003cp>“Move the boy to the school,” the voice intones. George complies. He supplies his own commentary.\u003c/p>\n\u003cp>“OK, he’s going to school, see? Cutting, smoking cigarettes in the back.”\u003c/p>\n\u003cp>Researchers tend to avoid the term “video games.” These exercises are about as much fun as brushing your teeth. The idea here is to train George to tune out distractions and focus on simple instructions.\u003c/p>\n\u003cp>Another exercise repeats a word, like asking the user to click on the emotion that best describes how the word is said. They’re given four choices: happy, angry, sad and neutral.\u003c/p>\n\u003cp>\u003cstrong>For Some People, Not All. \u003c/strong>\u003c/p>\n\u003cp>The idea here isn’t to replace anti-psychotic drugs, at least not for everyone. Vinogradov says there are some people whose voices or delusions are so destructive, so violent, that they need to be turned off.\u003c/p>\n\u003cp>But for another group of people, doctors might be able to focus on a different set of questions, Vinogradov says.\u003c/p>\n\u003cp>“Is this person able to have the kind of life they want? Are they able to have friends, to have people who they can love, who can love them back? Are they able to keep food and shelter?”\u003c/p>\n\u003cp>Vinogradov, Mathalon and others point to studies showing that delusions and hallucinations aren’t always the factors that interfere with a person’s ability to lead a fulfilling life.\u003c/p>\n\u003cp>By focusing on cognitive problems, says Mathalon, “we might have greater impact on outcomes for patients. We might have a greater impact on whether they can successfully work, have relationships, than if we just quell their psychotic symptoms, keep the voices from intruding.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"audio-wrap\">\n\u003ch2>Listen:\u003c/h2>\n\u003cp>http://www.kqed.org/.stream/anon/radio/science/2014/07/20140728science.mp3\u003c/p>\n\u003c/div>\n\u003cfigure id=\"attachment_19747\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Unknown-1-e1406323367960.jpeg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Unknown-1-e1406323367960.jpeg\" alt=\"Reagan was 19 when she started having hallucinations. (Marvi Lacar/KQED)\" width=\"640\" height=\"360\" class=\"size-full wp-image-19747\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Reagan was 19 when she started having hallucinations. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>The important thing is that Reagan knew something was wrong.\u003c/p>\n\u003cp>When I met her, she was 23, a smart, wry young woman living with her mother and stepdad in Simi Valley, about an hour east of Ventura.\u003c/p>\n\u003cp>“Reagan” had just started a program that would train her to be a respiratory therapist. Concerned about future job prospects, she asked me not to use her real name.\u003c/p>\n\u003cp>Five years ago, Reagan’s prospects weren’t nearly so bright. At 19, she had been severely depressed, on and off, for years. During the bad times, she’d hide out in her room making thin, neat cuts with a razor on her upper arm.\u003c/p>\n\u003cp>“I didn’t do much of anything,” Reagan recalls. “It required too much brain power.”\u003c/p>\n\u003caside class=\"pullquote alignleft\">\nIn schizophrenia, the loss of insight signals a psychotic break, the formal commencement of the disease itself.\u003c/aside>\n\u003cp>“Her depression just sucked the life out of you,” Kathy, Reagan’s mother, recalls. “I had no idea what to do or where to go with it.”\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>One night in 2010, Reagan’s mental state took an ominous new turn. Driving home from her job at McDonald’s, she found herself fascinated by the headlights of an oncoming car.\u003c/p>\n\u003cp>“I had the weird thought of, you know, I’ve never noticed this, but their headlights really look like eyes.” To Reagan, the car seemed malicious. It wanted to hurt her.\u003c/p>\n\u003cp>Kathy tried to reason with her.\u003c/p>\n\u003cp>“I’m like ‘honey you know it’s a car, right? You know those are headlights, right?’ ‘Yes.’ ‘So you understand that this makes no sense.’ ‘I know, but this is what I see, and it’s scaring me.’”\u003c/p>\n\u003cp>In other words, Reagan had insight, defined in psychiatry as the ability to understand that one’s experiences are attributable to a mental illness. \u003c/p>\n\u003cp>What Reagan saw did not fit with what she believed. She knew she was hallucinating.\u003c/p>\n\u003cp>\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe loading=\"lazy\" src=\"http://projects1.kqed.org/imageslider/schizophreniasliders.html\" width=\"640\" height=\"680\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>\u003cstrong>A Disease That Unfolds Over Time\u003c/strong>\u003c/p>\n\u003cp>In schizophrenia, the loss of insight signals a psychotic break, the formal commencement of the disease itself. Typically, a first psychotic break occurs in a person’s late teens or early 20s. In men, the range is 15-24; in women, 25-34.\u003c/p>\n\u003cp>Often, says Rachel Loewy, an associate professor of psychiatry at UCSF, the onset coincides with an abrupt change in a young person’s life, such as leaving home for the first time.\u003c/p>\n\u003cp>“Every November we get a huge influx of people who went off to college, into a stressful environment, heading into finals. That’s when we see a lot of first psychotic episodes.”\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments\u003c/strong>This is the first story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part Two: \u003ca href=\"http://ww2.kqed.org/science/audio/what-is-schizophrenia-scientists-call-for-new-thinking/\">What Is Schizophrenia? Scientists Call for New Thinking\u003c/a>\u003c/li>\n\u003cli>Part Three: \u003ca href=\"http://ww2.kqed.org/science/audio/schizophrenia-what-its-like-to-hear-voices/\">Schizophrenia: What It’s Like to Hear Voices\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Loewy, who has helped develop several \u003ca href=\"http://prepwellness.org/prep-san-francisco/\">early-intervention programs\u003c/a> in San Francisco and elsewhere, says schizophrenia’s timeline –- hitting a young person at what should be the brink of independence — can make the disease devastating for parents.\u003c/p>\n\u003cp>“The [young person] drops out of college, goes home, doesn’t get a job. He or she never transitions to adulthood,” Loewy says.\u003c/p>\n\u003cp>That first psychotic break can precede a cavalcade of disasters: social isolation, hospitalization, medications with sometimes disabling side effects.\u003c/p>\n\u003cp>So, what if you could intervene earlier, before any of that? Could you stop the process from snowballing?\u003c/p>\n\u003cp>At 19, Reagan hadn’t had a psychotic break. She still had insight. That made her eligible for a new type of program taking shape in California that aims to prevent schizophrenia before it officially begins.