Quantum mechanics and Foosball? Credit: RickyDavid.

When I began this story, it seemed pretty simple. I'd heard that scientists at Lawrence Berkeley National Lab were working to mimic photosynthesis and create a man-made version of the process that could supply us with renewable energy.

The premise is to create a "closed-loop" energy system. Artificial leaves would use water, sunlight and carbon dioxide as inputs to create fuels like butane. Those fuels would be used for transportation or fuel cells. And by burning those fuels, we would produce carbon dioxide. The cycle goes on from there.

I never thought that quantum mechanics would enter the picture. That's what I discovered at the UC Berkeley lab of Graham Fleming. He says we have a lot to thank photosynthesis for. It produces the oxygen we breathe and is the basis for the entire food chain on the planet.

Fleming's lab is dedicated to understanding how photosynthesis works so well. And one of the things they've found is that plants are somehow tapping into quantum mechanics to improve their efficiency. It's pretty complicated – but with the help of the folks in Fleming's lab, they helped me understand it through, of all things, Foosball. Here's an audio version of it to help you out.

Listen to the Building an Artificial Leaf radio report online, and listen to our Web Extra: Photosynthesis and Foosball.

You've probably heard about some of the breakthroughs in personal genome sequencing, where companies take a look at your DNA and send back your risk profile. That can be confusing information to have (check out this post from Quest blogger Dr. Barry Starr for his take on it). But there's a flip side to all this genetic research that doesn't have to do with risk: personalized medicine. That's where doctors can customize medical treatments to fit your genetic profile.

Right now, there are only a handful of drugs that are labeled with genetic information, so doctors can take it into consideration. (Here's an article from the New York Times that gives an overview).  But that doesn't mean existing medications are left out.  I spent some time with Deanna Kroetz in this story, who studies pharmacogenomics at UC San Francisco.  She explained that differences in our DNA can cause some of us to process drugs at different rates. We all metabolize drugs with enzymes in the liver, but based on expression of our DNA, we may have different levels of enzymes or our enzymes may not function as well.

There are plenty of other things that affect how we process drugs, like our diet or other drugs we're taking. But these genetic differences mean some people metabolize drugs quickly and others metabolize them slowly. One example that many people are familiar with is codeine.  Codeine is converted into morphine by our bodies and it's the morphine that actually has an effect — but that conversion depends on a particular enzyme. Some people have very low levels of the enzyme that's needed, so codeine doesn't do much for them.

They're also studying another drug response mechanism at UCSF and it has to do with our cells. Many drugs have to go inside our cells in order to have an effect, but if you think back to high school biology, you might remember that cells are protected by membranes.  It takes transporters – those special gatekeepers sitting on the cell membranes — to allow things in.  They also can spit things out of cells.

I spent some time in the lab with Rachel LaFond, a graduate student at UCSF.  She was running experiments on one particular transporter known as ABCG2. This transporter is particularly good at spitting things out of cells. Normally its job is to kick toxins out, but some cancers have been able to hijack this machinery.  Cancer cells with an over expression of this transporter can spit out chemotherapy drugs, which means they aren't helping the patient.  LaFond is working to understand this variation better, so they could one day develop a genetic test for it.

Listen to the Personalized Medicine radio report online.

The noise of all these nesting and breeding birds is almost overwhelming (check out the slideshow below for a firsthand look), but these birds speak for a lot more than themselves. Our guides, PRBO Conservation Science, have been studying these birds for 40 years. As Biologist Russell Bradley explained, these seabirds are environmental samplers. In order to raise their chicks, they depend on the food web that blooms in the spring when coastal upwelling brings nutrient-rich water to the surface. If that is disrupted or delayed, the first place scientists will see it is in these bird populations, who will either have poor or non-existent breeding seasons.

Those changes in the upwelling patterns can be due to natural variability in the system. But increasing, scientists are asking whether the changes are due to climate change. That's not an easy question to answer. There are a lot of different factors in the mix.

I spoke with Zack Powell, a professor at UC Berkeley who studies climate and upwelling, and he said it all comes down to the timing of natural cycles. First, there's El Nino – where warm water spreads across the equator and heads up the California coast. That can happen every two to seven years and when it does, it acts a barrier to upwelling, interfering with the marine food web. Scientists recently confirmed that El Nino will return this year.

Looking at changes on a longer time frame, there's the Pacific Decadal Oscillation. It's a pattern of ocean warming and cooling that can last 30 years. Powell says it can also have an effect on marine life and fisheries.

And finally, there's climate change, which comparably may cause changes on the longest time frame. Powell says there's about 100 years of historical data about the ocean conditions off the California coast and it's not much when looking at such long-lived patterns. Powell and others work on climate modeling to help answer these questions. Some of the models show that the seasonal winds may become stronger, meaning upwelling patterns could be altered. And ocean temperatures could rise significantly, changing the way warmer surface water and nutrient-rich deep water mix.

