It will probably take more than a human FOXP2 gene to reach this future.Scientists have started to look at DNA to try to figure out why we can speak and other animals can't.  One gene that has caught their attention is called FOXP2.

People with a certain version of this gene have trouble forming words and speaking but are otherwise OK.  This is exactly what you would expect if a gene were primarily involved in speech.

One way to test this idea would be to put the human version of the gene into an animal and see what happens to that animal's speech.  A natural candidate would be the chimpanzee.  Humans and chimps are around 98.8% similar at the DNA level* and their FOXP2 gene has only two differences.

Unfortunately (or fortunately…), we can't yet do this experiment because we aren't very good at changing a chimp's genes.  But what we are good at is changing a mouse's gene.  And this is exactly what scientists did in a new study.

The scientists changed a mouse's FOXP2 gene into a human's.  Now no one expected that we'd have a Mickey Mouse on our hands.  Mice just don't have all the equipment for speech and it is really unlikely that the only difference between mice and people in terms of speech is this gene.

But by putting a human FOXP2 gene in mice, we can learn some things about how the gene influences human speech.  Does it change the vocalization part of the brain?  Does it change something with mouth anatomy?  Something with breathing?

The results with these mice were interesting.  They weren't suddenly chatty but changing the gene definitely caused the mice to emit different squeaks than their natural cousins.  The vocalization part of the mouse's brain also changed.

These results suggest that FOXP2 affects human speech at least partly through changes in the brain.  And that if you give a mouse a human Foxp2 gene, you change the way it communicates.

The next steps are a little harder to figure out.  We do know that Neanderthals had the same FOXP2 gene that we do.  Perhaps by comparing human, chimp and Neanderthal DNA we'll be able to find other genes involved in speech too.  We'll have to wait a few months for this kind of analysis as the Neanderthal genome isn't quite done yet.

*When we include extra copies of some DNA and missing DNA, the similarity goes down to 96%.

Here is a video discussing the results of the study.

Photo by: Melissa Batson

And how they put a snare in the plan for chimps and humans to live together.

In the Budongo Forests of Uganda, a large group of Chimpanzees, named by researchers The Sonso Group, attempt to thrive in their natural habitat, eating plants and small prey. At the same time, humans who live around the forest are also trying to survive, working at places like the local sugarcane plantation and living in straw and mud houses. For food, they set out into the forest with small snares and aim for duiker and or pig.

Most of these snares are made from wire. As chimpanzees walk through the forest, their hands or feet may become trapped in the snare. In two of the forests where chimpanzees are studied, researchers have observed up to 25 percent of chimpanzees are maimed due to snare injuries. More die.

This problem is typical all over the world. How do the chimps and people live together? How do elephants and people live together? Wolves and people? Mountain Lions and Bay Area people? Though solutions seem impossible at times, I am impressed by many of the solutions, one being that of the Budongo Snare Removal Project.

In January 2000, the Jane Goodall Institute in collaboration with the Budongo Forest Project initiated a snare removal program in the Budongo Forest Reserve. The objective is to reduce the number of snares set, reduce the number of animals caught in snares and traps, and increase the number of local people who obey wildlife laws and understand the need for protecting wildlife.

Teams of two men locate and remove snares. After the first year of operation, they found that the number of snares being set within the grid system of the research area dropped. The census teams found heavy poaching and illegal activities were being carried out in the southern end of the forest reserve, so the team near the research site extended their range.

A new education center reaches out to the local community and provides education around ecology, wildlife and the treasure that is the chimpanzees.

The Oakland Zoo adopted this project in 2001 and the support covers the salaries for four field assistants, two educators, two eco-guards, and allowances for transportation and bike repair, gum boots, rain gear, backpacks, and compasses.

Funds raised at an annual fall lecture and silent auction and on Primate Discovery Day go toward this project.This year’s Primate Day is September 27^th and the lecture, featuring Shirley McGreal, is on October 2^nd.

The Oakland Zoo also supports connection and awareness of this project by visiting the site in Uganda. Teens will be traveling there in July and adults will embark on the journey (including gorilla trecking) in October.

More spots are available on this once in a lifetime adventure. For details, email: amy@oaklandzoo.org.