\u003c/p>\n\u003cp>The programs draw on research suggesting that schizophrenia unfolds much more slowly than might be obvious, even to families.\u003c/p>\n\u003cp>A genetic predisposition, perhaps triggered by environmental factors, the thinking goes, sets the course of a process that can play out over months, even years.\u003c/p>\n\u003caside class=\"pullquote alignleft\">New research suggests schizophrenia unfolds much more slowly than might be obvious, even to families.\u003c/aside>\n\u003cp>“You start to see a decline in their functioning,” says Daniel Mathalon, who studies brain development in the early stages of psychosis at UCSF.\u003c/p>\n\u003cp>“They were doing better in school, now they’re doing worse,” he says. “Maybe they had friends but they’re starting to be more isolated.”\u003c/p>\n\u003cp>Eventually, these subtle behavioral shifts may take on a surreal quality. A young person may hear faint whispers or hissing, or see flashes of light or shadows on the periphery.\u003c/p>\n\u003cp>“They lack delusional conviction,” explains Mathalon. “They’re experiencing these things; maybe they’re suspicious. But they’re not sure.”\u003c/p>\n\u003cp>Scientists have a word for that state of uncertainty: prodromal.\u003c/p>\n\u003cp>\u003cstrong>‘We Can Stop the Progression of the Disease.’\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Reagan took a \u003ca href=\"http://www.schizophrenia.com/sztest/SIPS.details.htm\">screening test\u003c/a> developed at Yale University that identified her as, possibly, within the prodromal stage of psychosis.\u003c/p>\n\u003cp>She was referred to a clinic in an office park about an hour from her house called \u003ca href=\"http://www.telecarecorp.com/programs/124\">Ventura Early Intervention Prevention Services\u003c/a>, or VIPS, operated by Alameda-based \u003ca href=\"http://www.telecarecorp.com/\">Telecare Corporation\u003c/a> and run by an affable former football player with a doctorate in psychology named Barry Boatman.\u003c/p>\n\u003cp>“If we can slow or stop the progression of that thing as it’s beginning,” Boatman says, “not only are we changing that person’s life, forever, and those who love them, we can save the system millions of dollars.”\u003c/p>\n\u003cp>There are about ten clinics like this one in California. (Schizophrenia.com offers a \u003ca href=\"http://www.schizophrenia.com/earlypsychosis.htm\">resource guide\u003c/a> to early-intervention clinics across the U.S. and internationally.) VIPS, which has a $600,000 annual budget, is one of several run by for-profit companies that contract with counties to provide mental services. \u003c/p>\n\u003cp>Others partner with non-profit providers or research institutions like UCSF or UCLA.\u003c/p>\n\u003cp>In California, participants pay nothing. The programs are funded out of the state’s Mental Health Services Act, a one percent income tax on millionaires that voters passed in 2004.\u003c/p>\n\u003cp>That money buys what’s essentially a two-year, full-court press on kids like Reagan, whose symptoms could be early signs of schizophrenia: family therapy, individual therapy, homework help, job counseling, exercise, often medications. Clients can be as young as ten years old.\u003c/p>\n\u003cfigure id=\"attachment_19749\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1440-e1406326398447.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1440-e1406326398447.jpg\" alt=\"Ashley Wood, an occupational therapist at Kickstart in San Diego, took Tony, 13, out to an arcade as a reward for participating in family therapy sessions. (Marvi Lacar/KQED) \" width=\"640\" height=\"651\" class=\"size-full wp-image-19749\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ashley Wood, an occupational therapist at Kickstart in San Diego, took Tony, 13, out to an arcade as a reward for participating in family therapy sessions. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>After meeting Reagan, I went to San Diego to meet Ashley Wood and a 13-year-old named Tony at John’s Incredible Pizza Company, an arcade and all-you-can-eat buffet in a mall just south of town. They were playing Whack-a-Mole.\u003c/p>\n\u003cp>Wood is an occupational therapist for another prodrome-intervention program called \u003ca href=\"http://www.kickstartsd.org/\">Kickstart\u003c/a>, based in San Diego. Tony is one of her clients. He has spiky black hair and wears cargo shorts and a plastic rosary around his neck.\u003c/p>\n\u003cp>Before he started with Kickstart, Tony had been getting in fights. He was angry at his mom, angry in school. And there was something else.\u003c/p>\n\u003cp>“I used to see and hear stuff,” he tells me, “like weird objects.”\u003c/p>\n\u003cp>When I press him for more details, he turns the questions on me. “Are you a reporter?” he asks.\u003c/p>\n\u003cp>Wood laughs, looking at Tony. “Too many questions, eh?” He smiles.\u003c/p>\n\u003cp>Wood’s job is to help Tony with basic life skills, such as asking for things he needs without getting frustrated. When the pizza parlor’s ice cream machine sputters, she coaches him on how to ask an attendant for help.\u003c/p>\n\u003cp>“When he’s frustrated at school or at home, instead of immediately responding,” Wood says, she’s helping him “find a way to communicate.”\u003c/p>\n\u003cp>“We’re trying to work on the impulse control as well. He’s come a long way, I think.”\u003c/p>\n\u003cfigure id=\"attachment_19750\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1609-e1406326575325.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1609-e1406326575325.jpg\" alt=\"Wood is teaching Tony to control his anger and communicate better with his family. (Marvi Lacar/KQED) \" width=\"640\" height=\"640\" class=\"size-full wp-image-19750\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Wood is teaching Tony to control his anger and communicate better with his family. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>An Experiment Before Its Time?\u003c/strong>\u003c/p>\n\u003cp>Impulsive, unruly, prone to angry outbursts, Tony sounds like a lot of 13-year-old kids. And that’s what makes this type of program controversial.\u003c/p>\n\u003cp>Last year, the American Psychiatric Association \u003ca href=\"http://www.nature.com/news/psychosis-risk-syndrome-excluded-from-dsm-5-1.10610\">opted to exclude\u003c/a> the idea of “psychosis risk syndrome” from its DSM-5 manual of mental disorders, largely because the screening test is generally considered to be only 30 percent accurate. Of three kids who seem to fit the prodrome, only one will actually go on to develop psychosis, or schizophrenia.\u003c/p>\n\u003cp>In 2011, a \u003ca href=\"http://summaries.cochrane.org/CD004718/SCHIZ_early-intervention-for-psychosis\">review\u003c/a> of prodrome intervention programs called the idea of intervention in pre-schizophrenia “inconclusive.”