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"content": "\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_42_22.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir places E.coli bacteria onto a petri dish in the lab. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003cem>Reported for \u003ca href=\"http://www.kqed.org/news/\">KQEDnews.org\u003c/a>.\u003c/em>\u003c/p>\n\u003cp>Researchers at the University of California-San Francisco have hacked into the genetic wiring of billions of individual bacteria and outfitted them with the kind of on/off switches normally found in computer chips, not living organisms.\u003c/p>\n\u003cp>The switches, which are built out of genes, allow the bacteria to listen for chemical signals and respond, much like computer chips that can perform powerful tasks.\u003c/p>\n\u003cp>The switches may one day help the development of biofuels that are cheaper and more powerful than gasoline, or a new suite of pharmaceuticals that could more effectively target and kill tumor cells with fewer side effects.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>“Scientists have been trying to engineer bacteria to be more programmable, to do various things, but biology is hard to program” said Alvin Tamsir a doctoral student at UCSF. “I want to generate the technology so that bacteria can be more programmable in a more predictable way.”\u003c/p>\n\u003cp>Tasmir was the lead author of a study on the subject that was published last week in the journal, \u003cem>\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09565.html\">Nature\u003c/a>\u003c/em>.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_12_21.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>By building new molecular circuits into bacteria, Tamsir and his team can now make the bacteria perform specific tasks, much like the millions of wires which comprise the electrical circuitry of a modern computer chip enable the dizzying array of complex calculations and tasks a computer can do in micro-seconds.\u003c/p>\n\u003cp>It’s all part of the new field of synthetic biology, where principles from computer science, electrical engineering and genetics, along with other sciences, mix together to reveal the tools and strategies for reprogramming the cellular machinery of living organisms like bacteria and yeast. Scientists and companies in the Bay Area and elsewhere, working on other synthetic biology project, already are developing a new generation of drugs and biofuels with bionic bacteria and yeast.\u003c/p>\n\u003cp>“Some of these drugs that we are working on right now require 40 genes. And you have to control when those genes turn on and for how long and in what order, and for all that, you need a circuit,” said \u003ca href=\"http://www.voigtlab.ucsf.edu/\">Christopher Voigt\u003c/a>, an associate professor at UCSF’s Department of Pharmaceutical Chemistry and the senior author of the study.\u003c/p>\n\u003cp>Tamsir and Voigt looked to the world of electrical engineering, where circuits bring the necessary level of control to millions of precisely timed calculations that a computer chip must complete to execute any task, like spellchecking a document or surfing the web.\u003c/p>\n\u003cp>To do these tasks, microscopic switches called “logic gates” are etched into the silicon of computer chips. The logic gates function according to a set of rules and are connected with wires that make up a circuit on the chip. Each of these logic gates receives an input, such as an electrical current, from the wires, and responds based on the kind of gate it is. For example, if it’s an “AND” gate, it will turn on and send its output of an electrical signal to the gate next to it, but only if it is getting inputs from the two wires that feed into it. If it’s an “OR” gate, it will turn on even if it is getting a signal from just one of the wires connected to it.\u003c/p>\n\u003cp>“In computers, complex tasks like opening a document or performing a calculation can be boiled down to simpler calculations performed by these logic gates,” said Tamsir. A modern Pentium chip can have more than a million logic gates, each one performing a tiny piece of the calculation or task at hand.\u003c/p>\n\u003cp>“But you don't have an engineer at Intel that is choosing exactly where each wire goes,” said Voigt. Instead, programming languages have automated the process, quickly and reliably reproducing on the computer chip the precise circuits of logic gates needed to carry out functions specified by a computer engineer.\u003c/p>\n\u003cp>“We are trying to create a programming language for cells,” Voigt added, “and ultimately have it so you can take any function you can imagine and convert that into a DNA sequence that carries out that function.”\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_84_21.jpg\" alt=\"\">\u003c/a>\u003cem>Four colonies of E. coli bacteria cells plated onto a petri dish. Each colony contains a billion cells. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>But scientists can’t exactly take the hardware of tiny gates and wires on computer chips and insert them into living bacteria like E. coli. So Tamsir and his team had to engineer genes that would reprogram the DNA of E. coli, instructing it to make logic gates out of proteins that would help the bacteria perform more like a computer to carry out a specific task – in this case, to make a fluorescent yellow protein.