Lawrence Berkeley Lab's TEAM 0.5 is capable of resolving individual carbon atoms in the honeycomb crystal structure of graphene. See QUEST's video The World's Most Powerful Microscope for more information. Image source: Nano Letters

Fifty years later, a new field of nanotechnology has exploded. At the cutting edge, researchers are successfully manufacturing everything from corporate logos to radios that are all small enough to be stacked end-to-end perhaps a million items long across the proverbial head of a pin. The advent of personal computers and smart phones has brought the power of such miniaturization into sharp focus for the general public. In a very real sense, we have all become bottom feeders. Below is a brief progress report on the state of the field.

Microscopes: The old adage “seeing is believing” was not lost on Feynman back in the late fifties. He noted that many of the most fundamental questions in biology could be readily solved if we only had the ability to see the molecules directly. Today, new inventions such as the scanning tunneling microscope (STM), the atomic force microscope (AFM), and the transmission electron microscope (TEM) have all achieved resolution at the scale where individual atoms can actually be seen and manipulated.

Miniature Motors: Perhaps the speech’s most imaginative scenario, due to Feynman’s friend (and graduate student) Albert Hibbs, was the concept of being able to “swallow the surgeon.” Feynman imagined that we might some day be able to construct robots capable of repairing or investigating the inner reaches of an ailing patient’s body. Mixing engineering and biology like this can run quickly into thorny ethical questions. Nevertheless, interesting progress has been made. Researchers in Alex Zettl’s group at UC Berkeley have recently constructed a nano motor, for example.

Information Storage: Using order-of-magnitude arguments, Feynman argued that the Encyclopedia Britannica could be squeezed into a pin’s area if the text were reduced by a factor of 25,000. He offered a $1,000 prize to the first person capable of printing one page of any book at this scale. Tom Newman, a graduate student at Stanford, first accomplished this in 1986 with an impressive reprinting of the first page of Dickens’ classic A Tale of Two Cities. Today, you can buy the book in its entirety for only 1.9 megabytes. For a high-end smart phone with 30 gigabytes of memory, you could perhaps hold 15,000 books within the palm of your hand. Not bad.

Then again, at the extreme limit, Feynman also reasoned that you ought to be able to squeeze the text of every book that has ever been written (now more than 32 million titles according the Library of Congress) within the confines of a single speck of dust. We still have a long way to go.

When I was assigned to work on our QUEST story on nanotechnology, I braced myself for the complex terrain ahead. The focus is on the public policy implications of the surge in consumer goods containing nanoparticles. And just how big is the market for nano-manufactured goods? According to the Project on Emerging Nanotechnologies, a partnership between the Pew Charitable Trusts and the Woodrow Wilson International Center for Scholars, there are hundreds of products available to consumers that contain manufactured nanomaterials. They run the gamut from tennis rackets to toothpaste to air purifiers and even stuffed animals which contain antibacterial nanosilver. Lux Research projects that the worldwide market for nano-manufactured goods will exceed 2 trillion dollars by 2014.

Meanwhile, the federal government has been criticized for failing to regulate more stringently the use of nanoparticles and for not investing enough dollars to study the effects of their exposure. Even when the federal authorities do act, like when they ruled that germ-killing products laced with nanosilver must be registered as pesticides, it makes you scratch your head at how outdated some of our environmental laws are and ill-equipped to deal with materials that came online after the laws were written.

The nuts and bolts of producing this story were challenging as well. To lay out the public policy debate, we needed to get opinions and facts from an environmental organization, the federal government and a firm that is actually manufacturing products at the nano-scale. I was also fortunate to get access to Kent Pinkerton and his colleagues at UC Davis, who are studying the exposure effects of quantum dots and carbon nanotubes on rodents. Special thanks goes to my Associate Producer, Jenny Oh, for securing an important interview with Dr. John Howard, the director of the National Institute for Occupational Safety and Health. As I was about to commence my interview with Dr. Howard, I ran through with him the list of questions, including one about respirators and whether they would adequately protect exposure to materials that are thousands of times smaller than the human hair. Without missing a beat, Dr. Howard grabbed his pen, asked me for a sheet of paper and drew a sketch of a filter lattice, explaining how yes, thanks to Brownian motion, the tiny nanoparticles would be moving around so wildly that they would bounce off the surface of the lattice. Bigger particles, on the other hand, may get through the lattice.

Discussion about nanotechnology, its benefits, its risks, the knowns and unknowns will continue for some time. Perhaps QUEST will revisit nanotechnology as new breakthroughs emerge and science reveals more clearly how nanoparticles affect the environment and living organisms.

Watch the "Macro Concerns in a Nano World" TV Story online, as well as find additional links and resources.