\u003c/p>\n\u003cp>One of the most \u003ca href=\"http://www.huffingtonpost.com/allen-frances/psychosis-risk_b_1289022.html\">vocal critics\u003c/a> of prodrome intervention is Allen Frances, a former professor of psychiatry at Duke University.\u003c/p>\n\u003cp>“This is an experiment far before its time,” says Frances. “We need to be doing this as research before we spread this across the country and risk the harm to the individuals and risk the misallocation of resources in a society.”\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘We’re running up against the limits of what we can do for patients with chronic schizophrenia.’ \u003ccite>— Daniel Mathalon, UCSF\u003c/cite>\u003c/aside>\n\u003cp>Bill McFarlane, a Maine psychiatrist whose PIER Training Institute helped establish several prodrome clinics in California, says he’s seen clear benefits — including \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24632857\">reduced hospitalization rates\u003c/a> — in Portland, Maine, where the Portland Identification and Early Referral Program he established served psychosis risk clients for over a decade. \u003c/p>\n\u003cp>He and other proponents say schizophrenia’s early window may be too precious to miss.\u003c/p>\n\u003cp>“We’re running up against the limits of what we can do for patients who develop schizophrenia, once it goes to chronic stages,” UCSF’s Mathalon says. “I think this is a direction we have to go in, but we have to do it carefully.”\u003c/p>\n\u003cp>Of course when you’re the parent of a kid in trouble you aren’t asking those questions.\u003c/p>\n\u003cp>Before she started the program, Reagan’s mom and step-father, Charlie, say they saw very little future for their daughter.\u003c/p>\n\u003cp>“I thought we were going to have to take care of her for the rest of her life,” says Kathy. “I thought she’d forever be marginal, forever be medicated. I thought we’d just have to get used to it.”\u003c/p>\n\u003cp>Today Reagan is off all her medications. She’s animated, playing board games with her family, excited about going back to school.\u003c/p>\n\u003cp>Her family credits the VIPS program.\u003c/p>\n\u003cp>“We were blessed to have this for her,” Charlie says. “We really were. It saved her life.”\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>Reagan’s family will never know whether the program prevented her from developing schizophrenia. But even if the diagnosis didn’t fit, they say, the treatment did.\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/div>\n\u003cfigure id=\"attachment_19747\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Unknown-1-e1406323367960.jpeg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Unknown-1-e1406323367960.jpeg\" alt=\"Reagan was 19 when she started having hallucinations. (Marvi Lacar/KQED)\" width=\"640\" height=\"360\" class=\"size-full wp-image-19747\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Reagan was 19 when she started having hallucinations. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>The important thing is that Reagan knew something was wrong.\u003c/p>\n\u003cp>When I met her, she was 23, a smart, wry young woman living with her mother and stepdad in Simi Valley, about an hour east of Ventura.\u003c/p>\n\u003cp>“Reagan” had just started a program that would train her to be a respiratory therapist. Concerned about future job prospects, she asked me not to use her real name.\u003c/p>\n\u003cp>Five years ago, Reagan’s prospects weren’t nearly so bright. At 19, she had been severely depressed, on and off, for years. During the bad times, she’d hide out in her room making thin, neat cuts with a razor on her upper arm.\u003c/p>\n\u003cp>“I didn’t do much of anything,” Reagan recalls. “It required too much brain power.”\u003c/p>\n\u003caside class=\"pullquote alignleft\">\nIn schizophrenia, the loss of insight signals a psychotic break, the formal commencement of the disease itself.\u003c/aside>\n\u003cp>“Her depression just sucked the life out of you,” Kathy, Reagan’s mother, recalls. “I had no idea what to do or where to go with it.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>One night in 2010, Reagan’s mental state took an ominous new turn. Driving home from her job at McDonald’s, she found herself fascinated by the headlights of an oncoming car.\u003c/p>\n\u003cp>“I had the weird thought of, you know, I’ve never noticed this, but their headlights really look like eyes.” To Reagan, the car seemed malicious. It wanted to hurt her.\u003c/p>\n\u003cp>Kathy tried to reason with her.\u003c/p>\n\u003cp>“I’m like ‘honey you know it’s a car, right? You know those are headlights, right?’ ‘Yes.’ ‘So you understand that this makes no sense.’ ‘I know, but this is what I see, and it’s scaring me.’”\u003c/p>\n\u003cp>In other words, Reagan had insight, defined in psychiatry as the ability to understand that one’s experiences are attributable to a mental illness. \u003c/p>\n\u003cp>What Reagan saw did not fit with what she believed. She knew she was hallucinating.\u003c/p>\n\u003cp>\u003c!-- iframe plugin v.4.3 wordpress.org/plugins/iframe/ -->\u003cbr>\n\u003ciframe loading=\"lazy\" src=\"http://projects1.kqed.org/imageslider/schizophreniasliders.html\" width=\"640\" height=\"680\" frameborder=\"0\" scrolling=\"no\" class=\"iframe-class\">\u003c/iframe>\u003c/p>\n\u003cp>\u003cstrong>A Disease That Unfolds Over Time\u003c/strong>\u003c/p>\n\u003cp>In schizophrenia, the loss of insight signals a psychotic break, the formal commencement of the disease itself. Typically, a first psychotic break occurs in a person’s late teens or early 20s. In men, the range is 15-24; in women, 25-34.\u003c/p>\n\u003cp>Often, says Rachel Loewy, an associate professor of psychiatry at UCSF, the onset coincides with an abrupt change in a young person’s life, such as leaving home for the first time.\u003c/p>\n\u003cp>“Every November we get a huge influx of people who went off to college, into a stressful environment, heading into finals. That’s when we see a lot of first psychotic episodes.”\u003c/p>\n\u003caside class=\"alignright\">\u003cstrong>Schizophrenia: New Thinking, New Treatments\u003c/strong>This is the first story in a \u003ca href=\"http://ww2.kqed.org/science/series/schizophrenia-new-thinking-new-treatments/\">three-part series\u003c/a> looking at the changing science of schizophrenia and emerging treatments.\n\u003cul>\n\u003cli>Part Two: \u003ca href=\"http://ww2.kqed.org/science/audio/what-is-schizophrenia-scientists-call-for-new-thinking/\">What Is Schizophrenia? Scientists Call for New Thinking\u003c/a>\u003c/li>\n\u003cli>Part Three: \u003ca href=\"http://ww2.kqed.org/science/audio/schizophrenia-what-its-like-to-hear-voices/\">Schizophrenia: What It’s Like to Hear Voices\u003c/a>\u003c/li>\n\u003c/ul>\n\u003c/aside>\n\u003cp>Loewy, who has helped develop several \u003ca href=\"http://prepwellness.org/prep-san-francisco/\">early-intervention programs\u003c/a> in San Francisco and elsewhere, says schizophrenia’s timeline –- hitting a young person at what should be the brink of independence — can make the disease devastating for parents.