Powell says right now his focus is the granularity of the climate models. They simply can't predict changes on a small geographic scale. "For most models, the smallest footprint is about 100km and all the upwelling takes place closer to shore than that." But he's hoping there will be drastic improvements over the next few years. And if extreme changes do take place, for whatever reason, the birds will certainly tell us.

Listen to the Journey to the Farallones radio report online, and check out our Farallon Islands Interactive Map for the sights and sounds of the island. Or watch the audio slideshow below for a first-hand look.

Cal Poly's CP-4 mini-satellite in orbit. Credit: The Aerospace
Corporation.

It's a classic engineering story – a garage inventor spends years working in isolation, only to produce something that gets the attention of the world. Ok, the CubeSat story may not be quite as romantic, but it does have a lot of the same ingredients.

Professors at Stanford University and Cal Poly created CubeSats – 10 by 10 by 10 centimeter mini-satellites – as enginneering projects to give their students hands-on experience. Compared to standard satellite missions, which can run hundreds of millions of dollars and take years to complete, CubeSat missions are mean to be done cheaply and quickly.

CubeSat is also a standard – a basic blueprint that any university program can use. CubeSats are actually known as "FedEx satellites," since universities can mail them to Cal Poly to arrange a ride into space. They've created launching devices called P-Pods (a box that fits the CubeSats perfectly) so they can piggyback on larger rocket launches. Once the main cargo is deployed, the P-Pod releases the CubeSats into orbit. Depending how high they are, CubeSats can orbit for more than a decade before they burn up in the atmosphere.

What started at universities has spread – NASA, Boeing and other aerospace companies all have mini-satellite programs. Despite the small size, CubeSats are actually able to do valuable research. They can space test new technology, submitting it to all the rigors of space travel like solar radiation and launch stress. Recreating those conditions on the ground can be very expensive.

CubeSats can also gather scientific data. On Tuesday, NASA will be launching Pharmasat, which they hope will be their second nano-satellite in orbit. It will carry yeast samples, and once in orbit will hit them with an anti-fungal to see if their resistance is increased in space. NASA has previously observed that some bacteria are more resistant to antibiotics in space, something that could be dangerous for future human space travel.

You can tune in on Tuesday evening for the Pharmasat launch. Three other CubeSats from Cal Poly and other organizations will also be getting a lift into space.

Listen to the Do-It-Yourself Mini-Satellites radio report online, and see our Web Extra: Mini-Satellites Slideshow.

Hourly energy use data, now online.

I've never paid much attention to my electric meter. For most of us, it's just that box on the side of the house with a small white disk spinning inside, keeping track of our energy use. But over the next three years, all the meters of PG&E customers will be getting a major upgrade to a new, digital SmartMeter.

I met one customer, Ken Kube in Castro Valley, whose meter has already been upgraded. Since the new meters track his home energy use digitally, Kube can log into his PG&E account and see his real-time energy use. On one level, it's really the ultimate tool for parents who like to remind their kids to turn out the lights. But it's also a powerful conservation tool. Kube could see how much energy he uses at night, when his appliances are drawing power in stand-by more (what's known as "vampire" power).

These meters are just a small piece of the puzzle when it comes to a smart grid. Just what the smart grid is depends on whom you ask, but most people agree it comes down to one thing: communication. The energy landscape is changing rapidly. In addition to increasing demand, there's more renewable power like large-scale solar and wind coming online – which are often far from urban areas and are available intermittently. There's also small-scale solar on building rooftops – which means energy consumers are becoming energy producers. There will also be plug-in electric cars, which need to draw power from grid.

To manage all this, utilities and grid operators need more information than they have. And that's where meters come in. But as Kurt Yeager of the Galvin Electricity Initiative describes, it's a huge networking challenge – and a huge market opportunity.

A number of companies have jumped into the smart grid market as a result, from Silicon Valley start ups to international corporations. As Eric Miller, the Chief Solutions Officer for Trilliant describes, managing the information flow in smart grid will be the biggest challenge.

Other smart grid companies are banking on the consumer market. Google is developing the PowerMeter, an online tool that tracks home energy use. They're partnering with GE, who is positioned to work with utilities, with its meter technology, and with consumers, with smart appliances, as Sunil Sharan, the Director of the Smart Grid Initiative explains.

More on the smart grid: check out the Smart Grid at Home radio report and a slideshow of grid technology, old and new.

Chef Ryan Farr demonstrates the art of the butcher.

