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"content": "\u003cp>More than 10 million Americans have trouble distinguishing red from green or blue from yellow, and there's no treatment for colorblindness.\u003c/p>\n\u003cp>A biotech company and two scientists hope to change that.\u003c/p>\n\u003cp>On Wednesday, Avalanche Biotechnologies in Menlo Park and the University of Washington in Seattle \u003ca href=\"http://investors.avalanchebiotech.com/phoenix.zhtml?c=253634&p=irol-newsArticle&ID=2028354\">announced\u003c/a> a licensing agreement to develop the first treatment for colorblindness. The deal brings together a gene therapy technique developed by Avalanche with the expertise of vision researchers at the University of Washington.\u003c/p>\n\u003cp>\"Our goal is to be treating colorblindness in clinical trials in patients in the next one to two years,\" says \u003ca href=\"http://www.avalanchebiotech.com/founders-and-management-team.php\">Thomas Chalberg\u003c/a>, the founder and CEO of Avalanche.\u003c/p>\n\u003cp>The agreement has its roots in a scientific breakthrough that occurred six years ago. That's when two vision researchers at the University of Washington used gene therapy to \u003ca href=\"http://www.npr.org/templates/story/story.php?storyId=112897277\">cure\u003c/a> a common form of colorblindness in squirrel monkeys.\u003c/p>\n\u003cp>[ad fullwidth]\u003c/p>\n\u003cp>\"This opened the possibility of ultimately getting this to cure colorblindness in humans,\" says \u003ca href=\"http://depts.washington.edu/givemed/prof-chair/holders/jay-neitz/\">Jay Neitz\u003c/a>, who runs the \u003ca href=\"http://www.neitzvision.com/content/people.html\">Color Vision Lab\u003c/a> at UW along with his wife, \u003ca href=\"http://depts.washington.edu/givemed/prof-chair/holders/maureen-neitz/\">Maureen Neitz\u003c/a>.\u003c/p>\n\u003cp>The couple knew that transferring their success from monkey to man would be a challenge. But they were determined, says Maureen Neitz. \"We've spent our entire careers writing NIH grants where we say our goal is to improve human health.\"\u003c/p>\n\u003cp>Colorblindness is usually a genetic disorder. About 8 percent of men inherit a mutation on the X chromosome that makes it hard for them to distinguish between red and green. The condition affects only about 0.5 percent of women, who have two X chromosomes.\u003c/p>\n\u003cp>And color vision problems can be disabling. Emails arrive every day at Neitz lab with subject lines saying things like \"colorblindness ruined my life,\" says Jay Neitz.\u003c/p>\n\u003cp>The stories often come from people who say they are unable to pursue careers as pilots or fire fighters or even electricians, whose work involves a lot of color-coded wires.\u003c/p>\n\u003cfigure id=\"attachment_844\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde.jpg\">\u003cimg class=\"wp-image-844 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-800x507.jpg\" alt=\"Dalton the squirrel monkey during the color vision test. (Courtesy Neitz Laboratory)\" width=\"800\" height=\"507\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-800x507.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-400x253.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-1180x747.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-768x486.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-320x203.jpg 320w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde.jpg 1500w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Dalton the squirrel monkey during the color vision test.\u003cbr> (Courtesy Neitz Laboratory)\u003c/figcaption>\u003c/figure>\n\u003cp>Colorblindness can also make it hard to do things like drive after dark, says Maureen Neitz. That became a big problem for her brother, who is colorblind, after his community switched from mercury street lamps, which give off bluish light, to sodium street lamps, which produce orange light.\u003c/p>\n\u003cp>\"He came home and he was shaking,\" Maureen Neitz says. \"He said everything was just a sea of lights, it was all the same colors. (He) could not tell the street lights from the brake lights from the stoplights.\"\u003c/p>\n\u003cp>Curing colorblindness involves delivering new genes to cells in the retina that respond to color. That's how Jay and Maureen Neitz cured the squirrel monkeys six years ago. But the technique they used required surgery on the retina, which is risky.\u003c/p>\n\u003cp>For people they needed a nonsurgical approach, something that had eluded researchers for years. Then a team at the University of California, Berkeley found a way to deliver genes using a simple injection into the vitreous, the clear gel that fills most of the eyeball.\u003c/p>\n\u003cp>Avalanche Biotechnologies has been working to improve and commercialize the Berkeley technique, says Chalberg. When he met Jay and Maureen Neitz at a scientific conference in 2012, he says, it was clear they could work together.\u003c/p>\n\u003cp>It should be possible to begin experimentally treating patients within a couple of years, Chalberg says, because the human eye has proved to be a safe and relatively easy place to use gene therapy. \"We like to say what happens in the eye stays in the eye, because it's kind of this small enclosed space.