Flames exploded before dawn on the steep slopes of Sepulveda Pass, forcing the closure of Interstate 405, one of the main routes between the San Fernando Valley and the L.A. basin.
Firefighters, aided by night-flying helicopters, worked to save structures in the exclusive community of Bel Air. The Los Angeles Times reported several homes have been destroyed in the area.
The Skirball Fire grew to 475 acres and was 5 percent contained by Wednesday afternoon, according to the Los Angeles Fire Department.
About 700 homes, one apartment building and one elementary school have been evacuated, with an estimated 46,000 people affected.
Four residential structures have been destroyed, and 11 were damaged by the fire, LAFD Deputy Chief Chuck Butler said.
Evacuation orders may be lifted Wednesday night, contingent on the firefighters' progress containing the fire, Butler said at a news conference.
"Although conditions look favorable right now, we do have forecasted weather coming in tonight," Butler said at the news conference. "We anticipate that the Santa Ana Winds will return later this evening, so it's critically important that we get containment on this fire prior to that time."
Hundreds of homes burned in the area during the famous Bel Air Fire in November 1961.
The Getty Center art complex, on the west side of the pass, employs extensive fire protection methods including the thickness of the walls and doors to compartmentalize any fire.
Elsewhere, use of firefighting aircraft has been constrained by the same winds that have spread the fires.
The water-dropping planes and helicopters essential to taming and containing wildfires have been mostly grounded because it's too dangerous to fly them in the strong wind. Tuesday saw gusts of over 50 mph.
Commanders hoped to have them back in the air on Wednesday morning, but all indications were that the winds will be whipping then too, fanning the flames that spurred evacuation orders for nearly 200,000 people, destroyed nearly 200 homes and remained mostly out control.
"The prospects for containment are not good," Ventura County Fire Chief Mark Lorenzen said at a news conference Tuesday. "Really, Mother Nature's going to decide when we have the ability to put it out."
Southern California's Santa Ana winds have long contributed to some of the region's most disastrous wildfires. They blow from the inland toward the Pacific Ocean, speeding up as they squeeze through mountain passes and canyons.
The largest and most destructive of the incidents, the 90,000-acre Thomas Fire in Ventura County northwest of Los Angeles, had reached the Pacific on Tuesday night after starting 30 miles inland a day earlier.
The wildfire jumped the U.S. 101 freeway to a rocky beach northwest of Ventura, bringing new evacuations, though officials said the sparse population and lack of vegetation in the area meant it was not overly dangerous, and the highway was not closed.
The fire had destroyed at least 150 structures, but incident commander Todd Derum said he suspects hundreds more homes have already been lost, though firefighters have been unable to assess them.
Lisa Kermode and her children returned to their home Tuesday after evacuating Monday to find their home and world in ashes, including a Christmas tree and the presents they had just bought.
"We got knots in our stomach coming back up here," Kermode said. "We lost everything, everything, all our clothes, anything that was important to us. All our family heirlooms — it's not sort of gone, it's completely gone."
Mansions and modest homes alike were in flames in the city. Dozens of houses in one neighborhood burned to the ground.
John Keasler, 65, and his wife Linda raced out of their apartment building as the flames approached, then stood and watched the fire burn it to the ground.
"It is sad," Keasler said. "We loved this place. We lost everything."
Linda Keasler said they were just glad to be alive despite losing so much.
"Those things we can always get back," she said. "The truth is it is just things and thank god no one died."
Some 12,000 structures were under threat.
A spokesman for the American Red Cross says they expect a shelter in Ventura County to be at capacity Tuesday night.
Fred Mariscal says Red Cross officials expect about 400 people at the shelter Tuesday night.
He says the shelter is serving meals, providing a mobile shower truck and has doctors and nurses on hand to provide medication for residents who were displaced by the wildfire.
While the blazes brought echoes of the firestorm in Northern California that killed 44 people two months ago, no deaths and only a handful of injuries had been reported.
In the foothills of northern Los Angeles, 30 structures burned. Mayor Eric Garcetti said the gusty winds expected to last most of the week had created a dangerous situation and he urged 150,000 people under mandatory evacuation orders to leave their homes before it's too late.
"We have lost structures, we have not lost lives," he said. "Do not wait. Leave your homes."
Fires are not typical in Southern California this time of year but can break out when dry vegetation and too little rain combine with the Santa Ana winds. Hardly any measurable rain has fallen in the region over the past six months.
Fires in suburban settings like these are likely to become more frequent as climate change makes fire season a year-round threat and will put greater pressure on local budgets, said Char Miller, a professor of environmental analysis at Pomona College who has written extensively about wildfires.
"There are going to be far greater numbers that are going to be evacuated, as we're seeing now," Miller said. "These fires are not just fast and furious, but they're really expensive to fight."
In Los Angeles County, television shows with large outdoor sets including HBO's "Westworld" and CBS's "S.W.A.T." halted production of because of worries about the safety of cast and crew.
And the Los Angeles Rams of the NFL, which hold workouts near the Ventura County fire, canceled practice Wednesday.
Dalton reported from Los Angeles. Krysta Fauria in Santa Paula and Brian Melley, Robert Jablon, John Antczak, Chris Carlson and Michael Balsamo in Los Angeles contributed to this report.