\u003c/p>\n\u003cp>In computer chips, the metal wires that feed into a logic gate are physically separated so that the inputs going into one logic gate don’t cross with the wires of a nearby logic gate. But this isn’t the case with living bacteria. “Every gate is a molecule and they're all being run based on molecules and they're all crammed together in the bag that is the cell,” Voigt said.\u003c/p>\n\u003cp>Although the scientists created eight different colonies of bacteria, each with their own discrete logic gate, only four colonies were used at a time to see if they could link up to form a circuit that would yield the fluorescent protein.\u003c/p>\n\u003cp>One logic gate in one of the bacteria colonies may need two inputs, like a sugar and an antibiotic, to release its molecular output, such as an enzyme, that would then act as an input for a second set of logic gates. But this next set of logic gates may have been designed so that it produces its own molecular output only if it doesn’t receive the sugar and antibiotic inputs that triggered the activity of the first logic gate.\u003c/p>\n\u003cp>“It’s by combining multiple gates together that you get different behavior. And that's how electrical circuits behave - they use a lot of logic gates and combine them in various ways to get various functions,” said Tamsir. Similarly, the scientists were able to modify the behavior of their bacterial circuits by simply moving the location of the bacteria colonies in the petri dish, since each colony operated with its own set of logical rules for responding to the chemical inputs feeding into it.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Tamsir_3a_21.jpg\" alt=\"\">\u003c/a>\u003cem> An illustrated wiring diagram showing two different kinds of logic gates (NOR and Buffer) operating in four bacteria colonies on a petri dish. The last bacteria colony, indicated in brown, completes the circuit to make fluorescent yellow protein. (Credit: Alvin Tamsir, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Tamsir built 16 different kinds of genetic logic gates to program the bacterial 'computers'. Each one successfully suppressed or promoted the production of the fluorescent yellow protein depending on how it was linked together in the bacteria.\u003c/p>\n\u003cp>“The hard part,” said Tamsir, who has worked for more than two years on this research, “was combining different genetic parts so that when they are put together, they function as you want them to.”\u003c/p>\n\u003cp>Other researchers are taking note.\u003c/p>\n\u003cp>“They have begun the process of creating a characterized library of elements which can be used by other labs to build more complex systems,” said \u003ca href=\"http://www.bu.edu/ece/people/faculty/a-g/douglas-densmore/\">Douglas Densmore\u003c/a>, an assistant professor of computer and electrical engineering at Boston University who read the \u003cem>Nature \u003c/em>paper describing the UCSF team’s research.\u003c/p>\n\u003cp>Tamsir and his team now want to increase the complexity of their bacterial circuits by building even more sophisticated logic gates.\u003c/p>\n\u003cp>Voigt added that there are roughly 200 to 300 circuits that regulate different biological activities in E. coli bacteria.\u003c/p>\n\u003cp>“And that’s the good news – that it’s not millions,” he said. Unlike a computer chip, “the bacteria don’t require a lot of gates and if we had 100 gates, we could do some pretty amazing things,” Voigt said.\u003c/p>\n\u003cp>By designing more complex gates and more of them, he said a scientist could be “in full control of programming bacteria.” This arsenal of expanded logic gates could then coax the bacteria to produce more than just a biofuel or a low-cost malaria drug, like the one developed using synthetic biology by \u003ca href=\"http://www.amyrisbiotech.com/\">Amyris Biotechnologies\u003c/a> in Emeryville.\u003c/p>\n\u003cp>“Everything you see in biology -- such as a corn plant growing -- those complex processes are being implemented by natural circuitry,” said Voigt. “And one of the reasons that we can't access those functions is because we don't have that refined level of control.”\u003c/p>\n\u003cp>With the new system of logic gates snapping together to form synthetic circuits, the UCSF scientists have expanded that level of control and consequently, what bacteria or yeast could be programmed to do, like some day make synthetic wood, silk or antibiotics.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_55_21.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir handles test tubes containing E. coli bacteria. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://www.lifetechnologies.com/home.html\">Life Technologies\u003c/a>, a biotech firm based in Carlsbad, has partnered with Voigt’s lab to generate a software package that would allow other scientists to specify the kind of logic gates they want to run in the bacteria being used in their experiments. After a few keystrokes and some processing by the computer, the scientists would receive a recipe for making those logic gates, which could then be sequenced from the sugars and phosphates which make up genes, and inserted into their bacteria.\u003c/p>\n\u003cp>For Tamsir, the research is incredibly challenging but also extremely rewarding, a vital part of his doctorate degree in bioengineering which he hopes to complete in May. The 26 year-old scientist grew up tinkering with circuit boards and even derived programming inspiration from Lego Mindstorms, a line of robotic toys.