\u003c/p>\n\u003cp>“The [young person] drops out of college, goes home, doesn’t get a job. He or she never transitions to adulthood,” Loewy says.\u003c/p>\n\u003cp>That first psychotic break can precede a cavalcade of disasters: social isolation, hospitalization, medications with sometimes disabling side effects.\u003c/p>\n\u003cp>So, what if you could intervene earlier, before any of that? Could you stop the process from snowballing?\u003c/p>\n\u003cp>At 19, Reagan hadn’t had a psychotic break. She still had insight. That made her eligible for a new type of program taking shape in California that aims to prevent schizophrenia before it officially begins.\u003c/p>\n\u003cp>The programs draw on research suggesting that schizophrenia unfolds much more slowly than might be obvious, even to families.\u003c/p>\n\u003cp>A genetic predisposition, perhaps triggered by environmental factors, the thinking goes, sets the course of a process that can play out over months, even years.\u003c/p>\n\u003caside class=\"pullquote alignleft\">New research suggests schizophrenia unfolds much more slowly than might be obvious, even to families.\u003c/aside>\n\u003cp>“You start to see a decline in their functioning,” says Daniel Mathalon, who studies brain development in the early stages of psychosis at UCSF.\u003c/p>\n\u003cp>“They were doing better in school, now they’re doing worse,” he says. “Maybe they had friends but they’re starting to be more isolated.”\u003c/p>\n\u003cp>Eventually, these subtle behavioral shifts may take on a surreal quality. A young person may hear faint whispers or hissing, or see flashes of light or shadows on the periphery.\u003c/p>\n\u003cp>“They lack delusional conviction,” explains Mathalon. “They’re experiencing these things; maybe they’re suspicious. But they’re not sure.”\u003c/p>\n\u003cp>Scientists have a word for that state of uncertainty: prodromal.\u003c/p>\n\u003cp>\u003cstrong>‘We Can Stop the Progression of the Disease.’\u003cbr>\n\u003c/strong>\u003c/p>\n\u003cp>Reagan took a \u003ca href=\"http://www.schizophrenia.com/sztest/SIPS.details.htm\">screening test\u003c/a> developed at Yale University that identified her as, possibly, within the prodromal stage of psychosis.\u003c/p>\n\u003cp>She was referred to a clinic in an office park about an hour from her house called \u003ca href=\"http://www.telecarecorp.com/programs/124\">Ventura Early Intervention Prevention Services\u003c/a>, or VIPS, operated by Alameda-based \u003ca href=\"http://www.telecarecorp.com/\">Telecare Corporation\u003c/a> and run by an affable former football player with a doctorate in psychology named Barry Boatman.\u003c/p>\n\u003cp>“If we can slow or stop the progression of that thing as it’s beginning,” Boatman says, “not only are we changing that person’s life, forever, and those who love them, we can save the system millions of dollars.”\u003c/p>\n\u003cp>There are about ten clinics like this one in California. (Schizophrenia.com offers a \u003ca href=\"http://www.schizophrenia.com/earlypsychosis.htm\">resource guide\u003c/a> to early-intervention clinics across the U.S. and internationally.) VIPS, which has a $600,000 annual budget, is one of several run by for-profit companies that contract with counties to provide mental services. \u003c/p>\n\u003cp>Others partner with non-profit providers or research institutions like UCSF or UCLA.\u003c/p>\n\u003cp>In California, participants pay nothing. The programs are funded out of the state’s Mental Health Services Act, a one percent income tax on millionaires that voters passed in 2004.\u003c/p>\n\u003cp>That money buys what’s essentially a two-year, full-court press on kids like Reagan, whose symptoms could be early signs of schizophrenia: family therapy, individual therapy, homework help, job counseling, exercise, often medications. Clients can be as young as ten years old.\u003c/p>\n\u003cfigure id=\"attachment_19749\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1440-e1406326398447.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1440-e1406326398447.jpg\" alt=\"Ashley Wood, an occupational therapist at Kickstart in San Diego, took Tony, 13, out to an arcade as a reward for participating in family therapy sessions. (Marvi Lacar/KQED) \" width=\"640\" height=\"651\" class=\"size-full wp-image-19749\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Ashley Wood, an occupational therapist at Kickstart in San Diego, took Tony, 13, out to an arcade as a reward for participating in family therapy sessions. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>After meeting Reagan, I went to San Diego to meet Ashley Wood and a 13-year-old named Tony at John’s Incredible Pizza Company, an arcade and all-you-can-eat buffet in a mall just south of town. They were playing Whack-a-Mole.\u003c/p>\n\u003cp>Wood is an occupational therapist for another prodrome-intervention program called \u003ca href=\"http://www.kickstartsd.org/\">Kickstart\u003c/a>, based in San Diego. Tony is one of her clients. He has spiky black hair and wears cargo shorts and a plastic rosary around his neck.\u003c/p>\n\u003cp>Before he started with Kickstart, Tony had been getting in fights. He was angry at his mom, angry in school. And there was something else.\u003c/p>\n\u003cp>“I used to see and hear stuff,” he tells me, “like weird objects.”\u003c/p>\n\u003cp>When I press him for more details, he turns the questions on me. “Are you a reporter?” he asks.\u003c/p>\n\u003cp>Wood laughs, looking at Tony. “Too many questions, eh?” He smiles.\u003c/p>\n\u003cp>Wood’s job is to help Tony with basic life skills, such as asking for things he needs without getting frustrated. When the pizza parlor’s ice cream machine sputters, she coaches him on how to ask an attendant for help.\u003c/p>\n\u003cp>“When he’s frustrated at school or at home, instead of immediately responding,” Wood says, she’s helping him “find a way to communicate.”\u003c/p>\n\u003cp>“We’re trying to work on the impulse control as well. He’s come a long way, I think.”\u003c/p>\n\u003cfigure id=\"attachment_19750\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1609-e1406326575325.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/20140618_Schizo_1609-e1406326575325.jpg\" alt=\"Wood is teaching Tony to control his anger and communicate better with his family. (Marvi Lacar/KQED) \" width=\"640\" height=\"640\" class=\"size-full wp-image-19750\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Wood is teaching Tony to control his anger and communicate better with his family. (Marvi Lacar/KQED)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>An Experiment Before Its Time?\u003c/strong>\u003c/p>\n\u003cp>Impulsive, unruly, prone to angry outbursts, Tony sounds like a lot of 13-year-old kids. And that’s what makes this type of program controversial.