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>And a cure for colorblindness has the potential to help millions of people, Chalberg says. \"People with this vision disorder have a very limited sensation,\" he says. \"They can only see about 1 percent of the colors of a normal person. And so in some ways it's actually closer to being blind than it is to being sighted.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2015 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=University+And+Biotech+Firm+Team+Up+On+Colorblindness+Therapy&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/div>\n\n",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003cp>More than 10 million Americans have trouble distinguishing red from green or blue from yellow, and there's no treatment for colorblindness.\u003c/p>\n\u003cp>A biotech company and two scientists hope to change that.\u003c/p>\n\u003cp>On Wednesday, Avalanche Biotechnologies in Menlo Park and the University of Washington in Seattle \u003ca href=\"http://investors.avalanchebiotech.com/phoenix.zhtml?c=253634&p=irol-newsArticle&ID=2028354\">announced\u003c/a> a licensing agreement to develop the first treatment for colorblindness. The deal brings together a gene therapy technique developed by Avalanche with the expertise of vision researchers at the University of Washington.\u003c/p>\n\u003cp>\"Our goal is to be treating colorblindness in clinical trials in patients in the next one to two years,\" says \u003ca href=\"http://www.avalanchebiotech.com/founders-and-management-team.php\">Thomas Chalberg\u003c/a>, the founder and CEO of Avalanche.\u003c/p>\n\u003cp>The agreement has its roots in a scientific breakthrough that occurred six years ago. That's when two vision researchers at the University of Washington used gene therapy to \u003ca href=\"http://www.npr.org/templates/story/story.php?storyId=112897277\">cure\u003c/a> a common form of colorblindness in squirrel monkeys.\u003c/p>\n\u003cp>\u003c/p>\u003c/div>",
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"content": "\u003cdiv class=\"post-body\">\u003cp>\u003c/p>\n\u003cp>\"This opened the possibility of ultimately getting this to cure colorblindness in humans,\" says \u003ca href=\"http://depts.washington.edu/givemed/prof-chair/holders/jay-neitz/\">Jay Neitz\u003c/a>, who runs the \u003ca href=\"http://www.neitzvision.com/content/people.html\">Color Vision Lab\u003c/a> at UW along with his wife, \u003ca href=\"http://depts.washington.edu/givemed/prof-chair/holders/maureen-neitz/\">Maureen Neitz\u003c/a>.\u003c/p>\n\u003cp>The couple knew that transferring their success from monkey to man would be a challenge. But they were determined, says Maureen Neitz. \"We've spent our entire careers writing NIH grants where we say our goal is to improve human health.\"\u003c/p>\n\u003cp>Colorblindness is usually a genetic disorder. About 8 percent of men inherit a mutation on the X chromosome that makes it hard for them to distinguish between red and green. The condition affects only about 0.5 percent of women, who have two X chromosomes.\u003c/p>\n\u003cp>And color vision problems can be disabling. Emails arrive every day at Neitz lab with subject lines saying things like \"colorblindness ruined my life,\" says Jay Neitz.\u003c/p>\n\u003cp>The stories often come from people who say they are unable to pursue careers as pilots or fire fighters or even electricians, whose work involves a lot of color-coded wires.\u003c/p>\n\u003cfigure id=\"attachment_844\" class=\"wp-caption aligncenter\" style=\"max-width: 800px\">\u003ca href=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde.jpg\">\u003cimg class=\"wp-image-844 size-medium\" src=\"http://ww2.kqed.org/futureofyou/wp-content/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-800x507.jpg\" alt=\"Dalton the squirrel monkey during the color vision test. (Courtesy Neitz Laboratory)\" width=\"800\" height=\"507\" srcset=\"https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-800x507.jpg 800w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-400x253.jpg 400w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-1180x747.jpg 1180w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-768x486.jpg 768w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde-320x203.jpg 320w, https://ww2.kqed.org/app/uploads/sites/13/2015/03/dalton_enl-00dfdb2bfbf90d194783e9854671a7c715cebdde.jpg 1500w\" sizes=\"(max-width: 800px) 100vw, 800px\">\u003c/a>\u003cfigcaption class=\"wp-caption-text\">Dalton the squirrel monkey during the color vision test.\u003cbr> (Courtesy Neitz Laboratory)\u003c/figcaption>\u003c/figure>\n\u003cp>Colorblindness can also make it hard to do things like drive after dark, says Maureen Neitz. That became a big problem for her brother, who is colorblind, after his community switched from mercury street lamps, which give off bluish light, to sodium street lamps, which produce orange light.