\u003c/p>\n\u003cp>“I found out about the field of synthetic biology through Chris Voigt's lab. Right then, I knew that this was the right field of study for me,” he said. “It combines my love for computer programming with my love for biology.”\u003c/p>\n\u003cp>[ad floatright]\u003c/p>\n\u003cp>37.767050 -122.391139\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_42_22.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir places E.coli bacteria onto a petri dish in the lab. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003cem>Reported for \u003ca href=\"http://www.kqed.org/news/\">KQEDnews.org\u003c/a>.\u003c/em>\u003c/p>\n\u003cp>Researchers at the University of California-San Francisco have hacked into the genetic wiring of billions of individual bacteria and outfitted them with the kind of on/off switches normally found in computer chips, not living organisms.\u003c/p>\n\u003cp>The switches, which are built out of genes, allow the bacteria to listen for chemical signals and respond, much like computer chips that can perform powerful tasks.\u003c/p>\n\u003cp>The switches may one day help the development of biofuels that are cheaper and more powerful than gasoline, or a new suite of pharmaceuticals that could more effectively target and kill tumor cells with fewer side effects.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>“Scientists have been trying to engineer bacteria to be more programmable, to do various things, but biology is hard to program” said Alvin Tamsir a doctoral student at UCSF. “I want to generate the technology so that bacteria can be more programmable in a more predictable way.”\u003c/p>\n\u003cp>Tasmir was the lead author of a study on the subject that was published last week in the journal, \u003cem>\u003ca href=\"http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09565.html\">Nature\u003c/a>\u003c/em>.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_12_21.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>By building new molecular circuits into bacteria, Tamsir and his team can now make the bacteria perform specific tasks, much like the millions of wires which comprise the electrical circuitry of a modern computer chip enable the dizzying array of complex calculations and tasks a computer can do in micro-seconds.\u003c/p>\n\u003cp>It’s all part of the new field of synthetic biology, where principles from computer science, electrical engineering and genetics, along with other sciences, mix together to reveal the tools and strategies for reprogramming the cellular machinery of living organisms like bacteria and yeast. Scientists and companies in the Bay Area and elsewhere, working on other synthetic biology project, already are developing a new generation of drugs and biofuels with bionic bacteria and yeast.\u003c/p>\n\u003cp>“Some of these drugs that we are working on right now require 40 genes. And you have to control when those genes turn on and for how long and in what order, and for all that, you need a circuit,” said \u003ca href=\"http://www.voigtlab.ucsf.edu/\">Christopher Voigt\u003c/a>, an associate professor at UCSF’s Department of Pharmaceutical Chemistry and the senior author of the study.\u003c/p>\n\u003cp>Tamsir and Voigt looked to the world of electrical engineering, where circuits bring the necessary level of control to millions of precisely timed calculations that a computer chip must complete to execute any task, like spellchecking a document or surfing the web.\u003c/p>\n\u003cp>To do these tasks, microscopic switches called “logic gates” are etched into the silicon of computer chips. The logic gates function according to a set of rules and are connected with wires that make up a circuit on the chip. Each of these logic gates receives an input, such as an electrical current, from the wires, and responds based on the kind of gate it is. For example, if it’s an “AND” gate, it will turn on and send its output of an electrical signal to the gate next to it, but only if it is getting inputs from the two wires that feed into it. If it’s an “OR” gate, it will turn on even if it is getting a signal from just one of the wires connected to it.\u003c/p>\n\u003cp>“In computers, complex tasks like opening a document or performing a calculation can be boiled down to simpler calculations performed by these logic gates,” said Tamsir. A modern Pentium chip can have more than a million logic gates, each one performing a tiny piece of the calculation or task at hand.\u003c/p>\n\u003cp>“But you don't have an engineer at Intel that is choosing exactly where each wire goes,” said Voigt. Instead, programming languages have automated the process, quickly and reliably reproducing on the computer chip the precise circuits of logic gates needed to carry out functions specified by a computer engineer.\u003c/p>\n\u003cp>“We are trying to create a programming language for cells,” Voigt added, “and ultimately have it so you can take any function you can imagine and convert that into a DNA sequence that carries out that function.”\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_84_21.jpg\" alt=\"\">\u003c/a>\u003cem>Four colonies of E. coli bacteria cells plated onto a petri dish. Each colony contains a billion cells. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>But scientists can’t exactly take the hardware of tiny gates and wires on computer chips and insert them into living bacteria like E. coli. So Tamsir and his team had to engineer genes that would reprogram the DNA of E. coli, instructing it to make logic gates out of proteins that would help the bacteria perform more like a computer to carry out a specific task – in this case, to make a fluorescent yellow protein.