\u003c/p>\n\u003cp>Last year, the American Psychiatric Association \u003ca href=\"http://www.nature.com/news/psychosis-risk-syndrome-excluded-from-dsm-5-1.10610\">opted to exclude\u003c/a> the idea of “psychosis risk syndrome” from its DSM-5 manual of mental disorders, largely because the screening test is generally considered to be only 30 percent accurate. Of three kids who seem to fit the prodrome, only one will actually go on to develop psychosis, or schizophrenia.\u003c/p>\n\u003cp>In 2011, a \u003ca href=\"http://summaries.cochrane.org/CD004718/SCHIZ_early-intervention-for-psychosis\">review\u003c/a> of prodrome intervention programs called the idea of intervention in pre-schizophrenia “inconclusive.”\u003c/p>\n\u003cp>One of the most \u003ca href=\"http://www.huffingtonpost.com/allen-frances/psychosis-risk_b_1289022.html\">vocal critics\u003c/a> of prodrome intervention is Allen Frances, a former professor of psychiatry at Duke University.\u003c/p>\n\u003cp>“This is an experiment far before its time,” says Frances. “We need to be doing this as research before we spread this across the country and risk the harm to the individuals and risk the misallocation of resources in a society.”\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘We’re running up against the limits of what we can do for patients with chronic schizophrenia.’ \u003ccite>— Daniel Mathalon, UCSF\u003c/cite>\u003c/aside>\n\u003cp>Bill McFarlane, a Maine psychiatrist whose PIER Training Institute helped establish several prodrome clinics in California, says he’s seen clear benefits — including \u003ca href=\"http://www.ncbi.nlm.nih.gov/pubmed/24632857\">reduced hospitalization rates\u003c/a> — in Portland, Maine, where the Portland Identification and Early Referral Program he established served psychosis risk clients for over a decade. \u003c/p>\n\u003cp>He and other proponents say schizophrenia’s early window may be too precious to miss.\u003c/p>\n\u003cp>“We’re running up against the limits of what we can do for patients who develop schizophrenia, once it goes to chronic stages,” UCSF’s Mathalon says. “I think this is a direction we have to go in, but we have to do it carefully.”\u003c/p>\n\u003cp>Of course when you’re the parent of a kid in trouble you aren’t asking those questions.\u003c/p>\n\u003cp>Before she started the program, Reagan’s mom and step-father, Charlie, say they saw very little future for their daughter.\u003c/p>\n\u003cp>“I thought we were going to have to take care of her for the rest of her life,” says Kathy. “I thought she’d forever be marginal, forever be medicated. I thought we’d just have to get used to it.”\u003c/p>\n\u003cp>Today Reagan is off all her medications. She’s animated, playing board games with her family, excited about going back to school.\u003c/p>\n\u003cp>Her family credits the VIPS program.\u003c/p>\n\u003cp>“We were blessed to have this for her,” Charlie says. “We really were. It saved her life.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>Reagan’s family will never know whether the program prevented her from developing schizophrenia. But even if the diagnosis didn’t fit, they say, the treatment did.\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cfigure id=\"attachment_18390\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/03/187045612.jpg\">\u003cimg class=\"size-large wp-image-18390\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/03/187045612-640x426.jpg\" alt=\"(Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">(Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>By David Gorn,\u003c/strong>\u003ca href=\"http://www.californiahealthline.org/capitol-desk/2014/7/many-steps-to-go-before-authorizing-autism-therapy-as-benefit-state-says\" target=\"_blank\"> California Healthline\u003c/a>\u003c/p>\n\u003cp>State officials on Friday said they have not determined whether or not to offer applied behavior analysis (ABA therapy) as a Medi-Cal benefit to children with autism.\u003c/p>\n\u003cp>Federal officials \u003ca style=\"color: #6d1618\" href=\"http://ww2.kqed.org/stateofhealth/2014/07/08/feds-say-autism-aba-therapy-now-covered-as-childrens-medicaid-benefit/\" target=\"_blank\">earlier this month issued guidance\u003c/a> on the subject, saying it is covered for Medicaid beneficiaries under age 21 as part of the \u003ca href=\"http://www.medicaid.gov/Medicaid-CHIP-Program-Information/By-Topics/Benefits/Early-and-Periodic-Screening-Diagnostic-and-Treatment.html\" target=\"_blank\">Early and Periodic Screening, Diagnosis and Treatment\u003c/a> program.\u003c/p>\n\u003cp>\"Under the Medicaid state plan, services to address [autism spectrum disorder] may be covered under several different … benefit categories,\" the CMS guidance said. For children, it said, \"states must cover services that could otherwise be covered at state option under these categories consistent with the provisions … for Early and Periodic Screening, Diagnostic and Treatment services (EPSDT).\u003c!--more-->\u003c/p>\n\u003cp>According to René Mollow, deputy director of benefits and eligibility at the Department of Health Care Services, there are many steps before determination of coverage can be made.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"We are not changing course on this issue,\" Mollow said in an email. \"Now that we have federal guidance, we are beginning the process of planning and implementing policy based upon that federal guidance and state statutory requirements. It is a complex process involving the department and control agencies, stakeholders, Legislature, administration and federal government.\"\u003c/p>\n\u003cp>Mollow said the steps DHCS still needs to take to determine the state's course in regard to ABA therapy are laid out in law.\u003c/p>\n\u003cp>\"Specifically, the law states that DHCS will implement Behavioral Health Treatment (BHT) to the extent that it is required by the federal government to be covered by Medi-Cal for individuals under 21 years of age,\" Mollow said.\u003c/p>\n\u003cp>\"DHCS will implement BHT services only if: 1) it receives federal approval to obtain federal financial participation; 2) it seeks an appropriation of state funding required for the fiscal year; 3) statutory authority for the benefit is provided; and 4) it consults with stakeholders.\"\u003c/p>\n\u003cp>She said the department will solicit input from stakeholders at least 30 days prior to submitting a state plan amendment or waiver to CMS.\u003c/p>\n\u003cp>Mollow said she didn't know how long that process might take.\u003c/p>\n\u003cp>\"It is too early in our process to predict a timeline,\" she said. \"There are numerous contingencies ... All of them can have an impact on how we form and implement policy for these services.\"\u003c/p>\n\u003cp>The CMS guidance issued July 7 says:\u003c/p>\n\u003cp>\"States are required to arrange for and cover for individuals eligible for the EPSDT benefit any Medicaid coverable service … that is determined to be medically necessary to correct or ameliorate any physical or behavioral conditions.