On Thursday night, the Society of Agriculture and Food Ecology and Meatpaper Magazine co-hosted a panel discussion at UC Berkeley titled, "The Art of the Butcher". Using whole animals from local ranches was the topic of the night, and judging from the standing room only crowd, it's an area that the sustainable agriculture community is gravitating towards.

Marissa Guggiana of Sonoma Direct led the panel, which included both chefs and producers. Melanie Eisemann and David Budworth of Avedano's butcher shop discussed how butcher shops typically don't break down whole animals in-house, and usually provide only the most popular cuts of meat such as the tenderloin, ribs and chops. At Avedano's, they encourage their customers to try lesser-known cuts that can be cheaper and more flavorful depending on the method of preparation. They also offer regular classes on how to butcher your own meat.

Producer Mark Pasternak of Devil's Gulch Ranch described the change he has seen in the marketplace from both chefs and consumers. He's able to sell his pigs to restaurants and markets that are looking for local animals that are raised outdoors, and Bay Area customers are helping to increase the demand for this sustainably raised meat. Chefs Nate Appleman of A16 and Ryan Farr of Ivy Elegance are both dedicated to using every bit of the pig that they can, from the ears and skin all the way down to the hooves. Appleman serves 20 pounds to tripe of week.

The culmination of the evening was a demonstration by Chef Ryan Farr on how to break down an entire side of a pig. It was divided up into CSA shares, which were pre-sold to members of the audience. For more on local meat CSA's, check out this Quest story.

The Truckee River Canyon. Credit: Michael Conner.

Natural capital isn't something we hear about very often, and it certainly isn't a new idea. Aldo Leopold and other conservationists recognized the role that natural ecosystems play in our lives as early as the 1940's. But understanding and measuring that role hasn't been easy. That's where the Natural Capital Project comes in.

The project focuses on ecosystem services – the natural processes that ecosystems provide and humans benefit from. Those include how forests filter our drinking water, how wetlands provide protection from storm surges, and how bees and other pollinators support our agricultural industry. While these services may not be the first thing you think of when it comes to nature, researchers are discovering that they're vital to human health and decision makers are starting to factor that it.

A few examples:

In the 1990's, New York City's water quality dropped below EPA standards. The obvious option was to built a new water filtration plant – with a hefty price tag: $6-8 billion for construction and $300 million in yearly operating expenses. Instead, the city decided to invest in the natural processes that help keep water clean. That meant looking upstream to the Catskills watershed where intact ecosystems could help filter the water. The city bought land upstream and improved sewer treatment plants – all at a much lower price: $1-1.5 billion.

In China, the Yangtze River Basin experienced devastating floods in 1998. Many believed the vast deforestation of the surrounding area had been the major cause, since it had eliminated the natural buffer that existed. Since then, the Chinese Government has adopted a system of ecosystem payments – giving subsidies to farmers to plant trees and preserve forested areas.  All in all, their program in budgeted in the billions.

The Natural Capital project has created an online tool known as InVEST that's freely available to the public. It allows users to map ecosystem services in any landscape. The project's co-found Gretchen Daily is hopeful that the tool will make it much easier for natural capital to be part of land use decision-making – especially in countries where development pressures are strong. "It's stunning to see how rapidly things are changing globally. We're losing trillions of dollars of value in natural capital in the form of rain forests and other key natural assets" Daily said. The project is already working with the government of Colombia to use InVEST and to improve their resource permitting process. You can read more about where else they're working here.

Listen to the Putting a Price on Nature radio report online.

Here's how the idea would work: Using planes or other high-altitude transport, we'd disburse millions of tons of sulfur dioxide (or hydrogen sulfide) into the stratosphere, 13 miles above the Earth. Those gases would create tiny particles, which would reflect sunlight. This process already goes on in the stratosphere – about a third of the energy from the sun is reflected back into space thanks to this dynamic. But by adding more reflecting particles, scientists think it might be possible to cool the planet – and compensate for human-induced warming.

No one has tried this idea yet – but it's something scientists have already observed — through volcanoes. In 1991, Mount Pinatubo erupted in the Philippines, spewing 20 million tons of sulfur dioxide into the atmosphere. As a result, global temperatures temporarily dropped about one degree Fahrenheit.

That doesn't necessarily mean a scheme like this would work. As UCLA Scientist Richard Turco said, it's not easy to predict how the particles would react and disburse. "If the particles are too large, that would actually create a warming effect, a greenhouse warming. Small particles are not useful because they don't reflect much radiation."

This plan isn't just a one time deal. As Turco continued, "we would need a huge monitoring system and can't afford to make any mistakes. Once you start this process, you have to maintain it for two to three centuries."