\u003c/p>\n\u003cp>In computer chips, the metal wires that feed into a logic gate are physically separated so that the inputs going into one logic gate don’t cross with the wires of a nearby logic gate. But this isn’t the case with living bacteria. “Every gate is a molecule and they're all being run based on molecules and they're all crammed together in the bag that is the cell,” Voigt said.\u003c/p>\n\u003cp>Although the scientists created eight different colonies of bacteria, each with their own discrete logic gate, only four colonies were used at a time to see if they could link up to form a circuit that would yield the fluorescent protein.\u003c/p>\n\u003cp>One logic gate in one of the bacteria colonies may need two inputs, like a sugar and an antibiotic, to release its molecular output, such as an enzyme, that would then act as an input for a second set of logic gates. But this next set of logic gates may have been designed so that it produces its own molecular output only if it doesn’t receive the sugar and antibiotic inputs that triggered the activity of the first logic gate.\u003c/p>\n\u003cp>“It’s by combining multiple gates together that you get different behavior. And that's how electrical circuits behave - they use a lot of logic gates and combine them in various ways to get various functions,” said Tamsir. Similarly, the scientists were able to modify the behavior of their bacterial circuits by simply moving the location of the bacteria colonies in the petri dish, since each colony operated with its own set of logical rules for responding to the chemical inputs feeding into it.\u003c/p>\n\u003cp>\u003cspan class=\"right\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Tamsir_3a_21.jpg\" alt=\"\">\u003c/a>\u003cem> An illustrated wiring diagram showing two different kinds of logic gates (NOR and Buffer) operating in four bacteria colonies on a petri dish. The last bacteria colony, indicated in brown, completes the circuit to make fluorescent yellow protein. (Credit: Alvin Tamsir, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>Tamsir built 16 different kinds of genetic logic gates to program the bacterial 'computers'. Each one successfully suppressed or promoted the production of the fluorescent yellow protein depending on how it was linked together in the bacteria.\u003c/p>\n\u003cp>“The hard part,” said Tamsir, who has worked for more than two years on this research, “was combining different genetic parts so that when they are put together, they function as you want them to.”\u003c/p>\n\u003cp>Other researchers are taking note.\u003c/p>\n\u003cp>“They have begun the process of creating a characterized library of elements which can be used by other labs to build more complex systems,” said \u003ca href=\"http://www.bu.edu/ece/people/faculty/a-g/douglas-densmore/\">Douglas Densmore\u003c/a>, an assistant professor of computer and electrical engineering at Boston University who read the \u003cem>Nature \u003c/em>paper describing the UCSF team’s research.\u003c/p>\n\u003cp>Tamsir and his team now want to increase the complexity of their bacterial circuits by building even more sophisticated logic gates.\u003c/p>\n\u003cp>Voigt added that there are roughly 200 to 300 circuits that regulate different biological activities in E. coli bacteria.\u003c/p>\n\u003cp>“And that’s the good news – that it’s not millions,” he said. Unlike a computer chip, “the bacteria don’t require a lot of gates and if we had 100 gates, we could do some pretty amazing things,” Voigt said.\u003c/p>\n\u003cp>By designing more complex gates and more of them, he said a scientist could be “in full control of programming bacteria.” This arsenal of expanded logic gates could then coax the bacteria to produce more than just a biofuel or a low-cost malaria drug, like the one developed using synthetic biology by \u003ca href=\"http://www.amyrisbiotech.com/\">Amyris Biotechnologies\u003c/a> in Emeryville.\u003c/p>\n\u003cp>“Everything you see in biology -- such as a corn plant growing -- those complex processes are being implemented by natural circuitry,” said Voigt. “And one of the reasons that we can't access those functions is because we don't have that refined level of control.”\u003c/p>\n\u003cp>With the new system of logic gates snapping together to form synthetic circuits, the UCSF scientists have expanded that level of control and consequently, what bacteria or yeast could be programmed to do, like some day make synthetic wood, silk or antibiotics.\u003c/p>\n\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/12/UCSF_SynBio_Merrell_55_21.jpg\" alt=\"\">\u003c/a>\u003cem>UCSF bioengineering graduate student Alvin Tamsir handles test tubes containing E. coli bacteria. (Credit: Susan Merrell, UCSF)\u003c/em>\u003c/span>\u003c/p>\n\u003cp>\u003ca href=\"http://www.lifetechnologies.com/home.html\">Life Technologies\u003c/a>, a biotech firm based in Carlsbad, has partnered with Voigt’s lab to generate a software package that would allow other scientists to specify the kind of logic gates they want to run in the bacteria being used in their experiments. After a few keystrokes and some processing by the computer, the scientists would receive a recipe for making those logic gates, which could then be sequenced from the sugars and phosphates which make up genes, and inserted into their bacteria.