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"The EPSDT benefit is more robust than the Medicaid benefit package required for adults and is designed to assure that children receive early detection and preventive care, in addition to medically necessary treatment services, so that health problems are averted or diagnosed and treated as early as possible. All children, including children with [autism spectrum disorder], must receive EPSDT screenings designed to identify health and developmental issues, including ASD, as early as possible.\"\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_18390\" class=\"wp-caption aligncenter\" style=\"max-width: 640px\">\u003ca href=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/03/187045612.jpg\">\u003cimg class=\"size-large wp-image-18390\" title=\"\" src=\"http://ww2.kqed.org/stateofhealth/wp-content/uploads/sites/27/2014/03/187045612-640x426.jpg\" alt=\"(Getty Images)\" width=\"640\" height=\"426\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">(Getty Images)\u003c/figcaption>\u003c/figure>\n\u003cp>\u003cstrong>By David Gorn,\u003c/strong>\u003ca href=\"http://www.californiahealthline.org/capitol-desk/2014/7/many-steps-to-go-before-authorizing-autism-therapy-as-benefit-state-says\" target=\"_blank\"> California Healthline\u003c/a>\u003c/p>\n\u003cp>State officials on Friday said they have not determined whether or not to offer applied behavior analysis (ABA therapy) as a Medi-Cal benefit to children with autism.\u003c/p>\n\u003cp>Federal officials \u003ca style=\"color: #6d1618\" href=\"http://ww2.kqed.org/stateofhealth/2014/07/08/feds-say-autism-aba-therapy-now-covered-as-childrens-medicaid-benefit/\" target=\"_blank\">earlier this month issued guidance\u003c/a> on the subject, saying it is covered for Medicaid beneficiaries under age 21 as part of the \u003ca href=\"http://www.medicaid.gov/Medicaid-CHIP-Program-Information/By-Topics/Benefits/Early-and-Periodic-Screening-Diagnostic-and-Treatment.html\" target=\"_blank\">Early and Periodic Screening, Diagnosis and Treatment\u003c/a> program.\u003c/p>\n\u003cp>\"Under the Medicaid state plan, services to address [autism spectrum disorder] may be covered under several different … benefit categories,\" the CMS guidance said. For children, it said, \"states must cover services that could otherwise be covered at state option under these categories consistent with the provisions … for Early and Periodic Screening, Diagnostic and Treatment services (EPSDT).\u003c!--more-->\u003c/p>\n\u003cp>According to René Mollow, deputy director of benefits and eligibility at the Department of Health Care Services, there are many steps before determination of coverage can be made.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"We are not changing course on this issue,\" Mollow said in an email. \"Now that we have federal guidance, we are beginning the process of planning and implementing policy based upon that federal guidance and state statutory requirements. It is a complex process involving the department and control agencies, stakeholders, Legislature, administration and federal government.\"\u003c/p>\n\u003cp>Mollow said the steps DHCS still needs to take to determine the state's course in regard to ABA therapy are laid out in law.\u003c/p>\n\u003cp>\"Specifically, the law states that DHCS will implement Behavioral Health Treatment (BHT) to the extent that it is required by the federal government to be covered by Medi-Cal for individuals under 21 years of age,\" Mollow said.\u003c/p>\n\u003cp>\"DHCS will implement BHT services only if: 1) it receives federal approval to obtain federal financial participation; 2) it seeks an appropriation of state funding required for the fiscal year; 3) statutory authority for the benefit is provided; and 4) it consults with stakeholders.\"\u003c/p>\n\u003cp>She said the department will solicit input from stakeholders at least 30 days prior to submitting a state plan amendment or waiver to CMS.\u003c/p>\n\u003cp>Mollow said she didn't know how long that process might take.\u003c/p>\n\u003cp>\"It is too early in our process to predict a timeline,\" she said. \"There are numerous contingencies ... All of them can have an impact on how we form and implement policy for these services.\"\u003c/p>\n\u003cp>The CMS guidance issued July 7 says:\u003c/p>\n\u003cp>\"States are required to arrange for and cover for individuals eligible for the EPSDT benefit any Medicaid coverable service … that is determined to be medically necessary to correct or ameliorate any physical or behavioral conditions.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>\"The EPSDT benefit is more robust than the Medicaid benefit package required for adults and is designed to assure that children receive early detection and preventive care, in addition to medically necessary treatment services, so that health problems are averted or diagnosed and treated as early as possible. All children, including children with [autism spectrum disorder], must receive EPSDT screenings designed to identify health and developmental issues, including ASD, as early as possible.\"\u003c/p>\n\n\u003c/div>\u003c/p>",
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"headTitle": "New UC Berkeley Study Shows Oxytocin May Help Rejuvenate Aging Muscles | KQED",
"content": "\u003cfigure id=\"attachment_19403\" class=\"wp-caption alignleft\" style=\"max-width: 1608px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Oxytocin-Muscle-OneLayer.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Oxytocin-Muscle-OneLayer.jpg\" alt=\"images of muscle tissue cells from old and young mice \" width=\"1608\" height=\"715\" class=\"size-full wp-image-19403\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The left image shows healthy muscle tissue from a young mouse. The middle image demonstrates that the efficiency of muscle repair mechanisms decreases with age, resulting in a lower density of muscle fibers and increased scar tissue in an old mouse. Injecting oxytocin rapidly rejuvenates the old tissue, as shown on the right image. (Wendy Cousin and Christian Elabd)\u003c/figcaption>\u003c/figure>\n\u003cp>From birth until about the age of 30, your muscles continue to grow larger and stronger. But at some point in your 30s, you begin to lose muscle mass and strength which in turn affects your coordination. As part of the natural aging process, this disease, \u003ca href=\"http://www.iofbonehealth.org/what-sarcopenia\" title=\"sarcopenia\">sarcopenia\u003c/a>, is most commonly seen in inactive people but it also affects those who remain physically active throughout their lives. \u003c/p>\n\u003cp>Now UC Berkeley researchers have discovered that oxytocin – the “trust hormone” associated with maternal nurturing, social attachments, childbirth and sex – may combat this age-related muscle wasting. Their new study was \u003ca href=\"http://www.nature.com/ncomms/2014/140610/ncomms5082/full/ncomms5082.html\" title=\"Nature Communications journal article\">recently published\u003c/a> in \u003cem>Nature Communications\u003c/em>. \u003c/p>\n\u003cp>\u003cstrong>Role in Muscle Regeneration\u003c/strong>\u003c/p>\n\u003cp>Led by associate professor of bioengineering Irina Conboy, the researchers found in mice that oxytocin is required to maintain healthy muscles, but the level of oxytocin in the blood and the number of oxytocin receptors in muscle stem cells naturally reduce with age. For instance, old (18 to 24 months) mice were found to have 3 times lower circulating levels of oxytocin than young (2 to 4 months) mice.