Prion diseases are neurodegenerative, attacking the brain. Could they be responsible for the recent wave of Zombie attacks across the globe? Original photo: digitalsextant.

But what if there existed a substance that acted like a virus or bacteria but wasn’t living? Medicine made a revolutionary leap during the time of Louis Pasteur in the mid 1800's. The inventor of food pasteurization and one of the founding fathers of microbiology – he was able to prove germ theory. Food spoiled and organisms got sick because of the growth of bacteria and viruses within them. Within sterile environments, viruses and bacteria could be killed off and food could be preserved or organisms could recover from illness or infection. Sterilization works on living micro-organisms. Prions, however, are not living organisms.

Prions are infectious proteins. For unknown reasons, these proteins refold abnormally and cause a domino effect in surrounding proteins which in turn mutate into stable structures. Prions will then cause tissue damage and cell death to surrounding areas. Prion diseases are neurodegenerative, attacking the brain and are characterized by "holes" in the tissue. The incubation time for Prion diseases is quite long. They usually surface later in life but after they surface, the diseases are rapid and fatal. Such examples of Prion diseases include Mad Cow Disease in cattle, Scrapie in sheep and Fatal Familial Insomnia in humans. FFI is a disease that literally takes away the ability to sleep and in a few months leads to death. The Book “The Family That Couldn’t Sleep” by journalist D.T. Max follows a family in Italy that passes this disease from one generation to the next over subsequent centuries.

Prions have been and still are a medical mystery. What causes them to mutate and aggressively eat away at the brain? How can they be stopped? Because they are not living they are highly resistant to sterilization methods. While viruses and bacteria can be eradicated on equipment through heat, radiation or chemical reagents, Prions are strongly immune. Maybe Zombies are not so far off after all – lurking in the shadow of medicine has been a mutation that is resistant, brain-eating and neither alive or dead. It has some serious similarities to the zombies I have watched over and over again on the big screen.

If you want to learn more about Prions and their history, check out Down to a Science’s next reading group which is focusing on the book The Family that Couldn’t Sleep or check out the book Deadly Feasts: The "Prion" Controversy and the Public's Health by Richard Rhodes. And one more thing – Happy Halloween!

After some cajoling from the wife, I trekked down to the library to check out the science section. I was amazed at the bevy of great pop science books. Most are accessible, quick reads on pretty much every science topic under the sun. However, I'm a social creature, I wanted to discuss science books with peers.

A few quick searches and voila! Science book clubs exist right here in the Bay Area (one of them hosted by myself so I'd have more control on book selection). Lively discussion and science books, it's a good combination.

Down to a Science Book Club

Book: "How We Decide" by Jonah Lehrer

When: Monday, May 25th, 7-9 PM

Where: Books Inc, 601 Van Ness @ Turk, 2 blocks north of SF City Hall

Details: Ever had a experience of option paralysis? Like when you are looking at the 11 different types of Cheerios in the cereal aisle? If you're anything like me, decision making is an "interesting" process. Jonah Lehrer tackles the neurobiology of decision making and points out a few ways you may be able to overcome that paralysis. Watch Jonah discuss decision making at the Commonwealth Club or listen to him discuss Choice on RadioLab.

California Academy of Science Book Clubs

Teens Talk Books: Underwater Explorations

Book: Shark Life: True Stories about Sharks and the Sea by Peter Benchley

When: June 6th, 11:00 am in Education Classroom

Where: California Academy of Sciences

Coming face to face with the jaws of a great white shark.  Chasing leaping orcas near Vancouver.  Swimming with hoards of hammerheads in the Sea of Cortez.  Benchley, the author of Jaws, shares his many underwater adventures with sharks and other marine creatures, while helping the reader learn more about these majestic creatures, how to swim with them safely, and why it is vital for us to protect our oceasn.  Join us for a discussion of Benchley's fascinating read!

Reservations: Free with admission to the museum, but participants should call the Naturalist Center at 415-379-5494 to reserve a space.

Bookworms (Adult Book Group): Why Do Oceans Matter?

Book: Sea Change: A Message of the Oceans by Sylvia Earle

When: June 16th, 6:30 pm in the Naturalist Center

Where: California Academy of Sciences

Details: In recognition of World Ocean Day this month, the group will read and discuss noted marine biologist Sylvia Earle's book which is both a plea for ocean conservation and a very personal story of her own lifelong exploration of life in the deep.

Reservations: Free.  Reserve a space by calling 415-379-5494.

This Week In Science Online Book Club – Hosted by TWIS.org

An Ocean of Air: Why the Wind Blows and Other Mysteries of the Atmosphere

Details: Most of the time we hardly notice that we're moving through air. But when a storm system whips it into a whirling mass that grows into a tornado or a hurricane, then the air around us makes headlines. Science consultant Walker (Snowball Earth) presents a lively history of scientists' and adventurers' exploration of this important and complex contributor to life on Earth, from Galileo's early attempts to show that it has weight to the explorations by 20th-century scientists Oliver Heaviside and Edward Appleton of the ionosphere, which acts as a giant mirror bouncing radio waves from one side of the globe to another. Walker provides readers with easy-to-follow discussions of the science behind the discovery that carbon dioxide levels are rising exponentially.