\u003c/p>\n\u003cp>For Tamsir, the research is incredibly challenging but also extremely rewarding, a vital part of his doctorate degree in bioengineering which he hopes to complete in May. The 26 year-old scientist grew up tinkering with circuit boards and even derived programming inspiration from Lego Mindstorms, a line of robotic toys.\u003c/p>\n\u003cp>“I found out about the field of synthetic biology through Chris Voigt's lab. Right then, I knew that this was the right field of study for me,” he said. “It combines my love for computer programming with my love for biology.”\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cp>\u003cspan class=\"left\">\u003ca href=\"http://www.kqed.org/quest\">\u003cimg src=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/11/home-energy-score3001.jpg\" alt=\"\">\u003c/a>\u003cem>Along with your Home Energy Score you also get a list of cost-effective energy upgrades for your home. Click \u003ca href=\"http://ww2.kqed.org/quest/wp-content/uploads/sites/39/2010/11/home-energy-score1.jpg\">here\u003c/a> for a larger version of the image.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>For most men of my generation a first car was like a right of passage. The car could be an old beater, or a muscle car; it didn’t matter so much as long as we felt unique driving it. And we all knew the basic nomenclature—horsepower and miles per gallon.\u003c/p>\n\u003cp>I have a dream that someday homeowners across the land will feel about their houses and apartments the same way people of my generation felt about their first car. They will all know the basic nomenclature—kilowatt-hours and/or Btu per square foot per year. Or something like that.\u003c/p>\n\u003cp>\u003c!--more-->\u003c/p>\n\u003cp>This Tuesday I found out my dream is becoming a reality. The Department of Energy announced a project, the \u003ca href=\"http://www.homeenergyscore.gov\">Home Energy Score\u003c/a>, to:\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>• increase the energy literacy of homeowners;\u003c/p>\n\u003cp>• support a growing segment of the economy—people who do energy audits and retrofits on houses (think jobs, jobs, jobs);\u003c/p>\n\u003cp>• put our nation on a path of energy independence through conservation;\u003c/p>\n\u003cp>• make our planet a healthier place to live in; and\u003c/p>\n\u003cp>• do all of the above without creating any new legislation or spending taxpayer dollars.\u003c/p>\n\u003cp>The project is being piloted in nine cities throughout the United States and the plan is for it to go national by later 2011. The key components of the program include:\u003c/p>\n\u003cp>• a set of Workforce Guidelines for people entering the home energy field—what they need to do the job and do it well, and gain the trust of their customers;\u003c/p>\n\u003cp>• a software program that will allow home energy professionals to do a one- or two-hour audit of a home, give it a Home Energy Score from one to ten, compare it’s energy use to its neighbors, and immediately provide the homeowner with a list of cost-effective energy retrofit options; and\u003c/p>\n\u003cp>• low interest loans from qualifying lenders to finance the retrofits.\u003c/p>\n\u003cp>Soon every homeowner and me will be able to brag about our houses to friends, relatives, coworkers, and neighbors—as we used to brag about our cars. “I have a 1951 California Bungalow with three bedrooms, two baths, and it only uses 500 kilowatt-hours a year for heating and cooling. It’s got a Home Energy Score of 9. So, what are you living in?”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>37.8686 -122.267\u003c/p>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>• increase the energy literacy of homeowners;\u003c/p>\n\u003cp>• support a growing segment of the economy—people who do energy audits and retrofits on houses (think jobs, jobs, jobs);\u003c/p>\n\u003cp>• put our nation on a path of energy independence through conservation;\u003c/p>\n\u003cp>• make our planet a healthier place to live in; and\u003c/p>\n\u003cp>• do all of the above without creating any new legislation or spending taxpayer dollars.\u003c/p>\n\u003cp>The project is being piloted in nine cities throughout the United States and the plan is for it to go national by later 2011. The key components of the program include:\u003c/p>\n\u003cp>• a set of Workforce Guidelines for people entering the home energy field—what they need to do the job and do it well, and gain the trust of their customers;\u003c/p>\n\u003cp>• a software program that will allow home energy professionals to do a one- or two-hour audit of a home, give it a Home Energy Score from one to ten, compare it’s energy use to its neighbors, and immediately provide the homeowner with a list of cost-effective energy retrofit options; and\u003c/p>\n\u003cp>• low interest loans from qualifying lenders to finance the retrofits.\u003c/p>\n\u003cp>Soon every homeowner and me will be able to brag about our houses to friends, relatives, coworkers, and neighbors—as we used to brag about our cars. “I have a 1951 California Bungalow with three bedrooms, two baths, and it only uses 500 kilowatt-hours a year for heating and cooling. It’s got a Home Energy Score of 9. So, what are you living in?”\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>37.8686 -122.267\u003c/p>\n\n\u003c/div>\u003c/p>",