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘Extra oxytocin boosts aged tissue stem cells without making muscle stem cells divide uncontrollably.’ \u003ccite>–Wendy Cousin, Scientist\u003c/cite>\u003c/aside>\n\u003cp>The research team performed a series of experiments using young and old mice to better understand oxytocin’s role in muscle repair. They injected the mice daily with oxytocin (or a control solution) under the skin for nine consecutive days, while causing a muscle injury midway on day 4. The researchers found that the old mice that received the oxytocin were able to repair their muscle injury at a level comparable to the young mice – far better than the old control group that didn’t get oxytocin. Systemic administration of oxytocin appears to rapidly improve muscle regeneration by enhancing aged muscle stem cell proliferation. \u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>In contrast, the young mice already had sufficient levels of oxytocin and efficient muscle regeneration, so the oxytocin injections had no significant effect. This is important since most molecules that boost tissue repair are also associated with an increased risk of cancer. \u003c/p>\n\u003cp>“This is good because it demonstrates that extra oxytocin boosts aged tissue stem cells without making muscle stem cells divide uncontrollably,” explained Wendy Cousin, a senior scientist in Conboy’s lab, in a \u003ca href=\"http://newscenter.berkeley.edu/2014/06/10/oxytocin-helps-muscle-regeneration/\" title=\"UC Berkeley press release\">press release\u003c/a>. \u003c/p>\n\u003cp>The researchers also performed similar experiments using mice with an inactivated gene for oxytocin and control mice. At the young age of 3 months, the two groups of mice appeared to have comparable muscle mass and repair efficiency after a muscle injury. However, muscle atrophy and a significant decline in muscle regeneration were observed for the 1-year old adult mice with the disabled oxytocin gene, signifying premature aging due to a lack of oxytocin. \u003c/p>\n\u003cp>It is unclear how long it will take the researchers to move beyond mice studies to human use. However, oxytocin is already approved by the FDA for clinical use in humans for other applications. For instance, oxytocin is commonly used to help increase contractions and control bleeding during childbirth. So getting approval for human studies should be straightforward once the reseachers are ready.\u003c/p>\n\u003cp>Conboy’s research team is ultimately interested in applications beyond just maintaining healthy muscles. For instance, they are also investigating whether oxytocin could become a viable alternative to hormone replacement therapy to impede the symptoms of male and female aging. They believe that aging is the underlying cause of a number of chronic diseases, including Parkinson’s and Type 2 diabetes.\u003c/p>\n\u003cp>\u003cstrong>Oxytocin Hype\u003c/strong>\u003c/p>\n\u003cp>In fact, researchers around the world are studying the use of oxytocin for seemingly every condition imaginable, including using oxytocin nasal spray to alleviate symptoms associated with mental disorders such as autism, schizophrenia and dementia. However, this research currently demonstrates \u003ca href=\"http://www.newscientist.com/article/mg21328512.100-dark-side-of-the-love-hormone.html\" title=\"Ed Yong article\">mixed and inconsistent results\u003c/a>, particularly regarding oxytocin’s influence on social skills.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The current excitement about oxytocin, particularly as a remedy for autism, could lead to a dangerous situation given the widespread availability of oxytocin supplements – as an accelerator spray, sublingual liquid that is absorbed under the tongue, pills and mouth lozenges. It is important to consult your doctor before taking oxytocin. \u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cfigure id=\"attachment_19403\" class=\"wp-caption alignleft\" style=\"max-width: 1608px\">\u003ca href=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Oxytocin-Muscle-OneLayer.jpg\">\u003cimg loading=\"lazy\" decoding=\"async\" src=\"http://ww2.kqed.org/science/wp-content/uploads/sites/35/2014/07/Oxytocin-Muscle-OneLayer.jpg\" alt=\"images of muscle tissue cells from old and young mice \" width=\"1608\" height=\"715\" class=\"size-full wp-image-19403\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">The left image shows healthy muscle tissue from a young mouse. The middle image demonstrates that the efficiency of muscle repair mechanisms decreases with age, resulting in a lower density of muscle fibers and increased scar tissue in an old mouse. Injecting oxytocin rapidly rejuvenates the old tissue, as shown on the right image. (Wendy Cousin and Christian Elabd)\u003c/figcaption>\u003c/figure>\n\u003cp>From birth until about the age of 30, your muscles continue to grow larger and stronger. But at some point in your 30s, you begin to lose muscle mass and strength which in turn affects your coordination. As part of the natural aging process, this disease, \u003ca href=\"http://www.iofbonehealth.org/what-sarcopenia\" title=\"sarcopenia\">sarcopenia\u003c/a>, is most commonly seen in inactive people but it also affects those who remain physically active throughout their lives. \u003c/p>\n\u003cp>Now UC Berkeley researchers have discovered that oxytocin – the “trust hormone” associated with maternal nurturing, social attachments, childbirth and sex – may combat this age-related muscle wasting. Their new study was \u003ca href=\"http://www.nature.com/ncomms/2014/140610/ncomms5082/full/ncomms5082.html\" title=\"Nature Communications journal article\">recently published\u003c/a> in \u003cem>Nature Communications\u003c/em>. \u003c/p>\n\u003cp>\u003cstrong>Role in Muscle Regeneration\u003c/strong>\u003c/p>\n\u003cp>Led by associate professor of bioengineering Irina Conboy, the researchers found in mice that oxytocin is required to maintain healthy muscles, but the level of oxytocin in the blood and the number of oxytocin receptors in muscle stem cells naturally reduce with age. For instance, old (18 to 24 months) mice were found to have 3 times lower circulating levels of oxytocin than young (2 to 4 months) mice.