And then there's the "get out of jail free" aspect. If the focus of climate change policy becomes geoengineering, what happens to simply cutting emissions? As Professor Alan Robock of Rutgers University acknowledged, the costs and technology of geoengineering are uncertain — and it wouldn't curb other climate change impacts, like ocean acidification. "We have to focus on mitigation and keep this in our back pocket for emergencies."

According to Professor David Keith of the University of Calagry, it's worth studying geoengineering — just in case. Our greenhouse gas emissions will continue to grow. "We're not going to stop today, and even if we stopped today, there's enormous inertia," Keith said. In the event that climate change becomes catastrophic, Keith says we may need a last resort. "Whether you like or don't like this, it can be done quickly."

For more on what's new at the AGU, check out KQED's Climate Watch blog.

The Mars Science Laboratory. Credit: NASA/JPL-Caltech

When I hear about the search for alien life, it's hard not to think about all the science fiction movies with little green men and Earth-destroying spacecraft. But it's an idea that's far from science fiction for scientists at NASA Ames.

NASA is preparing to send their next rover to the surface of Mars, known as the Mars Science Laboratory. It follows the legacy of the twin rovers Spirit and Opportunity, who have survived far longer than NASA scientists expected. After four years, they're still sending data from the Martian surface. (For an update, check out this post from QUEST blogger Ben Burress).

The Mars Science Lab rover will have a few upgrades, though. It's much larger than Spirit and Opportunity and will be nuclear-powered — meaning no solar cells that are vulnerable to dust storms. It will also be carrying the most advanced lab equipment yet, some of which will look for organic matter on the surface. The goal to discover how habitable the surface could have been for life.

When it comes to what kind of life, it's microbial life that many scientists believe is the best case scenario. There have been a number of recent discoveries that are promising evidence that liquid water once existed on the surface. But if even the conditions were right for life then, they're certainly not right today. Thanks to a thin atmosphere, Mars is bombarded by solar radiation and conditions are dry and cold. Still, many scientists think there's a possibility that life could survive in the subsurface, where it's warmer and more sheltered.

The question most of us would ask, though, is: even if we found extraterrestrial life someday, how would we recognize it? NASA scientist Chris McKay explained his take to me. It turns out there are some basic things scientists believe they could look for. You can hear what he has to say in this audio clip:

McKay brought up another interesting point — we've already sent earthlings to Mars. The NASA rovers were built in clean rooms, but they're not completely sterile. Chances are there are microbes from Earth on Mars now, protected inside machinery we built. McKay believes this contamination is reversible, and there's already a policy in place to protect both Earth and Mars known as planetary protection.  You can hear McKay explain why it's so important in this clip.

No matter what the outcome of the Mars Science Lab mission, there's a lot more to discover about what Mars is like today and about its past.

Watch the Looking for Mars Life on Planet Earth report online.

The new FOCE experimental chamber being developed by MBARI scientists.

The scientists at the Monterey Bay Aquarium Research Institute (MBARI) are already well-known for uncovering some of the most extreme marine animals in the deep sea, like the incredible vampire squid. But recently, they're using their unique blend of biology and engineering to study one of the least-discussed impacts of climate change: ocean acidification.

When we hear about climate change, we tend of think of the atmosphere – and for good reason. But as MBARI scientists describe, the oceans are a key part of the process. The ocean acts like a giant sponge, absorbing carbon dioxide emissions from the air. And as we add more and more CO2 to air by burning fossil fuels, the ocean is absorbing it. On one level, it's done us a big favor. Scientists say that we would be experiencing much more extreme climate change were it not for the ocean's ability to remove the heat-trapping gas.

However, the carbon dioxide that the ocean absorbs is making the water more acidic. This isn't the first time that the oceans have become more acidic. But as is the case with many impacts of climate change, it's the rate at which acidification is happening that worries scientists the most.

As you can probably guess, the ocean is an incredibly complex system. So ocean acidification poses an interesting question to scientists: what will the impacts be on marine species and ecosystems? What they know already is that there will be winners and losers in more acidic waters. Some creatures may do fine, while others won't be able to adapt in time. Either way, food webs may feel the effects – including webs involving species that humans depend on , like salmon.

Another major concern has to do with marine animals with certain kinds of shells – known as "calcifiers." Corals, clams and others all use carbonate in the water to build their shells out of calcium carbonate. But ocean acidification reduces the amount of carbonate in the water, making it more difficult for them to make shells. That could be devastating for coral reefs, who are already facing a number of stresses.

Even if you're an animal without a shell, ocean acidification could make things difficult. Scientists are studying how much stress this could put on animals that can't regulate their internal pH, or how it could affect the larvae or reproduction of certain species. MBARI scientists are hoping that the flume they are developing to conduct FOCE experiments will help researchers answer some of these questions.

Check out the whole story – watch the "Acidic Seas" audio slide show online.