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"content": "\u003cp>\u003cspan class=\"left\">\u003cem>Ben Bustamante works on Leslie’s house—for free! Photo Courtesy of Leslie Jackson.\u003c/em>\u003c/span>\u003c/p>\n\u003cp>When \u003ca target=\"_blank\" href=\"http://www.homeenergy.org/\" rel=\"noopener\">Home Energy\u003c/a>’s part-time Associate Editor Leslie Jackson got home from a trip to New Orleans, where she did research on the rebuilding since Hurricane Karina, she got a message on her phone. It was \u003ca target=\"_blank\" class=\"zem_slink\" href=\"http://science.kqed.org/quest/2010/10/29/leslie-gets-weatherized%E2%80%94you-can-too/?utm_source=rss&utm_medium=rss&utm_campaign=leslie-gets-weatherized%25e2%2580%2594you-can-too\" rel=\"noopener\">…\u003c/a> \u003c/p>\n\u003cp>Source: \u003ca href=\"http://science.kqed.org/quest/2010/10/29/leslie-gets-weatherized%E2%80%94you-can-too/?utm_source=rss&utm_medium=rss&utm_campaign=leslie-gets-weatherized%25e2%2580%2594you-can-too\" target=\"_blank\" title=\"Leslie Gets Weatherized–You Can Too!\" rel=\"noopener\">QUEST – Energy\u003c/a>\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\u003cp>\u003c/p>\n",
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"id": "city-arts",
"title": "City Arts & Lectures",
"info": "A one-hour radio program to hear celebrated writers, artists and thinkers address contemporary ideas and values, often discussing the creative process. Please note: tapes or transcripts are not available",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/05/cityartsandlecture-300x300.jpg",
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"airtime": "SUN 1pm-2pm, TUE 10pm, WED 1am",
"meta": {
"site": "news",
"source": "City Arts & Lectures"
},
"link": "https://www.cityarts.net",
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"rss": "https://www.cityarts.net/feed/"
}
},
"closealltabs": {
"id": "closealltabs",
"title": "Close All Tabs",
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"info": "Close All Tabs breaks down how digital culture shapes our world through thoughtful insights and irreverent humor.",
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"officialWebsiteLink": "/podcasts/closealltabs",
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"order": 1
},
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"id": "code-switch-life-kit",
"title": "Code Switch / Life Kit",
"info": "\u003cem>Code Switch\u003c/em>, which listeners will hear in the first part of the hour, has fearless and much-needed conversations about race. Hosted by journalists of color, the show tackles the subject of race head-on, exploring how it impacts every part of society — from politics and pop culture to history, sports and more.\u003cbr />\u003cbr />\u003cem>Life Kit\u003c/em>, which will be in the second part of the hour, guides you through spaces and feelings no one prepares you for — from finances to mental health, from workplace microaggressions to imposter syndrome, from relationships to parenting. The show features experts with real world experience and shares their knowledge. Because everyone needs a little help being human.\u003cbr />\u003cbr />\u003ca href=\"https://www.npr.org/podcasts/510312/codeswitch\">\u003cem>Code Switch\u003c/em> offical site and podcast\u003c/a>\u003cbr />\u003ca href=\"https://www.npr.org/lifekit\">\u003cem>Life Kit\u003c/em> offical site and podcast\u003c/a>\u003cbr />",
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"meta": {
"site": "radio",
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},
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"id": "commonwealth-club",
"title": "Commonwealth Club of California Podcast",
"info": "The Commonwealth Club of California is the nation's oldest and largest public affairs forum. As a non-partisan forum, The Club brings to the public airwaves diverse viewpoints on important topics. The Club's weekly radio broadcast - the oldest in the U.S., dating back to 1924 - is carried across the nation on public radio stations and is now podcasting. Our website archive features audio of our recent programs, as well as selected speeches from our long and distinguished history. This podcast feed is usually updated twice a week and is always un-edited.",
"airtime": "THU 10pm, FRI 1am",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Commonwealth-Club-Podcast-Tile-360x360-1.jpg",
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"meta": {
"site": "news",
"source": "Commonwealth Club of California"
},
"link": "/radio/program/commonwealth-club",
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"google": "https://podcasts.google.com/feed/aHR0cDovL3d3dy5jb21tb253ZWFsdGhjbHViLm9yZy9hdWRpby9wb2RjYXN0L3dlZWtseS54bWw",
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}
},
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"id": "forum",
"title": "Forum",
"tagline": "The conversation starts here",
"info": "KQED’s live call-in program discussing local, state, national and international issues, as well as in-depth interviews.",
"airtime": "MON-FRI 9am-11am, 10pm-11pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Forum-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED Forum with Mina Kim and Alexis Madrigal",
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"source": "kqed",
"order": 9
},
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM5NTU3MzgxNjMz",
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"freakonomics-radio": {
"id": "freakonomics-radio",
"title": "Freakonomics Radio",
"info": "Freakonomics Radio is a one-hour award-winning podcast and public-radio project hosted by Stephen Dubner, with co-author Steve Levitt as a regular guest. It is produced in partnership with WNYC.",
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"officialWebsiteLink": "http://freakonomics.com/",
"airtime": "SUN 1am-2am, SAT 3pm-4pm",