\u003c/p>\n\u003caside class=\"pullquote alignleft\">‘Extra oxytocin boosts aged tissue stem cells without making muscle stem cells divide uncontrollably.’ \u003ccite>–Wendy Cousin, Scientist\u003c/cite>\u003c/aside>\n\u003cp>The research team performed a series of experiments using young and old mice to better understand oxytocin’s role in muscle repair. They injected the mice daily with oxytocin (or a control solution) under the skin for nine consecutive days, while causing a muscle injury midway on day 4. The researchers found that the old mice that received the oxytocin were able to repair their muscle injury at a level comparable to the young mice – far better than the old control group that didn’t get oxytocin. Systemic administration of oxytocin appears to rapidly improve muscle regeneration by enhancing aged muscle stem cell proliferation. \u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>In contrast, the young mice already had sufficient levels of oxytocin and efficient muscle regeneration, so the oxytocin injections had no significant effect. This is important since most molecules that boost tissue repair are also associated with an increased risk of cancer. \u003c/p>\n\u003cp>“This is good because it demonstrates that extra oxytocin boosts aged tissue stem cells without making muscle stem cells divide uncontrollably,” explained Wendy Cousin, a senior scientist in Conboy’s lab, in a \u003ca href=\"http://newscenter.berkeley.edu/2014/06/10/oxytocin-helps-muscle-regeneration/\" title=\"UC Berkeley press release\">press release\u003c/a>. \u003c/p>\n\u003cp>The researchers also performed similar experiments using mice with an inactivated gene for oxytocin and control mice. At the young age of 3 months, the two groups of mice appeared to have comparable muscle mass and repair efficiency after a muscle injury. However, muscle atrophy and a significant decline in muscle regeneration were observed for the 1-year old adult mice with the disabled oxytocin gene, signifying premature aging due to a lack of oxytocin. \u003c/p>\n\u003cp>It is unclear how long it will take the researchers to move beyond mice studies to human use. However, oxytocin is already approved by the FDA for clinical use in humans for other applications. For instance, oxytocin is commonly used to help increase contractions and control bleeding during childbirth. So getting approval for human studies should be straightforward once the reseachers are ready.\u003c/p>\n\u003cp>Conboy’s research team is ultimately interested in applications beyond just maintaining healthy muscles. For instance, they are also investigating whether oxytocin could become a viable alternative to hormone replacement therapy to impede the symptoms of male and female aging. They believe that aging is the underlying cause of a number of chronic diseases, including Parkinson’s and Type 2 diabetes.\u003c/p>\n\u003cp>\u003cstrong>Oxytocin Hype\u003c/strong>\u003c/p>\n\u003cp>In fact, researchers around the world are studying the use of oxytocin for seemingly every condition imaginable, including using oxytocin nasal spray to alleviate symptoms associated with mental disorders such as autism, schizophrenia and dementia. However, this research currently demonstrates \u003ca href=\"http://www.newscientist.com/article/mg21328512.100-dark-side-of-the-love-hormone.html\" title=\"Ed Yong article\">mixed and inconsistent results\u003c/a>, particularly regarding oxytocin’s influence on social skills.\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>The current excitement about oxytocin, particularly as a remedy for autism, could lead to a dangerous situation given the widespread availability of oxytocin supplements – as an accelerator spray, sublingual liquid that is absorbed under the tongue, pills and mouth lozenges. It is important to consult your doctor before taking oxytocin. \u003c/p>\n\n\u003c/div>\u003c/p>",
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"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
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"masters-of-scale": {
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"mindshift": {
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"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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"order": 12
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5",
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"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
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"info": "Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us",
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},
"pbs-newshour": {
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},
"perspectives": {
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"order": 14
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"info": "The economy explained. Imagine you could call up a friend and say, Meet me at the bar and tell me what's going on with the economy. Now imagine that's actually a fun evening.",
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"link": "/radio/program/planet-money",
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"title": "Political Breakdown",
"tagline": "Politics from a personal perspective",
"info": "Political Breakdown is a new series that explores the political intersection of California and the nation. Each week hosts Scott Shafer and Marisa Lagos are joined with a new special guest to unpack politics -- with personality — and offer an insider’s glimpse at how politics happens.",
"airtime": "THU 6:30pm-7pm",
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"order": 5
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"possible": {
"id": "possible",
"title": "Possible",
"info": "Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.",
"airtime": "SUN 2pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Possible-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.possible.fm/",
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"source": "Possible"
},
"link": "/radio/program/possible",
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"spotify": "https://open.spotify.com/show/730YpdUSNlMyPQwNnyjp4k"
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},
"pri-the-world": {
"id": "pri-the-world",
"title": "PRI's The World: Latest Edition",
"info": "Each weekday, host Marco Werman and his team of producers bring you the world's most interesting stories in an hour of radio that reminds us just how small our planet really is.",
"airtime": "MON-FRI 2pm-3pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-World-Podcast-Tile-360x360-1.jpg",
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},
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},
"radiolab": {
"id": "radiolab",
"title": "Radiolab",
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