\u003c/p>\n\u003cp>\"He came home and he was shaking,\" Maureen Neitz says. \"He said everything was just a sea of lights, it was all the same colors. (He) could not tell the street lights from the brake lights from the stoplights.\"\u003c/p>\n\u003cp>Curing colorblindness involves delivering new genes to cells in the retina that respond to color. That's how Jay and Maureen Neitz cured the squirrel monkeys six years ago. But the technique they used required surgery on the retina, which is risky.\u003c/p>\n\u003cp>For people they needed a nonsurgical approach, something that had eluded researchers for years. Then a team at the University of California, Berkeley found a way to deliver genes using a simple injection into the vitreous, the clear gel that fills most of the eyeball.\u003c/p>\n\u003cp>Avalanche Biotechnologies has been working to improve and commercialize the Berkeley technique, says Chalberg. When he met Jay and Maureen Neitz at a scientific conference in 2012, he says, it was clear they could work together.\u003c/p>\n\u003cp>It should be possible to begin experimentally treating patients within a couple of years, Chalberg says, because the human eye has proved to be a safe and relatively easy place to use gene therapy. \"We like to say what happens in the eye stays in the eye, because it's kind of this small enclosed space.\"\u003c/p>\n\u003cp>\u003c/p>\n\u003cp>And a cure for colorblindness has the potential to help millions of people, Chalberg says. \"People with this vision disorder have a very limited sensation,\" he says. \"They can only see about 1 percent of the colors of a normal person. And so in some ways it's actually closer to being blind than it is to being sighted.\"\u003c/p>\n\u003cdiv class=\"fullattribution\">Copyright 2015 NPR. To see more, visit http://www.npr.org/.\u003cimg src=\"http://www.google-analytics.com/__utm.gif?utmac=UA-5828686-4&utmdt=University+And+Biotech+Firm+Team+Up+On+Colorblindness+Therapy&utme=8(APIKey)9(MDAxOTAwOTE4MDEyMTkxMDAzNjczZDljZA004)\" alt=\"\">\u003c/div>\n\n\u003c/div>\u003c/p>",
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"info": "What kind of no sabo word is Hyphenación? For us, it’s about living within a hyphenation. Like being a third-gen Mexican-American from the Texas border now living that Bay Area Chicano life. Like Xorje! Each week we bring together a couple of hyphenated Latinos to talk all about personal life choices: family, careers, relationships, belonging … everything is on the table. ",
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"info": "The Political Mind of Jerry Brown brings listeners the wisdom of the former Governor, Mayor, and presidential candidate. Scott Shafer interviewed Brown for more than 40 hours, covering the former governor's life and half-century in the political game – and Brown has some lessons he'd like to share. ",
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"marketplace": {
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"info": "Our flagship program, helmed by Kai Ryssdal, examines what the day in money delivered, through stories, conversations, newsworthy numbers and more. Updated Monday through Friday at about 3:30 p.m. PT.",
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"mindshift": {
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"info": "The MindShift podcast explores the innovations in education that are shaping how kids learn. Hosts Ki Sung and Katrina Schwartz introduce listeners to educators, researchers, parents and students who are developing effective ways to improve how kids learn. We cover topics like how fed-up administrators are developing surprising tactics to deal with classroom disruptions; how listening to podcasts are helping kids develop reading skills; the consequences of overparenting; and why interdisciplinary learning can engage students on all ends of the traditional achievement spectrum. This podcast is part of the MindShift education site, a division of KQED News. KQED is an NPR/PBS member station based in San Francisco. You can also visit the MindShift website for episodes and supplemental blog posts or tweet us \u003ca href=\"https://twitter.com/MindShiftKQED\">@MindShiftKQED\u003c/a> or visit us at \u003ca href=\"/mindshift\">MindShift.KQED.org\u003c/a>",
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"info": "For decades, the process for how police police themselves has been inconsistent – if not opaque. In some states, like California, these proceedings were completely hidden. After a new police transparency law unsealed scores of internal affairs files, our reporters set out to examine these cases and the shadow world of police discipline. On Our Watch brings listeners into the rooms where officers are questioned and witnesses are interrogated to find out who this system is really protecting. Is it the officers, or the public they've sworn to serve?",
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"info": "Our weekly podcast explores how the media 'sausage' is made, casts an incisive eye on fluctuations in the marketplace of ideas, and examines threats to the freedom of information and expression in America and abroad. For one hour a week, the show tries to lift the veil from the process of \"making media,\" especially news media, because it's through that lens that we see the world and the world sees us",