"meta": {
"site": "radio",
"source": "WNYC"
},
"link": "/radio/program/freakonomics-radio",
"subscribe": {
"npr": "https://rpb3r.app.goo.gl/4s8b",
"apple": "https://itunes.apple.com/us/podcast/freakonomics-radio/id354668519",
"tuneIn": "https://tunein.com/podcasts/WNYC-Podcasts/Freakonomics-Radio-p272293/",
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},
"fresh-air": {
"id": "fresh-air",
"title": "Fresh Air",
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"link": "/radio/program/fresh-air",
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"apple": "https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=214089682&at=11l79Y&ct=nprdirectory",
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"rss": "https://feeds.npr.org/381444908/podcast.xml"
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"info": "A live production of NPR and WBUR Boston, in collaboration with stations across the country, Here & Now reflects the fluid world of news as it's happening in the middle of the day, with timely, in-depth news, interviews and conversation. Hosted by Robin Young, Jeremy Hobson and Tonya Mosley.",
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"rss": "https://feeds.npr.org/510051/podcast.xml"
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},
"hidden-brain": {
"id": "hidden-brain",
"title": "Hidden Brain",
"info": "Shankar Vedantam uses science and storytelling to reveal the unconscious patterns that drive human behavior, shape our choices and direct our relationships.",
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"officialWebsiteLink": "https://www.npr.org/series/423302056/hidden-brain",
"airtime": "SUN 7pm-8pm",
"meta": {
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"source": "NPR"
},
"link": "/radio/program/hidden-brain",
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},
"how-i-built-this": {
"id": "how-i-built-this",
"title": "How I Built This with Guy Raz",
"info": "Guy Raz dives into the stories behind some of the world's best known companies. How I Built This weaves a narrative journey about innovators, entrepreneurs and idealists—and the movements they built.",
"imageSrc": "https://ww2.kqed.org/news/wp-content/uploads/sites/10/2018/05/howIBuiltThis.png",
"officialWebsiteLink": "https://www.npr.org/podcasts/510313/how-i-built-this",
"airtime": "SUN 7:30pm-8pm",
"meta": {
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"source": "npr"
},
"link": "/radio/program/how-i-built-this",
"subscribe": {
"npr": "https://rpb3r.app.goo.gl/3zxy",
"apple": "https://itunes.apple.com/us/podcast/how-i-built-this-with-guy-raz/id1150510297?mt=2",
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},
"hyphenacion": {
"id": "hyphenacion",
"title": "Hyphenación",
"tagline": "Where conversation and cultura meet",
"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2025/03/Hyphenacion_FinalAssets_PodcastTile.png",
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"officialWebsiteLink": "/podcasts/hyphenacion",
"meta": {
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"order": 15
},
"link": "/podcasts/hyphenacion",
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"spotify": "https://open.spotify.com/show/2p3Fifq96nw9BPcmFdIq0o?si=39209f7b25774f38",
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"amazon": "https://music.amazon.com/podcasts/6c3dd23c-93fb-4aab-97ba-1725fa6315f1/hyphenaci%C3%B3n",
"rss": "https://feeds.megaphone.fm/KQINC2275451163"
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},
"jerrybrown": {
"id": "jerrybrown",
"title": "The Political Mind of Jerry Brown",
"tagline": "Lessons from a lifetime in politics",
"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game – and Brown has some lessons he'd like to share. ",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-Political-Mind-of-Jerry-Brown-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED The Political Mind of Jerry Brown",
"officialWebsiteLink": "/podcasts/jerrybrown",
"meta": {
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"source": "kqed",
"order": 18
},
"link": "/podcasts/jerrybrown",
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"apple": "https://itunes.apple.com/us/podcast/id1492194549",
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}
},
"latino-usa": {
"id": "latino-usa",
"title": "Latino USA",
"airtime": "MON 1am-2am, SUN 6pm-7pm",
"info": "Latino USA, the radio journal of news and culture, is the only national, English-language radio program produced from a Latino perspective.",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/latinoUsa.jpg",
"officialWebsiteLink": "http://latinousa.org/",
"meta": {
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"source": "npr"
},
"link": "/radio/program/latino-usa",
"subscribe": {
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"apple": "https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?s=143441&mt=2&id=79681317&at=11l79Y&ct=nprdirectory",
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"rss": "https://feeds.npr.org/510016/podcast.xml"
}
},
"marketplace": {
"id": "marketplace",
"title": "Marketplace",
"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
"airtime": "MON-FRI 4pm-4:30pm, MON-WED 6:30pm-7pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Marketplace-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.marketplace.org/",
"meta": {
"site": "news",
"source": "American Public Media"
},
"link": "/radio/program/marketplace",
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"rss": "https://feeds.publicradio.org/public_feeds/marketplace-pm/rss/rss"
