2. Bring in more vaccines
The two vaccines currently authorized in the U.S. — made by Pfizer and Moderna — are complicated to handle. They're both frozen — one requires storage at ultracold temperatures and dilution in the field — they require patients to be observed for at least 15 minutes after getting their shot, and patients need to return several weeks later for a second dose.
The complexity has slowed things down, and new, simpler vaccine candidates on the horizon could help.
Providers point out that clinical guidance for how to properly administer the two available vaccines came out at the same time that doses were arriving.
"It's not that the vaccines are rolling off the trucks and we're able to administer it immediately," says Dr. Jinlene Chan, deputy secretary of public health services at the Maryland Department of Health. "Training is important to make sure that we deliver the right amount of vaccines for every individual and do it in a safe manner and as efficiently as possible without waste."
Even as health care workers get the hang of handling these Pfizer and Moderna vaccines, officials are looking ahead to other promising vaccine candidates that would add to the available supply.
"We have heard that both Johnson & Johnson as well as AstraZeneca plan to submit their proposals for an [Emergency Use Authorization] by the end of this month or in February," says Levine of ASTHO. "We'll see how the science is and what the FDA and the CDC decide — but potentially the distribution of more vaccines, especially the one-dose Johnson and Johnson [vaccine], would ramp things up significantly."
Neither of these vaccines have the ultracold storage requirements that the Pfizer vaccine does — they can be kept at refrigerator or freezer temperatures for longer, giving planners much more flexibility.
Jason Schwartz, health policy professor at Yale University, agrees that there's a lot of enthusiasm for the Johnson & Johnson vaccine. "A one-dose vaccine would be a game changer for the vaccination program here in the United States in the months ahead," he says.
Since many vaccine candidates are already being manufactured and can be ready to go once federal health agencies give the green light, the stock of vaccine that's available could increase very quickly.
And once there are more vaccine doses to go around, "we can distribute more generously to doctors' offices, federally qualified health care centers, rural health centers, chain pharmacies, retail pharmacies, community pharmacies — we can't distribute to all of those places if we don't have enough quantity," says Kentucky public health commissioner Dr. Steven Stack.
3. Open up the 'mega-sites'
So far, the vaccines have been mostly delivered to hospitals to reach front-line health workers and long-term care facilities for residents and staff.
But several states, including New Jersey and Texas, are starting up "mega-sites" — vaccination clinics designed to vaccinate hundreds or thousands of people each day. More of these venues will likely crop up across the country as federal funding allows health officials to hire temporary staff and pay for space and supplies, and as soon as the supply of vaccine is steady enough to keep these clinics stocked at full volume.
There should be "mass vaccination clinics in high school gymnasiums, convention centers, and mall parking lots in every county in America," says Schwartz. These types of sites will be essential as the pool of people eligible to get vaccinated expands.
The key to making this work at the scale needed is federal funding and logistical support, Schwartz argues, since hospitals are already overstretched caring for COVID-19 patients, and local and state governments don't have the money to pull it off on their own.
4. Make the supply more predictable
If vaccine providers have doses of vaccine ready to go, but no one is scheduled to receive them, that's a problem. It's also a problem if there are patients scheduled — but no vaccine.
"[Once], our Moderna shipment just didn't show up; we have no idea where it went," says Dr. Grace Lee, a medical officer at Stanford Children's Hospital who serves as a vaccine adviser for the CDC and California. "We were planning around those doses, so we had to slow down for a little bit."
A match between supply and demand is key to making the vaccination campaign go smoothly. There was a major hiccup at the federal level early on: General Gus Perna, the logistics lead of Operation Warp Speed, had to apologize for telling states that more vaccine would be available than was actually ready to go. State and local officials say predictability has gotten better, but there are still inconsistencies.
A steadier supply of vaccine doses would help vaccine providers plan so that there are patients ready to go for every dose that comes in.
5. Unleash the public awareness campaigns
There's one more key to a speedy vaccine rollout: a public ready and eager to get vaccinated. Health officials in Kentucky, Ohio and other states say that hesitancy has slowed down their vaccination campaigns.
To combat misinformation and reassure the public that the vaccines are safe and effective, comprehensive public awareness campaigns will be crucial. That includes national efforts from the incoming Biden administration and a $50 million ad campaign planned by the Ad Council, alongside state and local efforts to get the word out.
"States need to have vaccine confidence outreach teams that are fully resourced to go out into communities and educate members of the public about the importance of these vaccines," says Dr. Kelly Moore, deputy director of the nonprofit advocacy group the Immunization Action Coalition. Those teams will need "to answer their questions, to dispel myths, to encourage them to make a decision to be vaccinated and to communicate with them about how they receive the vaccine in their own state."
The effort needs to be state-specific since every state has a slightly different distribution plan, says Adriane Casalotti, chief of government and public affairs at NACCHO, the National Association of County and City Health Officials. Otherwise, "people are watching the nightly news and really trying to figure out, 'Why do these people have access but these people [in another state] don't?'"
In Michigan, at the Washtenaw County Health Department, there's a team dedicated to answering emails and calls about vaccine distribution. "We've been inundated for weeks now with questions about 'When and where can I get my vaccine?' " says spokesperson Susan Ringler-Cerniglia. "It's been a challenge because people want and expect us to be able to tell them this date and this time, and we're just not there yet."
As the long-awaited federal funding comes in and health departments are able to ramp up vaccine administration and activate their communication plans, they're hoping to be able to get those answers out to the public soon.
Rob Stein and Allison Aubrey contributed to this report.
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