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"politicalbreakdown": {
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"tagline": "Politics from a personal perspective",
"info": "Political Breakdown is a new series that explores the political intersection of California and the nation. Each week hosts Scott Shafer and Marisa Lagos are joined with a new special guest to unpack politics -- with personality — and offer an insider’s glimpse at how politics happens.",
"airtime": "THU 6:30pm-7pm",
"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/Political-Breakdown-2024-Podcast-Tile-703x703-1.jpg",
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"possible": {
"id": "possible",
"title": "Possible",
"info": "Possible is hosted by entrepreneur Reid Hoffman and writer Aria Finger. Together in Possible, Hoffman and Finger lead enlightening discussions about building a brighter collective future. The show features interviews with visionary guests like Trevor Noah, Sam Altman and Janette Sadik-Khan. Possible paints an optimistic portrait of the world we can create through science, policy, business, art and our shared humanity. It asks: What if everything goes right for once? How can we get there? Each episode also includes a short fiction story generated by advanced AI GPT-4, serving as a thought-provoking springboard to speculate how humanity could leverage technology for good.",
"airtime": "SUN 2pm",
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"pri-the-world": {
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"title": "PRI's The World: Latest Edition",
"info": "Each weekday, host Marco Werman and his team of producers bring you the world's most interesting stories in an hour of radio that reminds us just how small our planet really is.",
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"imageSrc": "https://cdn.kqed.org/wp-content/uploads/2024/04/The-World-Podcast-Tile-360x360-1.jpg",
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},
"radiolab": {
"id": "radiolab",
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"info": "A two-time Peabody Award-winner, Radiolab is an investigation told through sounds and stories, and centered around one big idea. In the Radiolab world, information sounds like music and science and culture collide. Hosted by Jad Abumrad and Robert Krulwich, the show is designed for listeners who demand skepticism, but appreciate wonder. WNYC Studios is the producer of other leading podcasts including Freakonomics Radio, Death, Sex & Money, On the Media and many more.",
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"reveal": {
"id": "reveal",
"title": "Reveal",
"info": "Created by The Center for Investigative Reporting and PRX, Reveal is public radios first one-hour weekly radio show and podcast dedicated to investigative reporting. Credible, fact based and without a partisan agenda, Reveal combines the power and artistry of driveway moment storytelling with data-rich reporting on critically important issues. The result is stories that inform and inspire, arming our listeners with information to right injustices, hold the powerful accountable and improve lives.Reveal is hosted by Al Letson and showcases the award-winning work of CIR and newsrooms large and small across the nation. In a radio and podcast market crowded with choices, Reveal focuses on important and often surprising stories that illuminate the world for our listeners.",
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"officialWebsiteLink": "https://www.revealnews.org/episodes/",
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},
"rightnowish": {
"id": "rightnowish",
"title": "Rightnowish",
"tagline": "Art is where you find it",
"info": "Rightnowish digs into life in the Bay Area right now… ish. Journalist Pendarvis Harshaw takes us to galleries painted on the sides of liquor stores in West Oakland. We'll dance in warehouses in the Bayview, make smoothies with kids in South Berkeley, and listen to classical music in a 1984 Cutlass Supreme in Richmond. Every week, Pen talks to movers and shakers about how the Bay Area shapes what they create, and how they shape the place we call home.",
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"order": 16
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},
"science-friday": {
"id": "science-friday",
"title": "Science Friday",
"info": "Science Friday is a weekly science talk show, broadcast live over public radio stations nationwide. Each week, the show focuses on science topics that are in the news and tries to bring an educated, balanced discussion to bear on the scientific issues at hand. Panels of expert guests join host Ira Flatow, a veteran science journalist, to discuss science and to take questions from listeners during the call-in portion of the program.",
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},
"snap-judgment": {
"id": "snap-judgment",
"title": "Snap Judgment",
"tagline": "Real stories with killer beats",
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