}
},
"masters-of-scale": {
"id": "masters-of-scale",
"title": "Masters of Scale",
"info": "Masters of Scale is an original podcast in which LinkedIn co-founder and Greylock Partner Reid Hoffman sets out to describe and prove theories that explain how great entrepreneurs take their companies from zero to a gazillion in ingenious fashion.",
"airtime": "Every other Wednesday June 12 through October 16 at 8pm (repeats Thursdays at 2am)",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Masters-of-Scale-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://mastersofscale.com/",
"meta": {
"site": "radio",
"source": "WaitWhat"
},
"link": "/radio/program/masters-of-scale",
"subscribe": {
"apple": "http://mastersofscale.app.link/",
"rss": "https://rss.art19.com/masters-of-scale"
}
},
"mindshift": {
"id": "mindshift",
"title": "MindShift",
"tagline": "A podcast about the future of learning and how we raise our kids",
"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Mindshift-Podcast-Tile-703x703-1.jpg",
"imageAlt": "KQED MindShift: How We Will Learn",
"officialWebsiteLink": "/mindshift/",
"meta": {
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"source": "kqed",
"order": 12
},
"link": "/podcasts/mindshift",
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"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5tZWdhcGhvbmUuZm0vS1FJTkM1NzY0NjAwNDI5",
"npr": "https://www.npr.org/podcasts/464615685/mind-shift-podcast",
"stitcher": "https://www.stitcher.com/podcast/kqed/stories-teachers-share",
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}
},
"morning-edition": {
"id": "morning-edition",
"title": "Morning Edition",
"info": "\u003cem>Morning Edition\u003c/em> takes listeners around the country and the world with multi-faceted stories and commentaries every weekday. Hosts Steve Inskeep, David Greene and Rachel Martin bring you the latest breaking news and features to prepare you for the day.",
"airtime": "MON-FRI 3am-9am",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Morning-Edition-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.npr.org/programs/morning-edition/",
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"link": "/radio/program/morning-edition"
},
"onourwatch": {
"id": "onourwatch",
"title": "On Our Watch",
"tagline": "Deeply-reported investigative journalism",
"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/On-Our-Watch-Podcast-Tile-703x703-1.jpg",
"imageAlt": "On Our Watch from NPR and KQED",
"officialWebsiteLink": "/podcasts/onourwatch",
"meta": {
"site": "news",
"source": "kqed",
"order": 11
},
"link": "/podcasts/onourwatch",
"subscribe": {
"apple": "https://podcasts.apple.com/podcast/id1567098962",
"google": "https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy5ucHIub3JnLzUxMDM2MC9wb2RjYXN0LnhtbD9zYz1nb29nbGVwb2RjYXN0cw",
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"stitcher": "https://www.stitcher.com/show/on-our-watch",
"rss": "https://feeds.npr.org/510360/podcast.xml"
}
},
"on-the-media": {
"id": "on-the-media",
"title": "On The Media",
"info": "Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us",
"airtime": "SUN 2pm-3pm, MON 12am-1am",
"imageSrc": "https://ww2.kqed.org/radio/wp-content/uploads/sites/50/2018/04/onTheMedia.png",
"officialWebsiteLink": "https://www.wnycstudios.org/shows/otm",
"meta": {
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"source": "wnyc"
},
"link": "/radio/program/on-the-media",
"subscribe": {
"apple": "https://itunes.apple.com/us/podcast/on-the-media/id73330715?mt=2",
"tuneIn": "https://tunein.com/radio/On-the-Media-p69/",
"rss": "http://feeds.wnyc.org/onthemedia"
}
},
"pbs-newshour": {
"id": "pbs-newshour",
"title": "PBS NewsHour",
"info": "Analysis, background reports and updates from the PBS NewsHour putting today's news in context.",
"airtime": "MON-FRI 3pm-4pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/PBS-News-Hour-Podcast-Tile-360x360-1.jpg",
"officialWebsiteLink": "https://www.pbs.org/newshour/",
"meta": {
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"source": "pbs"
},
"link": "/radio/program/pbs-newshour",
"subscribe": {
"apple": "https://itunes.apple.com/us/podcast/pbs-newshour-full-show/id394432287?mt=2",
"tuneIn": "https://tunein.com/radio/PBS-NewsHour---Full-Show-p425698/",
"rss": "https://www.pbs.org/newshour/feeds/rss/podcasts/show"
}
},
"perspectives": {
"id": "perspectives",
"title": "Perspectives",
"tagline": "KQED's series of daily listener commentaries since 1991",
"info": "KQED's series of daily listener commentaries since 1991.",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2025/01/Perspectives_Tile_Final.jpg",
"imageAlt": "KQED Perspectives",
"officialWebsiteLink": "/perspectives/",
"meta": {
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"source": "kqed",
"order": 14
},
"link": "/perspectives",
"subscribe": {
"apple": "https://podcasts.apple.com/us/podcast/id73801135",
"npr": "https://www.npr.org/podcasts/432309616/perspectives",
"rss": "https://ww2.kqed.org/perspectives/category/perspectives/feed/",
"google": "https://podcasts.google.com/feed/aHR0cHM6Ly93dzIua3FlZC5vcmcvcGVyc3BlY3RpdmVzL2NhdGVnb3J5L3BlcnNwZWN0aXZlcy9mZWVkLw"
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},
"planet-money": {
"id": "planet-money",
"title": "Planet Money",
"info": "The economy explained. Imagine you could call up a friend and say, Meet me at the bar and tell me what's going on with the economy. Now imagine that's actually a fun evening.",
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